Charge-Variant Analysis of Antibody-Drug Conjugates with Cation-Exchange Chromatography
Technical notes | 2019 | WatersInstrumentation
HPLC
IndustriesPharma & Biopharma
ManufacturerWaters
Key wordsbioresolve, emtansine, variant, adcs, trastuzumab, ado, scx, charge, antibody, drug, mab, interactions, gradient, conjugation, conjugates, brief, monoclonal, hydrophobic, tumor, salt, adc, cysteine, mobile, entailing, lysine, generic, analysis, observed, exacerbate, linked, oncology, payloads, technology, secondary, repulsive, sulfhydryl, attenuate, kadcyla, brentuximab, interchain, residues, challenging, exchange, profile, were, judged, humanized, cytotoxic, denature, phase
Similar PDF
Thermo Bio LC Columns - See your protein therapeutics in high resolution
2020|Thermo Fisher Scientific|Brochures and specifications
See your protein therapeutics in high resolution Bio LC Columns Contents 2 Introduction to monoclonal antibody (mAb) characterization 3 Affinity titer determination 4 Aggregate separation 5 Charge variant analysis 6 Oxidation variant analysis 11 Antibody drug conjugates (ADCs) analysis 12…
Key words
mabpac, mabpacmab, mabhplc, hplccolumn, columncolumns, columnsformat, formatsize, sizescfc, scfcmau, mauparticle, particlemin, minantibody, antibodymmae, mmaecharge, chargevariant
Development of Monoclonal Antibody Charge Variant Analysis Methods Using a BioResolve SCX mAb Column
2019|Waters|Applications
[ APPLICATION NOTE ] Development of Monoclonal Antibody Charge Variant Analysis Methods Using a BioResolve SCX mAb Column Hua Yang, Bill Warren, and Stephan Koza Waters Corporation, Milford, MA, USA APPLICATION BENEFITS INTRODUCTION Method development parameters for cation Charge heterogeneity…
Key words
bioresolve, bioresolvecharge, chargemab, mabvariant, variantscx, scxgradient, gradientminutes, minutesmonoclonal, monoclonalslope, slopeantibody, antibodysalt, saltcetuximab, cetuximabdevelopment, developmentcolumn, columnpeak
Characterizing Antibody-Drug Conjugates and Assigning Drug Conjugation Sites
2017|Agilent Technologies|Applications
Characterizing Antibody-Drug Conjugates and Assigning Drug Conjugation Sites Using the Agilent 1290 Infinity II 2D-LC Solution Combined with the Agilent 6530 Quadrupole Time-of-Flight LC/MS System Application Note Biopharmaceuticals Authors Abstract Koen Sandra, Gerd Vanhoenacker, Antibody-drug conjugates (ADCs) are a promising…
Key words
conjugated, conjugatedantibody, antibodyrplc, rplcmmae, mmaeconjugation, conjugationbrentuximab, brentuximabdrug, drugpeptides, peptidesadcetris, adcetrisintrachain, intrachainscdk, scdkherceptin, herceptinkadcyla, kadcylainterchain, interchainpayload
Routine analysis of drug to antibody ratio and drug distribution with maXis II
2020|Bruker|Applications
Routine analysis of drug to antibody ratio and drug distribution with maXis II Antibody drug conjugates (ADC) are small molecule conjugated mAbs. These are rapidly emerging complex biological molecules in the biopharma space. Abstract Characterization of ADC’s includes intact mass…
Key words
dar, daradc, adcbruker, brukermaxis, maxisdrug, drugantibody, antibodylinker, linkerconjugation, conjugationaverage, averagemab, mabglycoforms, glycoformsdenaturing, denaturingconjugated, conjugatedpotency, potencyinterchain