A Comprehensive Approach for HCP Identification, Quantification, and Monitoring Based on a Single Dimension (1D) LC Separation

 

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AN EFFICIENT LC-MS WORKFLOW FOR IDENTIFICATION AND MONITORING OF HOST CELL PROTEINS FOR ASSISTING MONOCLONAL ANTIBODY PURIFICATION Catalin Doneanu1, Malcolm Anderson2, Alex Xenopoulos3, Romas Skudas4, Ying Qing Yu1, Asish Chakraborty1 and Weibin Chen1 1 Waters Corporation, Milford, MA, USA;2Waters Corporation,…
Key words
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An Efficient Workflow for Identification and Monitoring of Host Cell Proteins During Monoclonal Antibody Bioprocessing Catalin Doneanu1, Malcolm Anderson2, Alex Xenopoulos3, Romas Skudas4, Ying Qing Yu1, Asish Chakraborty1, Mark Bennett1 and Weibin Chen1 1 Waters Corporation, Milford, MA; 2 Waters…
Key words
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In Depth Analysis of Host Cell Proteins from Antibody Preparations using PASEF Introduction In the rapidly expanding arena of biotherapeutic analysis and bioprocess development, the analysis of host cell proteins (HCPs) at the ppm level is critical. ELISA is currently…
Key words
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Application Note Identification of Host Cell Proteins (HPCs) in Monoclonal Antibodies At Sub-ppm Levels Using the SYNAPT XS Mass Spectrometer Catalin E. Doneanu, Alexandre Gomes, Brad J. Williams, Ying Qing Yu, Weibin Chen Waters Corporation Abstract In this application note…
Key words
hcp, hcphdmse, hdmsehcps, hcpssynapt, synaptdiscovery, discoveryassay, assayhighly, highlyacquisition, acquisitionhost, hosthpcs, hpcsudmse, udmsesensitive, sensitivelut, lutmonoclonal, monoclonalsub
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