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An Efficient Workflow for Identification and Monitoring of Host CellProteins During Monoclonal Antibody BioprocessingCatalin Doneanu1, Malcolm Anderson2, Alex Xenopoulos3, Romas Skudas4, Ying Qing Yu1, Asish Chakraborty1, Mark Bennett1 and Weibin Chen11Waters Corporation, Milford, MA; 2 Waters Corporation, Wilmslow, UK; 3EMD...
Key words
hcp, hcpscx, scxprotocol, protocolmab, mabfied, fiedmse, mseiden, idenhcps, hcpsassays, assaysdiscovery, discoveryacquisitions, acquisitionsmonitoring, monitoringprotein, proteinsearched, searchedidentification
A Comprehensive Approach for HCP Identification, Quantification,and Monitoring Based on a Single Dimension (1D) LC SeparationCatalin Doneanu, 1 Sarah Lennon, 2 Malcolm Anderson, 2 Ian Reah, 3 Mal Ross, 3 Steven Anderson, 3 Ian Morns, 3 Ying Qin Yu, 1Asish...
Key words
aldolase, aldolasebiphosphate, biphosphatefructose, fructosehcp, hcpsonar, sonarhcps, hcpstpqiqvysr, tpqiqvysrtvywdrdm, tvywdrdmmse, msehost, hostnote, noteaddgrpfpqvik, addgrpfpqvikphpypaltpeqk, phpypaltpeqksqvqasytfk, sqvqasytfkquantification
Application NoteIdentification of Host Cell Proteins (HPCs)in Monoclonal Antibodies At Sub-ppmLevels Using the SYNAPT XS MassSpectrometerCatalin E. Doneanu, Alexandre Gomes, Brad J. Williams, Ying Qing Yu, Weibin ChenWaters Corporation AbstractIn this application note we describe a highly sensitive discovery HCP assay...
Key words
hcp, hcphdmse, hdmsehcps, hcpssynapt, synaptdiscovery, discoveryassay, assayhighly, highlyhost, hostacquisition, acquisitionhpcs, hpcsudmse, udmsesensitive, sensitivesub, submonoclonal, monoclonallut
Assay for Identification and Quantification of Host Cell Protein Impurities inHigh-Purity Monoclonal Antibodies Down to 1 ppm: An Inter-Laboratory StudyCatalin E. Doneanu, Malcolm Anderson, Brad J. Williams, Matthew A. Lauber, Asish Chakraborty, and Weibin ChenWaters Corporation, Milford, MA, USAA P...
Key words
hcp, hcphcps, hcpsmobility, mobilitypeptide, peptideenergy, energyspectrum, spectrumseparation, separationhdms, hdmsprecursor, precursorfragmentation, fragmentationconfirmatory, confirmatorymobilogram, mobilogramcell, cellplgs, plgsprotein
 

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An Efficient Workflow for Identification and Monitoring of Host CellProteins During Monoclonal Antibody BioprocessingCatalin Doneanu1, Malcolm Anderson2, Alex Xenopoulos3, Romas Skudas4, Ying Qing Yu1, Asish Chakraborty1, Mark Bennett1 and Weibin Chen11Waters Corporation, Milford, MA; 2 Waters Corporation, Wilmslow, UK; 3EMD...
Key words
hcp, hcpscx, scxprotocol, protocolmab, mabfied, fiedmse, mseiden, idenhcps, hcpsassays, assaysdiscovery, discoveryacquisitions, acquisitionsmonitoring, monitoringprotein, proteinsearched, searchedidentification
A Comprehensive Approach for HCP Identification, Quantification,and Monitoring Based on a Single Dimension (1D) LC SeparationCatalin Doneanu, 1 Sarah Lennon, 2 Malcolm Anderson, 2 Ian Reah, 3 Mal Ross, 3 Steven Anderson, 3 Ian Morns, 3 Ying Qin Yu, 1Asish...
Key words
aldolase, aldolasebiphosphate, biphosphatefructose, fructosehcp, hcpsonar, sonarhcps, hcpstpqiqvysr, tpqiqvysrtvywdrdm, tvywdrdmmse, msehost, hostnote, noteaddgrpfpqvik, addgrpfpqvikphpypaltpeqk, phpypaltpeqksqvqasytfk, sqvqasytfkquantification
Application NoteIdentification of Host Cell Proteins (HPCs)in Monoclonal Antibodies At Sub-ppmLevels Using the SYNAPT XS MassSpectrometerCatalin E. Doneanu, Alexandre Gomes, Brad J. Williams, Ying Qing Yu, Weibin ChenWaters Corporation AbstractIn this application note we describe a highly sensitive discovery HCP assay...
Key words
hcp, hcphdmse, hdmsehcps, hcpssynapt, synaptdiscovery, discoveryassay, assayhighly, highlyhost, hostacquisition, acquisitionhpcs, hpcsudmse, udmsesensitive, sensitivesub, submonoclonal, monoclonallut
Assay for Identification and Quantification of Host Cell Protein Impurities inHigh-Purity Monoclonal Antibodies Down to 1 ppm: An Inter-Laboratory StudyCatalin E. Doneanu, Malcolm Anderson, Brad J. Williams, Matthew A. Lauber, Asish Chakraborty, and Weibin ChenWaters Corporation, Milford, MA, USAA P...
Key words
hcp, hcphcps, hcpsmobility, mobilitypeptide, peptideenergy, energyspectrum, spectrumseparation, separationhdms, hdmsprecursor, precursorfragmentation, fragmentationconfirmatory, confirmatorymobilogram, mobilogramcell, cellplgs, plgsprotein
 

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