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C10G-E054Solutions forBiopharmaceuticalApplication NotebookFirst Edition: December, 2017© Shimadzu Corporation, 2017 Solutions forBiopharmaceuticalIndexApplication NotebookBioanalysisLCMS Bioanalysis of Antibody Drugs Using Fab-Selective Proteolysis nSMOL - Trastuzumab analysis nSMOL, which enables selective proteolysis of the Fab region of monoclonal antibodies, was applied to Trastuzumab bioanalysis.LCMS Bioanalysis...
Key words
acid, acidamino, aminoantibody, antibodyglycan, glycannsmol, nsmolerexim, ereximstructure, structurenews, newsaggregates, aggregatesnucleic, nucleicglycans, glycansanalysis, analysisaggregate, aggregatesizer, sizerprotein
LAAN-A-LC-E264ApplicationNewsL487High Performance Liquid ChromatographyAnalysis of Polysorbate 80 in IgG Aqueous Solution byOnline SPE Using a Shim-pack MAYI Column – Part 2No.Polysorbates play a role in maintaining the stability ofproteins to prevent their denaturation, so they are oftenadded to protein formulations....
Key words
polyoxyethylene, polyoxyethylenesorbitan, sorbitanmobile, mobilepolysorbate, polysorbatephase, phasenews, newsflowrate, flowratewoh, wohuvdetector, uvdetectorpolysorbates, polysorbatesfatty, fattydeproteinization, deproteinizationcolumn, columnmass, massgradual
PO-CON1450EAnalysis of polysorbates in biotherapeuticproducts using two-dimensionalHPLC coupled with mass spectrometerASMS 2014WP 182William Hedgepeth, Kenichiro TanakaShimadzu Scientific Instruments, Inc., Columbia MD Analysis of polysorbates in biotherapeutic productsusing two-dimensional HPLC coupled with mass spectrometerIntroductionPolysorbate 80 is commonly used for biotherapeuticproducts to prevent...
Key words
polysorbates, polysorbatespolyoxyethylene, polyoxyethylenebiotherapeutic, biotherapeuticmobile, mobiledimensional, dimensionalspectrometer, spectrometerphase, phasecoupled, coupledhplc, hplcmass, massflow, flowtwo, twoisosorbide, isosorbideproducts, productssorbitan
PO-CON1513EAnalysis of Polysorbate 80 in ProteinFormulations Using 2D LCMSPittcon 20152530-11PWilliam Hedgepeth1, Kenichiro Tanaka1, Keiko Yamabe21Shimadzu Scientific Instruments, Inc., Columbia MD;Shimadzu Corporation, Kyoto Japan2 Analysis of Polysorbate 80 in Protein Formulations Using 2D LCMSIntroductionPolysorbate 80 is commonly used for biotherapeuticproducts to prevent...
Key words
polyoxyethylene, polyoxyethylenemobile, mobilephase, phasepolysorbates, polysorbatesflow, flowsorbitan, sorbitanpolysorbate, polysorbatesample, samplecolumn, columnvalve, valvepretreatment, pretreatmentdetection, detectioninjection, injectionmodel, modelbiotherapeutic
 

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C10G-E054Solutions forBiopharmaceuticalApplication NotebookFirst Edition: December, 2017© Shimadzu Corporation, 2017 Solutions forBiopharmaceuticalIndexApplication NotebookBioanalysisLCMS Bioanalysis of Antibody Drugs Using Fab-Selective Proteolysis nSMOL - Trastuzumab analysis nSMOL, which enables selective proteolysis of the Fab region of monoclonal antibodies, was applied to Trastuzumab bioanalysis.LCMS Bioanalysis...
Key words
acid, acidamino, aminoantibody, antibodyglycan, glycannsmol, nsmolerexim, ereximstructure, structurenews, newsaggregates, aggregatesnucleic, nucleicglycans, glycansanalysis, analysisaggregate, aggregatesizer, sizerprotein
LAAN-A-LC-E264ApplicationNewsL487High Performance Liquid ChromatographyAnalysis of Polysorbate 80 in IgG Aqueous Solution byOnline SPE Using a Shim-pack MAYI Column – Part 2No.Polysorbates play a role in maintaining the stability ofproteins to prevent their denaturation, so they are oftenadded to protein formulations....
Key words
polyoxyethylene, polyoxyethylenesorbitan, sorbitanmobile, mobilepolysorbate, polysorbatephase, phasenews, newsflowrate, flowratewoh, wohuvdetector, uvdetectorpolysorbates, polysorbatesfatty, fattydeproteinization, deproteinizationcolumn, columnmass, massgradual
PO-CON1450EAnalysis of polysorbates in biotherapeuticproducts using two-dimensionalHPLC coupled with mass spectrometerASMS 2014WP 182William Hedgepeth, Kenichiro TanakaShimadzu Scientific Instruments, Inc., Columbia MD Analysis of polysorbates in biotherapeutic productsusing two-dimensional HPLC coupled with mass spectrometerIntroductionPolysorbate 80 is commonly used for biotherapeuticproducts to prevent...
Key words
polysorbates, polysorbatespolyoxyethylene, polyoxyethylenebiotherapeutic, biotherapeuticmobile, mobiledimensional, dimensionalspectrometer, spectrometerphase, phasecoupled, coupledhplc, hplcmass, massflow, flowtwo, twoisosorbide, isosorbideproducts, productssorbitan
PO-CON1513EAnalysis of Polysorbate 80 in ProteinFormulations Using 2D LCMSPittcon 20152530-11PWilliam Hedgepeth1, Kenichiro Tanaka1, Keiko Yamabe21Shimadzu Scientific Instruments, Inc., Columbia MD;Shimadzu Corporation, Kyoto Japan2 Analysis of Polysorbate 80 in Protein Formulations Using 2D LCMSIntroductionPolysorbate 80 is commonly used for biotherapeuticproducts to prevent...
Key words
polyoxyethylene, polyoxyethylenemobile, mobilephase, phasepolysorbates, polysorbatesflow, flowsorbitan, sorbitanpolysorbate, polysorbatesample, samplecolumn, columnvalve, valvepretreatment, pretreatmentdetection, detectioninjection, injectionmodel, modelbiotherapeutic
 

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