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CORRELATING DIFFERENTIAL ENDOGENOUS METABOLITE PROFILES WITH THE PHARMACOKINETICS OF GEFITINIBAND ITS ASSOCIATED DRUG METABOLITES USING AN ION MOBILITY BASED APPROACHLee A. Gethings1, Martin Palmer1, Adam King1, Lauren Mullin1, Ian D. Wilson2, Robert S. Plumb31Waters Corp., Wilmslow, UK; 2Imperial College, London,...
Key words
gefitinib, gefitiniburine, urineims, imscorrelation, correlationpathways, pathwaysmetabolites, metabolitesendogenous, endogenousdosed, dosedcorrelating, correlatingpearson, pearsonranked, rankedmetabolite, metabolitemice, miceoral, oraldose
Identifying changes in ethanol metabolism and endogenous metabolic profiles following the administration of alcohol as a liquid diet to miceSimon Ashton1; Neil J Loftus1; Alan Barnes1; Ian D Wilson2; Filippos Michopoulos2; Ji Cheng31ShimadzuMS/BU, Manchester, UK; 2Astra Zeneca, Alderley Park, Cheshire,...
Key words
diet, dietethyl, ethylliver, liveralcohol, alcoholretinol, retinolstudy, studydifferences, differencestargeted, targetedmetabolism, metabolismmouse, mouseendogenous, endogenousglucuronoide, glucuronoideintragastric, intragastricinterestingly, interestinglyethylated
Assessing metabolic profiles in chimeric PXB mouse with humanized livers following oral dosing of troglitazone.Alan Barnes1; Neil J Loftus1; Kirsten Hobby1; Ian Wilson2; Yoshio Morikawa31ShimadzuMS/BU, Manchester, UK; 2Astra Zeneca, Alderley Park, Cheshire, UK; 3PhoenixBio Co. Ltd, Higashi-Hiroshima, Japan1: IntroductionTable 1....
Key words
pxb, pxbscid, scidtgz, tgzhydroxy, hydroxyglucuronide, glucuronidediacylglycerophosphocholine, diacylglycerophosphocholinesulfate, sulfatetroglitazone, troglitazonehydrated, hydratedmetid, metidmice, micemsn, msnglycerophosphocholine, glycerophosphocholineenabled, enabledliver
PO-CON1251ESystems based LC-MSmetabolite profiling of micetreated with ethanol enrichedliquid dietsIMSC 2012PWe-095Simon Ashton1; Neil J Loftus1; Alan Barnes1;Ian D Wilson2; Filippos Michopoulos2;Ji Cheng31Shimadzu MS/BU, Manchester, UK;2Astra Zeneca, Alderley Park, Cheshire, UK;3University of Southern California, Los Angeles, CA Systems based LC-MS metabolite profiling...
Key words
diets, dietsmice, miceethanol, ethanoltreated, treatedenriched, enrichedprofiling, profilingliquid, liquidmetabolite, metabolitealcohol, alcoholintragastric, intragastricliver, livermetabolites, metabolitesstudy, studysystems, systemsdifferences
 

Similar PDF

CORRELATING DIFFERENTIAL ENDOGENOUS METABOLITE PROFILES WITH THE PHARMACOKINETICS OF GEFITINIBAND ITS ASSOCIATED DRUG METABOLITES USING AN ION MOBILITY BASED APPROACHLee A. Gethings1, Martin Palmer1, Adam King1, Lauren Mullin1, Ian D. Wilson2, Robert S. Plumb31Waters Corp., Wilmslow, UK; 2Imperial College, London,...
Key words
gefitinib, gefitiniburine, urineims, imscorrelation, correlationpathways, pathwaysmetabolites, metabolitesendogenous, endogenousdosed, dosedcorrelating, correlatingpearson, pearsonranked, rankedmetabolite, metabolitemice, miceoral, oraldose
Identifying changes in ethanol metabolism and endogenous metabolic profiles following the administration of alcohol as a liquid diet to miceSimon Ashton1; Neil J Loftus1; Alan Barnes1; Ian D Wilson2; Filippos Michopoulos2; Ji Cheng31ShimadzuMS/BU, Manchester, UK; 2Astra Zeneca, Alderley Park, Cheshire,...
Key words
diet, dietethyl, ethylliver, liveralcohol, alcoholretinol, retinolstudy, studydifferences, differencestargeted, targetedmetabolism, metabolismmouse, mouseendogenous, endogenousglucuronoide, glucuronoideintragastric, intragastricinterestingly, interestinglyethylated
Assessing metabolic profiles in chimeric PXB mouse with humanized livers following oral dosing of troglitazone.Alan Barnes1; Neil J Loftus1; Kirsten Hobby1; Ian Wilson2; Yoshio Morikawa31ShimadzuMS/BU, Manchester, UK; 2Astra Zeneca, Alderley Park, Cheshire, UK; 3PhoenixBio Co. Ltd, Higashi-Hiroshima, Japan1: IntroductionTable 1....
Key words
pxb, pxbscid, scidtgz, tgzhydroxy, hydroxyglucuronide, glucuronidediacylglycerophosphocholine, diacylglycerophosphocholinesulfate, sulfatetroglitazone, troglitazonehydrated, hydratedmetid, metidmice, micemsn, msnglycerophosphocholine, glycerophosphocholineenabled, enabledliver
PO-CON1251ESystems based LC-MSmetabolite profiling of micetreated with ethanol enrichedliquid dietsIMSC 2012PWe-095Simon Ashton1; Neil J Loftus1; Alan Barnes1;Ian D Wilson2; Filippos Michopoulos2;Ji Cheng31Shimadzu MS/BU, Manchester, UK;2Astra Zeneca, Alderley Park, Cheshire, UK;3University of Southern California, Los Angeles, CA Systems based LC-MS metabolite profiling...
Key words
diets, dietsmice, miceethanol, ethanoltreated, treatedenriched, enrichedprofiling, profilingliquid, liquidmetabolite, metabolitealcohol, alcoholintragastric, intragastricliver, livermetabolites, metabolitesstudy, studysystems, systemsdifferences
 

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