Analysis of Monoclonal Antibodies

Applications | 2016 | Agilent TechnologiesInstrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS, 2D-LC
Industries
Pharma & Biopharma
Manufacturer
Agilent Technologies
Key words
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Application Note Biopharma/Pharma Characterization of Antibody‑Drug Conjugates Using 2D-LC and Native MS Authors David L. Wong and Sarah M. Stow Agilent Technologies, Inc. Abstract Antibody drug conjugates (ADCs), which comprise a monoclonal antibody (mAb) conjugated to a small molecule drug…
Key words
dimension, dimensiondar, daradcs, adcsadc, adcsecond, secondnative, nativehic, hicadvancebio, advancebiocounts, countsmab, mabdrug, drugdeconvoluted, deconvolutedfirst, firstconjugated, conjugatedintact
Size Exclusion Chromatography/ Mass Spectrometry Analysis of Antibody Drug Conjugates Using the Agilent 1260 Infinity II Bio-Inert LC Application Note Biologics & Biosimilars Author Abstract Sonja Schneider Recombinant monoclonal antibodies (mAbs) have emerged as important Agilent Technologies, Inc. therapeutic agents…
Key words
adcs, adcsdeconvoluted, deconvolutedadc, adctrastuzumab, trastuzumabdeglycosylated, deglycosylatedmass, masscounts, countsdrug, drugantibody, antibodysec, seclinker, linkerspectrum, spectrumcharge, chargedar, darconjugates
Analysis of Antibody-Drug Conjugates Using Size Exclusion Chromatography and Mass Spectrometry Application Note Biologics and Biosimilars Author Abstract Sonja Schneider Recombinant monoclonal antibodies (mAbs) have emerged as important Agilent Technologies, Inc. therapeutic agents for the treatment of different diseases. This…
Key words
trastuzumab, trastuzumabadcs, adcsadc, adcemtansine, emtansinedeconvoluted, deconvolutedcounts, countsdrug, drugdeglycosylated, deglycosylatedamu, amusec, secmass, massmabs, mabsspectrum, spectrumbuffer, bufferantibody
Application Note Biopharma/Pharma Determination of Multiple Attributes of Monoclonal Antibodies Simultaneous and parallel multi-attribute analysis using 3D-LC/MS with 2D multimethod option mAb SEC Size variants Protein A CEX LC/MS mAb Titer Charge variants Mol wt (MW) AA sequence PTM Cell…
Key words
trastuzumab, trastuzumaboriginator, originatorcex, cexmau, mauhmw, hmwhic, hiccho, choprotein, proteinvariants, variantscounts, countsdeconvoluted, deconvolutedclone, cloneclones, clonesvalve, valvemin
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