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3D spheroid culture as a tool for studying drug metabolism
2019|Thermo Fischer Scientific|Applications
APPLICATION NOTE Human spheroid-qualified hepatocytes 3D spheroid culture as a tool for studying drug metabolism Introduction The primary human hepatocyte (PHH) three-dimensional (3D) culture model developed by Thermo Fisher Scientific holds promise for disease modeling and functional studies. As the…
Key words
gibco, gibcodextrorphan, dextrorphanhepatocyte, hepatocytespheroid, spheroidhydroxybupropion, hydroxybupropionabundance, abundancerelative, relativeacetaminophen, acetaminophencyp, cyphepatocytes, hepatocyteswilliams, williamstolbutamide, tolbutamidehepatic, hepaticbupropion, bupropionexactive
High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Cytochrome P450 Inhibition Application Note Authors Vaughn Miller Agilent Technologies, Inc. Wakefield, MA, USA Introduction Analysis of cytochrome P450 (CYP) inhibition is an important component of the drug discovery process as…
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remainingactivity, activityinhibition, inhibitioncyp, cypdrug, drugazamulin, azamulincytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Cytochrome P450 Inhibition Application Note Authors Vaughn Miller Agilent Technologies, Inc. Wakefield, MA, USA Introduction Analysis of cytochrome P450 (CYP) inhibition is an important component of the drug discovery process as…
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remainingactivity, activityinhibition, inhibitioncyp, cypazamulin, azamulindrug, drugcytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
METABOQUAN-R UPLC/MS/MS ANALYSIS OF 9 METABOLITES FOR CYTOCHROME P450 INHIBITION STUDIES IN A SINGLE ANALYTICAL RUN Billy Joe Molloy1, Catherine Pearson2, Phil Butler2, Robert Plumb1, Robert Riley2 1) Waters Corporation 2) Cyprotex RESULTS METHODS MetaboQuan-R is a high-throughput, generic UPLC…
Key words
dextrorphan, dextrorphanmetaboquan, metaboquandmpk, dmpkacetaminophen, acetaminophencassetting, cassettingmephenytoin, mephenytoindiscovery, discoverymetabolites, metabolitesplatform, platformpaclitaxel, paclitaxelphenacetin, phenacetinseparate, separateinitial, initialbiomedical, biomedicalmetoprolol
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