UPLC/MS/MS ANALYSIS OF 9 METABOLITES FOR CYTOCHROME P450 INHIBITION STUDIES IN A SINGLE ANALYTICAL RUNPosters | 2019 | WatersInstrumentation
LC/MS, LC/MS/MS, LC/QQQ
Industries
Metabolomics
Manufacturer
Waters
Key words

 

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3D spheroid culture as a tool for studying drug metabolism
2019|Thermo Fischer Scientific|Applications
APPLICATION NOTEHuman spheroid-qualified hepatocytes3D spheroid culture as a tool for studyingdrug metabolismIntroductionThe primary human hepatocyte (PHH) three-dimensional(3D) culture model developed by Thermo Fisher Scientificholds promise for disease modeling and functional studies.As the liver is the principal site of metabolism for...
Key words
gibco, gibcospheroid, spheroiddextrorphan, dextrorphanhepatocyte, hepatocytehydroxybupropion, hydroxybupropionabundance, abundancerelative, relativewilliams, williamsacetaminophen, acetaminophenvanquish, vanquishhepatocytes, hepatocytescyp, cyphepatic, hepatictolbutamide, tolbutamideexactive
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugazamulin, azamulincytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugazamulin, azamulincytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput Analysis ofCytochrome P450 Inhibition in IntactHuman HepatocytesApplication NoteAuthorsAbstractKari E. Schlicht and Vaughn P. MillerUltrafast methods of analysis were developed using the Agilent RapidFireAgilent Technologies, Inc.High‑Throughput Mass Spectrometry System in combination with an AgilentWakefield, MA6490 Triple Quadrupole Mass Spectrometer for...
Key words
hepatocytes, hepatocytesinhibition, inhibitionsip, sipcyp, cyprapidfire, rapidfiresensor, sensoractivity, activityvitro, vitrolog, logdesethylamodiaquine, desethylamodiaquinehlms, hlmshydralazine, hydralazinenaphthoflavone, naphthoflavonethroughput, throughputcryopreserved

UPLC/MS/MS ANALYSIS OF 9 METABOLITES FOR CYTOCHROME P450 INHIBITION STUDIES IN A SINGLE ANALYTICAL RUNPosters | 2019 | WatersInstrumentation
LC/MS, LC/MS/MS, LC/QQQ
Industries
Metabolomics
Manufacturer
Waters
Key words

 

Similar PDF

Toggle
3D spheroid culture as a tool for studying drug metabolism
2019|Thermo Fischer Scientific|Applications
APPLICATION NOTEHuman spheroid-qualified hepatocytes3D spheroid culture as a tool for studyingdrug metabolismIntroductionThe primary human hepatocyte (PHH) three-dimensional(3D) culture model developed by Thermo Fisher Scientificholds promise for disease modeling and functional studies.As the liver is the principal site of metabolism for...
Key words
gibco, gibcospheroid, spheroiddextrorphan, dextrorphanhepatocyte, hepatocytehydroxybupropion, hydroxybupropionabundance, abundancerelative, relativewilliams, williamsacetaminophen, acetaminophenvanquish, vanquishhepatocytes, hepatocytescyp, cyphepatic, hepatictolbutamide, tolbutamideexactive
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugazamulin, azamulincytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugazamulin, azamulincytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput Analysis ofCytochrome P450 Inhibition in IntactHuman HepatocytesApplication NoteAuthorsAbstractKari E. Schlicht and Vaughn P. MillerUltrafast methods of analysis were developed using the Agilent RapidFireAgilent Technologies, Inc.High‑Throughput Mass Spectrometry System in combination with an AgilentWakefield, MA6490 Triple Quadrupole Mass Spectrometer for...
Key words
hepatocytes, hepatocytesinhibition, inhibitionsip, sipcyp, cyprapidfire, rapidfiresensor, sensoractivity, activityvitro, vitrolog, logdesethylamodiaquine, desethylamodiaquinehlms, hlmshydralazine, hydralazinenaphthoflavone, naphthoflavonethroughput, throughputcryopreserved
 

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