UPLC/MS/MS ANALYSIS OF 9 METABOLITES FOR CYTOCHROME P450 INHIBITION STUDIES IN A SINGLE ANALYTICAL RUN | LabRulez LCMS_EN
 

Similar PDF

Toggle
3D spheroid culture as a tool for studying drug metabolism
2019|Thermo Fischer Scientific|Applications
APPLICATION NOTEHuman spheroid-qualified hepatocytes3D spheroid culture as a tool for studyingdrug metabolismIntroductionThe primary human hepatocyte (PHH) three-dimensional(3D) culture model developed by Thermo Fisher Scientificholds promise for disease modeling and functional studies.As the liver is the principal site of metabolism for...
Key words
gibco, gibcospheroid, spheroiddextrorphan, dextrorphanhepatocyte, hepatocytehydroxybupropion, hydroxybupropionabundance, abundancerelative, relativeacetaminophen, acetaminophenwilliams, williamscyp, cyphepatocytes, hepatocytestolbutamide, tolbutamidehepatic, hepaticvanquish, vanquishexactive
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugazamulin, azamulincytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugazamulin, azamulincytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput Analysis ofCytochrome P450 Inhibition in IntactHuman HepatocytesApplication NoteAuthorsAbstractKari E. Schlicht and Vaughn P. MillerUltrafast methods of analysis were developed using the Agilent RapidFireAgilent Technologies, Inc.High‑Throughput Mass Spectrometry System in combination with an AgilentWakefield, MA6490 Triple Quadrupole Mass Spectrometer for...
Key words
hepatocytes, hepatocytesinhibition, inhibitionsip, sipcyp, cyprapidfire, rapidfireactivity, activitysensor, sensorvitro, vitrolog, logdesethylamodiaquine, desethylamodiaquinehlms, hlmshydralazine, hydralazinenaphthoflavone, naphthoflavonecryopreserved, cryopreservedthroughput
 

Similar PDF

Toggle
3D spheroid culture as a tool for studying drug metabolism
2019|Thermo Fischer Scientific|Applications
APPLICATION NOTEHuman spheroid-qualified hepatocytes3D spheroid culture as a tool for studyingdrug metabolismIntroductionThe primary human hepatocyte (PHH) three-dimensional(3D) culture model developed by Thermo Fisher Scientificholds promise for disease modeling and functional studies.As the liver is the principal site of metabolism for...
Key words
gibco, gibcospheroid, spheroiddextrorphan, dextrorphanhepatocyte, hepatocytehydroxybupropion, hydroxybupropionabundance, abundancerelative, relativeacetaminophen, acetaminophenwilliams, williamscyp, cyphepatocytes, hepatocytestolbutamide, tolbutamidehepatic, hepaticvanquish, vanquishexactive
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugazamulin, azamulincytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugazamulin, azamulincytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput Analysis ofCytochrome P450 Inhibition in IntactHuman HepatocytesApplication NoteAuthorsAbstractKari E. Schlicht and Vaughn P. MillerUltrafast methods of analysis were developed using the Agilent RapidFireAgilent Technologies, Inc.High‑Throughput Mass Spectrometry System in combination with an AgilentWakefield, MA6490 Triple Quadrupole Mass Spectrometer for...
Key words
hepatocytes, hepatocytesinhibition, inhibitionsip, sipcyp, cyprapidfire, rapidfireactivity, activitysensor, sensorvitro, vitrolog, logdesethylamodiaquine, desethylamodiaquinehlms, hlmshydralazine, hydralazinenaphthoflavone, naphthoflavonecryopreserved, cryopreservedthroughput
 

Related content

Overcoming the challenges of liquid chromatography method transfer: A CDMO perspective

Technical notes
| 2022 | Thermo Fischer Scientific
Instrumentation
HPLC
Manufacturer
Thermo Fischer Scientific
Industries
---

Method for the determination of 431 Residual Pesticides in Honey using LCMS-8050 and GCMS-TQ8040 NX

Applications
| 2022 | Shimadzu
Instrumentation
GC/MSD, GC/MS/MS, GC/QQQ, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Shimadzu
Industries
Food & Agriculture

ASMS: IMPROVEMENTS IN SENSITIVITY, QUANTITATIVE LINEARITY, AND ROBUSTNESS USING A MODIFIED BENCH-TOP QUADRUPOLE ORTHOGONAL TIME-OF-FLIGHT MASS SPECTROMETER (Q-TOF MS)

Posters
| 2022 | Waters
Instrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Manufacturer
Waters
Industries
---

Determination of Per and Polyfluoroalkyl Substances in Soils Using Carbon S SPE by LC/MS/MS

Applications
| 2022 | Agilent Technologies
Instrumentation
Sample Preparation, Consumables, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Environmental

ASTM D4327-03 Compliant Analysis of Anions in Wastewater

Applications
| 2022 | Shimadzu
Instrumentation
Ion chromatography
Manufacturer
Shimadzu
Industries
Environmental
 

Related content

Overcoming the challenges of liquid chromatography method transfer: A CDMO perspective

Technical notes
| 2022 | Thermo Fischer Scientific
Instrumentation
HPLC
Manufacturer
Thermo Fischer Scientific
Industries
---

Method for the determination of 431 Residual Pesticides in Honey using LCMS-8050 and GCMS-TQ8040 NX

Applications
| 2022 | Shimadzu
Instrumentation
GC/MSD, GC/MS/MS, GC/QQQ, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Shimadzu
Industries
Food & Agriculture

ASMS: IMPROVEMENTS IN SENSITIVITY, QUANTITATIVE LINEARITY, AND ROBUSTNESS USING A MODIFIED BENCH-TOP QUADRUPOLE ORTHOGONAL TIME-OF-FLIGHT MASS SPECTROMETER (Q-TOF MS)

Posters
| 2022 | Waters
Instrumentation
LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
Manufacturer
Waters
Industries
---

Determination of Per and Polyfluoroalkyl Substances in Soils Using Carbon S SPE by LC/MS/MS

Applications
| 2022 | Agilent Technologies
Instrumentation
Sample Preparation, Consumables, LC/MS, LC/MS/MS, LC/QQQ
Manufacturer
Agilent Technologies
Industries
Environmental

ASTM D4327-03 Compliant Analysis of Anions in Wastewater

Applications
| 2022 | Shimadzu
Instrumentation
Ion chromatography
Manufacturer
Shimadzu
Industries
Environmental
Other projects
Follow us
More information
WebinarsAbout usContact usTerms of use

LabRulez s.r.o., all rights reserved.