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3D spheroid culture as a tool for studying drug metabolism
2019|Thermo Fischer Scientific|Aplikace
APPLICATION NOTEHuman spheroid-qualified hepatocytes3D spheroid culture as a tool for studyingdrug metabolismIntroductionThe primary human hepatocyte (PHH) three-dimensional(3D) culture model developed by Thermo Fisher Scientificholds promise for disease modeling and functional studies.As the liver is the principal site of metabolism for...
Key words
gibco, gibcospheroid, spheroiddextrorphan, dextrorphanhepatocyte, hepatocytehydroxybupropion, hydroxybupropionabundance, abundancerelative, relativeacetaminophen, acetaminophenwilliams, williamsvanquish, vanquishcyp, cyphepatocytes, hepatocytestolbutamide, tolbutamidehepatic, hepaticexactive
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugcytochrome, cytochromeazamulin, azamulinritonavir, ritonavirwithout, withoutthroughput
Application NotePharma & BiopharmaQuantitation of the Chiral Shift inMetabolism of Propranolol Using2D-LC/MS/MSThe Agilent InfinityLab 2D-LC Solutions forachiral‑chiral analysis of complex samplesAuthorsLukas C. Harps,Felix Bredendiek, andMaria K. ParrFreie Universitaet BerlinBerlin, GermanySonja Schipperges,Bernhard Wuest, andAndreas BorowiakAgilent Technologies, Inc.AbstractChiral recognition of drugs and...
Key words
propranolol, propranololacquisition, acquisitionhydroxy, hydroxycounts, countschiral, chiralmin, minenantiomers, enantiomersexcretion, excretionmetabolism, metabolismtime, timeenantiomeric, enantiomericshifts, shiftsunits, unitsmetabolites, metaboliteswere
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugcytochrome, cytochromeazamulin, azamulinritonavir, ritonavirwithout, withoutthroughput
 

Similar PDF

3D spheroid culture as a tool for studying drug metabolism
2019|Thermo Fischer Scientific|Aplikace
APPLICATION NOTEHuman spheroid-qualified hepatocytes3D spheroid culture as a tool for studyingdrug metabolismIntroductionThe primary human hepatocyte (PHH) three-dimensional(3D) culture model developed by Thermo Fisher Scientificholds promise for disease modeling and functional studies.As the liver is the principal site of metabolism for...
Key words
gibco, gibcospheroid, spheroiddextrorphan, dextrorphanhepatocyte, hepatocytehydroxybupropion, hydroxybupropionabundance, abundancerelative, relativeacetaminophen, acetaminophenwilliams, williamsvanquish, vanquishcyp, cyphepatocytes, hepatocytestolbutamide, tolbutamidehepatic, hepaticexactive
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugcytochrome, cytochromeazamulin, azamulinritonavir, ritonavirwithout, withoutthroughput
Application NotePharma & BiopharmaQuantitation of the Chiral Shift inMetabolism of Propranolol Using2D-LC/MS/MSThe Agilent InfinityLab 2D-LC Solutions forachiral‑chiral analysis of complex samplesAuthorsLukas C. Harps,Felix Bredendiek, andMaria K. ParrFreie Universitaet BerlinBerlin, GermanySonja Schipperges,Bernhard Wuest, andAndreas BorowiakAgilent Technologies, Inc.AbstractChiral recognition of drugs and...
Key words
propranolol, propranololacquisition, acquisitionhydroxy, hydroxycounts, countschiral, chiralmin, minenantiomers, enantiomersexcretion, excretionmetabolism, metabolismtime, timeenantiomeric, enantiomericshifts, shiftsunits, unitsmetabolites, metaboliteswere
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugcytochrome, cytochromeazamulin, azamulinritonavir, ritonavirwithout, withoutthroughput
 

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