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UPLC/MS/MS ANALYSIS OF 9 METABOLITES FOR CYTOCHROME P450 INHIBITION STUDIES IN A SINGLE ANALYTICAL RUN

 

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High-Throughput Analysis of Cytochrome P450 Inhibition in Intact Human Hepatocytes Application Note Authors Abstract Kari E. Schlicht and Vaughn P. Miller Ultrafast methods of analysis were developed using the Agilent RapidFire Agilent Technologies, Inc. High‑Throughput Mass Spectrometry System in combination…
Key words
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3D spheroid culture as a tool for studying drug metabolism
2019|Thermo Fisher Scientific|Applications
APPLICATION NOTE Human spheroid-qualified hepatocytes 3D spheroid culture as a tool for studying drug metabolism Introduction The primary human hepatocyte (PHH) three-dimensional (3D) culture model developed by Thermo Fisher Scientific holds promise for disease modeling and functional studies. As the…
Key words
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High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Cytochrome P450 Inhibition Application Note Authors Vaughn Miller Agilent Technologies, Inc. Wakefield, MA, USA Introduction Analysis of cytochrome P450 (CYP) inhibition is an important component of the drug discovery process as…
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remainingactivity, activityinhibition, inhibitioncyp, cypazamulin, azamulindrug, drugcytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
High-Throughput In Vitro ADME Analysis with Agilent RapidFire/MS Systems: Cytochrome P450 Inhibition Application Note Authors Vaughn Miller Agilent Technologies, Inc. Wakefield, MA, USA Introduction Analysis of cytochrome P450 (CYP) inhibition is an important component of the drug discovery process as…
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remainingactivity, activityinhibition, inhibitioncyp, cypdrug, drugazamulin, azamulincytochrome, cytochromeritonavir, ritonavirwithout, withoutthroughput
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