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High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugcytochrome, cytochromeazamulin, azamulinritonavir, ritonavirwithout, withoutthroughput
Fragment-Based Drug Discovery:Comparing Labeled and Label-FreeScreening of β-Amyloid Secretase(BACE-1) Using FluorescenceSpectroscopy and UltrafastSPE/MS/MSApplication NoteAuthorsIntroductionLauren E. Frick and William A. LaMarrAgilent Technologies, Inc.Wakefield, MA, USAFragment-based screening offers advantages over traditional high-throughputscreening by allowing more comprehensive coverage of chemical space, but thetypical...
Key words
unlabeled, unlabeledlfs, lfssubstrate, substrateums, umshits, hitslabeled, labeledlms, lmsrapidfire, rapidfirewere, werepeptide, peptidefluorescently, fluorescentlyassays, assayshit, hitautofluorescence, autofluorescenceinhibition
High-Throughput Analysis ofCytochrome P450 Inhibition in IntactHuman HepatocytesApplication NoteAuthorsAbstractKari E. Schlicht and Vaughn P. MillerUltrafast methods of analysis were developed using the Agilent RapidFireAgilent Technologies, Inc.High‑Throughput Mass Spectrometry System in combination with an AgilentWakefield, MA6490 Triple Quadrupole Mass Spectrometer for...
Key words
hepatocytes, hepatocytesinhibition, inhibitionsip, sipcyp, cyprapidfire, rapidfiresensor, sensoractivity, activityvitro, vitrolog, logdesethylamodiaquine, desethylamodiaquinehlms, hlmshydralazine, hydralazinenaphthoflavone, naphthoflavonethroughput, throughputcryopreserved
Ultrafast Histone DeacetylaseSelectivity Screening Using theAgilent RapidFire High-ThroughputMass Spectrometry SystemApplication NoteAuthorsAbstractLauren E. Frick and William A. LaMarrSelectivity screening of a promising new compound requires testing against aAgilent Technologies, Inc.host of enzymes related to the target of interest, resulting in the...
Key words
multiplex, multiplexunit, unitpos, posnormalized, normalizedsubstrate, substrateinhibition, inhibitionindividual, individualrapidfire, rapidfiremultiplexed, multiplexeddeacetylase, deacetylasetubacin, tubacinreactions, reactionsbottleneck, bottleneckthroughput, throughputselectivity
 

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High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugcytochrome, cytochromeazamulin, azamulinritonavir, ritonavirwithout, withoutthroughput
Fragment-Based Drug Discovery:Comparing Labeled and Label-FreeScreening of β-Amyloid Secretase(BACE-1) Using FluorescenceSpectroscopy and UltrafastSPE/MS/MSApplication NoteAuthorsIntroductionLauren E. Frick and William A. LaMarrAgilent Technologies, Inc.Wakefield, MA, USAFragment-based screening offers advantages over traditional high-throughputscreening by allowing more comprehensive coverage of chemical space, but thetypical...
Key words
unlabeled, unlabeledlfs, lfssubstrate, substrateums, umshits, hitslabeled, labeledlms, lmsrapidfire, rapidfirewere, werepeptide, peptidefluorescently, fluorescentlyassays, assayshit, hitautofluorescence, autofluorescenceinhibition
High-Throughput Analysis ofCytochrome P450 Inhibition in IntactHuman HepatocytesApplication NoteAuthorsAbstractKari E. Schlicht and Vaughn P. MillerUltrafast methods of analysis were developed using the Agilent RapidFireAgilent Technologies, Inc.High‑Throughput Mass Spectrometry System in combination with an AgilentWakefield, MA6490 Triple Quadrupole Mass Spectrometer for...
Key words
hepatocytes, hepatocytesinhibition, inhibitionsip, sipcyp, cyprapidfire, rapidfiresensor, sensoractivity, activityvitro, vitrolog, logdesethylamodiaquine, desethylamodiaquinehlms, hlmshydralazine, hydralazinenaphthoflavone, naphthoflavonethroughput, throughputcryopreserved
Ultrafast Histone DeacetylaseSelectivity Screening Using theAgilent RapidFire High-ThroughputMass Spectrometry SystemApplication NoteAuthorsAbstractLauren E. Frick and William A. LaMarrSelectivity screening of a promising new compound requires testing against aAgilent Technologies, Inc.host of enzymes related to the target of interest, resulting in the...
Key words
multiplex, multiplexunit, unitpos, posnormalized, normalizedsubstrate, substrateinhibition, inhibitionindividual, individualrapidfire, rapidfiremultiplexed, multiplexeddeacetylase, deacetylasetubacin, tubacinreactions, reactionsbottleneck, bottleneckthroughput, throughputselectivity
 

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