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3D spheroid culture as a tool for studying drug metabolism
2019|Thermo Fischer Scientific|Aplikace
APPLICATION NOTEHuman spheroid-qualified hepatocytes3D spheroid culture as a tool for studyingdrug metabolismIntroductionThe primary human hepatocyte (PHH) three-dimensional(3D) culture model developed by Thermo Fisher Scientificholds promise for disease modeling and functional studies.As the liver is the principal site of metabolism for...
Key words
gibco, gibcospheroid, spheroiddextrorphan, dextrorphanhepatocyte, hepatocytehydroxybupropion, hydroxybupropionabundance, abundancerelative, relativeacetaminophen, acetaminophenwilliams, williamsvanquish, vanquishcyp, cyphepatocytes, hepatocytestolbutamide, tolbutamidehepatic, hepaticexactive
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugcytochrome, cytochromeazamulin, azamulinritonavir, ritonavirwithout, withoutthroughput
Application NoteDrug DiscoveryUltrafast Analysis of MetabolicStability Assays UsingAgilent RapidFire High-Resolution MSAuthorsMichelle V. Romm,Nikunj Parikh, andVaughn P. MillerAgilent Technologies, Inc.Wakefield, MAYuqin DaiAgilent Technologies, Inc.Santa Clara, CAAbstractThe analysis of in vitro ADME assays such as metabolic stability is often athroughput bottleneck in...
Key words
rapidfire, rapidfiremetabolic, metabolicstability, stabilitybinned, binnedhalf, halfcarryover, carryoverwere, weregeneric, genericlife, lifevitro, vitrousing, usingassay, assaydrug, drugliver, liverincubations
Fragment-Based Drug Discovery:Comparing Labeled and Label-FreeScreening of β-Amyloid Secretase(BACE-1) Using FluorescenceSpectroscopy and UltrafastSPE/MS/MSApplication NoteAuthorsIntroductionLauren E. Frick and William A. LaMarrAgilent Technologies, Inc.Wakefield, MA, USAFragment-based screening offers advantages over traditional high-throughputscreening by allowing more comprehensive coverage of chemical space, but thetypical...
Key words
unlabeled, unlabeledlfs, lfssubstrate, substrateums, umshits, hitslabeled, labeledlms, lmsrapidfire, rapidfirewere, werepeptide, peptidefluorescently, fluorescentlyassays, assayshit, hitinhibition, inhibitionautofluorescence
 

Similar PDF

3D spheroid culture as a tool for studying drug metabolism
2019|Thermo Fischer Scientific|Aplikace
APPLICATION NOTEHuman spheroid-qualified hepatocytes3D spheroid culture as a tool for studyingdrug metabolismIntroductionThe primary human hepatocyte (PHH) three-dimensional(3D) culture model developed by Thermo Fisher Scientificholds promise for disease modeling and functional studies.As the liver is the principal site of metabolism for...
Key words
gibco, gibcospheroid, spheroiddextrorphan, dextrorphanhepatocyte, hepatocytehydroxybupropion, hydroxybupropionabundance, abundancerelative, relativeacetaminophen, acetaminophenwilliams, williamsvanquish, vanquishcyp, cyphepatocytes, hepatocytestolbutamide, tolbutamidehepatic, hepaticexactive
High-Throughput In VitroADME Analysis with AgilentRapidFire/MS Systems:Cytochrome P450 InhibitionApplication NoteAuthorsVaughn MillerAgilent Technologies, Inc.Wakefield, MA, USAIntroductionAnalysis of cytochrome P450 (CYP) inhibition is an important component of thedrug discovery process as adverse drug-drug interactions can lead to terminationof a drug development program,...
Key words
rapidfire, rapidfirenadph, nadphinhibitor, inhibitornaph, naphmidazolam, midazolamremaining, remaininginhibition, inhibitionactivity, activitycyp, cypdrug, drugcytochrome, cytochromeazamulin, azamulinritonavir, ritonavirwithout, withoutthroughput
Application NoteDrug DiscoveryUltrafast Analysis of MetabolicStability Assays UsingAgilent RapidFire High-Resolution MSAuthorsMichelle V. Romm,Nikunj Parikh, andVaughn P. MillerAgilent Technologies, Inc.Wakefield, MAYuqin DaiAgilent Technologies, Inc.Santa Clara, CAAbstractThe analysis of in vitro ADME assays such as metabolic stability is often athroughput bottleneck in...
Key words
rapidfire, rapidfiremetabolic, metabolicstability, stabilitybinned, binnedhalf, halfcarryover, carryoverwere, weregeneric, genericlife, lifevitro, vitrousing, usingassay, assaydrug, drugliver, liverincubations
Fragment-Based Drug Discovery:Comparing Labeled and Label-FreeScreening of β-Amyloid Secretase(BACE-1) Using FluorescenceSpectroscopy and UltrafastSPE/MS/MSApplication NoteAuthorsIntroductionLauren E. Frick and William A. LaMarrAgilent Technologies, Inc.Wakefield, MA, USAFragment-based screening offers advantages over traditional high-throughputscreening by allowing more comprehensive coverage of chemical space, but thetypical...
Key words
unlabeled, unlabeledlfs, lfssubstrate, substrateums, umshits, hitslabeled, labeledlms, lmsrapidfire, rapidfirewere, werepeptide, peptidefluorescently, fluorescentlyassays, assayshit, hitinhibition, inhibitionautofluorescence
 

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