Fast and Efficient Peptide Mapping of a Monoclonal Antibody (mAb): UHPLC Performance with Superficially Porous ParticlesApplications | 2013 | Agilent Technologies Instrumentation Consumables, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS, LC columnsIndustriesPharma & BiopharmaManufacturerAgilent TechnologiesKey wordspeptide, mapping, advancebio, counts, column, deamidated, uhplc, acquisition, min, time, efficient, native, agilent, non, tryptic, maps, during, flexibility, peptides, mau, highly, fast, digest, separation, porous, mfe, resolved, rapid, analysis, ptm, entire, shortened, times, deamidation, sacrificing, performance, gradient, superficially, translational, generated, information, achieve, across, compromise, map, agient, can, delivered, speed, comparison
AdvanceBio Peptide Mapping - An HPLC Column Technology for Faster Protein Biocharacterizations
AdvanceBio PeptideMappingAn HPLC Column Technology forFaster Protein BiocharacterizationsTim RiceBioColumn Technical Specialist1September 10, 2014What Is Peptide Mapping?•The chemical or enzymatic treatment of a protein to produce peptidefragments•Separation and identification of these fragments in a reproducible manner•For bio-therapeutic proteins and peptides peptide...
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Peptide Mapping - Agilent BioHPLC Columns Application Compendium
Agilent-NISTmAbPeptide MappingAgilent BioHPLC ColumnsApplication CompendiumContentsAgilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted fromNISTmAb RM 8671 batch. Quality control (QC) testing is performed usingAgilent LC-MS system. QC batch release test includes aggregate profile, chargevariants and intact mass information. A certificate of analysis...
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Enhancing The Quality Of Peptide Mapping Separation For The Analysis Of PTM
Enhancing The Quality Of PeptideMapping Separation For TheAnalysis Of PTMApplication NoteBiotherapeutics and BiosimilarsAuthorIntroductionSuresh Babu C.V.Post-translational modifications (PTMs) on proteins such as monoclonal antibodies(mAbs) are critical quality attributes (CQAs) that define the drug efficacy andsafety. Characterization of PTMs is a difficult...
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High Resolution and Rapid Peptide Mapping of Monoclonal Antibody Using an Agilent 1290 Infi nity UHPLC and an Agilent 6550 iFunnel Q-TOF LC/MS System
High Resolution and Rapid PeptideMapping of Monoclonal AntibodyUsing an Agilent 1290 Inﬁnity UHPLCand an Agilent 6550 iFunnel Q-TOFLC/MS SystemApplication NoteAuthorsIntroductionNing TangPeptide mapping is the common analytical technique for characterizing biologictherapeutic proteins. The protein is ﬁrst digested into smaller peptides enzymaticallyusing...
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