Rapid Analysis of Synthetic mRNA Cap Structure Using Ion-Pairing RPLC with the BioAccord LC-MS System
Applications | 2021 | WatersInstrumentation
LC/TOF, LC/HRMS, LC/MSIndustries
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Size-Exclusion Chromatography Method for Poly(A) Tail Analysis of mRNA
Application NoteSize-Exclusion Chromatography Method forPoly(A) Tail Analysis of mRNAMartin GilarWaters CorporationAbstractThe first in-class therapeutic messenger RNA (mRNA) vaccines were successfully developed against SARS-CoV2 virus. Therapeutic mRNA molecules can also be used for protein replacement therapy or vaccinationapproaches in cancer treatment....
tail, tailpoly, polymrna, mrnaexclusion, exclusionsize, sizechromatography, chromatographymethod, methodanalysis, analysissec, secqsm, qsmftn, ftnpremier, premiergilar, gilaruplc, uplclength
Ion-Pair Reversed-Phase Liquid Chromatography Method for Analysis of mRNA Poly(A) Tail Heterogeneity
Application NoteIon-Pair Reversed-Phase LiquidChromatography Method for Analysis ofmRNA Poly(A) Tail HeterogeneityMartin Gilar, Maissa M. GayeWaters CorporationAbstractMessenger RNA (mRNA) biopolymers are new therapeutic modalities. Development of effective mRNA vaccinesagainst SARS-CoV-2 virus accelerated the research of novel mRNA therapies. Promising mRNA applicationsinclude...
tail, tailmrna, mrnapoly, polyheterogeneity, heterogeneitypair, pairreversed, reversedphase, phaseliquid, liquidion, ionchromatography, chromatographymethod, methodanalysis, analysisssystem, ssystempremier, premierdiisopropylethylamine
CRISPR Single Guide RNA Characterization by IP- RP-LC-MS with a Premier Oligonucleotide BEH 300 Å C18 Column
Application NoteCRISPR Single Guide RNA Characterizationby IP- RP-LC-MS with a PremierOligonucleotide BEH 300 Å C18 ColumnMaissa M. Gaye, Chris Knowles, Balasubrahmanyam Addepalli, Matthew A. LauberWaters CorporationAbstractThe high speed, low cost, and reduced need for animal use has made CRISPR/Cas systems...
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