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Ion-Pair Reversed-Phase Liquid Chromatography Method for Analysis of mRNA Poly(A) Tail Heterogeneity

 

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Application Note Size-Exclusion Chromatography Method for Poly(A) Tail Analysis of mRNA Martin Gilar Waters Corporation Abstract The first in-class therapeutic messenger RNA (mRNA) vaccines were successfully developed against SARS-CoV2 virus. Therapeutic mRNA molecules can also be used for protein replacement…
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Application note | 001183 Biopharma Characterization of in vitro-transcribed (IVT) mRNA poly(A) tail by LC-HRAM-MS and BioPharma Finder 5.0 software Authors Application benefits Robert L. Ross1, Jenny England2, Rhonda • Confident identification and sequence confirmation of polyadenylated tails in synthetic…
Key words
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Characterizing LNP mRNA
2024|Waters|Guides
CONSUMABLES GUIDE BOOK Characterizing LNP mRNA LC tools for purity, identity, integrity and concentration determining measurements A Changing Industry mRNA based medicine helped address the COVID-19 pandemic. The viability of using an mRNA construct as a human drug substance has…
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Characterization of Intact mRNA Using Ion Pair-Reversed Phase-Time of Flight-MS, Size Exclusion Chromatography-Multi Angle Light Scattering, and Charge Detection Mass Spectrometry Patrick Brophy1; Henry Shion1; Catalin E Doneanu1; Hua Yang1; Benjamin Draper2; Daniel Botamanenko2; Susan Abbatiello1; Andy Jarrell1; Stephan Koza1;…
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