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Implementing Comet search engine into Proteome Discoverer to improve TMT Real-Time Search data processing

Posters | 2021 | Thermo Fisher Scientific | ASMSInstrumentation
Software, LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Industries
Proteomics
Manufacturer
Thermo Fisher Scientific
Key words
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Thermo Scientific Proteome Discoverer software
2022|Thermo Fisher Scientific|Brochures and specifications
The intelligent protein informatics platform Thermo Scientific Proteome Discoverer software Transform proteomics mass spectrometry data into insights Thermo Scientific™ Proteome Discoverer™ software enables comprehensive proteomics data processing workflows empowered by artificial intelligence. • Powerful and flexible framework: Optimized analysis for…
Key words
inferys, inferysrescoring, rescoringdiscoverer, discovererproteome, proteomepsms, psmschimerys, chimerysworkflows, workflowslfq, lfqpeptides, peptidessearch, searchpeptide, peptidetmt, tmtproteomics, proteomicssequest, sequestprotein
Use of carry-over models in false-discovery rate filtering in real-time search Jesse Canterbury, William Barshop, Graeme McAlister, and Philip Remes, Thermo Fisher Scientific, San Jose, CA 95134 ABSTRACT Real-time spectral scoring based on FDR Static model carry-over Model continuation Purpose:…
Key words
lda, ldapsms, psmsdiscriminant, discriminantrun, runcarry, carrycontinuation, continuationweights, weightsfiltering, filteringreal, realscore, scorepsm, psmfdr, fdrsequest, sequestrts, rtsfeature
APPLICATION NOTE 65729 Real-Time Search enables a new gold standard for TMT quantitation accuracy on the Orbitrap Eclipse Tribrid mass spectrometer Authors: Aaron M. Robitaille1, Romain Huguet1, Ryan Bomgarden2, Jesse D. Canterbury1, Daniel Lopez-Ferrer1 Thermo Fisher Scientific, San Jose, CA…
Key words
search, searchtmt, tmtreal, realcomet, cometxcorr, xcorrsps, spstribrid, tribridorbitrap, orbitrapmass, masstime, timeeclipse, eclipsequantitation, quantitationinterference, interferenceaccuracy, accuracyengine
CHIMERYS: An AI-Driven Leap Forward in Peptide Identification Martin Frejno1; Daniel P Zolg1; Tobias Schmidt1; Siegfried Gessulat1; Michael Graber1; Florian Seefried1; Magnus Rathke-Kuhnert1; Samia Ben Fredj1; Shyamnath Premnadh1; Kai Fritzemeier2; Frank Berg2; Waqas Nasir2; David Horn3; Bernard Delanghe2; Christoph Henrich2;…
Key words
chimerys, chimerysidentified, identifiedpsms, psmssequest, sequestpeptides, peptidesentrapment, entrapmentchimeric, chimericspectra, spectraspectrum, spectrumproteins, proteinspercolator, percolatorprotein, proteinprecursors, precursorssearch, searchcloud
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