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LC-UV-MS Peptide Mapping Development for Easy Transfer to LC-UV QA/QC

Applications | 2016 | Thermo Fisher ScientificInstrumentation
HPLC, LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Industries
Pharma & Biopharma
Manufacturer
Thermo Fisher Scientific
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Martin Samonig1, Kai Scheffler2, Remco Swart1, and Jonathan Josephs3 Thermo Fisher Scientific, Germering, Germany 2 Thermo Fisher Scientific, Dreieich, Germany 3 Thermo Fisher Scientific, San Jose, CA, USA 1 Appli cat i on N ote 1 1 3 5 High-Throughput…
Key words
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High Throughput Peptide Mapping with the Vanquish UHPLC System and the Q Exactive HF Mass Spectrometer Martin Samonig1, Remco Swart1, Kai Scheffler2 and Jonathan Josephs3 1 Thermo Fisher Scientific, Germering, Germany; 2 Thermo Fisher Scientific, Dreieich, Germany; 3 Thermo Fisher…
Key words
fair, fairrituximab, rituximabgood, goodchain, chainpeptide, peptidepeptides, peptidesmapping, mappingabundance, abundanceterminal, terminaldisulfide, disulfideexactive, exactiveenabling, enablingmass, massdelivers, deliversheavy
Table of Contents Introduction Faster and More Sensitive Protein Characterization and Quantitation Easier Digestion Faster Digestion Highly Reproducible Digestion Automation of Digestion Improving Sensitivity and Speed SMART Digest Peptide Mapping and Quantitation Compendium Peptide Mapping Peptide Quantitation Product and Method…
Key words
mapping, mappingpeptide, peptidedigestion, digestionsmart, smartmodifications, modificationsdigest, digestchain, chainposttranslational, posttranslationalheavy, heavymonoclonal, monoclonaltrypsin, trypsinantibodies, antibodiesthroughput, throughputprotein, proteinautomated
APPLICATION NOTE Authors: Martin Samonig1, Alexander Schwahn2, Ken Cook3, Mike Oliver4, and Remco Swart1 Thermo Fisher Scientific, Germering, Germany; 2Thermo Fisher Scientific, Basel, Switzerland; 3Thermo Fisher Scientific, Hemel Hempstead, United Kingdom; 4 Thermo Fisher Scientific, Runcorn, United Kingdom 1 Key…
Key words
smart, smartdigest, digestdigestion, digestiondeamidation, deamidationurea, ureamodifications, modificationscarbamylation, carbamylationpeptide, peptiderituximab, rituximabmodification, modificationrelative, relativeabundance, abundanceheat, heatscientific, scientificthermo
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