Thermo Scientific Vanquish – Quaternary Pump F - Product Specifications

Significance of the Topic

The ability to deliver precise, stable and flexible solvent gradients is critical in modern UHPLC applications, enabling high-resolution separations, faster analyses and reliable quantification across industries such as pharmaceuticals, environmental testing and food safety.

Objectives and Overview of the Article

This document presents the technical specifications and key performance characteristics of the Thermo Scientific Vanquish Quaternary Pump F, detailing its design features, operational capabilities and benefits for advanced chromatographic workflows.

Methodology and Instrumentation

The Vanquish Quaternary Pump F operates as a serial dual-piston UHPLC pump featuring SmartFlow™ technology, which compensates for changes in solvent compressibility to maintain flow and gradient precision up to 103 MPa. Core components and functionality include:

• Four solvent lines with low-pressure proportioning for ternary/quaternary gradients
• Built-in 4-channel degassing for consistent baseline stability
• Ultra-precise piston drives achieving ±0.1% flow accuracy and <0.05% RSD precision
• Thermo Scientific Viper™ fingertight fittings for rapid, leak-free fluidic setup
• Materials biocompatible across pH 2–12 and chloride concentrations up to 1 M

Main Results and Discussion

Performance metrics demonstrate exceptional reliability and reproducibility:

• Flow range: 0.001–8.0 mL/min in 1 µL/min increments
• Pressure capability: up to 103 MPa (15,000 psi) with linear decrease above 5 mL/min
• Gradient proportioning accuracy: ±0.5% full scale; precision <0.15% SD
• Pulsation: typically <1.0% or <0.2 MPa
• Dwell volume: 679 µL; mixer volume options from 100 to 1550 µL

These specifications translate into unrivaled retention time stability, high sensitivity and minimal maintenance interruptions, supported by predictive GLP performance scheduling and comprehensive audit trail logging via Chromeleon™ CDS.

Benefits and Practical Applications

The Vanquish Quaternary Pump F enhances laboratory productivity and method flexibility by:

• Enabling complex gradient profiles for challenging separations and specialty column chemistries
• Supporting high throughput with rapid gradient equilibration and robust operation
• Simplifying system setup and maintenance through intuitive fittings and diagnostic functions
• Ensuring reproducible quantification in QA/QC workflows across varied solvent compositions

Future Trends and Opportunities

Emerging directions in UHPLC solvent delivery include integration with machine-learning algorithms for real-time method optimization, expanded use of eco-friendly solvent systems, advanced online degassing methods and remote system monitoring to further streamline workflow efficiency and sustainability.

Conclusion

The Thermo Scientific Vanquish Quaternary Pump F represents a state-of-the-art solvent delivery solution, combining high precision, flexibility and durability to meet the demands of advanced UHPLC applications while reducing downtime and total cost of ownership.