Thermo Scientific Vanquish—Dual Pump F - PRODUCT SPECIFICATIONS

Importance of the topic

The Thermo Scientific Vanquish Dual Pump F represents a significant advancement in UHPLC technology by combining two independent ternary solvent-blending pumps in a single, biocompatible housing. This innovation directly addresses the need for higher productivity, greater method flexibility and uncompromised analytical precision in pharmaceutical, environmental and industrial laboratories.

Objectives and Overview of the Article

This product specification sheet aims to present key performance characteristics, system architecture and practical benefits of the Vanquish Dual Pump F. It highlights how dual-pump delivery enhances application versatility and data confidence in demanding analytical workflows.

Methodology and Instrumentation

The Dual Pump F integrates two serial dual-piston pumps, each capable of independent ternary mixing with SmartFlow™ technology for automatic compensation of eluent compressibility. Key instrumental details include:

• Flow range: 0.001–8 mL/min in 1 µL increments
• Pressure capability: up to 1 034 bar (decreasing linearly above 5 mL/min)
• Built-in six-channel solvent degassing for enhanced baseline stability
• Mixer volume: default 400 µL (50 µL capillary + 350 µL static mixer); dwell volume: 679 µL
• GLP-compliant predictive maintenance scheduling and Chromeleon™ CDS Audit Trail logging
• Robust wetted materials: MP35N, titanium, ceramics, sapphire, PEEK and fluoropolymers for biocompatible operation (pH 2–12, Cl– up to 1 M)

Main Results and Discussion

Performance evaluations demonstrate:

• Exceptional flow accuracy (±0.1%) and precision (<0.05% RSD or <0.01 min SD)
• Gradient proportioning accuracy within ±0.5% full scale and precision <0.15% SD
• Pulsation levels under 1.0% or 0.2 MPa, ensuring stable baselines
• High retention time reproducibility independent of eluent composition or backpressure
• Reliable leak detection, excess pressure monitoring and simplified maintenance via Thermo Scientific Viper™ fingertight fittings

Practical Benefits and Applications

• Increased throughput by running two distinct methods or gradients without hardware changeover
• Reduced bench space and installation costs by housing dual pumps in one enclosure
• Enhanced LC-MS performance through dedicated fluidics and low-noise baseline
• Greater confidence in quantitative analyses in QA/QC, pharmaceutical development and environmental testing
• Automated degassing and GLP features minimize downtime and ensure regulatory compliance

Future Trends and Opportunities

The modular dual-pump design paves the way for:

• Integration with advanced automation and lab-of-the-future platforms
• Adoption of green solvents and mixed aqueous/organic gradients for sustainable workflows
• Remote monitoring and diagnostics via IoT-enabled chromatography systems
• Miniaturization toward micro- and nano-flow dual-pump solutions for proteomics and metabolomics

Conclusion

The Vanquish Dual Pump F delivers unparalleled flexibility, precision and robustness for modern UHPLC applications. By combining dual ternary mixing, advanced fluidics and comprehensive monitoring within a single unit, it empowers analysts to tackle complex separations with increased productivity and confidence.

Reference

No literature references were provided in the original document.