Comparing ELSD and CAD Performance on Polysorbate Quantification in Infliximab Drug Products
Applications | 2022 | WatersInstrumentation
HPLC
IndustriesPharma & Biopharma
ManufacturerWaters
Key wordspolysorbate, elsd, cad, infliximab, comparing, drug, quantification, products, performance, intact, subtraction, aerosolized, processing, concentration, manufacturing, same, baseline, curation, nitrogen, electrometer, settings, veo, based, accessibility, waters, where, deployed, droplets, corona, gradient, biopharmaceuticals, analysis, environments, aerosol, utilization, hydrolysis, slow, plotted, formulation, yields, events, method, employing, subsequently, quantifying, reliably, relationship, consistency, detecting, readily
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ELSD Performance on Polysorbate Quantification in Infliximab Drug Products Duanduan Han, Robert Birdsall, Jennifer Simeone, Michael Fogwill, Ying Qing Yu Waters Corporation, Milford, MA INTRODUCTION Polar head-group METHODS Principles of evaporative light scattering Hydrophobic ester tail Step 3: Detection PS80…
Key words
polysorbate, polysorbatesubtraction, subtractionelsd, elsdlsu, lsuresponse, responsebaseline, baselinelog, logminutes, minutesinfliximab, infliximabcad, cadrsd, rsdretention, retentionavsola, avsolarenflexis, renflexisinflectra
Simultaneous analysis of polysorbate 80 and poloxamer 188 in biopharmaceutical formulations using charged aerosol detector and single quadrupole mass spectrometer
2023|Thermo Fisher Scientific|Posters
Simultaneous analysis of polysorbate 80 and poloxamer 188 in biopharmaceutical formulations using charged aerosol detector and single quadrupole mass spectrometer Xuepu Li 1, Sissi White 2, Mauro De Pra 3, Yu Cui 1, Min Du 2 1Thermo Fisher Scientific, Shanghai,…
Key words
poloxamer, poloxamerpoe, poeoleate, oleatesorbitan, sorbitanromiplostim, romiplostimisosorbide, isosorbideprotein, proteinconcentration, concentrationcad, cadsurfactants, surfactantsisq, isqformulations, formulationspolysorbates, polysorbatespolysorbate, polysorbatersd
Quantitative Analysis of Polysorbate 20/80 in Protein-Based Biopharmaceuticals Using A One-Pot RPLC-MS Based Platform Method
2021|Waters|Applications
Application Note Quantitative Analysis of Polysorbate 20/80 in Protein-Based Biopharmaceuticals Using A One-Pot RPLC-MS Based Platform Method Robert E. Birdsall, David Dao, Brooke M. Koshel, Ying Qing Yu, Aude Smeets, Michel Gerodez, Xavier Taillieu Waters Corporation, GlaxoSmithKline Abstract A high…
Key words
polysorbate, polysorbatemethyl, methylhydrolysis, hydrolysisqda, qdaacquity, acquitylaurate, laurateoleate, oleatebased, basedfatty, fattysir, sirdetection, detectionneighboring, neighboringmyristate, myristatemethod, methodpalmitate
An Efficient UV-Based Method for the Assessment of Oleic Acid Content in Biotherapeutic Drug Products Containing Polysorbate-80
2018|Waters|Applications
[ APPLICATION NOTE ] An Efficient UV-Based Method for the Assessment of Oleic Acid Content in Biotherapeutic Drug Products Containing Polysorbate-80 Robert E. Birdsall and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ A robust and…
Key words
oleic, oleicacid, acidbiotherapeutic, biotherapeuticassessment, assessmenttuv, tuvinfliximab, infliximabefficient, efficientneat, neatdrug, drugacquity, acquitycontent, contentmecn, mecnsir, sirbased, baseduplc