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Targeted and Non-Targeted Identification and Characterization of the Forced Degradation Products of Glipizide Using the ACQUITY RDa Detector and UNIFI Software Workflows

 

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DEMONSTRATING AN EASE-OF-USE BENCHTOP TIME OF FLIGHT DETECTOR AS AN EASE-OF-USE SOLUTION FOR ACCURATE MASS MEASUREMENTS IN FORCED DEGRADATION STUDIES Authors Chris Henry1([email protected]), Paul Rainville2 Affiliations: 1Waters Corporation, Stamford Avenue. Altrincham Road, Wilmslow, Cheshire, SK9 4AX, UK 2 Waters Corporation,…
Key words
glipizide, glipizideimpurity, impuritydegradants, degradantsrda, rdaacquity, acquitystressing, stressingiii, iiienergy, energyfragmentation, fragmentationdegradation, degradationunder, underforced, forcedgenerated, generatedapi, apioxidation
Application Note Demonstrating the Waters ACQUITY RDa Detector as an Ease of Use Solution for Routine Accurate Mass Measurements in Forced Degradation Studies Chris Henry, Paul D. Rainville Waters Corporation Abstract Forced degradation is a critical analytical study for the…
Key words
simvastatin, simvastatinunifi, unifidegradation, degradationrda, rdaacquity, acquityforced, forceddegradants, degradantsautomatically, automaticallycleavage, cleavageidentify, identifyhrms, hrmsvisualised, visualisedequips, equipstimepoints, timepointsbiotransformations
Application Note Demonstrating the Waters ACQUITY RDa Detector as an Ease of Use Solution for Routine Accurate Mass Measurements in Forced Degradation Studies Chris Henry, Paul D. Rainville Waters Corporation Abstract Forced degradation is a critical analytical study for the…
Key words
simvastatin, simvastatinunifi, unifidegradation, degradationrda, rdaacquity, acquityforced, forceddegradants, degradantsautomatically, automaticallycleavage, cleavageidentify, identifyhrms, hrmstimepoints, timepointsvisualised, visualisedbiotransformations, biotransformationsequips
[ APPLICATION NOTE ] Employing UPLC-UV-ToF MSE and the UNIFI Scientific Information System for the Analysis of the Forced Degradation of Glipizide Jayne Kirk, 1 Russell Mortishire-Smith, 1 Yun Alelyunas, 2 Jeff Robitaille, 2 Jim Henriksen, 2 Jeff Goshawk1 and…
Key words
glipizide, glipizideunifi, unifimse, mseforced, forceduplc, uplcdegradation, degradationemploying, employingtof, tofscientific, scientificimpurities, impuritiesinformation, informationsystem, systemnote, notecalculation, calculationimpurity
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