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Quantitative Top-Down Proteomics of Human Tears Reveals Proteoform Changes Related to Age

Posters | 2020 | Thermo Fisher Scientific | ASMSInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Industries
Clinical Research
Manufacturer
Thermo Fisher Scientific
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Improvements to ProSightPD nodes in the Thermo Scientific Proteome Discoverer Software Framework David M. Horn,1 Tara L. Schroeder,1 Ioanna Ntai,1 Richard D. Leduc,2 Ryan T. Fellers,2 Joseph B. Greer,2 and Neil L. Kelleher2, 1Thermo Fisher Scientific, San Jose, CA, 2Northwestern…
Key words
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Thermo Scientific Proteome Discoverer software
2022|Thermo Fisher Scientific|Brochures and specifications
The intelligent protein informatics platform Thermo Scientific Proteome Discoverer software Transform proteomics mass spectrometry data into insights Thermo Scientific™ Proteome Discoverer™ software enables comprehensive proteomics data processing workflows empowered by artificial intelligence. • Powerful and flexible framework: Optimized analysis for…
Key words
inferys, inferysrescoring, rescoringdiscoverer, discovererproteome, proteomepsms, psmschimerys, chimerysworkflows, workflowslfq, lfqpeptides, peptidessearch, searchtmt, tmtpeptide, peptidesequest, sequestproteomics, proteomicsconsensus
proteins on a proteomics scale is challenging and requires significant method optimization of front–end separation, instrument parameters and data analysis. In this study, we developed a general RP-LC-MS method for intact/ top-down analysis on an Orbitrap Fusion mass spectrometer using…
Key words
protein, proteinfusion, fusionintact, intacttop, toporbitrap, orbitrapfigure, figuredown, downenolase, enolasefragmentation, fragmentationmixture, mixtureproteins, proteinsyeast, yeastethcd, ethcdhorse, horsewere
Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer
2020|Thermo Fisher Scientific|Brochures and specifications
Go beyond today’s discovery Orbitrap Eclipse Tribrid mass spectrometer Go beyond today’s discovery When complex analytical questions require a definitive answer, you need a powerful and versatile solution that will allow you to accurately resolve subtle differences, distinguish the right…
Key words
ptcr, ptcrlll, lllsearch, searchprotein, proteinreal, realsps, spsproteoforms, proteoformsnative, nativellll, llllcell, celltribrid, tribridfaims, faimsligand, ligandllllllll, llllllllcells
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