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Lipid Nanoparticle Analysis: Leveraging MS to Reduce Risk

 

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Lipid Nanoparticle Impurity Monitoring Using Single Quadrupole Mass Detection for Regulated Environments Authors: Duanduan Han, Kellen DeLaney, Robert E. Birdsall, Ying Qing Yu Affiliation: Waters Corporation, Milford, MA Results Introduction Lipid Nanoparticles UV 3 AU 2 Cholesterol • Important for…
Key words
elsd, elsddspc, dspcdesaturation, desaturationsaturation, saturationoxidation, oxidationdata, datalipid, lipidimpurity, impuritycompositional, compositionalcholesterol, cholesterolqda, qdamass, massassignment, assignmentcomplementary, complementaryvolatile
Application Note Characterizing and Monitoring Impurities in Lipid Nanoparticle Components Using the BioAccord™ LC-MS System with waters_connect™ Software Kellen DeLaney, Duanduan Han, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Lipid nanoparticles (LNP) have been used with high efficacy…
Key words
bioaccord, bioaccordlipid, lipidnanoparticle, nanoparticlecharacterizing, characterizingimpurities, impuritiesmonitoring, monitoringcomponents, componentssystem, systemlnp, lnpusing, usingfragment, fragmentvehicles, vehiclesmatching, matchingimpurity, impuritynanoparticles
Application Note Optimized ELSD Workflow for Improved Detection of Lipid Nanoparticle Components Kellen DeLaney, Duanduan Han, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Gene and nucleic acid-based therapeutics have received notable attention in recent years. In order for…
Key words
elsd, elsdnanoparticle, nanoparticlelipid, lipidworkflow, workflowcomponents, componentsoptimized, optimizedimproved, improveddetection, detectionlnp, lnpcritical, criticalworkflows, workflowsreconstituted, reconstitutedcarrying, carryingacquity, acquitydevelopment
M1030-01-02 Identification and Characterization of Impurities in Lipid Nanoparticle Components Using TOF-MS with Predictive In-silico Fragmentation and Automated Data Processing Kellen DeLaney, Duanduan Han, Robert E. Birdsall, Ying Qing Yu, Ann Gray Waters Corporation, Milford, MA PURPOSE The development of…
Key words
impurities, impuritieslipid, lipidcomponents, componentsnanoparticle, nanoparticleinterpretation, interpretationmodifications, modificationslowabundance, lowabundancespontaneously, spontaneouslyidentification, identificationann, annfragmentation, fragmentationlnps, lnpslnp, lnplocalize, localizeprocured
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