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Identification and Characterization of Impurities in Lipid Nanoparticle Components Using TOF-MS with Predictive In-silico Fragmentation and Automated Data Processing

 

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Application Note Characterizing and Monitoring Impurities in Lipid Nanoparticle Components Using the BioAccord™ LC-MS System with waters_connect™ Software Kellen DeLaney, Duanduan Han, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Lipid nanoparticles (LNP) have been used with high efficacy…
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Application Note Rapid Analysis of Lipid Nanoparticle Components Using BioAccord LC-MS System Giorgis Isaac, Nilini Ranbaduge, Bonnie A. Alden, Colette Quinn, Weibin Chen, Robert S. Plumb Waters Corporation Abstract The recent success of mRNA vaccines for COVID-19 is in part…
Key words
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Lipid Nanoparticle Impurity Monitoring Using Single Quadrupole Mass Detection for Regulated Environments Authors: Duanduan Han, Kellen DeLaney, Robert E. Birdsall, Ying Qing Yu Affiliation: Waters Corporation, Milford, MA Results Introduction Lipid Nanoparticles UV 3 AU 2 Cholesterol • Important for…
Key words
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Application Note Lipid Nanoparticle Analysis: Leveraging MS to Reduce Risk Duanduan Han, Kellen DeLaney, Bonnie A. Alden, Robert E. Birdsall, Ying Qing Yu Waters Corporation Abstract Lipid nanoparticles (LNPs) represent an elegant solution in the delivery of gene-based therapeutics that…
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