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PHARMSCI: Comprehensive AAV Characterizations Using HRMS: Peptide Mapping, Capsid Proteins, Intact ssDNA, and Intact Virus

 

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COMPREHENSIVE AAV CHARACTERIZATIONS USING HRMS: HRMS CAPSID PROTEINS, PROTEINS, EMPTY/FULL CAPSID RATIO AND SS SS SSDNA ANALYSIS 1 Hua Yang Yang, 2Ximo Zhang, Zhang 3Benjamin Draper, Draper 4Xiaoying Jin Jin, 4Lin Liu Liu, 4Zichuan Zhang, Zhang 1Ying Qing Yu, Yu…
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[ APPLICATION NOTE ] Optimizing Adeno-Associated Virus (AAV) Capsid Protein Analysis Using UPLC and UPLC-MS Ximo Zhang, Stephan Koza, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ ■ INTRODUCTION An optimized LC-MS solution for…
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Advanced Therapeutic Medicinal Products: Adeno-associated Virus (AAV) The Promise of Viral Vector Gene Therapy using AAV 7000 Monogenic Diseases 20 of 22 4 Years Children with spinal muscular atrophy (SMA) given the ability to thrive with Zolgensma® (AAV) at 91%…
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[ APPLICATION NOTE ] Anion-Exchange Chromatography for Determining Empty and Full Capsid Contents in Adeno-Associated Virus Hua Yang, Stephan Koza, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ ■ Empty and full AAV capsid separation Recombinant adeno-associated…
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