Optimizing Adeno-Associated Virus (AAV) Capsid Protein Analysis Using UPLC and UPLC-MSApplications | 2020 | WatersInstrumentationLC/TOF, LC/HRMS, LC/MSIndustriesClinical ResearchManufacturerWatersKey wordscapsid, aav, adeno, uplc, virus, associated, proteins, optimizing, raav, therapy, mass, flr, gene, acquity, protein, bioaccord, viral, recombinant, theoretical, serotype, stoichiometry, dfa, sequence, renders, optical, vectors, characterization, note, rda, application, phosphorylation, measurement, observed, analysis, settings, using, modifier, raavs, judicious, infectivity, intact, vps, detector, mobile, method, throughout, difluoroacetic, serotypes, acid, chromatographic
Characterization of Viral Vector Particles Using the Agilent 6545XT AdvanceBio LC/Q-TOF
Application NotePharma & BiopharmaCharacterization of Viral VectorParticles Using the Agilent 6545XTAdvanceBio LC/Q-TOFAuthorsWendi A. Hale andChristopher M. ColangeloAgilent Technologies, Inc.,Lexington, MA, USARoy Hegedus andNorman GarceauLake Pharma,Worcester, MA, USAAbstractThis application note describes a workflow for the characterization anddetermination of critical quality attributes...
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Sensitive AAV Capsid Protein Impurity Analysis by CE Using Easy to Label Fluorescent Chromeo Dye P503
Sensitive AAV Capsid Protein Impurity Analysis by CE UsingEasy to Label Fluorescent Chromeo Dye P503Marcia Santos; SCIEX, Brea, CaliforniaIntroductionAAV or Adeno associated virus (Figure 1) is a popular class of genetherapy delivery vehicle used mostly due to non-pathogenicity andhigh stability....
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Developing the analytics and analytical workflows supporting the analysis of the next generation of biotherapeutic and gene therapies
Developing the analytics and analytical workflows supporting the analysisof the next generation of biotherapeutic and gene therapies.Scott J. Berger, Ph.D. and Ximo Zhang, Ph.D.Waters Lunch SeminarTuesday January 28, 2020WCBP 2020DiamondProgram Partner©2020 Waters Corporation. COMPANY CONFIDENTIAL1Ralph Waldo Emersonb. 1803 - d.1882©2020...
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LC/MS of Intact Adeno-Associated Virus Capsid Proteins for Rapid Confirmation of Product Identity
Application NoteLC/MS of Intact Adeno-AssociatedVirus Capsid Proteins for RapidConfirmation of Product IdentityAuthorBrian LiauAgilent Technologies, Inc.IntroductionAdeno-associated viruses (AAVs) are a promising new class of biotherapeuticcapable of treating a host of rare and intractable genetic diseases such as spinalmuscular atrophy and inherited...
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