Assessing key attributes of adeno-associated viral proteins using HPLC-FLD-intact mass analysis
Applications | 2022 | Thermo Fisher ScientificInstrumentation
HPLC, LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
IndustriesPharma & Biopharma
ManufacturerThermo Fisher Scientific
Key wordsmass, aav, truncated, fld, viral, intact, intensity, theoretical, relative, error, ppm, sequence, observed, protein, proteins, orbitrap, measurement, adeno, proteoforms, thermo, hram, accurate, scientific, min, serotype, associated, vanquish, assessment, nanoviper, exploris, gene, hplc, uhplc, offered, abundant, volume, were, capillary, ratio, raav, vps, value, method, structural, transduction, processes, wavelength, serotypes, data, quick
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Assessing key attributes of adeno-associated viral proteins using UHPLC-FLD-intact accurate mass analysis
2022|Thermo Fisher Scientific|Posters
Assessing key attributes of adeno-associated viral proteins using UHPLC-FLD-intact accurate mass analysis Reiko Kiyonami1, Roberto Gamez1, Min Du2, Kenneth Thompson3, Chao Yan Liu3, Julia Kraegenbring4, Catharina Crone4 1Thermo Fisher Scientific, San Jose, CA, USA; 2Thermo Fisher Scientific, Cambridge, MA, USA;…
Key words
viral, viralaav, aavproteins, proteinsptms, ptmsfld, fldintact, intactorbitrap, orbitrapmass, massexploris, explorisassociated, associatedvps, vpssummarized, summarizedenabled, enabledserotype, serotypeattributes
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2020|Waters|Applications
[ APPLICATION NOTE ] Optimizing Adeno-Associated Virus (AAV) Capsid Protein Analysis Using UPLC and UPLC-MS Ximo Zhang, Stephan Koza, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■ ■ INTRODUCTION An optimized LC-MS solution for…
Key words
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Characterization of Adeno-Associated Viral assemblies on an Ultra-High Mass Range Hybrid Quadrupole-Orbitrap Mass Spectrometer
2021|Thermo Fisher Scientific|Posters
Characterization of Adeno-Associated Viral assemblies on an Ultra-High Mass Range Hybrid QuadrupoleOrbitrap Mass Spectrometer Kristina Srzentić1, Eugen Damoc2, Marc Günder1 1Thermo Fisher Scientific, Reinach, Switzerland 2Thermo Fisher Scientific, Bremen, Germany ABSTRACT Purpose: Evaluate the performance of the Thermo Scientific™ Q…
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viral, viralaav, aavintact, intactmass, massadeno, adenoanalysis, analysisassemblies, assembliesdenaturing, denaturingunder, underassociated, associatedstoichiometries, stoichiometriesnative, nativeassembly, assemblyvanquish, vanquishnear
Highly sensitive intact mass analysis of AAV capsid proteins using a UHPLC-FLD- HRAM MS platform
2021|Thermo Fisher Scientific|Applications
APPLICATION NOTE 000253 Highly sensitive intact mass analysis of AAV capsid proteins using a UHPLC-FLDHRAM MS platform Authors: Reiko Kiyonami¹, Kristina Srzentić², Rosa Viner¹, Weijing Liu¹, Min Du², Katy Irvin³, Kenneth Thompson³, Chao Yan Liu³, Jon Zmuda³ ¹ Thermo Fisher…
Key words
capsid, capsidaav, aavintact, intactviral, viraltop, topdown, downproteins, proteinsprotein, proteinmass, masssequence, sequenceintensity, intensityrelative, relativevanquish, vanquishfragment, fragmentthermo