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T1530 ‐09‐54 Sensitive Bioanalysis of Antisense Oligonucleotides through Mitigation of Non‐specific Binding and Improved LC‐MS/MS Performance Suma Veeramachineni, Mark D Wrona Waters Corporation, Milford, MA CONTACT INFORMATION: [email protected]; [email protected] PURPOSE RESULT(S) Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes…
Key words
eluforsen, eluforsenmipomersen, mipomersenfomivirsen, fomivirsenrsd, rsdaccuracy, accuracynusinersen, nusinersengalnac, galnacoligonucleotide, oligonucleotidestd, stdpolythymidine, polythymidinepremier, premierconc, conconts, ontsname, namewaters
Application Note Sensitive LC-MS/MS Bioanalytical Quantitation of Antisense Oligonucleotides Suma Veeramachineni, Mark D. Wrona Waters Corporation Abstract This application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ Absolute Tandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for…
Key words
antisense, antisenseoligonucleotides, oligonucleotidesbioanalytical, bioanalyticalsensitive, sensitivequantitation, quantitationpremier, premiertandem, tandemacquity, acquityabsolute, absolutewaters, watershps, hpsmaxpeak, maxpeakoligonucleotide, oligonucleotidehuman, humansurfaces
Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High Performance Tandem Quadrupole Mass Spectrometer Suma Veeramachineni1; Suraj Dhungana1; Ying-Qing Yu1; Mark Wrona1; 1Waters Corporation, Milford, MA Introduction Results Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes has been of…
Key words
oligonucleotide, oligonucleotideaccuracy, accuracyoligonucleotides, oligonucleotidesosts, ostsperformance, performanceantisense, antisensequantitation, quantitationbioanalytical, bioanalyticallloq, lloqpolythymidine, polythymidinestd, stdpremier, premierconc, conconts, ontswaters
Application Note HRMS Quantitation of Oligonucleotides Using Xevo G2-XS QTof Mass Spectrometer Mark D. Wrona, Suma Veeramachineni Waters Corporation Abstract This application demonstrates the quantitative and qualitative capabilities of the Xevo G2-XS QTof and its suitability for oligonucleotide bioanalysis. We…
Key words
mew, mewhrms, hrmsisotopes, isotopesstates, statescharge, chargetriple, tripleselectivity, selectivityenables, enablesmaxpeak, maxpeakquadrupole, quadrupoleoligonucleotide, oligonucleotideoligonucleotides, oligonucleotidesbioanalytical, bioanalyticaldetail, detailfine
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