ASMS: ©2022 Waters Corporation Download scientific posters at waters.com/posters Improving LC-MS/MS Bioanalytical Quantitation of Oligonucleotides using New High Performance Tandem Quadrupole Mass Spectrometer
Posters | 2022 | WatersInstrumentation
LC/MS, LC/MS/MS, LC/QQQ
IndustriesClinical Research
ManufacturerWaters
Key wordsoligonucleotide, accuracy, oligonucleotides, osts, performance, antisense, quantitation, bioanalytical, lloq, polythymidine, premier, std, conc, onts, waters, high, phosphorothioated, especially, improving, challenging, tandem, acquity, massprep, negative, nonspecific, hps, maxpeak, were, assessing, overlaid, binding, characterized, cone, surfaces, therapeutic, attention, developing, xevo, sub, absolute, methods, range, special, green, stock, generate, capabilities, biological, impact, here
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DEVELOPMENT OF A BIOANALYTICAL SPE LC-MS/MS ASSAY FOR OLIGONUCLEOTIDES 
2020|Waters|Posters
DEVELOPMENT OF A BIOANALYTICAL SPE LC-MS/MS ASSAY FOR OLIGONUCLEOTIDES Mary Lame, Kathryn Brennan, Michael Donegan, Thanai Paxton, and Ian Edwards Waters Corporation, 34 Maple Street, Milford, MA , USA INTRODUCTION RESULTS Over the past decade, there has been a dramatic…
Key words
ost, ostmassprep, masspreparea, areaspe, speoasis, oasisoligonucleotide, oligonucleotidetea, tearecovery, recoverywax, waxtime, timehlb, hlbtic, ticoligonucleotides, oligonucleotidesbioanalytical, bioanalyticalwaters
Sensitive Bioanalysis of Antisense Oligonucleotides through Mitigation of Non‐specific Binding and Improved LC‐MS/MS Performance
2022|Waters|Posters
T1530 ‐09‐54 Sensitive Bioanalysis of Antisense Oligonucleotides through Mitigation of Non‐specific Binding and Improved LC‐MS/MS Performance Suma Veeramachineni, Mark D Wrona Waters Corporation, Milford, MA CONTACT INFORMATION: [email protected]; [email protected] PURPOSE RESULT(S) Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes…
Key words
eluforsen, eluforsenmipomersen, mipomersenrsd, rsdfomivirsen, fomivirsenaccuracy, accuracynusinersen, nusinersengalnac, galnacoligonucleotide, oligonucleotidepolythymidine, polythymidinestd, stdpremier, premieronts, ontsconc, concmers, merswaters
Sensitive LC-MS/MS Bioanalytical Quantitation of Antisense Oligonucleotides
2022|Waters|Applications
Application Note Sensitive LC-MS/MS Bioanalytical Quantitation of Antisense Oligonucleotides Suma Veeramachineni, Mark D. Wrona Waters Corporation Abstract This application demonstrates the quantitative and qualitative capabilities of the Waters™ Xevo™ TQ Absolute Tandem Quadrupole Mass Spectrometer (MS/MS) and its suitability for…
Key words
antisense, antisenseoligonucleotides, oligonucleotidesbioanalytical, bioanalyticalsensitive, sensitivequantitation, quantitationpremier, premiertandem, tandemacquity, acquityabsolute, absolutewaters, watershps, hpsmaxpeak, maxpeakoligonucleotide, oligonucleotidehuman, humansurfaces
Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology
2020|Waters|Applications
Application Note Improved Oligonucleotide SPE-LC-MS Analysis Using MaxPeak High Performance Technology Kathryn Brennan, Mary Trudeau Lame, Michael Donegan, Paul D. Rainville Waters Corporation Abstract The demand for highly selective and sensitive LC-MS bioanalytical assays in support of research and development…
Key words
oligonucleotide, oligonucleotideacquity, acquityspe, spexevo, xevomaxpeak, maxpeakuplc, uplctargetlynx, targetlynxyielded, yieldedbioanalytical, bioanalyticalpremier, premiertea, teaassays, assaysquantification, quantificationdemand, demandaquity