Sensitive LC-MS/MS quantitation of antisense oligonucleotides in plasma using the TSQ Altis Plus mass spectrometer
Applications | 2023 | Thermo Fisher ScientificInstrumentation
LC/MS, LC/MS/MS, LC/QQQ
IndustriesPharma & Biopharma
ManufacturerThermo Fisher Scientific
Key wordsnusinersen, fomivirsen, altis, asos, quantitation, tsq, plasma, quan, aso, plus, sensitive, counts, matrix, lle, human, qual, iprp, method, minutes, diff, thermo, mass, spectrometer, scientific, oligonucleotides, formivirsen, tacgcgcama, istd, srm, signal, micromat, developed, quantitative, peak, gas, chromeleon, sri, still, source, cds, lba, nuclease, details, integration, from, report, antisense, sun, supernatants, summary
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Sensitive quantitation of antisense oligonucleotides in plasma using high-resolution, accurate-mass (HRAM) mass spectrometry
2023|Thermo Fisher Scientific|Applications
Application note | 002679 Biopharma Sensitive quantitation of antisense oligonucleotides in plasma using high-resolution, accurate-mass (HRAM) mass spectrometry Authors Application benefits Hao Yang , Xuguang Yan , Moo-Young Kim , Sensitive and reproducible quantitation of antisense oligonucleotides with human Jon…
Key words
fomivirsen, fomivirsennusinersen, nusinersenplasma, plasmahuman, humanquantitation, quantitationiprp, iprpaso, asohram, hramsensitive, sensitivecounts, countsarb, arbasos, asosquan, quanqual, qualminutes
Sensitive Bioanalysis of Antisense Oligonucleotides through Mitigation of Non‐specific Binding and Improved LC‐MS/MS Performance
2022|Waters|Posters
T1530 ‐09‐54 Sensitive Bioanalysis of Antisense Oligonucleotides through Mitigation of Non‐specific Binding and Improved LC‐MS/MS Performance Suma Veeramachineni, Mark D Wrona Waters Corporation, Milford, MA CONTACT INFORMATION: [email protected]; [email protected] PURPOSE RESULT(S) Improving LC-MS/MS bioanalytical performance especially for ESI negative analytes…
Key words
eluforsen, eluforsenmipomersen, mipomersenrsd, rsdaccuracy, accuracyfomivirsen, fomivirsennusinersen, nusinersengalnac, galnacoligonucleotide, oligonucleotidestd, stdpolythymidine, polythymidinepremier, premierwaters, watersconc, concmers, mersonts
Sensitive Bioanalysis of Antisense Oligonucleotides of Various Lengths and Modifications
2022|Waters|Applications
English Denmark | Application Note Sensitive Bioanalysis of Antisense Oligonucleotides of Various Lengths and Modifications Suma Veeramachineni, Mark D. Wrona Waters Corporation This is an Application Brief and does not contain a detailed Experimental section. Abstract This application brief demonstrates…
Key words
antisense, antisenseoligonucleotides, oligonucleotidesbioanalysis, bioanalysislengths, lengthsmodifications, modificationssensitive, sensitivevarious, variousabsolute, absolutedemonstrates, demonstratesenglish, englishsitemap, sitemapcareers, careersprivacy, privacycookie, cookiecookies
Improve Sensitivity for Quantification of Antisense Oligonucleotides in Plasma Using Microflow LC MRM Methodology
2020|SCIEX|Posters
Improve Sensitivity for Quantification of Antisense Oligonucleotides in Plasma Using Microflow LC-MRM Methodology Ji Jiang, Sean McCarthy, Esme Candish, Lei Xiong SCIEX, 500 Old Connecticut Path, Framingham, MA 01520 INTRODUCTION Oligonucleotide therapeutics are rapidly growing as a class of therapeutic…
Key words
microflow, microflowoligonucleotides, oligonucleotidesantisense, antisensefomivirsen, fomivirsentechnote, technotepercent, percentactual, actualelute, elutemean, meanoptimization, optimizationplasma, plasmacomponent, componentchromatography, chromatographyname, nameaccuracy