CRM Ba, Ca, K, Li, Mg, Na, NH4 + , Sr - Aqueous calibration solution ASTASOL® AN9103MHIC

Importance of the Topic

This certified reference material (CRM) ensures reliable calibration for quantitative elemental analysis in aqueous matrices. Traceability to SI units and strict quality control are critical for accurate results in fields such as environmental monitoring, pharmaceutical testing, and quality assurance.

Study Objectives and Overview

This certificate describes an aqueous calibration solution ASTASOL® AN9103MHIC containing eight key cations (Ba, Ca, K, Li, Mg, Na, NH4+, Sr) each at 100 mg/L. The material is prepared and certified to ISO Guide 31 and ISO 17034 standards to support method validation and instrument calibration across atomic spectrometry and related techniques.

Methodology and Instrumentation

The CRM is gravimetrically prepared using high-purity nitrate salts dissolved in ultrapure water. Homogeneity and stability studies confirm consistent concentration over shelf life. Primary analytical methods include:

• Gravimetric determination (Ba, Sr)
• Complexometric titration with EDTA (Ca, Mg)
• Alkalimetric titration (NH4+)
• ICP-OES for K, Li, Na

Trace impurities were assessed by AAS, ICP-OES, and ICP-MS to inform users of background levels.

Instrumentation

• Atomic Absorption Spectrometry (AAS)
• Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES)
• Inductively Coupled Plasma Mass Spectrometry (ICP-MS)
• Ion Chromatography (IC)
• Titrimetric systems

Main Results and Discussion

Each analyte concentration is certified at 100.0 ± 0.2 mg/L (expanded uncertainty, k=2). Mass fraction values are derived from density measurements (1.0003 ± 0.0005 g/cm³). The material exhibits excellent homogeneity and stability when stored between 5–30 °C, with a three-year shelf life and a 12-month use period after opening.

Benefits and Practical Applications

This CRM supports calibration and validation for methods such as AAS, AES, ICP-OES, ICP-MS, IC, and selected electroanalytical techniques. Its certified traceability and low uncertainty enhance confidence in analytical results and regulatory compliance.

Future Trends and Potential Applications

Increasing demand for multi-element calibration standards in environmental and clinical analysis will drive development of matrices with additional species and lower uncertainty. Integration of digital CRM data platforms may further streamline laboratory workflows.

Conclusion

ASTASOL® AN9103MHIC provides a robust, traceable, and versatile calibration solution for quantitative elemental analysis, aligning with international quality standards and ensuring reliable analytical performance.

References

ISO Guide 31; ČSN EN ISO 17034:2017; NIST SRM series