CRM Ag, Al, As, B, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ga, K, Li, Mg, Mn, Mo, Na, Ni, Pb, Rb, Se, Sr, Te, Tl, U, V, Zn - Aqueous calibration solution ASTASOL® AN9104MN

Importance of the Topic

Aqueous multi‐element calibration solutions are essential for accurate quantitative analysis in atomic and molecular spectrometry. Certified reference materials (CRMs) like ASTASOL® AN9104MN ensure traceability, comparability and reliability of results across laboratories in environmental, pharmaceutical and industrial sectors.

Objectives and Overview

This certificate describes the production, characterization and use of ASTASOL® AN9104MN, a 5% HNO₃‐based aqueous solution containing 28 elements at certified concentrations. It outlines the gravimetric preparation, primary and instrumental validation methods, homogeneity, stability and intended applications.

Methodology and Instrumentation

The solution was formulated by weighing high‐purity starting compounds under SI‐traceable conditions. Certified values and uncertainties (k=2) were assigned through:

• Gravimetric determinations
• Complexometric titrations with EDTA
• Iodometric and acid‐base titrations
• Instrumental calibrations using AAS, AES, ICP‐OES and ICP‐MS

Traceability was established using NIST SRMs and internal CRMs.

Used Instrumentation

• Atomic Absorption Spectrometry (AAS)
• Atomic Emission Spectrometry (AES)
• Inductively Coupled Plasma Optical Emission Spectrometry (ICP‐OES)
• Inductively Coupled Plasma Mass Spectrometry (ICP‐MS)

Main Results and Discussion

Certified concentrations at 20 °C:

• Calcium: 1000 ± 2 mg/L
• As, B, Be, Fe, Se, Zn: 100.0 ± 0.2 mg/L
• Remaining 22 elements: 10.00 ± 0.05 mg/L

Density was determined as 1.0381 ± 0.0005 g/cm³. Trace impurities were quantified at sub‐µg/L levels, confirming high purity. Homogeneity and stability tests guarantee consistent performance over a one‐year shelf life if stored at 5–30 °C.

Benefits and Practical Applications

This CRM supports calibration and method validation in:

• Flame and graphite furnace AAS
• AES and ICP‐OES
• ICP‐MS
• Molecular absorption and electroanalytical techniques

It enhances quality control, ensures compliance with regulatory standards and facilitates interlaboratory comparisons.

Future Trends and Opportunities

Advances in miniaturized spectrometers and on‐site analysis will increase demand for stable, multi‐element CRMs. Integration with digital certification and blockchain could further improve traceability. Custom formulations for emerging contaminants and tailored matrices represent potential growth areas.

Conclusion

ASTASOL® AN9104MN provides a well‐characterized, SI‐traceable multi‐element solution, combining rigorous gravimetric preparation with comprehensive instrumental validation. It offers reliable calibration across a broad concentration range and supports diverse analytical methods in modern laboratories.