A Comparative Study of the Intact Mass, Subunit Mass, and Released Glycans of Two Rituximab Biosimilars Using High-Resolution LC/MSApplications | 2020 | Agilent TechnologiesInstrumentationSample Preparation, LC/TOF, LC/HRMS, LC/MS, LC/MS/MSIndustriesPharma & BiopharmaManufacturerAgilent TechnologiesKey wordsinnovator, glycan, glycans, mab, subunits, released, intact, ides, counts, assaymap, bravo, agilent, mass, deconvoluted, advancebio, subunit, biosimilars, instantpc, amu, reduced, biosimilar, sensitivity, glykoprep, sample, deconvolution, abundance, were, preparation, fluorescence, mapping, therapeutic, acquisition, glycoforms, percentage, heavy, glycosylation, digested, high, lysine, handling, entropy, units, time, analysis, plrp, rituximab, rapid, average, from, charge
Intact & Subunit Analysis Using Reversed Phase - Agilent BioHPLC Columns Application Compendium
Agilent-NISTmAbIntact & Subunit AnalysisUsing Reversed PhaseAgilent BioHPLC ColumnsApplication CompendiumContentsAgilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted fromNISTmAb RM 8671 batch. Quality control (QC) testing is performed usingAgilent LC-MS system. QC batch release test includes aggregate profile, chargevariants and intact mass information....
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An Integrated Workflow for Intact and Subunits of Monoclonal Antibody Accurate Mass Measurements
An Integrated Workflow for Intactand Subunits of Monoclonal AntibodyAccurate Mass MeasurementsApplication NoteBiotherapeutics and BiosimilarsAuthorsIntroductionShuai Wu and Maryann ShenMonoclonal antibody (mAb) based entities represent a rapidly growing class ofbiologics that require extensive characterization to obtain approval for clinical trials andsubsequent market...
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Profiling Glycosylation of Monoclonal Antibodies at Three Levels Using the Agilent 6545XT AdvanceBio LC/Q‑TOF
Application NoteBiotherapeutics andBiosimilarsProfiling Glycosylation of MonoclonalAntibodies at Three Levels Using theAgilent 6545XT AdvanceBio LC/Q‑TOFAuthorIntroductionDavid L. WongAgilent Technologies, Inc.Santa Clara, CA, USAMonoclonal antibodies (mAbs) and their derivatives represent a very important classof biopharmaceutical molecules with a wide range of applications. With...
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Agilent BioHPLC Columns - Characterization of NIST Monoclonal Antibody Critical Quality Attributes - Application Compendium
Agilent BioHPLC ColumnsCharacterization of NIST MonoclonalAntibody Critical Quality AttributesApplication CompendiumContentsAgilent-NISTmAb Standard (P/N 5191-5744; 5191-5745) was aliquoted fromNISTmAb RM 8671 batch. Quality control (QC) testing is performed usingAgilent LC-MS system. QC batch release test includes aggregate profile, chargevariants and intact mass...
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