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Routine analysis of drug to antibody ratio and drug distribution with maXis II

 

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APPLICATION NOTE 72511 Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping Authors Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs1 Thermo Fisher Scientific 1 San…
Key words
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Integrated characterization of a lysine-linked antibody-drug conjugate by native intact mass analysis and peptide mapping performed on a hybrid quadrupole-Orbitrap mass spectrometer with high mass range Aaron O. Bailey 1, Stephane Houel 1, Eugen Damoc 2, Kai Scheffler 3, Jonathan…
Key words
linker, linkerkvepk, kvepkpeptide, peptidenative, nativeintact, intactdrug, drugmcc, mccemtansine, emtansineadc, adcmass, massmapping, mappingtrastuzumab, trastuzumabantibody, antibodyspectra, spectraforms
Size Exclusion Chromatography/ Mass Spectrometry Analysis of Antibody Drug Conjugates Using the Agilent 1260 Infinity II Bio-Inert LC Application Note Biologics & Biosimilars Author Abstract Sonja Schneider Recombinant monoclonal antibodies (mAbs) have emerged as important Agilent Technologies, Inc. therapeutic agents…
Key words
adcs, adcsdeconvoluted, deconvolutedadc, adctrastuzumab, trastuzumabdeglycosylated, deglycosylatedmass, masscounts, countsdrug, drugantibody, antibodysec, seclinker, linkerspectrum, spectrumcharge, chargedar, darconjugates
[ APPLICATION NOTE ] Analytical Scale Native SEC-MS for Antibody-Drug Conjugates (ADCs) Characterization Henry Shion, Ying Qing Yu, and Weibin Chen Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ ■■ An improved native mass spectrometry with analytical scale Size…
Key words
adcs, adcsnative, nativesec, secdar, dardrug, drugantibody, antibodyhic, hicscale, scaleconjugated, conjugatedconjugates, conjugatescharacterization, characterizationprotein, proteinuplc, uplcvion, vionconjugation
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