Characterization of Monoclonal Antibodies and ADCs using a Benchtop Orbitrap Mass SpectrometerPosters | 2015 | Thermo Fischer ScientificInstrumentationLC/HRMS, LC/MS, LC/MS/MS, LC/OrbitrapIndustriesClinical ResearchManufacturerThermo Fischer ScientificKey wordsintact, abundance, peptide, figure, relative, light, molecule, adcs, mass, weight, mapping, pepfinder, heavy, glycoforms, thermo, full, adc, hplc, min, xiaoxi, chain, scientific, accela, were, characterization, orbitrap, esi, different, iaa, spectrometer, benchtop, chymotrypsin, determination, chains, biopharmaceutical, base, its, time, conditions, drugs, antibodies, ben, linker, dtt, mab, monoclonal, flow, herceptin, reduced, labeled
Similar PDF
Thermo Scientific Q Exactive hybrid quadrupole-Orbitrap mass spectrometers with ZipChip system
2017|Thermo Fischer Scientific|Brochures and specifications
A comprehensive CE/ESI-MSsolution for BioPharma applicationsThermo Scientific Q Exactive hybrid quadrupole-Orbitrapmass spectrometers with ZipChip systemFast CE SeparationNanospray SensitivityHRAM SpectrometryA unique and powerful combination of CE/ESI andMS technology designed for BioPharmaceuticalapplicationsThermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap™ mass spectrometerplatforms coupled with the...
Key words
zipchip, zipchipbiopharma, biopharmaexactive, exactiverelative, relativefinder, finderabundance, abundancemab, mabmass, massemtasine, emtasineoption, optionlysine, lysinecarbohydrates, carbohydratestrastuzumab, trastuzumabides, idesinfliximab
Characterization of Monoclonal Antibodies Oxidation Variants Using Middle-down Approach and Hydrogen/Deuterium Exchange Mass Spectrometry
2015|Thermo Fischer Scientific|Posters
There is a growing trend to obtain intact mass information aswell as the glycan profile in the QC of mAbs using highresolution mass spectrometers. The most commonly employedLC/MS method is to desalt mAbs via reverse phase liquidchromatography and perform an...
Key words
trastuzumab, trastuzumabscfc, scfcoxidized, oxidizedmab, mabfigure, figuredeuterium, deuteriumides, idesmabpac, mabpacfragments, fragmentsoxidation, oxidationfab, fabtic, ticdtt, dttpapain, papainerml
ASMS 2021: Comprehensive Characterization of Cysteine-conjugated Antibody Drug Conjugate (ADC) on a Hybrid Quadrupole-Orbitrap Mass Spectrometer
2021|Thermo Fischer Scientific|Posters
Comprehensive Characterization of Cysteine-conjugated Antibody Drug Conjugate (ADC)on a Hybrid Quadrupole-Orbitrap Mass SpectrometerXiaoxi Zhang1, Kristina Srzentić2 and Min Du2, Thermo Fisher Scientific 1 Shanghai, China; 2 Cambridge, Massachusetts, USPurpose: In-depth characterization of an antibody cysteine-fluorophore conjugate standard on aThermo Scientific™...
Key words
abundance, abundancerelative, relativelinker, linkerpeptide, peptideintact, intactdrug, drugftms, ftmsadc, adctvaptecs, tvaptecscarboxymethylation, carboxymethylationconjugate, conjugatemapping, mappingdenatured, denaturedscdk, scdkmin
ASMS 2020: Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid Quadrupole- Orbitrap Mass Spectrometer
2020|Thermo Fischer Scientific|Posters
Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass SpectrometerKristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher Scientific,...
Key words
herceptin, herceptinchain, chainnative, nativeadc, adcantibody, antibodyintact, intactabundance, abundancemass, masspeptide, peptideiyptngytr, iyptngytrcharacterization, characterizationrelative, relativesigma, sigmamab, mabmonoclonal