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A comprehensive CE/ESI-MSsolution for BioPharma applicationsThermo Scientific Q Exactive hybrid quadrupole-Orbitrapmass spectrometers with ZipChip system Fast CE SeparationNanospray SensitivityHRAM SpectrometryA unique and powerful combination of CE/ESI andMS technology designed for BioPharmaceuticalapplicationsThermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap™ mass spectrometerplatforms coupled with the...
Key words
zipchip, zipchipbiopharma, biopharmaexactive, exactiverelative, relativefinder, finderabundance, abundancemab, mabmass, massemtasine, emtasineoption, optionlysine, lysinecarbohydrates, carbohydratesides, idestrastuzumab, trastuzumabvariants
There is a growing trend to obtain intact mass information aswell as the glycan profile in the QC of mAbs using highresolution mass spectrometers. The most commonly employedLC/MS method is to desalt mAbs via reverse phase liquidchromatography and perform an...
Key words
trastuzumab, trastuzumabscfc, scfcoxidized, oxidizedmab, mabfigure, figuredeuterium, deuteriumides, idesmabpac, mabpacfragments, fragmentsoxidation, oxidationfab, fabdtt, dtttic, ticpapain, papainerml
Poster Note 643 98Fast Analysis of Therapeutic MonoclonalAntibodies, Fragments, and OxidationVariants Using a Super-Macro PorousReversed-PhaseCoupledwith anFragments,FastAnalysisAnalysisof TherapeuticTherapeuticColumnMonoclonalAntibodies,FastofMonoclonalAntibodies,Fragments, aOrbitrapMassSpectrometerColumn CoupledCoupled withwith ananOrbitrapOrbitrap MassMass SpectrometerSpectrometerColumnLin, Terry Zhang,22Hongxia Wang, Jonathan Josephs,and Xiaodong Liu1, Terry22, ,JonathanShanhuaLinLin1ShanhuaZhangHongxiaWangJonathanJosephs22, and Xiaodong Liu11Shanhua,ThermoTerry, ,HongxiaWangFisherZhangScientific, Sunnyvale,CA; ThermoFisher Scientific, San...
Key words
oxidized, oxidizedscfc, scfcherceptin, herceptinmab, mabides, idesmabfragments, mabfragmentsfigure, figurefragments, fragmentsabundance, abundancedtt, dttmabpac, mabpacrelative, relativepapain, papainrapidseparation, rapidseparationfab
Evaluation of a microfluidic electrophoresis device coupled to an Orbitrap mass spectrometer for the characterizationof biotherapeutics proteins.Stephane Houel1, Terry Zhang1, Erin Redman2, Scott Mellors2, Aaron Bailey1, Chris Petty2, Aran Paulus1, Kai Zhou1, Jonathan Josephs1., 1Thermo Fisher Scientific, San Jose, CA,...
Key words
electrophoresis, electrophoresismab, mabnist, nistzipchip, zipchiplysine, lysineemtansine, emtansineintact, intactmass, massmicrofluidic, microfluidicabundance, abundanceorbitrap, orbitrapcharacterize, characterizerelative, relativecentimeter, centimeternanoelectrospray
 

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A comprehensive CE/ESI-MSsolution for BioPharma applicationsThermo Scientific Q Exactive hybrid quadrupole-Orbitrapmass spectrometers with ZipChip system Fast CE SeparationNanospray SensitivityHRAM SpectrometryA unique and powerful combination of CE/ESI andMS technology designed for BioPharmaceuticalapplicationsThermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap™ mass spectrometerplatforms coupled with the...
Key words
zipchip, zipchipbiopharma, biopharmaexactive, exactiverelative, relativefinder, finderabundance, abundancemab, mabmass, massemtasine, emtasineoption, optionlysine, lysinecarbohydrates, carbohydratesides, idestrastuzumab, trastuzumabvariants
There is a growing trend to obtain intact mass information aswell as the glycan profile in the QC of mAbs using highresolution mass spectrometers. The most commonly employedLC/MS method is to desalt mAbs via reverse phase liquidchromatography and perform an...
Key words
trastuzumab, trastuzumabscfc, scfcoxidized, oxidizedmab, mabfigure, figuredeuterium, deuteriumides, idesmabpac, mabpacfragments, fragmentsoxidation, oxidationfab, fabdtt, dtttic, ticpapain, papainerml
Poster Note 643 98Fast Analysis of Therapeutic MonoclonalAntibodies, Fragments, and OxidationVariants Using a Super-Macro PorousReversed-PhaseCoupledwith anFragments,FastAnalysisAnalysisof TherapeuticTherapeuticColumnMonoclonalAntibodies,FastofMonoclonalAntibodies,Fragments, aOrbitrapMassSpectrometerColumn CoupledCoupled withwith ananOrbitrapOrbitrap MassMass SpectrometerSpectrometerColumnLin, Terry Zhang,22Hongxia Wang, Jonathan Josephs,and Xiaodong Liu1, Terry22, ,JonathanShanhuaLinLin1ShanhuaZhangHongxiaWangJonathanJosephs22, and Xiaodong Liu11Shanhua,ThermoTerry, ,HongxiaWangFisherZhangScientific, Sunnyvale,CA; ThermoFisher Scientific, San...
Key words
oxidized, oxidizedscfc, scfcherceptin, herceptinmab, mabides, idesmabfragments, mabfragmentsfigure, figurefragments, fragmentsabundance, abundancedtt, dttmabpac, mabpacrelative, relativepapain, papainrapidseparation, rapidseparationfab
Evaluation of a microfluidic electrophoresis device coupled to an Orbitrap mass spectrometer for the characterizationof biotherapeutics proteins.Stephane Houel1, Terry Zhang1, Erin Redman2, Scott Mellors2, Aaron Bailey1, Chris Petty2, Aran Paulus1, Kai Zhou1, Jonathan Josephs1., 1Thermo Fisher Scientific, San Jose, CA,...
Key words
electrophoresis, electrophoresismab, mabnist, nistzipchip, zipchiplysine, lysineemtansine, emtansineintact, intactmass, massmicrofluidic, microfluidicabundance, abundanceorbitrap, orbitrapcharacterize, characterizerelative, relativecentimeter, centimeternanoelectrospray
 

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