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Characterization of Monoclonal Antibodies and ADCs using a Benchtop Orbitrap Mass Spectrometer

Posters | 2015 | Thermo Fisher ScientificInstrumentation
LC/HRMS, LC/MS, LC/MS/MS, LC/Orbitrap
Industries
Clinical Research
Manufacturer
Thermo Fisher Scientific
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APPLICATION NOTE 72511 Complete characterization of a lysine-linked antibody drug conjugate by native LC/MS intact mass analysis and peptide mapping Authors Aaron O. Bailey,1 Stephane Houel,1 Kai Scheffler,2 Eugen Damoc,3 Jennifer Sutton,1 Jonathan L. Josephs1 Thermo Fisher Scientific 1 San…
Key words
chain, chainheavy, heavypeptide, peptideadc, adcmass, massintact, intactnative, nativesetting, settingmapping, mappingconjugation, conjugationdrug, drugemtansine, emtansinelinker, linkerantibody, antibodylysine
Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass Spectrometer Kristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher…
Key words
herceptin, herceptinchain, chainnative, nativeadc, adcantibody, antibodyintact, intactabundance, abundancemass, masspeptide, peptideiyptngytr, iyptngytrrelative, relativecharacterization, characterizationsigma, sigmamonoclonal, monoclonalmab
APPLICATION NOTE 73885 Complete characterization of monoclonal antibodies under native and denaturing conditions Kristina Srzentić1, Eugen Damoc2, Kai Scheffler3, Tom Buchanan4, Krisztina Radi4, Jennifer Sutton1 Thermo Fisher Scientific, 1 Cambridge, Massachusetts, US 2 Bremen, Germany 3 Germering, Germany 4 Hemel…
Key words
intact, intacttrastuzumab, trastuzumabnative, nativehcd, hcdmass, massmab, mabthermo, thermodown, downsubunit, subunitdeconvolution, deconvolutionscientific, scientificsubunits, subunitsmiddle, middlepeptide, peptideheavy
Characterization of monoclonal antibodies and antibody drug conjugates using iCIEF-MS online coupling platform Xiaoxi Zhang1, Tiemin Huang2, Tony Chen2, Tao Bo3, Min Du4. 1 Thermo Fisher Scientific, Shanghai, China, 2 Advanced Electrophoresis Solutions Ltd., Cambridge, Ontario, Canada, 3 Thermo Fisher…
Key words
icief, iciefpembrolizumab, pembrolizumabraw, rawpyro, pyroglu, gluspectra, spectracharge, chargegln, glndeconvolution, deconvolutionzoom, zoommobilization, mobilizationcief, ciefvariants, variantsclipping, clippingmain
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