Characterization of Monoclonal Antibodies and ADCs using a Benchtop Orbitrap Mass Spectrometer | LabRulez LCMS_EN
 

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A comprehensive CE/ESI-MSsolution for BioPharma applicationsThermo Scientific Q Exactive hybrid quadrupole-Orbitrapmass spectrometers with ZipChip system Fast CE SeparationNanospray SensitivityHRAM SpectrometryA unique and powerful combination of CE/ESI andMS technology designed for BioPharmaceuticalapplicationsThermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap™ mass spectrometerplatforms coupled with the...
Key words
zipchip, zipchipbiopharma, biopharmaexactive, exactiverelative, relativefinder, finderabundance, abundancemab, mabmass, massemtasine, emtasineoption, optionlysine, lysinecarbohydrates, carbohydratestrastuzumab, trastuzumabides, idesinfliximab
There is a growing trend to obtain intact mass information aswell as the glycan profile in the QC of mAbs using highresolution mass spectrometers. The most commonly employedLC/MS method is to desalt mAbs via reverse phase liquidchromatography and perform an...
Key words
trastuzumab, trastuzumabscfc, scfcoxidized, oxidizedmab, mabfigure, figuredeuterium, deuteriumides, idesmabpac, mabpacfragments, fragmentsoxidation, oxidationfab, fabtic, ticdtt, dttpapain, papainerml
Comprehensive Characterization of Cysteine-conjugated Antibody Drug Conjugate (ADC)on a Hybrid Quadrupole-Orbitrap Mass SpectrometerXiaoxi Zhang1, Kristina Srzentić2 and Min Du2, Thermo Fisher Scientific 1 Shanghai, China; 2 Cambridge, Massachusetts, USPurpose: In-depth characterization of an antibody cysteine-fluorophore conjugate standard on aThermo Scientific™...
Key words
abundance, abundancerelative, relativelinker, linkerpeptide, peptideintact, intactdrug, drugftms, ftmsadc, adctvaptecs, tvaptecscarboxymethylation, carboxymethylationconjugate, conjugatemapping, mappingdenatured, denaturedscdk, scdkmin
Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass SpectrometerKristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher Scientific,...
Key words
herceptin, herceptinchain, chainnative, nativeadc, adcantibody, antibodyintact, intactabundance, abundancemass, masspeptide, peptideiyptngytr, iyptngytrcharacterization, characterizationrelative, relativesigma, sigmamab, mabmonoclonal
 

Similar PDF

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A comprehensive CE/ESI-MSsolution for BioPharma applicationsThermo Scientific Q Exactive hybrid quadrupole-Orbitrapmass spectrometers with ZipChip system Fast CE SeparationNanospray SensitivityHRAM SpectrometryA unique and powerful combination of CE/ESI andMS technology designed for BioPharmaceuticalapplicationsThermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap™ mass spectrometerplatforms coupled with the...
Key words
zipchip, zipchipbiopharma, biopharmaexactive, exactiverelative, relativefinder, finderabundance, abundancemab, mabmass, massemtasine, emtasineoption, optionlysine, lysinecarbohydrates, carbohydratestrastuzumab, trastuzumabides, idesinfliximab
There is a growing trend to obtain intact mass information aswell as the glycan profile in the QC of mAbs using highresolution mass spectrometers. The most commonly employedLC/MS method is to desalt mAbs via reverse phase liquidchromatography and perform an...
Key words
trastuzumab, trastuzumabscfc, scfcoxidized, oxidizedmab, mabfigure, figuredeuterium, deuteriumides, idesmabpac, mabpacfragments, fragmentsoxidation, oxidationfab, fabtic, ticdtt, dttpapain, papainerml
Comprehensive Characterization of Cysteine-conjugated Antibody Drug Conjugate (ADC)on a Hybrid Quadrupole-Orbitrap Mass SpectrometerXiaoxi Zhang1, Kristina Srzentić2 and Min Du2, Thermo Fisher Scientific 1 Shanghai, China; 2 Cambridge, Massachusetts, USPurpose: In-depth characterization of an antibody cysteine-fluorophore conjugate standard on aThermo Scientific™...
Key words
abundance, abundancerelative, relativelinker, linkerpeptide, peptideintact, intactdrug, drugftms, ftmsadc, adctvaptecs, tvaptecscarboxymethylation, carboxymethylationconjugate, conjugatemapping, mappingdenatured, denaturedscdk, scdkmin
Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass SpectrometerKristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher Scientific,...
Key words
herceptin, herceptinchain, chainnative, nativeadc, adcantibody, antibodyintact, intactabundance, abundancemass, masspeptide, peptideiyptngytr, iyptngytrcharacterization, characterizationrelative, relativesigma, sigmamab, mabmonoclonal
 

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