Characterization of Monoclonal Antibodies and ADCs using a Benchtop Orbitrap Mass SpectrometerPosters | 2015 | Thermo Fischer ScientificInstrumentationLC/HRMS, LC/MS, LC/MS/MS, LC/OrbitrapIndustriesClinical ResearchManufacturerThermo Fischer ScientificKey wordsintact, abundance, peptide, figure, relative, light, molecule, adcs, mass, weight, mapping, pepfinder, heavy, glycoforms, thermo, full, adc, hplc, min, xiaoxi, chain, scientific, accela, were, characterization, orbitrap, esi, different, iaa, spectrometer, benchtop, chymotrypsin, determination, chains, biopharmaceutical, base, its, time, conditions, drugs, antibodies, ben, linker, dtt, mab, monoclonal, flow, herceptin, reduced, labeled
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A comprehensive CE/ESI-MSsolution for BioPharma applicationsThermo Scientific Q Exactive hybrid quadrupole-Orbitrapmass spectrometers with ZipChip system Fast CE SeparationNanospray SensitivityHRAM SpectrometryA unique and powerful combination of CE/ESI andMS technology designed for BioPharmaceuticalapplicationsThermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap™ mass spectrometerplatforms coupled with the...
Key words
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There is a growing trend to obtain intact mass information aswell as the glycan profile in the QC of mAbs using highresolution mass spectrometers. The most commonly employedLC/MS method is to desalt mAbs via reverse phase liquidchromatography and perform an...
Key words
trastuzumab, trastuzumabscfc, scfcoxidized, oxidizedmab, mabfigure, figuredeuterium, deuteriumides, idesmabpac, mabpacfragments, fragmentsoxidation, oxidationfab, fabtic, ticdtt, dttpapain, papainerml
ASMS 2021: Comprehensive Characterization of Cysteine-conjugated Antibody Drug Conjugate (ADC) on a Hybrid Quadrupole-Orbitrap Mass Spectrometer
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Comprehensive Characterization of Cysteine-conjugated Antibody Drug Conjugate (ADC)on a Hybrid Quadrupole-Orbitrap Mass SpectrometerXiaoxi Zhang1, Kristina Srzentić2 and Min Du2, Thermo Fisher Scientific 1 Shanghai, China; 2 Cambridge, Massachusetts, USPurpose: In-depth characterization of an antibody cysteine-fluorophore conjugate standard on aThermo Scientific™...
Key words
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Key words
herceptin, herceptinchain, chainnative, nativeadc, adcantibody, antibodyintact, intactabundance, abundancemass, masspeptide, peptideiyptngytr, iyptngytrcharacterization, characterizationrelative, relativesigma, sigmamab, mabmonoclonal