Characterization of Monoclonal Antibodies and ADCs using a Benchtop Orbitrap Mass Spectrometer | LabRulez LCMS
 

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Poster Note 643 98Fast Analysis of Therapeutic MonoclonalAntibodies, Fragments, and OxidationVariants Using a Super-Macro PorousReversed-PhaseCoupledwith anFragments,FastAnalysisAnalysisof TherapeuticTherapeuticColumnMonoclonalAntibodies,FastofMonoclonalAntibodies,Fragments, aOrbitrapMassSpectrometerColumn CoupledCoupled withwith ananOrbitrapOrbitrap MassMass SpectrometerSpectrometerColumnLin, Terry Zhang,22Hongxia Wang, Jonathan Josephs,and Xiaodong Liu1, Terry22, ,JonathanShanhuaLinLin1ShanhuaZhangHongxiaWangJonathanJosephs22, and Xiaodong Liu11Shanhua,ThermoTerry, ,HongxiaWangFisherZhangScientific, Sunnyvale,CA; ThermoFisher Scientific, San...
Key words
oxidized, oxidizedscfc, scfcherceptin, herceptinmab, mabides, idesmabfragments, mabfragmentsfigure, figurefragments, fragmentsabundance, abundancedtt, dttrelative, relativemabpac, mabpacpapain, papainerml, ermlrapidseparation
Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass SpectrometerKristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher Scientific,...
Key words
herceptin, herceptinchain, chainnative, nativeadc, adcantibody, antibodyintact, intactabundance, abundancemass, masspeptide, peptideiyptngytr, iyptngytrcharacterization, characterizationrelative, relativesigma, sigmamonoclonal, monoclonalmab
APPLICATION NOTE 72511Complete characterization of a lysine-linkedantibody drug conjugate by native LC/MSintact mass analysis and peptide mappingAuthorsAaron O. Bailey,1 Stephane Houel,1Kai Scheffler,2 Eugen Damoc,3Jennifer Sutton,1Jonathan L. Josephs1Thermo Fisher Scientific1San Jose, CA, USA2Dreieich, Germany3Bremen, GermanyKeywordsNative MS, intact mass, peptidemapping, characterization, antibodydrug...
Key words
chain, chainheavy, heavypeptide, peptideadc, adcmass, massintact, intactsetting, settingnative, nativemapping, mappingconjugation, conjugationdrug, drugemtansine, emtansinelinker, linkerantibody, antibodylight
APPLICATION NOTE73885Complete characterization of monoclonalantibodies under native and denaturing conditionsKristina Srzentić1, Eugen Damoc2,Kai Scheffler3, Tom Buchanan4,Krisztina Radi4, Jennifer Sutton1Thermo Fisher Scientific,1Cambridge, Massachusetts, US2Bremen, Germany3Germering, Germany4Hemel Hempstead, UKKeywords: Monoclonal antibodysubunits, Top-Down and Middle-Down,characterization, biotherapeutics, native anddenaturing conditions, IdeS, peptide mappingApplication benefits•...
Key words
intact, intacttrastuzumab, trastuzumabnative, nativemass, masshcd, hcdmab, mabdown, downsubunit, subunitthermo, thermodeconvolution, deconvolutionscientific, scientificsubunits, subunitsheavy, heavypeptide, peptidemiddle
 

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Poster Note 643 98Fast Analysis of Therapeutic MonoclonalAntibodies, Fragments, and OxidationVariants Using a Super-Macro PorousReversed-PhaseCoupledwith anFragments,FastAnalysisAnalysisof TherapeuticTherapeuticColumnMonoclonalAntibodies,FastofMonoclonalAntibodies,Fragments, aOrbitrapMassSpectrometerColumn CoupledCoupled withwith ananOrbitrapOrbitrap MassMass SpectrometerSpectrometerColumnLin, Terry Zhang,22Hongxia Wang, Jonathan Josephs,and Xiaodong Liu1, Terry22, ,JonathanShanhuaLinLin1ShanhuaZhangHongxiaWangJonathanJosephs22, and Xiaodong Liu11Shanhua,ThermoTerry, ,HongxiaWangFisherZhangScientific, Sunnyvale,CA; ThermoFisher Scientific, San...
Key words
oxidized, oxidizedscfc, scfcherceptin, herceptinmab, mabides, idesmabfragments, mabfragmentsfigure, figurefragments, fragmentsabundance, abundancedtt, dttrelative, relativemabpac, mabpacpapain, papainerml, ermlrapidseparation
Comprehensive Characterization of Monoclonal Antibody and Antibody Drug Conjugate on a Hybrid QuadrupoleOrbitrap Mass SpectrometerKristina Srzentić1, Eugen Damoc2, Krisztina Radi3, Tom Buchanan3 , Angela Criscuolo2, Jennifer Sutton1 1Thermo Fisher Scientific, Massachusetts, US, 2Thermo Fisher Scientific, Germany, and 3Thermo Fisher Scientific,...
Key words
herceptin, herceptinchain, chainnative, nativeadc, adcantibody, antibodyintact, intactabundance, abundancemass, masspeptide, peptideiyptngytr, iyptngytrcharacterization, characterizationrelative, relativesigma, sigmamonoclonal, monoclonalmab
APPLICATION NOTE 72511Complete characterization of a lysine-linkedantibody drug conjugate by native LC/MSintact mass analysis and peptide mappingAuthorsAaron O. Bailey,1 Stephane Houel,1Kai Scheffler,2 Eugen Damoc,3Jennifer Sutton,1Jonathan L. Josephs1Thermo Fisher Scientific1San Jose, CA, USA2Dreieich, Germany3Bremen, GermanyKeywordsNative MS, intact mass, peptidemapping, characterization, antibodydrug...
Key words
chain, chainheavy, heavypeptide, peptideadc, adcmass, massintact, intactsetting, settingnative, nativemapping, mappingconjugation, conjugationdrug, drugemtansine, emtansinelinker, linkerantibody, antibodylight
APPLICATION NOTE73885Complete characterization of monoclonalantibodies under native and denaturing conditionsKristina Srzentić1, Eugen Damoc2,Kai Scheffler3, Tom Buchanan4,Krisztina Radi4, Jennifer Sutton1Thermo Fisher Scientific,1Cambridge, Massachusetts, US2Bremen, Germany3Germering, Germany4Hemel Hempstead, UKKeywords: Monoclonal antibodysubunits, Top-Down and Middle-Down,characterization, biotherapeutics, native anddenaturing conditions, IdeS, peptide mappingApplication benefits•...
Key words
intact, intacttrastuzumab, trastuzumabnative, nativemass, masshcd, hcdmab, mabdown, downsubunit, subunitthermo, thermodeconvolution, deconvolutionscientific, scientificsubunits, subunitsheavy, heavypeptide, peptidemiddle
 

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