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APPLICATION NOTE 72358Quick screening of intact antibody and antibodydrug conjugates with integrated microfluidiccapillary electrophoresis and mass spectrometryAuthorsChien-Hsun Alex Chen,1 StephaneHouel,1 Terry Zhang,1 Brian J.Agnew,2 Shanhua Lin,3 Kai Zhou,1Jonathan Josephs,1 Aran Paulus,1and Andreas F. R. Huhmer1Thermo Fisher Scientific,1San Jose, CA, 2Eugene,...
Key words
mab, mabadc, adcnist, nistmass, massrelative, relativevariants, variantszipchip, zipchipbiopharma, biopharmaexactive, exactiveabundance, abundancelysine, lysinemodification, modificationdrug, drugintact, intactconjugates
A comprehensive CE/ESI-MSsolution for BioPharma applicationsThermo Scientific Q Exactive hybrid quadrupole-Orbitrapmass spectrometers with ZipChip system Fast CE SeparationNanospray SensitivityHRAM SpectrometryA unique and powerful combination of CE/ESI andMS technology designed for BioPharmaceuticalapplicationsThermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap™ mass spectrometerplatforms coupled with the...
Key words
zipchip, zipchipbiopharma, biopharmaexactive, exactiverelative, relativefinder, finderabundance, abundancemab, mabmass, massemtasine, emtasineoption, optionlysine, lysinecarbohydrates, carbohydratestrastuzumab, trastuzumabides, idesvariants
Evaluation of a microfluidic electrophoresis device coupled to an Orbitrap mass spectrometer for the characterizationof biotherapeutics proteins.Stephane Houel1, Terry Zhang1, Erin Redman2, Scott Mellors2, Aaron Bailey1, Chris Petty2, Aran Paulus1, Kai Zhou1, Jonathan Josephs1., 1Thermo Fisher Scientific, San Jose, CA,...
Key words
electrophoresis, electrophoresismab, mabnist, nistzipchip, zipchiplysine, lysineemtansine, emtansineintact, intactmass, massmicrofluidic, microfluidicabundance, abundanceorbitrap, orbitrapcharacterize, characterizerelative, relativecentimeter, centimeternanoelectrospray
ZipChip™ System for Selected Thermo Scientific™ Mass Spectrometers-- for CE/ESI-MS AnalysesThe world leader in serving science ContentZipChip System IntroductionZipChip Separation MechanismBiopharmaceutical Application ExamplesMetabolomics Application and System TestResources and Ordering Information2 What is the ZipChip System?• The ZipChip system uses integratedmicrofluidic technology to...
Key words
zipchip, zipchipexactive, exactivebiopharma, biopharmaabundance, abundancerelative, relativeassay, assayseparation, separationmab, mabbge, bgeachieved, achievedkit, kitintact, intactsystem, systemchip, chipvariants
 

Similar PDF

APPLICATION NOTE 72358Quick screening of intact antibody and antibodydrug conjugates with integrated microfluidiccapillary electrophoresis and mass spectrometryAuthorsChien-Hsun Alex Chen,1 StephaneHouel,1 Terry Zhang,1 Brian J.Agnew,2 Shanhua Lin,3 Kai Zhou,1Jonathan Josephs,1 Aran Paulus,1and Andreas F. R. Huhmer1Thermo Fisher Scientific,1San Jose, CA, 2Eugene,...
Key words
mab, mabadc, adcnist, nistmass, massrelative, relativevariants, variantszipchip, zipchipbiopharma, biopharmaexactive, exactiveabundance, abundancelysine, lysinemodification, modificationdrug, drugintact, intactconjugates
A comprehensive CE/ESI-MSsolution for BioPharma applicationsThermo Scientific Q Exactive hybrid quadrupole-Orbitrapmass spectrometers with ZipChip system Fast CE SeparationNanospray SensitivityHRAM SpectrometryA unique and powerful combination of CE/ESI andMS technology designed for BioPharmaceuticalapplicationsThermo Scientific™ Q Exactive™ hybrid quadrupole-Orbitrap™ mass spectrometerplatforms coupled with the...
Key words
zipchip, zipchipbiopharma, biopharmaexactive, exactiverelative, relativefinder, finderabundance, abundancemab, mabmass, massemtasine, emtasineoption, optionlysine, lysinecarbohydrates, carbohydratestrastuzumab, trastuzumabides, idesvariants
Evaluation of a microfluidic electrophoresis device coupled to an Orbitrap mass spectrometer for the characterizationof biotherapeutics proteins.Stephane Houel1, Terry Zhang1, Erin Redman2, Scott Mellors2, Aaron Bailey1, Chris Petty2, Aran Paulus1, Kai Zhou1, Jonathan Josephs1., 1Thermo Fisher Scientific, San Jose, CA,...
Key words
electrophoresis, electrophoresismab, mabnist, nistzipchip, zipchiplysine, lysineemtansine, emtansineintact, intactmass, massmicrofluidic, microfluidicabundance, abundanceorbitrap, orbitrapcharacterize, characterizerelative, relativecentimeter, centimeternanoelectrospray
ZipChip™ System for Selected Thermo Scientific™ Mass Spectrometers-- for CE/ESI-MS AnalysesThe world leader in serving science ContentZipChip System IntroductionZipChip Separation MechanismBiopharmaceutical Application ExamplesMetabolomics Application and System TestResources and Ordering Information2 What is the ZipChip System?• The ZipChip system uses integratedmicrofluidic technology to...
Key words
zipchip, zipchipexactive, exactivebiopharma, biopharmaabundance, abundancerelative, relativeassay, assayseparation, separationmab, mabbge, bgeachieved, achievedkit, kitintact, intactsystem, systemchip, chipvariants
 

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