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MethodsCalibratorsCalibrators containing cyclosporin A, everolimus, sirolimus, and tacrolimus in whole bloodwere purchased from Chromsystems Instruments & Chemicals GmbH (TABLE 1).Evaluation of Benchtop QuadrupoleOrbitrap Ultra-High-Resolution MassSpectrometer in Rapid QuantitativeAnalysisof ImmunosuppressantEvaluationof BenchtopQuadrupole Orbitrap Ultra-High-ResolutioDrugs in BloodSamplesImmunosuppressantDrugsin Blood SamplesTABLE 1. Concentrations of calibrators.Cal...
Key words
cyclosporin, cyclosporintacrolimus, tacrolimuseverolimus, everolimussirolimus, sirolimusimmunosuppressant, immunosuppressantquantifier, quantifierrelative, relativeanalyte, analyteabundance, abundanceblood, bloodascomycin, ascomycinpositive, positiveorbitrap, orbitrapquadrupole, quadrupoleclinical
TECHNICAL NOTE 64916Quantification of immunosuppressants in humanwhole blood by liquid chromatography-tandemmass spectrometry for clinical researchAuthorsClaudio De Nardi,1 Katharina Kern,2Steffen Peters2Thermo Fisher Scientific GmbH,Dreieich, Germany2RECIPE Chemicals + InstrumentsGmbH, Munich, Germany1KeywordsImmunosuppressants,cyclosporin A, tacrolimus, sirolimus,everolimus, human blood, massspectrometryApplication benefits• Quantification of four very...
Key words
cyclosporin, cyclosporineverolimus, everolimussirolimus, sirolimustacrolimus, tacrolimusconcentration, concentrationrecipe, recipeaverage, averagebias, biasimmunosuppressants, immunosuppressantsprecipitation, precipitationminutes, minutesendura, enduraabundance, abundancecontrols, controlscalibrator
TECHNICAL NOTE 64969Testing robustness: Immunosuppressant drugs inblood with a TSQ Quantis MS for clinical researchAuthorsKristine Van Natta, Neloni Wijeratne,Claudia MartinsThermo Fisher Scientific,San Jose, CAKeywordsImmunosuppressant,tacrolimus, sirolimus, everolimus,cyclosporin A, TSQ Quantis MS,TraceFinder, clinical research,robustnessGoalDemonstrate the robustness of the Thermo Scientific™ TSQ Quantis™...
Key words
quantis, quantistsq, tsqcyclosporin, cyclosporincalibrators, calibratorsblood, bloodmonitored, monitoredrobustness, robustnessimmunosuppressant, immunosuppressanttriple, tripleclinical, clinicalcalculated, calculatedquadrupole, quadrupolewere, werethermo, thermomass
TECHNICAL NOTE 65206Tomorrow’s quantitation: increased robustness forquantitation of immunosuppressant drugs in bloodwith the TSQ Fortis MS for clinical researchAuthorsNeloni Wijeratne, Claudia Martins,Kristine Van Natta, Xiaolei Xie,Thermo Fisher Scientific,San Jose, CADebadeep Bhattacharyya,Thermo Fisher Scientific,Boston, MAKeywordsImmunosuppressant drugs,LC-MS/MS, tacrolimus, sirolimus,everolimus, cyclosporin A, triplequadrupole...
Key words
fortis, fortiscleaning, cleaningtsq, tsqimmunosuppressant, immunosuppressantcyclosporin, cyclosporintriple, triplesirolimus, sirolimustacrolimus, tacrolimuseverolimus, everolimusquantitation, quantitationblood, bloodafter, afterdrugs, drugsbefore, beforetube
 

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MethodsCalibratorsCalibrators containing cyclosporin A, everolimus, sirolimus, and tacrolimus in whole bloodwere purchased from Chromsystems Instruments & Chemicals GmbH (TABLE 1).Evaluation of Benchtop QuadrupoleOrbitrap Ultra-High-Resolution MassSpectrometer in Rapid QuantitativeAnalysisof ImmunosuppressantEvaluationof BenchtopQuadrupole Orbitrap Ultra-High-ResolutioDrugs in BloodSamplesImmunosuppressantDrugsin Blood SamplesTABLE 1. Concentrations of calibrators.Cal...
Key words
cyclosporin, cyclosporintacrolimus, tacrolimuseverolimus, everolimussirolimus, sirolimusimmunosuppressant, immunosuppressantquantifier, quantifierrelative, relativeanalyte, analyteabundance, abundanceblood, bloodascomycin, ascomycinpositive, positiveorbitrap, orbitrapquadrupole, quadrupoleclinical
TECHNICAL NOTE 64916Quantification of immunosuppressants in humanwhole blood by liquid chromatography-tandemmass spectrometry for clinical researchAuthorsClaudio De Nardi,1 Katharina Kern,2Steffen Peters2Thermo Fisher Scientific GmbH,Dreieich, Germany2RECIPE Chemicals + InstrumentsGmbH, Munich, Germany1KeywordsImmunosuppressants,cyclosporin A, tacrolimus, sirolimus,everolimus, human blood, massspectrometryApplication benefits• Quantification of four very...
Key words
cyclosporin, cyclosporineverolimus, everolimussirolimus, sirolimustacrolimus, tacrolimusconcentration, concentrationrecipe, recipeaverage, averagebias, biasimmunosuppressants, immunosuppressantsprecipitation, precipitationminutes, minutesendura, enduraabundance, abundancecontrols, controlscalibrator
TECHNICAL NOTE 64969Testing robustness: Immunosuppressant drugs inblood with a TSQ Quantis MS for clinical researchAuthorsKristine Van Natta, Neloni Wijeratne,Claudia MartinsThermo Fisher Scientific,San Jose, CAKeywordsImmunosuppressant,tacrolimus, sirolimus, everolimus,cyclosporin A, TSQ Quantis MS,TraceFinder, clinical research,robustnessGoalDemonstrate the robustness of the Thermo Scientific™ TSQ Quantis™...
Key words
quantis, quantistsq, tsqcyclosporin, cyclosporincalibrators, calibratorsblood, bloodmonitored, monitoredrobustness, robustnessimmunosuppressant, immunosuppressanttriple, tripleclinical, clinicalcalculated, calculatedquadrupole, quadrupolewere, werethermo, thermomass
TECHNICAL NOTE 65206Tomorrow’s quantitation: increased robustness forquantitation of immunosuppressant drugs in bloodwith the TSQ Fortis MS for clinical researchAuthorsNeloni Wijeratne, Claudia Martins,Kristine Van Natta, Xiaolei Xie,Thermo Fisher Scientific,San Jose, CADebadeep Bhattacharyya,Thermo Fisher Scientific,Boston, MAKeywordsImmunosuppressant drugs,LC-MS/MS, tacrolimus, sirolimus,everolimus, cyclosporin A, triplequadrupole...
Key words
fortis, fortiscleaning, cleaningtsq, tsqimmunosuppressant, immunosuppressantcyclosporin, cyclosporintriple, triplesirolimus, sirolimustacrolimus, tacrolimuseverolimus, everolimusquantitation, quantitationblood, bloodafter, afterdrugs, drugsbefore, beforetube
 

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