Ultrafast Analysis of Metabolic Stability Assays Using Agilent RapidFire High-Resolution MS
Applications | 2019 | Agilent TechnologiesInstrumentation
Sample Preparation, LC/TOF, LC/HRMS, LC/MS, LC/MS/MS
IndustriesClinical Research
ManufacturerAgilent Technologies
Key wordsrapidfire, metabolic, stability, binned, half, carryover, were, generic, life, using, vitro, drug, assay, liver, microsomal, incubations, adme, assays, clearance, integrator, mrm, intrinsic, agilent, optimizer, compound, cycle, ultrafast, tof, analyzed, development, system, erthyromycin, pamameter, human, eliminated, bufuralol, dicolfenac, nefazadone, remaining, bupivicaine, values, yuqin, determined, mephenytoin, raphy, cinnarizine, dai, hlm, discovery, tripolidine
Similar PDF
Ultrafast Analysis of Metabolic Stability Assays using an Agilent Ultivo Triple Quadrupole LC/MS
2019|Agilent Technologies|Applications
Application Note Drug Discovery Ultrafast Analysis of Metabolic Stability Assays using an Agilent Ultivo Triple Quadrupole LC/MS Author Kevin McCann Agilent Technologies, Inc. Abstract A previous Application Note1 highlighted the advantages of using the Agilent RapidFire 365 high-throughput MS to…
Key words
rapidfire, rapidfireultivo, ultivopropafenone, propafenonenicardipine, nicardipineticlopidine, ticlopidinethioridazine, thioridazinemetabolic, metabolicremaining, remainingfluconazole, fluconazolehaloperidol, haloperidolpromethazine, promethazineclearance, clearancebuffer, bufferamitriptyline, amitriptylineagilent
RapidFire for Automated High-Throughput LC/MS
2023|Agilent Technologies|Guides
RapidFire for Automated High-Throughput LC/MS Proven. Rapid. Complete. Application Compendium Table of Contents Introduction3 Application Notes Method Development High-Throughput (Sub-2.5 Second) Direct Injection Analysis by Mass Spectrometry 4 Automated Method Development Using the Agilent RapidFire High-Throughput Mass Spectrometry…
Key words
rapidfire, rapidfirecounts, countsthroughput, throughputsip, sipwere, wereoligo, oligomass, masstof, tofagilent, agilentcartridge, cartridgehigh, highmethod, methoddata, dataoligos, oligosfrom
Ultrafast Plasma Protein Binding Analysis
2022|Agilent Technologies|Applications
Application Note Ultrafast Plasma Protein Binding Analysis Using the Agilent RapidFire high-throughput mass spectrometry system and accurate mass Q-TOF Authors Abstract Kari E. Schlicht and Vaughn P. Miller Agilent Technologies, Inc. There has been increased demand for higher throughput in…
Key words
bound, boundrapidfire, rapidfiretof, tofspe, spedialysis, dialysisvoltage, voltagesheath, sheathwere, wereequilibrium, equilibriumthroughput, throughputgas, gasmethod, methoddrying, dryingplasma, plasmarate
Automating Metabolic Stability Assays and Analyses using a Robotic Autosampler and LC/MS/MS Platform
2019|Agilent Technologies|Applications
GERSTEL Application Note No. 206, 2019 Automating Metabolic Stability Assays and Analyses using a Robotic Autosampler and LC/MS/MS Platform Fredrick D. Foster, John R. Stuff, Laurel A. Vernarelli, Jacqueline A. Whitecavage GERSTEL, Inc., 701 Digital Drive, Suite J, Linthicum, MD,…
Key words
gerstel, gerstelstability, stabilitymetabolic, metabolicmicrosomes, microsomesmicrosomal, microsomalmps, mpsliver, liverautomated, automateddrug, drugassays, assayshigh, highroboticpro, roboticprousing, usingrobotic, roboticincubation