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Online IEX-MS Characterization and Monitoring of mAbCharge Heterogeneity Using an Optimized Cation ExchangeResin and Compact TOF Mass SpectrometerSamantha Ippoliti1, Qi Wang1, Ying Qing Yu1, Matthew A. Lauber1, Henry Shion11Waters Corporation, Milford, MA, USAINTRODUCTIONRESULTSIon exchange chromatography (IEX) is a method of...
Key words
variants, variantsiex, iexcharge, chargedeamidation, deamidationacidic, acidictrastuzumab, trastuzumabmab, mabmain, mainconformational, conformationalexchange, exchangebasic, basicnative, nativeassignmentb, assignmentbpossible, possiblevariant
Automated Analytical Cation-Exchange Chromatography Fraction Collectionand Structural Characterization of Monoclonal Antibody Charge VariantsHua Yang, Bill Warren, and Stephan KozaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Cation-exchange separation onCharge variant levels in therapeutic proteins, including monoclonalBioResolve™ SCX mAb Columnsantibodies (mAbs), are often considered...
Key words
fraction, fractionfractions, fractionsmab, mabcharge, chargevariants, variantscex, cexscfc, scfcwfm, wfmanalytical, analyticalcollection, collectionstructural, structuraluplc, uplcacquity, acquitycharacterization, characterizationbioresolve
Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAbColumn, IonHance CX-MS pH Concentrates, and BioAccord SystemSamantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing YuWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■INTRODUCTIONA novel salt mediated pH gradient ionCharacterization of...
Key words
iex, iexcharge, chargemab, mabmass, massacquity, acquitybioresolve, bioresolverda, rdabioaccord, bioaccordides, idesmain, mainacidic, acidicvariant, variantscx, scxvariants, variantselectrophoresis
Characterization and Monitoring of mAb Charge Variantsvia Online IEX-MSSamantha IppolitiWaters MS User MeetingASMS 2019Atlanta, GAJune 1, 2019©2019 Waters Corporation1 Agenda1. mAb CQA Characterization2. Reverse Phase vs Ion Exchange Chromatography3. Online IEX-MS: Considerations for Method Development4. Case Studies5. Summary and Q &...
Key words
iex, iexvariants, variantsmab, mabcharge, chargeacidic, acidicdeamidation, deamidationvariant, variantonline, onlinemain, mainintact, intactspecieslikely, specieslikelyexchange, exchangebasic, basicinfliximab, infliximabspecies
 

Similar PDF

Online IEX-MS Characterization and Monitoring of mAbCharge Heterogeneity Using an Optimized Cation ExchangeResin and Compact TOF Mass SpectrometerSamantha Ippoliti1, Qi Wang1, Ying Qing Yu1, Matthew A. Lauber1, Henry Shion11Waters Corporation, Milford, MA, USAINTRODUCTIONRESULTSIon exchange chromatography (IEX) is a method of...
Key words
variants, variantsiex, iexcharge, chargedeamidation, deamidationacidic, acidictrastuzumab, trastuzumabmab, mabmain, mainconformational, conformationalexchange, exchangebasic, basicnative, nativeassignmentb, assignmentbpossible, possiblevariant
Automated Analytical Cation-Exchange Chromatography Fraction Collectionand Structural Characterization of Monoclonal Antibody Charge VariantsHua Yang, Bill Warren, and Stephan KozaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Cation-exchange separation onCharge variant levels in therapeutic proteins, including monoclonalBioResolve™ SCX mAb Columnsantibodies (mAbs), are often considered...
Key words
fraction, fractionfractions, fractionsmab, mabcharge, chargevariants, variantscex, cexscfc, scfcwfm, wfmanalytical, analyticalcollection, collectionstructural, structuraluplc, uplcacquity, acquitycharacterization, characterizationbioresolve
Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAbColumn, IonHance CX-MS pH Concentrates, and BioAccord SystemSamantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing YuWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■INTRODUCTIONA novel salt mediated pH gradient ionCharacterization of...
Key words
iex, iexcharge, chargemab, mabmass, massacquity, acquitybioresolve, bioresolverda, rdabioaccord, bioaccordides, idesmain, mainacidic, acidicvariant, variantscx, scxvariants, variantselectrophoresis
Characterization and Monitoring of mAb Charge Variantsvia Online IEX-MSSamantha IppolitiWaters MS User MeetingASMS 2019Atlanta, GAJune 1, 2019©2019 Waters Corporation1 Agenda1. mAb CQA Characterization2. Reverse Phase vs Ion Exchange Chromatography3. Online IEX-MS: Considerations for Method Development4. Case Studies5. Summary and Q &...
Key words
iex, iexvariants, variantsmab, mabcharge, chargeacidic, acidicdeamidation, deamidationvariant, variantonline, onlinemain, mainintact, intactspecieslikely, specieslikelyexchange, exchangebasic, basicinfliximab, infliximabspecies
 

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