Improving IEX Technology and IEX-MS Applications for Domain Specific Charge Variant Analysis of mAbPrezentace | 2019 | WatersInstrumentationLC/TOF, LC/HRMS, LC/MSIndustriesFarmaceutická analýzaManufacturerWatersKey wordsconfidential, company, iex, variant, mab, charge, batch, buffer, ionhance, vanguard, bioresolve, ides, scx, acidic, trastuzumab, variants, basic, fit, freshly, feedback, online, species, reproducibility, ammonium, digested, protein, fouling, main, deamidation, gradient, purposeful, pending, patent, prototyping, new, reception, metal, gift, informatics, appreciated, hardware, lysine, phase, specific, cief, pens, likely, bioaccord, infliximab, bicarbonate
Online IEX-MS Characterization and Monitoring of mAb Charge Heterogeneity Using an Optimized Cation Exchange Resin and Compact TOF Mass Spectrometer
Online IEX-MS Characterization and Monitoring of mAbCharge Heterogeneity Using an Optimized Cation ExchangeResin and Compact TOF Mass SpectrometerSamantha Ippoliti1, Qi Wang1, Ying Qing Yu1, Matthew A. Lauber1, Henry Shion11Waters Corporation, Milford, MA, USAINTRODUCTIONRESULTSIon exchange chromatography (IEX) is a method of...
variants, variantsiex, iexcharge, chargedeamidation, deamidationacidic, acidictrastuzumab, trastuzumabmab, mabmain, mainconformational, conformationalexchange, exchangebasic, basicnative, nativeassignmentb, assignmentbpossible, possiblevariant
Automated Analytical Cation-Exchange Chromatography Fraction Collection and Structural Characterization of Monoclonal Antibody Charge Variants
Automated Analytical Cation-Exchange Chromatography Fraction Collectionand Structural Characterization of Monoclonal Antibody Charge VariantsHua Yang, Bill Warren, and Stephan KozaWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Cation-exchange separation onCharge variant levels in therapeutic proteins, including monoclonalBioResolve™ SCX mAb Columnsantibodies (mAbs), are often considered...
fraction, fractionfractions, fractionsmab, mabcharge, chargevariants, variantscex, cexscfc, scfcwfm, wfmanalytical, analyticalcollection, collectionstructural, structuraluplc, uplcacquity, acquitycharacterization, characterizationbioresolve
Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column, IonHance CX-MS pH Concentrates, and BioAccord System
Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAbColumn, IonHance CX-MS pH Concentrates, and BioAccord SystemSamantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing YuWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■INTRODUCTIONA novel salt mediated pH gradient ionCharacterization of...
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Characterization and Monitoring of mAb Charge Variants via Online IEX-MS
Characterization and Monitoring of mAb Charge Variantsvia Online IEX-MSSamantha IppolitiWaters MS User MeetingASMS 2019Atlanta, GAJune 1, 2019©2019 Waters Corporation1Agenda1. mAb CQA Characterization2. Reverse Phase vs Ion Exchange Chromatography3. Online IEX-MS: Considerations for Method Development4. Case Studies5. Summary and Q &...
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