Online IEX-MS Characterization and Monitoring of mAb Charge Heterogeneity Using an Optimized Cation Exchange Resin and Compact TOF Mass Spectrometer

 

Similar PDF

Toggle
ONLINE IEX-MS CHARACTERIZATION AND MONITORING OF MAB CHARGE HETEROGENEITY USING AN OPTIMIZED CATION EXCHANGE RESIN AND COMPACT TOF MASS SPECTROMETER Samantha Ippoliti1, Qi Wang1, Ying Qing Yu1, Matthew A. Lauber1, Henry Shion1 1 Waters Corporation, Milford, MA, USA IdeS-Digested Trastuzumab…
Key words
iex, iexvariants, variantsdeamidation, deamidationcharge, chargeacidic, acidictrastuzumab, trastuzumabmab, mabmain, mainconformational, conformationalassignmentb, assignmentbbasic, basicnative, nativetof, tofpossible, possiblemass
Characterization and Monitoring of mAb Charge Variants via Online IEX-MS Samantha Ippoliti Waters MS User Meeting ASMS 2019 Atlanta, GA June 1, 2019 ©2019 Waters Corporation 1 Agenda 1. mAb CQA Characterization 2. Reverse Phase vs Ion Exchange Chromatography 3.…
Key words
iex, iexvariants, variantsmab, mabcharge, chargeacidic, acidicdeamidation, deamidationvariant, variantmain, mainonline, onlineintact, intactspecieslikely, specieslikelyinfliximab, infliximabbasic, basicexchange, exchangespecies
[ APPLICATION NOTE ] Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAb Column, IonHance CX-MS pH Concentrates, and BioAccord System Samantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION…
Key words
iex, iexcharge, chargemab, mabmass, massacquity, acquitybioresolve, bioresolverda, rdaides, idesbioaccord, bioaccordmain, mainacidic, acidicscx, scxvariant, variantelectrophoresis, electrophoresisvariants
Welcome to Waters Luncheon Seminar ©2019 Waters Corporation COMPANY CONFIDENTIAL 1 Your Feedback will be very much appreciated! Please provide your feedback and you will get a gift set at reception! Column-shaped pens ©2019 Waters Corporation COMPANY CONFIDENTIAL 2 Improving…
Key words
confidential, confidentialcompany, companyiex, iexvariant, variantmab, mabcharge, chargebatch, batchionhance, ionhancebuffer, buffervanguard, vanguardbioresolve, bioresolveides, idesscx, scxacidic, acidictrastuzumab
Other projects
Follow us
More information
WebinarsAbout usContact usTerms of use
LabRulez s.r.o., all rights reserved.