Online IEX-MS Characterization and Monitoring of mAb Charge Heterogeneity Using an Optimized Cation Exchange Resin and Compact TOF Mass Spectrometer
Posters | 2019 | WatersInstrumentation
LC/TOF, LC/HRMS, LC/MS
IndustriesPharma & Biopharma
ManufacturerWaters
Key wordsvariants, iex, charge, deamidation, acidic, trastuzumab, main, mab, conformational, assignmentb, basic, native, exchange, possible, mass, variant, peak, tof, compact, cation, monitoring, potency, heterogeneity, species, well, disulfide, resin, caveat, nonreduced, salt, case, degradation, recipes, compatible, bioresolve, volatile, accessibility, susceptibility, ides, glycoform, stressed, infliximab, bioaccord, subunits, sialic, establishment, unmodified, time, optimized, increase
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ONLINE IEX-MS CHARACTERIZATION AND MONITORING OF MAB CHARGE HETEROGENEITY USING AN OPTIMIZED CATION EXCHANGE RESIN AND COMPACT TOF MASS SPECTROMETER
2019|Waters|Posters
ONLINE IEX-MS CHARACTERIZATION AND MONITORING OF MAB CHARGE HETEROGENEITY USING AN OPTIMIZED CATION EXCHANGE RESIN AND COMPACT TOF MASS SPECTROMETER Samantha Ippoliti1, Qi Wang1, Ying Qing Yu1, Matthew A. Lauber1, Henry Shion1 1 Waters Corporation, Milford, MA, USA IdeS-Digested Trastuzumab…
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Characterization and Monitoring of mAb Charge Variants via Online IEX-MS
2019|Waters|Presentations
Characterization and Monitoring of mAb Charge Variants via Online IEX-MS Samantha Ippoliti Waters MS User Meeting ASMS 2019 Atlanta, GA June 1, 2019 ©2019 Waters Corporation 1 Agenda 1. mAb CQA Characterization 2. Reverse Phase vs Ion Exchange Chromatography 3.…
Key words
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2019|Waters|Applications
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iex, iexcharge, chargemab, mabmass, massacquity, acquitybioresolve, bioresolverda, rdaides, idesbioaccord, bioaccordmain, mainacidic, acidicscx, scxvariant, variantelectrophoresis, electrophoresisvariants
HPLC 2019: Improving IEX Technology and IEX-MS Applications for Domain Specific Charge Variant Analysis of mAb
2019|Waters|Presentations
Welcome to Waters Luncheon Seminar ©2019 Waters Corporation COMPANY CONFIDENTIAL 1 Your Feedback will be very much appreciated! Please provide your feedback and you will get a gift set at reception! Column-shaped pens ©2019 Waters Corporation COMPANY CONFIDENTIAL 2 Improving…
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confidential, confidentialcompany, companyiex, iexvariant, variantmab, mabcharge, chargebatch, batchionhance, ionhancebuffer, buffervanguard, vanguardbioresolve, bioresolveides, idesscx, scxacidic, acidictrastuzumab