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Welcome toWaters Luncheon Seminar©2019 Waters CorporationCOMPANY CONFIDENTIAL1 Your Feedback will be very much appreciated!Please provide your feedback and you will get agift set at reception!Column-shaped pens©2019 Waters CorporationCOMPANY CONFIDENTIAL2 Improving IEX Technology and IEX-MS Applications forDomain Specific Charge Variant Analysis of mAb©2019...
Key words
confidential, confidentialcompany, companyiex, iexvariant, variantmab, mabcharge, chargebatch, batchbuffer, bufferionhance, ionhancevanguard, vanguardbioresolve, bioresolveides, idesscx, scxacidic, acidictrastuzumab
ONLINE IEX-MS CHARACTERIZATION AND MONITORING OF MAB CHARGE HETEROGENEITY USING AN OPTIMIZED CATIONEXCHANGE RESIN AND COMPACT TOF MASS SPECTROMETERSamantha Ippoliti1, Qi Wang1, Ying Qing Yu1, Matthew A. Lauber1, Henry Shion11Waters Corporation, Milford, MA, USAIdeS-Digested Trastuzumab T0 & 1 weekINTRODUCTIONLC Conditions:Column:ACQUITY...
Key words
iex, iexvariants, variantsdeamidation, deamidationcharge, chargeacidic, acidictrastuzumab, trastuzumabmab, mabmain, mainconformational, conformationalbasic, basicnative, nativeassignmentb, assignmentbtof, tofpossible, possiblevariant
Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAbColumn, IonHance CX-MS pH Concentrates, and BioAccord SystemSamantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing YuWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■INTRODUCTIONA novel salt mediated pH gradient ionCharacterization of...
Key words
iex, iexcharge, chargemab, mabmass, massacquity, acquitybioresolve, bioresolverda, rdabioaccord, bioaccordides, idesmain, mainacidic, acidicscx, scxvariant, variantvariants, variantselectrophoresis
Characterization and Monitoring of mAb Charge Variantsvia Online IEX-MSSamantha IppolitiWaters MS User MeetingASMS 2019Atlanta, GAJune 1, 2019©2019 Waters Corporation1 Agenda1. mAb CQA Characterization2. Reverse Phase vs Ion Exchange Chromatography3. Online IEX-MS: Considerations for Method Development4. Case Studies5. Summary and Q &...
Key words
iex, iexvariants, variantsmab, mabcharge, chargeacidic, acidicdeamidation, deamidationvariant, variantonline, onlinemain, mainintact, intactspecieslikely, specieslikelyexchange, exchangebasic, basicinfliximab, infliximabspecies
 

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Welcome toWaters Luncheon Seminar©2019 Waters CorporationCOMPANY CONFIDENTIAL1 Your Feedback will be very much appreciated!Please provide your feedback and you will get agift set at reception!Column-shaped pens©2019 Waters CorporationCOMPANY CONFIDENTIAL2 Improving IEX Technology and IEX-MS Applications forDomain Specific Charge Variant Analysis of mAb©2019...
Key words
confidential, confidentialcompany, companyiex, iexvariant, variantmab, mabcharge, chargebatch, batchbuffer, bufferionhance, ionhancevanguard, vanguardbioresolve, bioresolveides, idesscx, scxacidic, acidictrastuzumab
ONLINE IEX-MS CHARACTERIZATION AND MONITORING OF MAB CHARGE HETEROGENEITY USING AN OPTIMIZED CATIONEXCHANGE RESIN AND COMPACT TOF MASS SPECTROMETERSamantha Ippoliti1, Qi Wang1, Ying Qing Yu1, Matthew A. Lauber1, Henry Shion11Waters Corporation, Milford, MA, USAIdeS-Digested Trastuzumab T0 & 1 weekINTRODUCTIONLC Conditions:Column:ACQUITY...
Key words
iex, iexvariants, variantsdeamidation, deamidationcharge, chargeacidic, acidictrastuzumab, trastuzumabmab, mabmain, mainconformational, conformationalbasic, basicnative, nativeassignmentb, assignmentbtof, tofpossible, possiblevariant
Online IEX-MS of mAb Charge Variants Using a BioResolve SCX mAbColumn, IonHance CX-MS pH Concentrates, and BioAccord SystemSamantha Ippoliti, Andrew Schmudlach, Matthew A. Lauber, and Ying Qing YuWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■INTRODUCTIONA novel salt mediated pH gradient ionCharacterization of...
Key words
iex, iexcharge, chargemab, mabmass, massacquity, acquitybioresolve, bioresolverda, rdabioaccord, bioaccordides, idesmain, mainacidic, acidicscx, scxvariant, variantvariants, variantselectrophoresis
Characterization and Monitoring of mAb Charge Variantsvia Online IEX-MSSamantha IppolitiWaters MS User MeetingASMS 2019Atlanta, GAJune 1, 2019©2019 Waters Corporation1 Agenda1. mAb CQA Characterization2. Reverse Phase vs Ion Exchange Chromatography3. Online IEX-MS: Considerations for Method Development4. Case Studies5. Summary and Q &...
Key words
iex, iexvariants, variantsmab, mabcharge, chargeacidic, acidicdeamidation, deamidationvariant, variantonline, onlinemain, mainintact, intactspecieslikely, specieslikelyexchange, exchangebasic, basicinfliximab, infliximabspecies
 

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