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COMPLETE AUTOMATED WORKFLOWFOR COMPARING THE N-GLYCAN PROFILE OF INNOVATOR AND BIO-SIMILARINFLIXIMAB SAMPLESCorey E. Reed¹, Ximo Zhang¹Waters Corporation, 34 Maple Street, Milford, MA 01757¹OVERVIEWRESULTS Improved N-glycanpreparation on theAndrew Alliancepipetting robot withautomated vacuumcontrols HILIC separationand ToF massdetection forefficient biotherapeuticcharacterizationusing a LC/MSsystem specificallydesigned...
Key words
glycan, glycaninnovator, innovatorinfliximab, infliximabautomated, automatedandrew, andrewbiosimilar, biosimilarµelution, µelutionunifi, unifiglycoworks, glycoworksprofiles, profilescontrols, controlsplate, platealliance, alliancepublication, publicationencapsulates
[ TECHNOLOGY BRIEF ]Released N-linked Glycan Analysis Using the BioAccord SystemXimo Zhang, Corey Reed, Henry Shion, William Alley, Robert Birdsall, and Ying Qing YuWaters Corporation, Milford, MA, USAThe BioAccord System with SmartMS™ bringscomprehensive N-linked glycan analysis to a new level.GOALTo...
Key words
bioaccord, bioaccordglycan, glycanflr, flrunifi, unifiglycans, glycansrfms, rfmspurposefully, purposefullyreleased, releasedbrief, briefimprove, improvesystem, systemhilicflr, hilicflroptical, opticaldesigned, designedlinked
Increasing Productivity and Confidence for N-linked Glycan Analysisof Biosimilars Using the BioAccord SystemXimo Zhang, Corey Reed, Henry Shion, William Alley, Robert Birdsall, and Ying Qing YuWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■A compliance ready all-encompassingMonoclonal antibody (mAb) based therapeutics have been...
Key words
glycan, glycanbioaccord, bioaccordbiosimilar, biosimilarbiosimilars, biosimilarsconfidence, confidencelinked, linkedflr, flrglycans, glycansreleased, releasedrda, rdaproductivity, productivityacquity, acquityinnovator, innovatorsystem, systemworkflow
BIOPHARMACEUTICALPLATFORM SOLUTIONKey Applications TABLE OF CONTENTSBiopharmaceutical Platform Solution with UNIFI:Key ApplicationsIntact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I BioseparationsBiotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drugconjugates (ADCs) – are among the fastest growing...
Key words
unifi, unifibiopharmaceutical, biopharmaceuticaluplc, uplcglycan, glycanacquity, acquityplatform, platformglycoworks, glycoworksglycans, glycanspeptide, peptidesolution, solutionbiosimilar, biosimilarintact, intactanalysis, analysisinnovator, innovatorwaters
 

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COMPLETE AUTOMATED WORKFLOWFOR COMPARING THE N-GLYCAN PROFILE OF INNOVATOR AND BIO-SIMILARINFLIXIMAB SAMPLESCorey E. Reed¹, Ximo Zhang¹Waters Corporation, 34 Maple Street, Milford, MA 01757¹OVERVIEWRESULTS Improved N-glycanpreparation on theAndrew Alliancepipetting robot withautomated vacuumcontrols HILIC separationand ToF massdetection forefficient biotherapeuticcharacterizationusing a LC/MSsystem specificallydesigned...
Key words
glycan, glycaninnovator, innovatorinfliximab, infliximabautomated, automatedandrew, andrewbiosimilar, biosimilarµelution, µelutionunifi, unifiglycoworks, glycoworksprofiles, profilescontrols, controlsplate, platealliance, alliancepublication, publicationencapsulates
[ TECHNOLOGY BRIEF ]Released N-linked Glycan Analysis Using the BioAccord SystemXimo Zhang, Corey Reed, Henry Shion, William Alley, Robert Birdsall, and Ying Qing YuWaters Corporation, Milford, MA, USAThe BioAccord System with SmartMS™ bringscomprehensive N-linked glycan analysis to a new level.GOALTo...
Key words
bioaccord, bioaccordglycan, glycanflr, flrunifi, unifiglycans, glycansrfms, rfmspurposefully, purposefullyreleased, releasedbrief, briefimprove, improvesystem, systemhilicflr, hilicflroptical, opticaldesigned, designedlinked
Increasing Productivity and Confidence for N-linked Glycan Analysisof Biosimilars Using the BioAccord SystemXimo Zhang, Corey Reed, Henry Shion, William Alley, Robert Birdsall, and Ying Qing YuWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■A compliance ready all-encompassingMonoclonal antibody (mAb) based therapeutics have been...
Key words
glycan, glycanbioaccord, bioaccordbiosimilar, biosimilarbiosimilars, biosimilarsconfidence, confidencelinked, linkedflr, flrglycans, glycansreleased, releasedrda, rdaproductivity, productivityacquity, acquityinnovator, innovatorsystem, systemworkflow
BIOPHARMACEUTICALPLATFORM SOLUTIONKey Applications TABLE OF CONTENTSBiopharmaceutical Platform Solution with UNIFI:Key ApplicationsIntact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I BioseparationsBiotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drugconjugates (ADCs) – are among the fastest growing...
Key words
unifi, unifibiopharmaceutical, biopharmaceuticaluplc, uplcglycan, glycanacquity, acquityplatform, platformglycoworks, glycoworksglycans, glycanspeptide, peptidesolution, solutionbiosimilar, biosimilarintact, intactanalysis, analysisinnovator, innovatorwaters
 

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