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IMPROVING CONFIDENCE AND PRODUCTIVITY FOR N-LINKED GLYCAN ANALYSIS IN BIOTHERAPEUTICS DEVELOPMENT USING AN INTEGRATED UPLC-FLR-HRMS SYSTEM

 

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[ APPLICATION NOTE ] Increasing Productivity and Confidence for N-linked Glycan Analysis of Biosimilars Using the BioAccord System Ximo Zhang, Corey Reed, Henry Shion, William Alley, Robert Birdsall, and Ying Qing Yu Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■…
Key words
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BIOPHARMACEUTICAL PLATFORM SOLUTION Key Applications TABLE OF CONTENTS Biopharmaceutical Platform Solution with UNIFI: Key Applications Intact Protein MS Analysis I Peptide Mapping I Released Glycan Analysis I Bioseparations Biotherapeutic proteins – such as monoclonal antibodies (mAbs), biosimilars, and antibody drug…
Key words
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WP 023 Automated Glycan Assignment Using Mass Measurement with a Calibrated Retention Time in Glucose Unit Ying Qing Yu1, and Weibin Chen1, Mark Hillard2, Niaobh McLoughlin2 and Pauline M. Rudd2 1. Waters Corporation, Milford USA; 2. National Institute of Bioprocessing…
Key words
glycan, glycaninnovator, innovatorglycans, glycansflr, flrbiosimilar, biosimilarwaterslibrary, waterslibraryinfliximab, infliximabneugc, neugcunifi, unifiassignment, assignmentbatches, batchestrending, trendinglibrary, librarycomparability, comparabilityworkflow
COMPLETE AUTOMATED WORKFLOW FOR COMPARING THE N-GLYCAN PROFILE OF INNOVATOR AND BIO-SIMILAR INFLIXIMAB SAMPLES Corey E. Reed¹, Ximo Zhang¹ Waters Corporation, 34 Maple Street, Milford, MA 01757¹ OVERVIEW RESULTS  Improved N-glycan preparation on the Andrew Alliance pipetting robot with…
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