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Improving LC-MS Separations of Peptides with Difluoroacetic Acid Ion PairingJennifer Nguyen, Xiaoxiao Liu, and Matthew A. LauberWaters Corporation, Milford, MA, USAINTRODUCTIONPeptide mapping is an important and critical techniquein the characterization of biopharmaceuticals. Theseseparations are based upon reversed-phase liquidchromatography that can...
Key words
dfa, dfapeptide, peptidecarbamidomethyl, carbamidomethylseparations, separationstfa, tfaabundances, abundancesdifluoroacetic, difluoroaceticcharge, chargetryptic, trypticionhance, ionhancepurified, purifiedminimizing, minimizingmab, mabalkylated, alkylatedform
[ TECHNOLOGY BRIEF ]Low Adduct Peptide LC-MS Obtained with IonHance DFAand Certified LDPE ContainersJennifer Nguyen, Xiaoxiao Liu, and Matthew LauberWaters Corporation, Milford, MA, USAMinimizing metal ion contamination for low adductLC-MS separations using high purity mobile phaseadditives and containers.GOALTo minimize metal...
Key words
metal, metalionhance, ionhanceldpe, ldpepeptide, peptidecontamination, contaminationadducts, adductscontainers, containersspectra, spectradfa, dfapfa, pfaexternally, externallyquality, qualitysourced, sourcedcertified, certifiedmobile
Comparing Mobile Phase Additives for the Separation of mAb TrypticPeptides: A Case Study on Formic, Difluoroacetic, and Trifluoroacetic AcidJennifer M. Nguyen, Xiaoxiao Liu, and Matthew A. LauberWaters Corporation, Milford, MA, USAAPPLICATION BENEFITSINTRODUCTIONAlternative chromatographic selectivityPeptide mapping is an important technique for...
Key words
dfa, dfaseparations, separationstfa, tfatryptic, trypticmab, mabcsh, cshpeptide, peptidepeptides, peptidesadditives, additivesbeh, behcomparing, comparingmobile, mobiledeamidated, deamidatedphase, phasedifluoroacetic
Selecting a Reversed-Phase Column for the Peptide Mapping Analysisof a Biotherapeutic ProteinStephan M. Koza and Erin E. ChambersWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Side-by-side performance of tenThe peptide mapping of proteins is a fundamental tool that has been appliedreversed-phase columns for...
Key words
peptide, peptidemapping, mappingbiotherapeutic, biotherapeuticreversed, reversedpeptides, peptidesselecting, selectingprotein, proteinangiotensin, angiotensintfa, tfaxic, xicphase, phasemassprep, masspreptryptic, trypticparticle, particlebradykinin
 

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Improving LC-MS Separations of Peptides with Difluoroacetic Acid Ion PairingJennifer Nguyen, Xiaoxiao Liu, and Matthew A. LauberWaters Corporation, Milford, MA, USAINTRODUCTIONPeptide mapping is an important and critical techniquein the characterization of biopharmaceuticals. Theseseparations are based upon reversed-phase liquidchromatography that can...
Key words
dfa, dfapeptide, peptidecarbamidomethyl, carbamidomethylseparations, separationstfa, tfaabundances, abundancesdifluoroacetic, difluoroaceticcharge, chargetryptic, trypticionhance, ionhancepurified, purifiedminimizing, minimizingmab, mabalkylated, alkylatedform
[ TECHNOLOGY BRIEF ]Low Adduct Peptide LC-MS Obtained with IonHance DFAand Certified LDPE ContainersJennifer Nguyen, Xiaoxiao Liu, and Matthew LauberWaters Corporation, Milford, MA, USAMinimizing metal ion contamination for low adductLC-MS separations using high purity mobile phaseadditives and containers.GOALTo minimize metal...
Key words
metal, metalionhance, ionhanceldpe, ldpepeptide, peptidecontamination, contaminationadducts, adductscontainers, containersspectra, spectradfa, dfapfa, pfaexternally, externallyquality, qualitysourced, sourcedcertified, certifiedmobile
Comparing Mobile Phase Additives for the Separation of mAb TrypticPeptides: A Case Study on Formic, Difluoroacetic, and Trifluoroacetic AcidJennifer M. Nguyen, Xiaoxiao Liu, and Matthew A. LauberWaters Corporation, Milford, MA, USAAPPLICATION BENEFITSINTRODUCTIONAlternative chromatographic selectivityPeptide mapping is an important technique for...
Key words
dfa, dfaseparations, separationstfa, tfatryptic, trypticmab, mabcsh, cshpeptide, peptidepeptides, peptidesadditives, additivesbeh, behcomparing, comparingmobile, mobiledeamidated, deamidatedphase, phasedifluoroacetic
Selecting a Reversed-Phase Column for the Peptide Mapping Analysisof a Biotherapeutic ProteinStephan M. Koza and Erin E. ChambersWaters Corporation, Milford, MA, USAAPPLICATION BENEFITS■■■■Side-by-side performance of tenThe peptide mapping of proteins is a fundamental tool that has been appliedreversed-phase columns for...
Key words
peptide, peptidemapping, mappingbiotherapeutic, biotherapeuticreversed, reversedpeptides, peptidesselecting, selectingprotein, proteinangiotensin, angiotensintfa, tfaxic, xicphase, phasemassprep, masspreptryptic, trypticparticle, particlebradykinin
 

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