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UNIVERSITY OF COPENHAGEN FA C U LT Y O F S C I E N C E Improving LC-MS Separations of Peptides with Difluoroacetic Acid Ion Pairing Jennifer M. Nguyen1,2, Xiaoxiao Liu2, and Matthew A. Lauber2 1University of Copenhagen, Frederiksberg,…
Key words
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[ APPLICATION NOTE ] Comparing Mobile Phase Additives for the Separation of mAb Tryptic Peptides: A Case Study on Formic, Difluoroacetic, and Trifluoroacetic Acid Jennifer M. Nguyen, Xiaoxiao Liu, and Matthew A. Lauber Waters Corporation, Milford, MA, USA APPLICATION BENEFITS…
Key words
dfa, dfaseparations, separationstfa, tfatryptic, trypticmab, mabcsh, cshpeptide, peptidepeptides, peptidesadditives, additivesbeh, behcomparing, comparingdeamidated, deamidatedmobile, mobilephase, phasedifluoroacetic
[ TECHNOLOGY BRIEF ] Low Adduct Peptide LC-MS Obtained with IonHance DFA and Certified LDPE Containers Jennifer Nguyen, Xiaoxiao Liu, and Matthew Lauber Waters Corporation, Milford, MA, USA Minimizing metal ion contamination for low adduct LC-MS separations using high purity…
Key words
metal, metalionhance, ionhanceldpe, ldpepeptide, peptidecontamination, contaminationadducts, adductsspectra, spectradfa, dfacontainers, containersexternally, externallysourced, sourcedquality, qualitypfa, pfacertified, certifiedmobile
[ APPLICATION NOTE ] Selecting a Reversed-Phase Column for the Peptide Mapping Analysis of a Biotherapeutic Protein Stephan M. Koza and Erin E. Chambers Waters Corporation, Milford, MA, USA APPLICATION BENEFITS ■■ ■■ Side-by-side performance of ten The peptide mapping…
Key words
peptide, peptidemapping, mappingbiotherapeutic, biotherapeuticreversed, reversedpeptides, peptidesselecting, selectingprotein, proteinangiotensin, angiotensintfa, tfaxic, xicphase, phasemassprep, masspreptryptic, trypticcolumn, columnparticle
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