Phenomenex Biozen Oligo LC columns

Advanced Oligonucleotide Analysis

Biozen Oligo is an organo-silica, core-shell particle bonded with a C18 stationary phase. This column offers a unique combination of Core-Shell performance gains such as speed, sensitivity and resolution plus the high pH ruggedness necessary for oligonucleotide separations. Additionally, Biozen Oligo is packaged in BioTi™, a novel bio-inert hardware that serves to alleviate the sample loss and adsorption issues.

Increased Recovery and Reproducibility with NEW Biozen Oligo

• BioTi™ Hardware Reduces Sample Loss and Adsorption
• Robustness at High pH and Temperature
• Core-Shell Advantage for High Efficiency

Phenomenex: Biozen Oligo HPLC Column

• Separation Mode: Reversed Phase
• Particle size: 1.7, 2.6
• Recommended Use: Analytical characterization of oligonucleotides

Patented Technology and Advanced Core-Shell Particle Chemistry

Biozen Oligo utilizes organo-silica core-shell technology to:​

• Minimize band broadening associated with diffusion and oligonucleotide mass transfer kinetics​
• Increase efficiency to produce narrower peaks, ideal for resolving closely eluting impurities​
• Patented grafting process ensures high pH and temperature resistance from ethylene cross-linking.​

Phenomenex: Patented Technology and Advanced Core-Shell Particle Chemistry

BioTi vs Stainless Steel Column Hardware​

Biozen Oligo's bioinert hardware enhances recovery, sensitivity, and chromatographic reproducibility by mitigating non-specific adsorption. Stainless steel equivalents fails to prevent this resulting in poor recovery, peak tailing, and residual carryover.​

Phenomenex Biozen Biologics LC Columns

With a new titanium BioTi™ biocompatible hardware to minimize priming, four particle platforms for optimal versatility and nine particle chemistries to maximize selectivity and sensitivity, Biozen UHPLC/HPLC columns for protein analysis are seamlessly designed to bring peace of mind to your analysis of biologics through:

• Charge Variant Analysis
• Aggregate Analysis
• Peptide Mapping
• Intact Mass Analysis
• Intact and Subunit Analysis
• Glycan Analysis
• Peptide Quantitation
• Drug Antibody Ratio (DAR)
• Oligonucleotide Characterization

Biocompatible Flow Path with BioTi™ Hardware

Keep your mind at ease knowing that we’ve minimized the need for priming with a new titanium infused biocompatible hardware and frit that doesn’t interfere with protein or peptide integrity!

Phenomenex: BioTi Hardware

4 Advanced Particle Platforms

All four of the Biozen particle platforms were individually designed and built by Phenomenex to take advantage of integral levels of performance, ruggedness, and reproducibility for protein characterization applications. Individually, each platform differs in the proprietary processing techniques used to control particle size and morphology.

Phenomenex: Advanced Particle Platforms