Thermo Scientific Syncronis PREP HILIC HPLC Columns

Maintain consistent, predictable separations for your scale up purification needs with Thermo Scientific™ Syncronis™ HILIC preparative HPLC columns for polar and hydrophilic analytes. Highly pure, high surface area silica and dense stationary phase coverage minimize secondary interactions and deliver reproducible high-resolution separations. 

The zwitterionic stationary phase results in a neutral, highly polar surface and provides optional selectivity to C18 columns without ion-pairing or derivatization. Our columns come in a wide range of dimensions and an option for XtendedLife hardware which improves column lifetime by maintaining a uniform packed bed.

Alternative Selectivity

• Zwitterionic bonded phase enhances retention of polar and hydrophilic analytes.
• No need for ion-pair or derivatization.
• Enhanced sensitivity with MS detection.
• Highly organic mobile phase facilitates desolvation in ESI-MS

Preparative HPLC Column Hardware Options - based on column inner diameter (i.d.) and column performance needs.

Standard Threaded and Standard Flange Hardware

• Designed for standard applications, expertly packed and robustly designed to provide versatile products for routine use.
• Standard threaded hardware for column i.d. < 40mm.
• Standard flange hardware for column i.d. ≥ 40mm.
• Standard hardware can be modified on request to be compatible with SFC.

XtendedLife Hardware

• Improves column lifetime by incorporating an internal Dynamic Axial Compression (DAC) system, ensuring the media bed is continuously packed tightly.
• Compatible with SFC and is available in dimensions up to 50mm i.d.

Preparative Guards are a proven and cost effective way to extend the lifetime of your prep column. Our preparative guard columns require the use of a preparative guard holder.

Specifications

• Column type: HILIC
• Endcapped: No
• Max. Pressure: 2000 psi (140 bar)
• Packing Material: Spherical, Fully Porous, Ultrapure Silica
• Stationary phase: Zwitterionic
• Surface Area: 320 m²/g
• Temperature: 60°C
• Carbon load: 5%
• Phase: HILIC
• Pore Size: 100 Å
• pH: 2 to 8

Syncronis HPLC and UHPLC Columns

Enter a new world of chromatography

When developing a new method, one of the most important goals for the chromatographer is to achieve a consistent, reproducible separation. This makes selecting an HPLC column that offers highly-reproducible results essential to attaining this goal.

Features of Syncronis columns

Thermo Scientific Syncronis LC columns achieve high levels of consistency and reproducibility through:

• Highly-pure, high-surface-area silica
• Dense bonding and double endcapping
• Stringent manufacturing and testing protocols