<p><strong>Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from deoxyribonucleic acid (DNA) into ribonucleic acid (RNA) can be initiated. The researchers focused on a specific class of molecules known as alarmones, which are found in cells across a wide range of organisms and whose levels often increase under conditions of cellular stress. The results were published in the prestigious scientific journal </strong><i><strong>Nature Chemical Biology</strong></i><strong>.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Hana Cahová, head of the Chemical Biology of Nucleic Acids research group." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Molecules of ribonucleic acid can carry a variety of chemical modifications at one end, known as caps. In eukaryotic organisms, including human cells, the best-known cap plays an important role in RNA stability and in regulating its subsequent fate. In recent years, however, it has become clear that alternative, non-canonical RNA caps also exist, although their formation and the mechanisms by which they are attached to RNA remain only partially understood. These include alarmone caps, formed by dinucleoside polyphosphate molecules, that protect cellular RNA at moments when the cell is under threat.</p><p>In their study,<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://cahova.group.uochb.cz/en"><strong>Dr. Hana Cahová</strong></a> and colleagues examined bacterial RNA polymerase and investigated how this enzyme can initiate transcription using dinucleoside polyphosphates (NpNs) instead of the standard RNA building blocks. For the first time, the scientists described, at the atomic level, how RNA bearing an alarmone cap can be generated directly at the initiation of gene transcription. They also observed that NpNs bind through a different type of base pairing than is typically observed.</p><p>The work was significantly shaped by <strong>Valentina Serianni from Hana Cahová’s team</strong>, who demonstrated the ability of dinucleoside polyphosphates to initiate gene transcription, and by <strong>Jana Škerlová</strong>, who focused on the structural analysis of RNA polymerase. Using cryogenic electron microscopy data, she showed how dinucleoside polyphosphate molecules bind within the active site of RNA polymerase – that is, the core of the enzyme where genetic information is transcribed. Together, their findings help to elucidate the processes that accompany the transcription of genetic information from DNA to RNA.</p><p>Hana Cahová adds: <i>“We’re describing something that truly occurs in cells and that we’re now able to observe directly at the level of individual molecules. This allows us to answer fundamental questions about cellular processes, such as how cells adapt to stress. RNA plays a central role in this, as it carries the cascade of information underlying any cellular response – for example, to threatening conditions caused by nutrient deprivation or temperature shock.”</i></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Tomáš Kouba, head of the Cryogenic Electron Microscopy core facility." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Cryogenic electron microscopy (cryo-EM) was central to the project. This part of the work was led by<strong> Dr. Tomáš Kouba</strong>, one of the authors of the study. <i>“Cryogenic electron microscopy allows us to freeze biological molecules in a state very close to their natural form and then determine their three-dimensional structure. This makes it possible to look directly into the active centers of enzymes and observe their function down to the atomic level,”</i> he explains.</p><p>Last year, IOCB Prague opened a new <a target="_blank" rel="noopener noreferrer" href="https://cryoem.group.uochb.cz/en"><strong>cryo-EM center</strong></a><strong> </strong>that is unique within the Czech research environment. State-of-the-art cryogenic electron microscopes are housed in a specially designed building and enable the study of biological processes with exceptional structural precision.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg" alt="IOCB Prague: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: This work shows how NpnNs initiate bacterial transcription. Cryo-EM reveals how nucleobases pair with the template: one in canonical and one in reverse Watson–Crick mode, providing a structural basis for their function as non-canonical RNA caps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg 245w," sizes="100vw" width="2000" height="1077"></p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-025-02134-5"><strong>Molecular insight into 5′ RNA capping with Np<sub>n</sub>Ns by bacterial RNA polymerase</strong></a></h4><p>Valentina M. Serianni, Jana Škerlová, Anna Knopp Dubánková, Anton Škríba, Hana Šváchová, Tereza Vučková, Anatolij Filimoněnko, Milan Fábry, Pavlína Řezáčová, Tomáš Kouba &amp; Hana Cahova&nbsp;</p><p>Nat. Chem. Biol. 21 (2026)</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-025-02134-5">https://doi.org/10.1038/s41589-025-02134-5</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>RNA capped with dinucleoside polyphosphates has been discovered in bacteria and eukaryotes only recently. The likely mechanism of this specific capping involves direct incorporation of dinucleoside polyphosphates by RNA polymerase as noncanonical initiating nucleotides. However, how these compounds bind into the active site of RNA polymerase during transcription initiation is unknown. Here, we explored transcription initiation in vitro, using a series of DNA templates in combination with dinucleoside polyphosphates and model RNA polymerase from <i>Thermus</i> <i>thermophilus</i>. We observed that the transcription start site can vary on the basis of the compatibility of the specific template and dinucleoside polyphosphate. Cryo-electron microscopy structures of transcription initiation complexes with dinucleoside polyphosphates revealed that both nucleobase moieties can pair with the DNA template. The first encoded nucleotide pairs in a canonical Watson–Crick manner, whereas the second nucleobase pairs noncanonically in a reverse Watson–Crick manner. Our work provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription.</p></div></div>

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

<p><strong>Food adulteration is a phenomenon with a long history that has gained increasing importance in recent years due to the globalization of food supply chains and strong economic pressures. Whether it involves diluting olive oil with cheaper oils, adding sugar to honey, or the hidden use of substitutes in protein supplements, the result is a loss of consumer trust and, in some cases, a potential risk to health. Analytical chemistry plays a key role in this area by providing methods and technologies capable of identifying and quantifying target compounds as well as unwanted impurities in a wide range of food matrices.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Praha_Falsovani_potravin_a_jak_ho_odhali_analyticka_chemie_6912db5492.jpg" alt="Watrex: Food Adulteration and How It Is Revealed by Analytical Chemistry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Praha_Falsovani_potravin_a_jak_ho_odhali_analyticka_chemie_6912db5492.jpg 245w," sizes="100vw" width="1600" height="900"></p><h4><strong>The Role of Chromatography in Forensic Food Analysis</strong></h4><p>Chromatography, particularly liquid chromatography (HPLC), is one of the most effective analytical tools for separating complex mixtures of molecules. It enables:</p><ul><li>qualitative identification of individual components in a sample,</li><li>quantitative determination of their concentrations,</li><li>detection of impurities and unexpected components that may indicate<br>adulteration.</li></ul><p>In practice, HPLC is often combined with various types of detectors (UV/VIS, DAD, refractive index detectors) or with other techniques (e.g., mass spectrometry) to increase selectivity and sensitivity.</p><h4><strong>Isocratic vs. Gradient Elution</strong></h4><p>In the analysis of food samples, chromatographic methods are selected according to the analytical goal:</p><ul><li><strong>Isocratic HPLC </strong>uses a constant mobile phase composition throughout the analysis. It is simple, robust, and ideal for routine determinations of well-defined target analytes (e.g., sugars or vitamins).</li><li><strong>Gradient HPLC</strong> changes the mobile phase composition during separation, enabling better resolution of complex mixtures with a wide range of polarities (e.g., peptides or phenolic compounds).</li></ul><p>Gradient methods are particularly useful when analytes have very different properties and high separation efficiency is required.</p><h4><strong>Watrex Praha and the Contribution of Modern Systems to Food Analysis</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha, s.r.o.</strong></a> is one of the leading Czech manufacturers and distributors of liquid chromatography systems and instruments, with a long tradition dating back to 1990. The company has successfully transformed from a distributor into a manufacturer of its own HPLC and related technologies, focusing on modular, robust systems suitable even for demanding analytical tasks.</p><p>Their <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?manufacturerItems=93&amp;search=streamline"><strong>Streamline™ product line</strong></a><strong> </strong>includes several HPLC system concepts suitable for food analysis:</p><ul><li><strong>Isocratic HPLC system</strong> – a simple yet precise configuration with a single pump, column thermostat, and UV/VIS detector; suitable for routine determination of known analytes (e.g., basic carbohydrates, food additives).</li><li><strong>Binary gradient HPLC system</strong> – equipped with two pumps enabling mobile phase gradient formation, which enhances separation performance for complex mixtures<br>(e.g., phenolic profiles of wine, components of aromatic extracts).</li><li><strong>GPC/SEC system (Gel Permeation / Size Exclusion Chromatography)</strong> – a specialized solution for the determination of macromolecules and polymers, also relevant for the analysis of high-molecular-weight components in foods (e.g., polysaccharides).</li></ul><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Watrex_catalog_2024_ba97395f92.pdf"><strong>Product catalogue HERE</strong></a></p></blockquote><p>Thanks to the modular nature of these systems, analysts can easily adapt the configuration to a specific analytical problem, from simple routine analyses to complex characterization of food samples.</p><h4><strong>Practical Examples of Adulteration Revealed by HPLC</strong></h4><ul><li><strong>Detection of olive oil dilution: </strong>HPLC can separate and quantify characteristic triacylglycerols and fatty acids; unusual patterns indicate the presence of cheaper oils.</li><li><strong>Estimation of sugar addition in honey:</strong> Isocratic HPLC with a refractive index detector can determine sugar profiles (glucose, fructose, sucrose), revealing dilution or the addition of sugar syrups.</li><li><strong>Identification of aromatic adulterants in wine:</strong> Gradient HPLC with a PDA detector can reveal phenolic and aromatic profiles that are altered by the addition of synthetic compounds.</li></ul><h4><strong>Conclusion</strong></h4><p>Food adulteration remains a current issue that requires reliable and sensitive analytical methods. Liquid chromatography, and in particular modern HPLC systems, represent one of the most powerful tools for detecting unwanted additives, impurities, and unexpected components in complex food samples. Manufacturers such as <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha</strong></a> provide flexible chromatographic platforms covering a wide range of analytical tasks from simple isocratic to advanced gradient and GPC/SEC applications thereby supporting analysts in ensuring food quality and consumer protection.</p><blockquote><p>Did you find this article interesting? Follow <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha</strong></a> on their social media (<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/company/watrex/?viewAsMember=true"><strong>LinkedIn</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://www.facebook.com/WatrexPrague"><strong>Facebook</strong></a>) for more engaging topics.</p></blockquote>

Food Adulteration and How It Is Revealed by Analytical Chemistry

<p><strong>Join us for a fascinating conversation with Dr. Subhoja Chakraborty from the University of Central Florida, whose cutting-edge research targets the global challenge of malaria drug resistance. Dr. Chakraborty shares her journey from structure-based drug design during her PhD to her recent collaborative work repurposing human kinase inhibitors as rapid, selective antimalarials against drug-resistant Plasmodium falciparum strains.</strong></p><h4><strong>In this episode, you'll learn:</strong></h4><ul><li>How structure-guided approaches reveal potential drug targets, including cysteine proteases like falcipain-2, and kinases implicated in malaria's complex life cycle.</li><li>The power of repurposing kinase inhibitors originally developed for cancer and other diseases, focusing on compound 12, which blocks hemozoin formation and protein kinase 6—key steps in parasite survival.</li><li>Lab techniques such as affinity, gel filtration, and size exclusion chromatography for recombinant protein purification—and how troubleshooting is crucial for high-yield, stable complexes.</li><li>Advances in mass spectrometry for characterizing protein interactions, validating drug targets, and mapping molecular pathways pivotal to malaria therapeutics.</li><li>Tips and lessons for new researchers facing the challenges of sample preparation, complex protocols, and working as part of a collaborative team.</li></ul><p>Dr. Chakraborty’s insights bridge the gap between basic science and translational drug discovery, offering hope for more effective, targeted malaria treatments in a world where resistance to frontline therapies threatens millions.</p><h4><strong>Referenced Papers:</strong></h4><ul><li>"Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity" (Cell Chemical Biology, 2025)</li><li>"New insights of falcipain 2 structure from Plasmodium falciparum 3D7 strain" (BBRC, 2022)</li><li>"Structure-Based Optimization of Protease−Inhibitor Interactions to Enhance Specificity of Human Stefin‑A against Falcipain‑2 from the Plasmodium falciparum 3D7 Strain" (Biochemistry, 2023)</li></ul><p>If you’re a student, scientist, or simply passionate about advances in infectious disease research, this episode offers actionable insights, inspiring advice, and a front-row seat to innovation in combating malaria.</p><h3><strong>Video Transcription</strong></h3><h4><strong>From Structural Biology to Drug Discovery: Chromatography and Mass Spectrometry in Malaria Research</strong></h4><h5><strong>Introduction</strong></h5><p>In this discussion, Subhoja shares insights into her research journey, focusing on malaria drug discovery and the role of modern analytical techniques in biological and biomedical research. The conversation is aimed primarily at undergraduate students and early-career researchers interested in chemistry, biotechnology, and life sciences.</p><h5><strong>Research Focus: Malaria Drug Discovery and Kinase Targets</strong></h5><p>Subhoja is currently involved in malaria drug discovery research at the University of Central Florida, where she has been working since beginning her postdoctoral position two years ago. Her earlier PhD research focused on structure-based drug design in malaria, using a combination of in silico approaches, recombinant protein expression, and X-ray crystallography to determine precise three-dimensional structures of target proteins and their inhibitors.</p><p>This structural perspective provided a foundation for her current work, which centers on drug discovery through compound screening and repurposing. A recent publication from her laboratory explores the use of repurposed mammalian CDK-like kinase inhibitors as potential antimalarial agents. While such kinase inhibitors are well known in cancer and cardiovascular research, their application to malaria targets represents a novel and promising approach.</p><p>Kinases are attractive drug targets because of their central role in cell signaling and growth pathways. By targeting specific kinases involved in different stages of the malaria parasite life cycle—whether asexual growth, gametocytogenesis, or differentiation—it may be possible to significantly inhibit parasite growth and progression.</p><h5><strong>Chromatography in Protein Expression and Purification Workflows</strong></h5><p>Chromatography plays a critical role throughout Subhoja’s research. Her experience spans from basic chromatography techniques during her early training to advanced protein purification workflows using affinity chromatography, gel filtration (size exclusion chromatography), and ion exchange chromatography.</p><p>Recombinant proteins are routinely purified using affinity resins such as nickel or cobalt, followed by further purification to remove contaminants. Fast Protein Liquid Chromatography (FPLC) enables compact, stepwise purification workflows suitable for producing proteins for in vitro assays.</p><p>A recurring challenge in this process is the expression of high-molecular-weight proteins, which often accumulate in insoluble fractions or inclusion bodies. Careful selection of expression vectors, host systems, and induction conditions is therefore essential to maximize yield and solubility.</p><h5><strong>Integrating Size Exclusion Chromatography into the Workflow</strong></h5><p>Size exclusion chromatography (SEC) is typically used after affinity purification to further improve protein purity. Following elution with imidazole or glutathione, desalting is required to prevent buffer components from interfering with downstream assays. This is often achieved using desalting columns such as G-25 or PD-10.</p><p>To remove lower-molecular-weight contaminants, finer SEC media—such as Superdex or Sephacryl columns—are employed. Concentration steps using molecular-weight cut-off filters are then applied to obtain the desired protein concentration for functional studies.</p><p>These iterative purification and troubleshooting steps are a routine part of protein biochemistry and reflect the importance of methodical optimization and careful validation.</p><h5><strong>The Role of Mass Spectrometry in Biomolecular Characterization</strong></h5><p>Mass spectrometry is a key analytical tool in Subhoja’s research pipeline, particularly for target identification and validation. In both malaria and cancer research, MS is used alongside chromatography, immunoprecipitation, and pull-down assays to study protein interactions and molecular recognition events.</p><p>Affinity-based mass spectrometry enables the identification of binding partners and interactors, whether studying proteins, long non-coding RNAs, or protein complexes. Techniques such as native MS, tandem affinity purification, and proximity labeling (e.g., TurboID-based workflows) provide deeper insights into molecular networks and signaling pathways.</p><p>These approaches are essential for understanding how candidate drug targets function within complex biological systems.</p><h5><strong>Sample Preparation Challenges in Biological Research</strong></h5><p>Sample preparation remains one of the most challenging aspects of biological experimentation. Whole-cell lysates contain proteases, nucleases, and other components that can rapidly degrade target molecules. Preventing degradation requires minimizing preparation time, maintaining low temperatures, and using appropriate inhibitor cocktails.</p><p>Reproducibility is also critical: biological experiments require multiple replicates, and variability is often unavoidable. Careful handling, protocol optimization, and continuous troubleshooting are essential to ensure reliable results, whether preparing samples for chromatography, mass spectrometry, sequencing, or immunoprecipitation.</p><h5><strong>Advances in Chromatography and MS for Malaria Research</strong></h5><p>Modern advances in chromatography and mass spectrometry significantly enhance malaria research by enabling precise target identification, quantification, and functional characterization. Drug discovery workflows begin with construct design and recombinant expression, followed by purification and interaction studies.</p><p>In malaria research, stage-specific parasite biology requires careful extraction and analysis of proteins from different life cycle stages. Tandem affinity MS, immunoprecipitation, and in vivo validation studies help confirm target relevance and therapeutic potential.</p><p>Recent work on repurposed kinase inhibitors has shown promising results, including inhibition of hemozoin formation—a key detoxification pathway for the malaria parasite—highlighting the potential of such compounds for further development.</p><h5><strong>Malaria, Drug Resistance, and Global Impact</strong></h5><p>Malaria remains a major global health burden, with over 600,000 deaths annually and widespread drug resistance complicating treatment. Artemisinin resistance, particularly associated with mutations in the K13 propeller domain, has driven the search for new targets and therapies.</p><p>During her PhD, Subhoja focused on falcipain-2, a cysteine protease involved in hemoglobin degradation within the parasite. This pathway is critical for parasite survival and has emerged as a promising drug target. Her work revealed that falcipain-2 operates within a larger protein complex responsible for hemoglobin processing and amino acid release.</p><p>Understanding these molecular mechanisms is essential for developing robust, stage-specific antimalarial strategies.</p><h5><strong>Advice for Early-Career Researchers</strong></h5><p>For researchers just starting out, Subhoja emphasizes the importance of hands-on experience. Working directly with cells, lysates, and analytical tools is essential for truly understanding experimental systems. Failure is an inherent part of research, and perseverance is key.</p><p>Motivation, teamwork, careful sample handling, and thorough preparation all contribute to long-term success. Reading extensively, critically evaluating one’s own work, and appreciating incremental progress are vital aspects of a sustainable research career.</p><p>Every successful experiment—no matter how small—represents meaningful progress and contributes to the broader goals of science and medicine.</p><h5><strong>Closing Remarks</strong></h5><p>The discussion highlights how interdisciplinary approaches combining chromatography, mass spectrometry, structural biology, and biochemistry are driving advances in malaria drug discovery. Through careful experimental design, analytical rigor, and collaborative teamwork, researchers can address complex biological challenges and contribute to global health solutions.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria

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Product

Video

Scientists

Food

Interview

Science and research

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

WATREX Prague is the distributor and producer of HPLC techniques in the Czech Republic and Slovakia. Main Chromatografic and Related Techniques Supported: LC, GPC, IC, IEC, Automated SPE, LC Columns and special column packings, LC method development, Software development, Laboratory Robots.

Watrex Praha

Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer

Triple quadrupole Thermo Scientific TSQ Certis built for long-term robustness, up to 900 SRMs/s, and stable performance across tens of thousands of injections using OptaMax Plus ion source and advanced Stellar ion optics.

<p><strong>The Thermo Scientific TSQ Certis is a high-performance triple quadrupole LC-MS/MS system designed for targeted quantitative analysis in demanding routine and regulated environments. Built on the proven </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/404"><strong>TSQ Altis Plus </strong></a><strong>platform, it integrates advanced front-end hardware, innovative ion optics, and compliance-ready software to deliver superior performance and uptime.</strong></p><p>Powered by the <strong>OptaMax Plus ion source</strong> and <strong>Stellar ion vector optics</strong>, TSQ Certis provides exceptional sensitivity, long-term robustness, and reproducible performance even for complex sample matrices. With an acquisition speed of up to <strong>900 SRMs per second</strong>, the system is ideally suited for <strong>pharmaceutical, clinical, forensic toxicology, environmental, and food safety laboratories</strong>.</p><p>Its rugged design supports <strong>tens of thousands of injections between cleanings</strong>, while an integrated <strong>early-warning maintenance system</strong> helps prevent unplanned downtime. Full compatibility with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon CDS</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77"><strong>TraceFinder</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758"><strong>Xcalibur</strong></a><strong>, FreeStyle, and </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764"><strong>mzCloud</strong> </a>ensures seamless integration into both routine and advanced analytical workflows.</p><h4><strong>Key features</strong></h4><ul><li>Triple quadrupole LC-MS/MS for targeted quantitation</li><li>Up to <strong>900 SRMs/s</strong> for high-throughput workflows</li><li>OptaMax Plus ion source with enhanced vaporizer temperatures</li><li>Excellent sensitivity and signal stability</li><li>Fast polarity switching <strong>&lt; 5 ms</strong></li><li>Rugged design with extended maintenance intervals</li><li>Compliance-ready software ecosystem</li><li><strong>3-year standard factory warranty</strong></li></ul><h4><strong>Selected specifications</strong></h4><ul><li><strong>Type:</strong> Triple Quadrupole LC-MS</li><li><strong>Mass range:</strong> 2–2010 m/z</li><li><strong>Resolution:</strong> 0.2 FWHM</li><li><strong>Acquisition speed:</strong> 900 SRMs/s</li><li><strong>Weight:</strong> 112 kg</li><li><strong>Dimensions (W × D × H):</strong> 833 × 660 × 703 mm</li><li><strong>LC compatibility:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=37&amp;search=vanquish">Vanquish LC</a>, Transcend LC</li><li><strong>Ion sources:</strong> OptaMax Plus, OptiSpray, EASY-Spray NG, FAIMS Pro Duo, VeriSpray</li></ul><div><div><div><div><div><h3><strong>Clinical research application: long-term instrument stability even with contaminant-heavy matrices</strong></h3></div></div><div><div><p>Analyzing human whole blood by LC-MS presents persistent challenges: matrix contaminants can accumulate within the ion source and API stack, compromising signal integrity and reproducibility. Restoring data quality demands time-consuming maintenance. The TSQ Certis Mass Spectrometer proves its durability by maintaining stable, precise performance through tens of thousands of injections—minimizing downtime and maximizing throughput.</p></div></div></div></div></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_0ec820459f.jpg" alt="Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: Raw peak area of 15pg Ascomycin on column was determined in whole blood for 10,209 injections. The experiment was run over a 5-week period, and the system delivered an RSD of 13.8% with no cleaning of the ion transfer tube or the sweep cone." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_0ec820459f.jpg 245w," sizes="100vw" width="2048" height="1152"></p><div><div><div><div><div><h3><strong>Endocrinology application: superior performance for steroid quantitation</strong></h3></div></div><div><div><p>Liquid chromatography coupled with triple quadrupole (LC–QqQ) mass spectrometry has become the industry standard for the quantitative determination of steroids in biological matrices. Compared to immunoassays, LC–QqQ MS offers superior analytical specificity, lower detection limits, and improved reproducibility, making it ideal for regulated pharmacokinetic, endocrinological, and clinical research applications. The TSQ Certis Mass Spectrometer provides the speed, specificity, and ultra-high sensitivity necessary for reliable steroid quantitation.&nbsp;</p></div></div></div></div></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_2_3a48cc4deb.jpg" alt="Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: LC SRM chromatogram of 18 steroids in BSA run using the Thermo Scientific Vanquish Flex UHPLC System and TSQ Certis Mass Spectrometer. This is an 8-minute chromatography run utilizing the Thermo Scientific Hypersil Gold C18 Column for separation. The samples were protein crashed from 0.05% BSA in PBS, and injecting 5µL." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_2_3a48cc4deb.jpg 245w," sizes="100vw" width="2048" height="1152"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_3_62ede15e59.jpg" alt="Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: Highly sensitive triple quadrupole instrumentation, often with advanced ion optics, is needed for Dihydrotestosterone (DHT) quantitation. The DHT quantitation peak and calibration curve of DHT run at 0.4pg on column with an RSD of 8.2%." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_3_62ede15e59.jpg 245w," sizes="100vw" width="2048" height="1152"></p>

Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer

Overcome quantitative workflow challenges with the TSQ Altis Plus MS, which ensures superior speed, sensitivity, and precision for low-level detection in complex matrices.

<p class="cke-user_style-important"><strong>Advance quantitative workflows and increase productivity</strong></p><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><h2><strong>TSQ Altis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3><strong>Ultimate quantitative performance made possible</strong></h3><p>Overcome the most demanding quantitative workflow challenges. With superior <strong>acquisition speeds, enhanced sensitivity, prototypical selectivity</strong>, and <strong>exceptional robustness</strong>, the <strong>TSQ Altis Plus mass spectrometer </strong>delivers unprecedented accuracy and precision <strong>for low-level compound detection</strong> and <strong>quantitation in complex matrices </strong>that redefines ultimate instrument performance.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_dddb4870a2/Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg" alt="Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_dddb4870a2/thumbnail_Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt7" comp-id="A1"><div><h3 style="text-align:left;"><strong>Achieve the highest confidence in targeted compound detection and quantitation through leading sensitivity&nbsp;</strong></h3><p>Greater than <strong>6 orders</strong> of linear dynamic range with high selectivity. Enhanced acquisition speeds empower large-scale studies for translational workflow development or method optimization with effective dwell time settings as low as <strong>0.3 milliseconds — 5 millisecond</strong> polarity switching maximizes productivity in fewer experiments.</p><p>Where data confidence is required, the instrumental features on the TSQ Altis Plus triple quadrupole mass spectrometer drive high-performance targeted experiments for complex matrices.</p><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>High-throughput screening and quantitation</strong></h3><p>Innovations in the ion source, mass analyzer, active <strong>Q2 collision cell</strong>, and <strong>RF electronics </strong>offer high sensitivity, selectivity, and superior acquisition speeds/polarity switching times that are ideal with ultra-high performance liquid chromatography (UHPLC) separations. With scheduled SRM acquisition and<strong> 600 SRMs/second</strong>, <strong>1000’s of compounds</strong> can be screened or quantified per method. Fast data acquisition reaches the number of required data points for outstanding confidence at extremely low concentrations, in the most challenging matrices.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Expanded experimental capabilities</strong></h3><p>Integrated workflow solutions centered on the TSQ Altis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and ion chromatography (IC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. <strong>Thermo Scientific Chromeleon Chromatographic Data System</strong> (CDS) software controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_4_bc3264af33/Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-4.jpg" alt="Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_4_bc3264af33/thumbnail_Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-4.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3><strong>Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. Simplified calibration approach consolidates steps needed by the operator, combining an intelligent instrument check and calibration routine. <strong>Direct method transfer </strong>from the previous generation Thermo Scientific TSQ mass spectrometers can be performed for equal or better performance <strong>without optimization</strong>.</p><p>Experimental determination of dwell times assigned to each transition has been automated based on user-defined chromatographic peak width and the option of fixed cycle time or optimal number of data points per chromatographic peak.&nbsp;Prioritization settings allow further adjustments.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Database integration</strong></h3><p>Method development for targeted acquisition methods requires a prior knowledge of optimal product ions and energetics. Utilization of <strong>experimental libraries </strong>created from discovery experiments can by-pass the need for purified standards and lengthy optimization routines. The output from processed data in <strong>Thermo Scientific TraceFinder software</strong> can be directly imported into the instrument method editor, streamlining large-scale study creation.</p><p>Discovery experiments, however, may not contain all compounds targeted in a study. Integration with <strong>Thermo Scientific mzCloud databases</strong> enables selection of additional compounds from the most advanced mass spectral database to be added into existing experimental methods.</p></div></div></div></div></div></div></div></div>

Thermo Scientific TSQ Quantis Plus Triple Quadrupole Mass Spectrometer

The Thermo Scientific TSQ Quantis Plus mass spectrometer provides effortless method set up with industry-leading multi-channel solutions and automated reporting.

<h3><strong>Advance quantitative workflows and increase productivity</strong></h3><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h2><strong>TSQ Quantis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Extended quantitative performance made accessible</strong></h3><p>Experience reliability and sensitivity, and report results with confidence. The <strong>Thermo Scientific TSQ Quantis Plus mass spectrometer </strong>provides effortless method set up with <strong>industry-leading multi-channel solutions</strong> and <strong>automated reporting</strong> that enable robust high-throughput quantitation.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg" alt="Thermo Scientific TSQ Quantis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt1" comp-id="A1"><div><p><strong>Advanced instrument control software, compound database integration,</strong> and <strong>predefined method templates</strong> simplify operations, enabling LC-MS/MS users of all skill sets to obtain high-confidence data.</p><p>Achieve next-level productivity, versatility, and performance for method development and routine sample analysis. The Thermo Scientific TSQ Quantis Plus triple quadrupole mass spectrometer combines <strong>enhanced acquisition speed</strong> and <strong>sensitivity with proven robustness and reliability </strong>to deliver confident targeted screening and quantitation for high-throughput applications.</p><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Reducing the barrier to productivity: Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. <strong>Predefined method templates</strong> with<strong> integration to databases</strong>, including the <strong>Thermo Scientific mzCloud database</strong>, enable targeted quantitation method creation based on empirical knowledge. Also, direct method transfer from previous Thermo Scientific TSQ Quantis mass spectrometers can be loaded and operated <strong>without optimization</strong>.</p><p>Experimental determination of dwell times assigned to transitions is automated based on user-defined chromatographic peak width, with the option of fixed cycle time or optimal number of data points per chromatographic peak.&nbsp;Prioritization settings allow further adjustments.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg" alt="Thermo Scientific TSQ Quantis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Speed with selectivity and sensitivity</strong></h3><p>Achieve superior acquisition speeds on the TSQ Quantis Plus mass spectrometer, which can acquire <strong>600 SRMs/sec</strong> and when combined with a new power supply enables <strong>5 ms polarity switching</strong> and allows the required number of data points to be acquired for expanded number of target compounds, even with ultra-high performance liquid chromatography (UHPLC) separation.</p><p>The TSQ Quantis Plus mass spectrometer delivers excellent quantitative performance in both selected reaction monitoring (SRM) and high-resolution selected reaction monitoring (H-SRM) for fit-for-purpose selectivity. The enhanced active<strong> Q2 collision cell </strong>improves product ion transmission, especially for low-mass product ions, which can increase detection efficiency.</p></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Expanded experimental capabilities</strong></h3><p>Integrated workflow solutions centered on the TSQ Quantis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and high performance ion chromotagraphy (HPIC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. Thermo Scientific<strong> Chromeleon Chromatography Data System</strong> (CDS) controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Robust and reliable quantitation</strong></h3><p>Innovative designs in the ion source, neutral blocker, and mass analyzers maintain optimal performance while maximizing instrument uptime. The ion transfer tube enables simple extraction and cleaning in minutes, without breaking the instrument vacuum or requiring instrument calibration. New integrated instrument performance check and calibration routine reduce manual interaction, maximizing data acquisition and instrument productivity.</p></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific TSQ Fortis Plus Triple Quadrupole Mass Spectrometer

The TSQ Fortis Plus provides a seamless user experience for clinical research laboratories that focus on processing and analyzing a large number of samples.

<p class="cke-user_style-important"><strong>Advance quantitative workflows and increase productivity</strong></p><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><h2><strong>TSQ Fortis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Robust quantitative performance made simple</strong></h3><p>The <strong>TSQ Fortis Plus</strong> provides a seamless user experience for <strong>clinical research laboratories</strong> that focus on processing and analyzing a <strong>large number of samples</strong>. Designed for ease, it enables confident quantitation of hundreds of <strong>samples in complex matrices</strong>, every day.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_1_5021103aa3/Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-1.jpg" alt="Thermo Scientific TSQ Fortis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_1_5021103aa3/thumbnail_Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2 id="menu1"><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt1" comp-id="A1"><div><p>Accelerate your path to quantitative productivity with the <strong>Thermo Scientific TSQ Fortis Plus triple quadrupole mass spectrometer</strong>. Enhanced acquisition speed and sensitivity, combined with proven robustness and reliability, deliver next-level performance and value for <strong>high-throughput analyses</strong>. Simplified operations integrated with powerful Thermo Scientific chromatographic systems and market-leading software ensure users of all skill levels obtain reproducible, high-confidence results that meet laboratory requirements.</p><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Reducing the barrier to productivity: Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. <strong>Predefined method templates</strong> with integration to databases, including the <strong>Thermo Scientific mzCloud database</strong>, enable targeted quantitation method creation based on empirical knowledge. Also, <strong>direct method transfer from previous TSQ Fortis mass spectrometers </strong>can be loaded and operated without optimization.</p><p>Experimental determination of dwell times assigned to transitions is automated based on user-defined chromatographic peak width, with the option of fixed cycle time or optimal number of data points per chromatographic peak. Prioritization settings allow further adjustments.&nbsp;</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Speed with selectivity and sensitivity</strong></h3><p>Achieve superior acquisition speeds on the <strong>TSQ Fortis Plus mass spectrometer</strong>, which can acquire <strong>600 SRMs/sec</strong> and when combined with a new power supply enables <strong>5 ms </strong>polarity switching and allows the required number of data points to be acquired for expanded number of target compounds, even with ultra-high performance liquid chromatography (UHPLC) separation.</p><p>The TSQ&nbsp;Fortis Plus mass spectrometer delivers excellent quantitative performance in both selected reaction monitoring (SRM) and high-resolution selected reaction monitoring (H-SRM) for fit-for-purpose selectivity. The enhanced active <strong>Q2 collision cell </strong>improves product ion transmission, especially for low-mass product ions, which can increase detection efficiency.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_a876fda658/Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg" alt="Thermo Scientific TSQ Fortis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_a876fda658/thumbnail_Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Expanded experimental capabilities</strong></h3><p>Integrated workflow solutions centered on the <strong>TSQ Fortis Plus mass spectrometer</strong> address regulated requirements targeting a growing list of diverse compounds. New UHPLC and high performance ion chromotagraphy (HPIC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. The <strong>Thermo Scientific Chromeleon Chromatography Data System</strong> (CDS) controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Robust and reliable quantitation</strong></h3><p><strong>Innovative designs in the ion source, neutral blocker</strong>, and<strong> mass analyzers</strong> maintain optimal performance while maximizing instrument uptime. The ion transfer tube enables simple extraction and cleaning in minutes, without breaking the instrument vacuum or requiring instrument calibration. New integrated instrument performance checks and calibration routine reduce manual interaction, maximizing data acquisition and instrument productivity.</p></div></div></div></div></div></div></div></div>

Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer

The Thermo Scientific™ TSQ Quantis™ Triple Quadrupole MS offers best-in-class sensitivity, robustness, and seamless integration for efficient targeted quantitation across diverse molecular species.

<p><strong>Easily answer critical analytical challenges during targeted quantitation workflows in your laboratory. With its segmented quadrupoles, faster rod drivers, and improved electron multipliers, the Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer delivers unprecedented robustness with best-in-class sensitivity for everyday use and for every user.</strong></p><p>The <strong>TSQ Quantis MS</strong> seamlessly integrates with <strong>industry-leading quantitation software</strong>, <strong>HPLCs and UHPLCs</strong>, and <strong>sample preparation solutions</strong>; it also offers <strong>enhanced efficiency</strong> during targeted quantitation workflows for a <strong>wide array of molecular species</strong>. Other benefits include:</p><ul><li><strong>Superb sensitivity</strong> that generates data for all molecular species, even in <strong>complex matrices</strong>.</li><li><strong>Outstanding robustness</strong> that enables <strong>increased confidence in data</strong> while <strong>prolonging instrument uptime</strong>.</li><li><strong>Reliability and reproducibility</strong> improve <strong>data quality</strong> for <strong>every run and every sample</strong>.</li><li><strong>Close integration with application-specific software</strong> ensures <strong>increased productivity</strong> across all application markets.</li><li><strong>Simplicity and ease-of-use</strong> allow users of all expertise levels to acquire <strong>high quality data</strong> with <strong>improved confidence in results</strong>.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg" alt="Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></p><h3><strong>Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer Specifications</strong></h3><ul><li><strong>For Use With (Application):</strong> Pharmaceutical, Environmental, Food Safety, Clinical Research, and Forensic Toxicology</li><li><strong>Mass Range:</strong> 5 to 3000 m/z</li><li><strong>Type:</strong> Triple Quadrupole LC-MS</li><li><strong>Unit Size:</strong> Each</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg" alt="Thermo Scientific™ TSQ Quantis™ Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg 156w," sizes="100vw" width="650" height="650"></p>

Products from category Triple quadrupoles from Thermo Fisher Scientific distributed by Thermo Fisher Scientific (EMEA) - page 1

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