Quantifying steroids in biological matrices has always presented analytical challenges. Complex structures, isobaric interferences, and matrix effects often limit accuracy and throughput — demanding a new approach beyond incremental improvements.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Advancing_Steroid_Quantification_Unlocking_Sensitivity_and_Selectivity_with_the_Thermo_Scientific_Stellar_Mass_Spectrometer_6e03ce7f59.jpg" alt="Thermo Fisher Scientific: Advancing Steroid Quantification: Unlocking Sensitivity and Selectivity with the Thermo Scientific Stellar Mass Spectrometer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Advancing_Steroid_Quantification_Unlocking_Sensitivity_and_Selectivity_with_the_Thermo_Scientific_Stellar_Mass_Spectrometer_6e03ce7f59.jpg 245w," sizes="100vw" width="1024" height="512">The<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1149"> Thermo Scientific Stellar MS</a> redefines how analysts approach steroid quantification, enabling rapid method optimization through advanced scanning flexibility, complementary fragmentation mechanisms, and enhanced selectivity.Rather than focusing on a single metric, this application note demonstrates how researchers can quickly develop more effective methods by leveraging the full capability of the Stellar MS to characterize compounds comprehensively in a single acquisition.<h3>A new paradigm for analytical quantitation</h3>Traditional LC-MS approaches often rely on incremental improvements in sensitivity or speed. Stellar MS instead provides a new analytical framework, designed to optimize every parameter of quantitative method creation.Key attributes include:<ol><li>PRM vs. SRM/MRM — improving instrument efficiency Parallel Reaction Monitoring (PRM) on Stellar MS provides comprehensive ion information for each target steroid, improving quantitation accuracy and efficiency over traditional MRM methods.</li><li>Complementary dissociation mechanisms — HCD and CID Stellar’s unique ability to combine beam-type (HCD) and resonant (CID) dissociation ensures full coverage of all 17 targeted steroids. This dual-mode approach effectively overcomes neutral water loss product ions — one of the key challenges in steroid analysis.</li><li>Next-level selectivity — MS² to MS³ transition The platform’s ability to perform MS³ experiments enhances selectivity and confidence, particularly in complex biological matrices, where interferences are common.</li><li>Product ion accumulation vs. dwell time — improved ion ratios and sensitivity By accumulating product ions rather than relying on fixed dwell times, Stellar MS achieves superior ion ratio precision and reproducibility — even at low spiking levels — without sacrificing throughput.</li></ol>&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Advancing_Steroid_Quantification_Unlocking_Sensitivity_and_Selectivity_with_the_Thermo_Scientific_Stellar_Mass_Spectrometer_2_21e509451a.jpg" alt="Thermo Fisher Scientific: Advancing Steroid Quantification: Unlocking Sensitivity and Selectivity with the Thermo Scientific Stellar Mass Spectrometer: Figure 1. Representative EIC of 17 steroids in human serum using the Thermo Scientific Stellar mass spectrometer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Advancing_Steroid_Quantification_Unlocking_Sensitivity_and_Selectivity_with_the_Thermo_Scientific_Stellar_Mass_Spectrometer_2_21e509451a.jpg 245w," sizes="100vw" width="800" height="412"><h3>From characterization to confident method creation</h3>The power of Stellar MS lies in its comprehensive acquisition strategy. In this application note, a single injection per spiking level generated 125 distinct scan events, combining:<ul><li>HCD and CID MS² experiments</li><li>Targeted MS³ scans</li><li>Positive/negative polarity switching</li></ul>This workflow enables analysts to rapidly evaluate:<ol><li>Which dissociation mechanism produces the most informative spectra</li><li>Whether MS² or MS³ is best suited for each compound</li><li>The optimal product ions for confident post-acquisition quantitation</li></ol>By providing this complete dataset in a single run, Stellar MS dramatically accelerates method optimization and validation, supporting more efficient and reliable quantitation strategies.<h3>Driving method development efficiency</h3>The real strength of the Stellar MS isn’t just its speed or sensitivity — it’s the ability to experiment, compare, and decide in one workflow. Through simultaneous HCD/CID fragmentation, MS² and MS³ switching, and polarity control, users can determine the optimal analytical conditions across complex steroid panels quickly and confidently.This approach helps labs:<ul><li>Reduce development time</li><li>Maximize data quality</li><li>Improve long-term robustness and reproducibility</li></ul><h3>Conclusion</h3>The Stellar MS platform empowers analytical scientists to move beyond incremental performance metrics toward methodological innovation.By integrating comprehensive characterization and advanced scanning control, it enables faster, more confident decisions in quantitative steroid analysis — setting a new benchmark for flexibility and precision in LC-MS.Ask the Experts: On-Demand WebinarLearn more about how Stellar MS enhances steroid profiling and quantitative workflows. Watch the on-demand webinar where Thermo Fisher scientists discuss:<ul><li>Advanced method development strategies</li><li>Insights from the steroid panel dataset</li><li>Practical examples of leveraging Stellar’s flexibility for confident quantitation</li></ul><blockquote>Watch now: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5117">Unlocking the Power of Quantitative Analysis with Stellar MS</a>Read the full application note: <a target="_blank" rel="noopener noreferrer" href="https://lcms.cz/paper/32415">Selective and sensitive measurement of 17 steroids in human serum using a Stellar mass spectrometer</a></blockquote><ul><li>Learn more about <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/stellar-mass-spectrometer/stellar-mass-spectrometer-applications.html">Stellar Mass Spectrometer applications</a></li><li>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#MassSpectrometry #ClinicalResearch #LCMS #StellarMS</li></ul><blockquote><h5>Dane Walker</h5>Dane Walker is Regional Marketing Manager at Thermo Fisher Scientific, focused on LC-MS systems across EMEA. With a PhD in Surface Science and a background in scientific instrumentation, he blends technical expertise with strategic marketing to drive data-led campaigns. Passionate about communicating science and enabling innovation, Dane enjoys powerboating, cycling, stargazing, and talking endlessly about mass spectrometry.</blockquote>

Advancing Steroid Quantification: Unlocking Sensitivity and Selectivity with the Thermo Scientific Stellar Mass Spectrometer

<h4>The problem&nbsp;</h4>We live in a “global village” but we are all different and we use many different languages to communicate.&nbsp;Even when people speak the same language, the same words may be used with different meanings. See, for example, some different uses of the word “standard” in English – a normative document, a solution of known concentration or even a type of flag.&nbsp;Even in the same area of activity misunderstandings do occur which may result in a waste of time and money, or even worse consequences.&nbsp;When talking about laboratory tests, lack of a full understanding of key terms and inappropriate translations leaves room for different interpretations of stated requirements. For example, there have historically been a number of different but related uses of the term ‘detection limit’. This may lead to inadequate fulfilment of those requirements, thus becoming an obstacle to the production of analytical data that is fit for its intended use. A shared interpretation of concepts related to quality in measurement between laboratories and accreditation bodies is also crucial for a fair and harmonised approach to laboratory assessment across the world.&nbsp;<h4>A common language&nbsp;</h4>We need a common language; clear and unambiguous. We need a common vocabulary to provide consistent definitions of concepts with their associated terms. To this end, several organisations participate in a joint effort to develop and maintain an international vocabulary of metrology (VIM) [1], which aims to achieve a unique understanding of concepts related to measurements across all sectors. The VIM is a normative reference in the standards ISO/IEC 17025, ISO 15189 and ISO/IEC 17043, and is therefore a key document for all organisations seeking accreditation.&nbsp;<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_Standards_8d947dbd5f.jpg" alt="Eurachem: You talk, we understand – The way out of the tower of Babel_A common language" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_Standards_8d947dbd5f.jpg 245w," sizes="100vw" width="1126" height="499"><h4>Is this enough?&nbsp;</h4>For laboratory staff some problems still stand and need to be addressed:&nbsp;<ul><li>Many people are confused about both concepts and terms.&nbsp;</li><li>It may be difficult to understand the “formal” VIM definitions – they are short statements intended to apply to many different measurement sectors.</li><li>Translations into local languages may add to the confusion, e.g. if different terms are used in different sectors for the same VIM concept and the translator overlooks this issue.</li><li>Some substantial changes to terminology have been made in an attempt to accommodate chemical and biological measurements. Some “old” concepts still stand but have new names, e.g. “within laboratory reproducibility” vs. “intermediate precision”.&nbsp;</li></ul>To address these issues Eurachem has produced a guide [2] which provides an accessible reference containing simple and in context explanations of terms most relevant to analysts, with additional examples relating those concepts to chemical and biological measurements.&nbsp;<h4>Do you understand the meaning of these terms?&nbsp;</h4>Are you interested in a quantity or a quality? Depending on the answer, will you use a measurement procedure or an examination? Is method verification the same or less demanding than method validation? Do you need a calibration or just performance verification? Do you have a measurement standard in your laboratory? Is metrological traceability something you worry about? These are examples of the terms supporting the reliability of any measurement result that need to be clearly understood.&nbsp;<h5>Example – Accuracy, trueness, precision: are they synonyms?&nbsp;</h5><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_accuracy_231e1e005e.jpg" alt="Eurachem: You talk, we understand – The way out of the tower of Babel_Example – Accuracy, trueness, precision" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eurachem_You_talk_we_understand_The_way_out_of_the_tower_of_Babel_accuracy_231e1e005e.jpg 146w," sizes="100vw" width="754" height="807"><ul><li>Closeness between measurement results (relating to the concept of precision)</li><li>Closeness of the average of the measurement results to a reference value (relating to the concept of trueness)&nbsp;</li><li>Closeness of an individual measurement result to the true value (relating to the concept of accuracy)&nbsp;</li></ul>The different situations in the figure show the effect of:&nbsp;<ol style="list-style-type:lower-latin;"><li>poor precision and trueness (imprecise and biased)&nbsp;</li><li>good precision, poor trueness (precise but biased)&nbsp;</li><li>poor precision, good trueness (imprecise but unbiased)&nbsp;</li><li>good precision and trueness (precise and unbiased)&nbsp;</li></ol>Improving both precision and trueness is expected to improve accuracy.&nbsp;<h4>Is all this relevant to you?&nbsp;</h4>Do you work in a laboratory, either as an analyst, quality manager or director? Are you involved in other activities related to analytical work, such as providing proficiency tests, producing reference materials or accrediting any such activity? Do you teach or study subjects related to measurements? Do you use measurement results or prescribe how to use them? If the answer is yes to any of these questions, the following reference documents are also for you.

You talk, we understand – The way out of the tower of Babel

Visit the LabRulez booth at <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/events/871">analytica 2026</a> in Munich, 24. - 27. March 2026! You can find us in Hall A1, Booth A1.506. At the booth, you will be able to explore live demonstrations of how the LabRulez portals work and see selected analytical instruments from our pre-owned marketplace section.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg" alt="LabRulez at Analytica 2026: Hall A1 Floor Plan and Booth Location" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_Analytica_2026_Floor_plan_55e1057e03.jpg 245w," sizes="100vw" width="1516" height="881"><h3>Would you like to learn how the LabRulez portals work?</h3>➡︎ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/">LabRulezLCMS</a> ➡︎ <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/">LabRulezGCMS</a> ➡︎ <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/">LabRulezICPMS</a><ul><li>A unique online solution for your marketing</li><li>A targeted audience from the analytical chemistry community</li><li>Modern technologies and a unique concept</li><li>Design optimized for most smart devices – PC, mobile, and tablet</li><li>Advanced statistical tools fully available to users</li></ul><h3>Services Offered</h3><h4>News + Company Updates</h4><ul><li>Publish news related to your instrumentation, applications, services, events, job openings, and more</li><li>News is shared both on our portals and across our social media channels</li></ul><h4>Library – All Documents in One Place</h4><ul><li>Applications, posters, presentations, technical articles, brochures, specifications</li><li>Fast and advanced search capabilities</li><li>Over 32,000 documents currently available in our database</li></ul><h4>Webinars</h4><ul><li>Upcoming and on-demand webinars from the field of analytical chemistry</li><li>More than 5,500 webinars covering chromatography, mass spectrometry, and spectroscopy</li></ul><h4>Careers</h4><ul><li>Targeted job listings in analytical chemistry</li><li>Clear filtering by specialization or location</li><li>Increased visibility for job postings</li></ul><h4>Companies</h4><ul><li>Company profile with key information and contacts</li><li>Integration of all your activities on our portal: News, Library documents, Webinars, Upcoming Events, Careers, and mentions by partners or customers</li><li>Connection to your Products listed on LabRulez portals</li></ul><h4>Products and Services</h4><ul><li>Comprehensive overview of instrumental techniques and services</li><li>Targeting the analytical chemistry community and customers in the growing online environment</li></ul><h4>Marketplace</h4><ul><li>Buying and selling pre-owned analytical equipment</li><li>We purchase analytical instrumentation of all brands and ages</li><li>Sell your equipment through LabRulez</li><li>Request and purchase complete systems, modules, or spare parts with warranty and service</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg" alt="LabRulez at analytica 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Lab_Rulez_at_analytica_2026_bazar_7edf4a0872.jpg 88w," sizes="100vw" width="1600" height="2844"><h3>What Will Be on Display at Our Booth?</h3>Come and explore selected spare parts and modules from our marketplace section. These include both new, tested, and pre-owned items.<h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar">LabRulezLCMS Marketplace</a></h4>Spare parts for LC/MS:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=378">Vacuum turbo pumps for LC/MS</a></li></ul>Spare parts for HPLC:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=397">Degassers for HPLC/UHPLC</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=368&amp;search=valve">Automatic valves for HPLC</a></li><li>HPLC components for Agilent 1100, 1200, and 1260 Infinity II series</li></ul>Consumables:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=377">HPLC lamps</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/bazaar?category=48">HPLC columns</a></li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar">LabRulezGCMS Marketplace</a></h4>Spare parts for GC/MS:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=367&amp;search=turbo">Turbo pumps for GC/MS</a></li></ul>Spare parts for GC:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=366&amp;search=EPC">EPC modules</a></li></ul>Sample injection<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar/432">Autosampler 7693A for GC</a></li></ul>Consumables:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/bazaar?category=7">GC columns </a>and selected accessories</li></ul>

LabRulez at analytica 2026

Article

Product

Events

Application

Science and research

Video

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Eurachem is a European network promoting international traceability of chemical measurements and good analytical practice. It provides expert guidance, supports method validation, uncertainty evaluation, proficiency testing, and facilitates discussion on technical and policy issues in analytical quality.

Eurachem

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

ECOM PREPBOX A3L8E Chromatography Separation System

PREPBOX is a compact alternative to modular preparative systems. It is assembled according to the customer's wishes.

<div style="display:block;" aria-labelledby="tab_item-0">Complete preparative modular system with one basic gradient pump and optionally secondary pump for repetitive sampling or with injection valve. Also switching valve for&nbsp;<abbr title="Countercurrent Chromatography">CCC</abbr> applications. PDA four channel detector up to 800&nbsp;nm.&nbsp;It is assembled according to the customer's wishes. It is used for high-capacity systems or with centrifugal chromatography systems like in pharmaceutical purification of cannabis extracts (<abbr title="Cannabidiol">CBD</abbr>, <abbr title="Cannabinol">CBN</abbr>, <abbr title="Cannabigerol">CBG</abbr>, <abbr title="Cannabichromene">CBC</abbr>, <abbr title="Tetrahydrocannabinol">THC</abbr>...).ECOMAC SW installed at internal PC controls the system. Fractions are collected by means of&nbsp;10 position valve&nbsp; It is necessary to purchase an operating system for the PREPBOX&nbsp;- in most cases we recommend Windows OS&nbsp;(P/N:&nbsp;ABB90000) or Linux&nbsp;(on request). The system also supports the Clarity software. It is also possible to purchase a wireless mouse and keyboard set&nbsp;(P/N:&nbsp;EPC-0028) and a computer monitor&nbsp;(P/N:&nbsp;EPC-0027).<h5>TOY18DAD 800L Detector</h5>It is UV-VIS diode array detector, which allow measuring absorbance of four wavelengths in range of 200-800&nbsp;nm simultaneously in one cell just as scanning of whole spectra.<h5>ECP201L Preparative HPLC Pump</h5>Preparative pump suited for preparative liquid chromatography with very high pressure up to 15&nbsp;MPa&nbsp;at flow rate of 1000&nbsp;ml/min. Advantage of this pump is a very stable run even at low flow rates.<h5>ECP2300 Preparative Gradient Pump</h5>Preparative HPLC pump suited for&nbsp;preparative&nbsp;applications in liquid chromatography with a pressure up to 15 MPa at flow rate of 300&nbsp;ml/min.&nbsp;New sophisticated unit allows achieving a precise&nbsp;low-pressure gradient, i.e. gradual changes of solvent composition by mixing&nbsp;up to four liquids&nbsp;at the pump entry.<h3>Parameters</h3><ul><li>Interface: 5x USB, HDMI, 2X RS232, LAN, VGA</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 490 W</li><li>Dimensions W x H x D: 405x490x525 mm (15.94x19.29x20.67 in)</li><li>Weight: 55 kg</li></ul></div>

ECOM COMPACT SEMI-PREPARATIVE SYSTEM (10 ml/min, ECS08)

A highly effective Compact semi-preparative system containing UV-VIS DAD detector, analytical gradient pump with degasser, automatic inject valve and fraction collector.

A highly effective Compact semi-preparative system containing&nbsp;UV-VIS DAD detector, analytical gradient pump with degasser, automatic inject valve and fraction collector. The detector allows absorbance measuring at four wavelengths at the same time or scanning through entire spectrum.The system is controlled by a built-in PC and touchscreen.A modular solution allows configuring the unit according to customer needs. This system contains a detector with a wavelength range of 200 –&nbsp; 800 nm, a pump with a flow rate up to 10 ml/min and a fraction collector.<h3>Main parts</h3><h5>TOY18DAD800L DETECTOR</h5>It is a UV-VIS diode array detector, which allows measuring the absorbance of&nbsp;four wavelengths in a range of 200–800 nm simultaneously in one cell&nbsp;just as scanning of whole spectra. Standardly is assembled with preparative cell PLCC07L, but other cells are available.<h5>ECF2096 FRACTION COLLECTOR</h5>Fractions are collected according to chosen method, which is simply created using a touch screen. Racks for 8, 21,40 ml tubes, 60 ml vials or 12 funnels, 30 mm.<h5>AUTOMATIC INJECT VALVE</h5>The valve is driven by a step motor and it is automatically switched by software. The system also allows manual sample injection by opening the column.<h5>SYSTEM PC INFO</h5>Installed industrial PC with Intel Atom 4 core processor. OS Linux, Touch screen 12,1“ 1024 x 786, SW QUEEN controls: gradient, flow rate, wavelengths, fractions collection etc. Remote administration is available. Possibility of measuring at four wavelengths at the same time or scanning through entire spectra. Furthermore, the possibility of displaying 3D data.&nbsp;<h5>ECP2010 ANALYTICAL GRADIENT PUMP</h5>Modified for the compact system,&nbsp;analytical gradient pump with degasser&nbsp;and with flow rate up to 10 ml/min&nbsp;(40 MPa, 5082 PSI).&nbsp;Unit software includes a new learning algorithm for pulsation suppression and many testing and diagnostic functions. Four gradient valves allow changing mobile phases without bottles alternation.&nbsp;<h3>COMPACT PREPARATIVE SYSTEM &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</h3><ul><li>Interface: 3xUSB, 2xLAN, RS232</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 400 W</li><li>Dimensions (W x H x D): 500 x 678 x 482 mm (19.69 x 26.69 x 18.98")</li><li>Weight: 55 kg (121.30 lb)</li></ul><h5>Detector</h5><ul><li>Wavelength range: 200 - 800 nm &nbsp; (256 elements on CCD)</li><li>Number of channels (Signals): 4</li><li>Scan: 200 - 800 nm,up to &nbsp;20 Hz, step 1 nm</li><li>Typical spectral half-width: 10 mn</li><li>Accuracy of adjustment / Reproducibility: ± 1 nm / ±0.5 nm</li><li>Noise level at test cell (254 nm, TC 0.75s): ± 5 x 10-5 AU</li><li>Drift at test cell (254 nm after 1 h): 1 x 10-3 AU/hr</li><li>Materials in contact with mobile phase: FEP; fused silica, stainless steel, PEEK</li><li>Time constant (T63): 0.5 s, 0.75 s, 1.0 s, 2.0 s, 4.0 s, 8.0 s, 16.0 s, 0.2 s, 0.1 s</li></ul><h5>Fraction collector</h5><ul><li>Available racks (two racks per unit)<ul><li>EC08 48 tubes of 8 ml</li><li>EC21 36 tubes of 21 ml</li><li>EC40 24 tubes of 40 ml</li><li>EC60 20 vials of 60 ml</li><li>F12A 12 funnels, 30 mm</li></ul></li><li>Maximum flow rate for tubes 8 ml: max. 50 ml/min</li><li>Maximum flow rate for tubes 21, 40 ml: max. 300 ml/min</li><li>Maximum flow rate for vials 60 ml: max. 300 ml/min</li><li>Maximum flow rate for funnels: max. 500 ml/min</li><li>Wetted materials: FEP, Tefzel®, PPS, KEL-F, PTFE, PEEK, SS 316, SIMAX glass</li><li>Input tubing: OD 1/8“ x ID 1/16“ FEP</li></ul><h5>Pump</h5><ul><li>Flow rate: 0.02 - 10.00 ml/min</li><li>Maximum operating pressure: 40 MPa (5082 PSI)</li><li>Repeatability of flow rate adjusting: ± 0.5 %</li><li>Accuracy of flow rate setting: ± 2 %</li><li>Wetted materials: stainless steel, sapphire, KEL-F, seals*</li><li>Output capillary outer diameter: 1/16”</li><li>Input tubing outer diameter: 1/8”</li><li>Gradient valves control module - OPTIONALLY: Up to four valves</li></ul>

ECOM COMPACT PREPARATIVE SYSTEM (50 ml/min, ECS58)

A highly effective Compact preparative system containing UV-VIS DAD detector, analytical gradient pump with degasser, automatic inject valve and fraction collector.

A highly effective Compact preparative system containing&nbsp;UV-VIS DAD detector, analytical gradient pump with degasser, automatic inject valve and fraction collector. The detector allows absorbance measuring at four wavelengths at the same time or scanning through entire spectrum.The system is controlled by a built-in PC and touchscreen.A modular solution allows configuring the unit according to customer needs. This system contains a detector with a wavelength range of 200 –&nbsp; 800 nm, a pump with a flow rate up to 10 ml/min and a fraction collector.<h3>Main parts</h3><h5>TOY18DAD800L DETECTOR</h5>It is a UV-VIS diode array detector, which allows measuring the absorbance of&nbsp;four wavelengths in a range of 200–800 nm simultaneously in one cell&nbsp;just as scanning of whole spectra. Standardly is assembled with preparative cell PLCC07L, but other cells are available.<h5>ECF2096 FRACTION COLLECTOR</h5>Fractions are collected according to chosen method, which is simply created using a touch screen. Racks for 8, 21,40 ml tubes, 60 ml vials or 12 funnels, 30 mm.<h5>AUTOMATIC INJECT VALVE</h5>The valve is driven by a step motor and it is automatically switched by software. The system also allows manual sample injection by opening the column.<h5>SYSTEM PC INFO</h5>Installed industrial PC with Intel Atom 4 core processor. OS Linux, Touch screen 12,1“ 1024 x 786, SW QUEEN controls: gradient, flow rate, wavelengths, fractions collection etc. Remote administration is available. Possibility of measuring at four wavelengths at the same time or scanning through entire spectra. Furthermore, the possibility of displaying 3D data.&nbsp;<h5>ECP2050 PREPARATIVE GRADIENT PUMP</h5>Modified for the compact system,&nbsp;quaternary gradient pumps&nbsp;with flow rate up to&nbsp;50 ml/min&nbsp;(30 MPa, 4351 PSI).&nbsp;Unit software includes a new learning algorithm for pulsation suppression and many testing and diagnostic functions.<h3>COMPACT PREPARATIVE SYSTEM &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</h3><ul><li>Interface: 3xUSB, 2xLAN, RS232</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 400 W</li><li>Dimensions (W x H x D): 500 x 678 x 482 mm (19.69 x 26.69 x 18.98")</li><li>Weight: 55 kg (121.30 lb)</li></ul><h5>Detector</h5><ul><li>Wavelength range: 200 - 800 nm &nbsp; (256 elements on CCD)</li><li>Number of channels (Signals): 4</li><li>Scan: 200 - 800 nm,up to &nbsp;20 Hz, step 1 nm</li><li>Typical spectral half-width: 10 mn</li><li>Accuracy of adjustment / Reproducibility: ± 1 nm / ±0.5 nm</li><li>Noise level at test cell (254 nm, TC 0.75s): ± 5 x 10-5 AU</li><li>Drift at test cell (254 nm after 1 h): 1 x 10-3 AU/hr</li><li>Materials in contact with mobile phase: FEP; fused silica, stainless steel, PEEK</li><li>Time constant (T63): 0.5 s, 0.75 s, 1.0 s, 2.0 s, 4.0 s, 8.0 s, 16.0 s, 0.2 s, 0.1 s</li></ul><h5>Fraction collector</h5><ul><li>Available racks (two racks per unit)<ul><li>EC08 48 tubes of 8 ml</li><li>EC21 36 tubes of 21 ml</li><li>EC40 24 tubes of 40 ml</li><li>EC60 20 vials of 60 ml</li><li>F12A 12 funnels, 30 mm</li></ul></li><li>Maximum flow rate for tubes 8 ml: max. 50 ml/min</li><li>Maximum flow rate for tubes 21, 40 ml: max. 300 ml/min</li><li>Maximum flow rate for vials 60 ml: max. 300 ml/min</li><li>Maximum flow rate for funnels: max. 500 ml/min</li><li>Wetted materials: FEP, Tefzel®, PPS, KEL-F, PTFE, PEEK, SS 316, SIMAX glass</li><li>Input tubing: OD 1/8“ x ID 1/16“ FEP</li></ul><h5>Pump</h5><ul><li>Flow rate: 0.1 – 50 ml/min</li><li>Maximum operating pressure: 30 MPa (4351 PSI)</li><li>Flow rate setting: 0.1 ml/min steps</li><li>Repeatability of flow rate adjusting: ± 0.5 %</li><li>Accuracy of flow rate setting: ± 2 %</li><li>Wetted materials: stainless steel, PEEK, TefzelTM, PE, ceramic, seals *</li><li>Output capillary outer diameter: 1/8”</li><li>Input tubing outer diameter: 1/8”</li><li>Gradient valves control module - OPTIONALLY: Up to six valves</li></ul>

ECOM COMPACT PREPARATIVE SYSTEM (250 ml/min, ECS28)

A highly effective Compact preparative system containing UV-VIS DAD detector, preparative gradient pump, an automatic inject valve, and a fraction collector. 

A highly effective Compact semi-preparative system containing&nbsp;UV-VIS DAD detector, preparative gradient pump, an automatic inject valve, and a fraction collector. The detector allows absorbance measuring at four wavelengths at the same time or scanning through entire spectrum.The system is controlled by a built-in PC and touchscreen.A modular solution allows configuring the unit according to customer needs. This system contains a detector with a wavelength range of 200 –&nbsp; 800 nm, a pump with a flow rate up to 10 ml/min and a fraction collector.<h3>Main parts</h3><h5>TOY18DAD800L DETECTOR</h5>It is a UV-VIS diode array detector, which allows measuring the absorbance of&nbsp;four wavelengths in a range of 200–800 nm simultaneously in one cell&nbsp;just as scanning of whole spectra. Standardly is assembled with preparative cell PLCC07L, but other cells are available.<h5>ECF2096 FRACTION COLLECTOR</h5>Fractions are collected according to chosen method, which is simply created using a touch screen. Racks for 8, 21,40 ml tubes, 60 ml vials or 12 funnels, 30 mm.<h5>AUTOMATIC INJECT VALVE</h5>The valve is driven by a step motor and it is automatically switched by software. The system also allows manual sample injection by opening the column.<h5>SYSTEM PC INFO</h5>Installed industrial PC with Intel Atom 4 core processor. OS Linux, Touch screen 12,1“ 1024 x 786, SW QUEEN controls: gradient, flow rate, wavelengths, fractions collection etc. Remote administration is available. Possibility of measuring at four wavelengths at the same time or scanning through entire spectra. Furthermore, the possibility of displaying 3D data.&nbsp;<h5>ECP2200 PREPARATIVE GRADIENT PUMP</h5>Modified for the compact system,&nbsp;quaternary gradient pumps&nbsp;with flow rate up to&nbsp;250 ml/min&nbsp;(30 MPa at 100 ml/min and then linearly down up to 15 MPa at 250 ml/min).&nbsp;Unit software includes a new learning algorithm for pulsation suppression and many testing and diagnostic functions.<h3>COMPACT PREPARATIVE SYSTEM &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</h3><ul><li>Interface: 3xUSB, 2xLAN, RS232</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 400 W</li><li>Dimensions (W x H x D): 500 x 678 x 482 mm (19.69 x 26.69 x 18.98")</li><li>Weight: 55 kg (121.30 lb)</li></ul><h5>Detector</h5><ul><li>Wavelength range: 200 - 800 nm (256 elements on CCD)</li><li>Number of channels (Signals): 4</li><li>Scan: 200 - 800 nm,up to &nbsp;20 Hz, step 1 nm</li><li>Typical spectral half-width: 10 mn</li><li>Accuracy of adjustment / Reproducibility: ± 1 nm / ±0.5 nm</li><li>Noise level at test cell (254 nm, TC 0.75s): ± 5 x 10-5 AU</li><li>Drift at test cell (254 nm after 1 h): 1 x 10-3 AU/hr</li><li>Materials in contact with mobile phase: FEP; fused silica, stainless steel, PEEK</li><li>Time constant (T63): 0.5 s, 0.75 s, 1.0 s, 2.0 s, 4.0 s, 8.0 s, 16.0 s, 0.2 s, 0.1 s</li></ul><h5>Fraction collector</h5><ul><li>Available racks (two racks per unit)<ul><li>EC08 48 tubes of 8 ml</li><li>EC21 36 tubes of 21 ml</li><li>EC40 24 tubes of 40 ml</li><li>EC60 20 vials of 60 ml</li><li>F12A 12 funnels, 30 mm</li></ul></li><li>Maximum flow rate for tubes 8 ml: max. 50 ml/min</li><li>Maximum flow rate for tubes 21, 40 ml: max. 300 ml/min</li><li>Maximum flow rate for vials 60 ml: max. 300 ml/min</li><li>Maximum flow rate for funnels: max. 500 ml/min</li><li>Wetted materials: FEP, Tefzel®, PPS, KEL-F, PTFE, PEEK, SS 316, SIMAX glass</li><li>Input tubing: OD 1/8“ x ID 1/16“ FEP</li></ul><h5>Pump</h5><ul><li>Flow rate: 0.5 – 250 ml/min</li><li>Maximum operating pressure: 30 MPa (4351 PSI) up to 100 ml/min then &nbsp;linearly down up to</li><li>Flow rate setting: 0.1 ml/min steps</li><li>Repeatability of flow rate adjusting: ± 1 %</li><li>Accuracy of flow rate setting: ± 2 %</li><li>Wetted materials: stainless steel, PEEK, TefzelTM, PE, ceramic, seals *</li><li>Output capillary outer diameter: 1/8”</li><li>Input tubing outer diameter: 1/8”</li><li>Gradient valves control module - OPTIONALLY: Up to six valves</li></ul>

<div style="display:block;" aria-labelledby="tab_item-0">Complete preparative modular system with one basic gradient pump and optionally secondary pump for repetitive sampling or with injection valve. Also switching valve for&nbsp;<abbr title="Countercurrent Chromatography">CCC</abbr> applications. PDA four channel detector up to 800&nbsp;nm.&nbsp;It is assembled according to the customer's wishes. It is used for high-capacity systems or with centrifugal chromatography systems like in pharmaceutical purification of cannabis extracts (<abbr title="Cannabidiol">CBD</abbr>, <abbr title="Cannabinol">CBN</abbr>, <abbr title="Cannabigerol">CBG</abbr>, <abbr title="Cannabichromene">CBC</abbr>, <abbr title="Tetrahydrocannabinol">THC</abbr>...).ECOMAC SW installed at internal PC controls the system. Fractions are collected by means of&nbsp;10 position valve&nbsp; It is necessary to purchase an operating system for the PREPBOX&nbsp;- in most cases we recommend Windows OS&nbsp;(P/N:&nbsp;ABB90000) or Linux&nbsp;(on request). The system also supports the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity software</a>. It is also possible to purchase a wireless mouse and keyboard set&nbsp;(P/N:&nbsp;EPC-0028) and a computer monitor&nbsp;(P/N:&nbsp;EPC-0027).<h5>TOY18DAD 800L Detector</h5>It is UV-VIS diode array detector, which allow measuring absorbance of four wavelengths in range of 200-800&nbsp;nm simultaneously in one cell just as scanning of whole spectra.<h5>ECP2300 Preparative Gradient Pump</h5>Two peparative HPLC pump suited for&nbsp;preparative&nbsp;applications in liquid chromatography with a pressure up to 15 MPa at flow rate of 300&nbsp;ml/min.&nbsp;New sophisticated unit allows achieving a precise&nbsp;low-pressure gradient, i.e. gradual changes of solvent composition by mixing&nbsp;up to four liquids&nbsp;at the pump entry.<h4>Complete preparative modular system with:</h4><ul><li>one basic gradient pump</li><li>for sampling secondary pump or injection valve</li><li>optionally switching valve for CCC</li><li>PDA detector up to 800 nm</li><li>10 positions valve for fractions collecting</li><li>PC board with ECOMAC SW</li></ul><h3>Parameters</h3><ul><li>Interface: 5x USB, HDMI, 2X RS232, LAN, VGA</li><li>Power supply: 100 - 240 V AC</li><li>Power input: 4900 W</li><li>Dimensions W x H x D: 405x490x525 mm (15.94x19.29x20.67 in)</li><li>Weight: 50 kg</li></ul></div>

ECOM PREPSYSTEM - Chromatography Separation System

A complete flash/preparative/pilot scale/production modular system ready for customizable to the application needs.

We would like to introduce an ECOM product news – a complete flash/preparative/pilot scale/production modular system with an excellent price/performance ratio.<h3>Applications</h3>The system can be used e.g. in:<ul><li>high-capacity systems or with centrifugal liquid/liquid chromatography systems, like in pharmaceutical purification of plant extracts – e.g. cannabinoids (CBD, CBN, CBG, CBC, THC, etc.), peptides, and oligonucleotides, algae extracts, oleoresins, etc.,&nbsp;</li><li>Also in new molecule development or synthesis.</li></ul><h3>Main parts</h3><h4>Pumps</h4><ul><li>The device has 3 pumps, 2 main ones are intended for a "high" pressure gradient (parallel pump connection), and one of them has a 6-solvent selection valve.&nbsp;</li><li>An optional third pump is used for repetitive sampling of high-volume samples. The unit also has a loop sample injection valve and a switching valve for CCC/CPC applications (ascending/descending mode).&nbsp;</li><li>The unit's universal PDA detector measures absorbance at four wavelengths at the same time up to 800 nm.</li></ul><h4>Software</h4><ul><li>The ECOMAC software or <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999">Clarity software</a> (FDA 21 CFR Part 11 compliant) is internally installed in the PC controlling the system.</li></ul><h4>Customization</h4><ul><li>The unit is completely customizable to the application needs to meet any scale criteria–from small flash sample separation testing through pilot scale prediction to high-capacity production.</li><li>It could work in ranges of 10 ml/min.–6000 ml/min and it can be easily and automatically switched between these scales.</li></ul>

ECOM ECS23PC Quaternary Preparative Gradient System with Fraction Collector

A highly effective preparative system containing a UV-VIS DAD detector, a preparative pump, a gradient box with PC, and a fraction collector. The detector allows measuring at four wavelengths at the same time or an informative scan.

<div style="display:block;" aria-labelledby="tab_item-0">A highly effective preparative system containing a UV-VIS DAD detector, a preparative pump, a gradient box with PC, and a fraction collector. The detector allows measuring at four wavelengths at the same time or an informative scan.Communication is through RS232 or Ethernet (LAN). An additional PC A/D converter card is not required for this system. The system contains a manual injector and ECOMAC software which include drivers for all ECOM units.It is necessary to purchase an OS for the system - in most cases, we recommend OEM Windows OS (P/N: ABB90000) or Linux (on request). It is also possible to purchase a wireless mouse and keyboard set (P/N: EPC-0028) and a computer monitor (P/N: EPC-0027).<h3>Main parts</h3><h4>TOY18DAD H 600 DETECTOR</h4>A UV-VIS diode array detector, which allows measuring the absorbance of four wavelengths in the range of 200 – 600 nm simultaneously in one cell just as visualization of whole spectra. It is possible to use the detector in flash and preparative applications. Standardly is assembled preparative cell PLCC 15 but other cells are available.<h4>ECP2300 PREPARATIVE PUMP</h4>This isocratic pump works with Gradient Box ECB2007PC as a quaternary gradient pump. The flow rate range is 0.1-300 ml/min and the pressure limit at 15 MPa. Unit software includes a new learning algorithm for pulsation suppression and many testing and diagnostic functions.<h4>ECB2005PC GRADIENT BOX WITH PC, WITHOUT DEGASSER</h4>The box is suited for handling liquids in ECOM gradient systems. It accommodates a container for solvent bottles and a four-way gradient valve. A four-way gradient valve is controlled from the pump ECP2300. In this box is assembled an industrial PC board. This solution allows the installation of OS (Windows or Linux) and chromatography SW ECOMAC or Clarity.&nbsp;<h4>ECF2096 FRACTION COLLECTOR</h4>Fractions are collected according to a chosen method which can be created manually by keyboard, just as using ECOMAC software. Analog input allows collecting based on detector signal. Racks for 9, 21, and 40 ml tubes.<h4>ECOMAC CHROMATOGRAPHY SOFTWARE</h4>This system is fully controlled by ECOMAC software, which is also a part of delivery. It allows all units control, gradient creation, and fraction collecting.<h3>SYSTEM CONTAINS&nbsp;</h3>Pcs / Description (P/N)<ul><li>1x / TOY18DAD H 600 Four Channel Detector (ANW0000X)</li><li>1x / ECB2005PC Gradient Box with PC, without Degasser (ABBPC00X)</li><li>1x / ECP2300 Preparative Pump (ACE0000X)</li><li>1x / ECOMAC software (SA100000)</li><li>1x / ECF2096 Fraction collector (AFA0000X)</li><li>1x / Preparative injection valve 1/8”; 2ml loop (SY2032022)</li><li>1x / Accessory for prep. system series 2000 (ASP00180)</li></ul>Note: The system can be equipped with detectors with different wavelengths ranges and pumps with different flow rates from ECOM production.</div>

Products from category Preparative chromatographs from ECOM - page 1

Related content

LabRulez at analytica 2026

Advancing Steroid Quantification: Unlocking Sensitivity and Selectivity with the Thermo Scientific Stellar Mass Spectrometer

You talk, we understand – The way out of the tower of Babel