EU Regulation 396/2005: Pesticide Residue Testing and the Critical Role of QuEChERS Evaporation in Food Safety

<div><div><p><strong>Researchers led by </strong><a target="_blank" rel="noopener noreferrer" href="https://kudova.group.uochb.cz/en"><strong>Eva Kudová</strong></a><strong> from IOCB Prague and Jitka Viktorová from UCT Prague have identified new androstane-based steroid derivatives that can significantly improve the effectiveness of existing antibiotics against multidrug-resistant </strong><i><strong>Staphylococcus aureus</strong></i><strong>.</strong></p></div></div><div><p>The team screened dozens of natural steroidal hormones and synthetic derivatives to see whether they could block bacterial efflux pumps – mechanisms that bacteria use to eject antibiotics and survive treatment. Two compounds emerged as particularly promising: they inhibited efflux pumps and lowered the effective doses of antibiotics such as ciprofloxacin and erythromycin.</p><p>Further analysis showed that one of the compounds also suppressed genes linked to bacterial virulence. Another key finding is that the most active molecules are non-toxic to human immune cells and showed no detectable endocrine activity, suggesting a favorable safety profile.</p><p>These findings support the idea that rationally designed steroid-based molecules could act as antibiotic adjuvants, helping existing drugs overcome bacterial resistance.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/IOCB_Prague_Steroidal_hormones_and_neurosteroids_novel_therapeutic_strategies_in_bacterial_infections_8e5d2a7b48.jpg" alt="IOCB Prague: Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_IOCB_Prague_Steroidal_hormones_and_neurosteroids_novel_therapeutic_strategies_in_bacterial_infections_8e5d2a7b48.jpg 222w," sizes="100vw" width="1258" height="886"></p><blockquote><h4><strong>Original Article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0223523426001613?via%3Dihub"><strong>Steroidal hormones and neurosteroids - novel therapeutic strategies in bacterial infections: Design, synthesis, and biological evaluation</strong></a></h4><p>Daniela Brdová, Bára Křížkovská, Jan Špaček, Zdeněk Míchal, Eva Jablonská, Ondřej Strnad, Hana Chodounská, Eszter Szánti-Pintér, Marina Morozovová, Václav Hanžl, Jan Tkadlec, Martijn Riool, Jan Lipov, Jitka Viktorová, Eva Kudová&nbsp;</p><p><i><strong>Eur. J. Med. Chem., 2026, 308, 118716</strong></i></p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.ejmech.2026.118716">https://doi.org/10.1016/j.ejmech.2026.118716</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>The global rise of antibiotic resistance necessitates novel therapeutic strategies for infectious diseases. Inhibition of bacterial efflux pumps, which contribute to multidrug resistance, represents a promising approach to restore or even increase the efficacy of existing antibiotics. Using fluorescence-based ethidium bromide accumulation, broth microdilution, and checkerboard assays, we evaluated 26 endogenous steroidal hormones and neurosteroids, along with 30 synthetic derivatives, for their ability to enhance antibiotic susceptibility in multidrug-resistant <i>Staphylococcus aureus</i>. Structure-activity relationship analysis identified compounds <strong>13</strong> and <strong>16</strong> as lead candidates, exhibiting strong efflux pump inhibition and marked reductions in the minimum inhibitory concentrations of ciprofloxacin and erythromycin. Both compounds showed additive effects in checkerboard assays. Modifications at C-3 (polar substitution) and C-17 (3α,5β-stereochemistry and nonpolar substitution) were essential for potent efflux inhibition and sensitization, although these modifications were not additive when combined. Transcriptome analysis further revealed that compound <strong>13</strong> significantly downregulated <i>S. aureus</i> virulence-associated genes when administered alone or in combination with antibiotics. Cytotoxicity assessment in human peripheral blood mononuclear cells and receptor transactivation assays for estrogen, androgen, and progesterone receptors indicated that the most active derivatives were non-toxic and lacked detectable endocrine activity, suggesting a favorable safety profile. Overall, these findings support the concept that rationally designed andostane-based steroidal scaffolds can function as competitive bacterial efflux pump inhibitors and serve as potential antibiotic adjuvants to mitigate efflux-mediated resistance.</p><h4><strong>Instrumentation</strong></h4><h5><strong>Structural characterization</strong></h5><ul><li><strong>AVANCE III 400 MHz NMR spectrometer</strong> (Bruker)</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=LTQ+Orbitrap+XL"><strong>LTQ Orbitrap XL HRMS</strong></a> (Thermo Fisher Scientific, ESI)</li></ul></div>

Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections

<p><strong>Metformin is currently the first-line oral drug of choice for the treatment of type 2 diabetes. It reduces glucose production in the liver, improves tissue sensitivity to insulin, and does not cause weight gain or hypoglycemia, which sets it apart from some other antidiabetic drugs. Moreover, its long-term beneficial effects on the risk of cardiovascular complications and mortality in people with type 2 diabetes have been well established. Researchers from the Institute of Physiology CAS (IPHYS) have identified a new group of blood metabolites that could help physicians objectively monitor whether patients with type 2 diabetes are taking their metformin as prescribed.</strong></p><h4><strong>New biomarkers for metformin use</strong></h4><p>A team led by Tomáš Čajka from the Laboratory of Translational Metabolism at IPHYS analyzed plasma samples from <strong>637 patients with type 2 diabetes treated with metformin</strong> and <strong>143 non-diabetic controls</strong> using advanced metabolomics and lipidomics. Among 614 detected metabolites, they identified five from the group of <strong>N-lactoyl-amino acids </strong>(e.g. N‑lactoyl-phenylalanine), which had previously been seen as unknown signals due to missing reference spectra in databases. The levels of these metabolites in the blood closely reflected the plasma concentrations of metformin. In patients with the highest metformin exposure, the concentrations of these metabolites were up to 7.2 times higher than in controls.</p><h4><strong>A sensitive “fingerprint” of the drug’s effect</strong></h4><p>N-Lactoyl-amino acids are formed in cells by combining lactate and amino acids, thus reflecting the metformin-induced changes in cellular energy metabolism. “<i>Importantly, even though they occur in plasma only at nanomolar concentrations, they reliably distinguish patients who take metformin regularly from those who take it irregularly or not at all</i>,” emphasizes T. Čajka.</p><h4><strong>Metabolomics in practice and international collaboration</strong></h4><p>The study also provides a detailed description of broader metabolic changes in type 2 diabetes, including increases in lactate, organic acids, and branched-chain amino acids, as well as extensive remodelling of the lipid profile. In addition to T. Čajka’s team, collaborators from the Institute for <strong>Clinical and Experimental Medicine in Prague</strong> and the <strong>West Coast Metabolomics Center</strong> (University of California, Davis) also participated in the study.</p><p>The results demonstrate that advanced metabolomics approaches developed at IPHYS within the <strong>CarDia project</strong> can find highly practical applications both in clinical studies and in personalized monitoring of treatment in patients with diabetes.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.70205"><strong>Untargeted Metabolomics Identifies N-Lactoyl-Amino Acids as Dose-Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes</strong></a></h4><p>Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik</p><p>Clin Pharmacol Ther, 119: 1057-1069</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/cpt.70205">https://doi.org/10.1002/cpt.70205</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites. Patients were stratified by plasma metformin into sub-therapeutic, therapeutic, and supra-therapeutic groups, and associations were evaluated by multiple linear regression and composite metabolite ranking. Five previously unannotated features were structurally identified as N-lactoyl-amino acids, whose levels correlated strongly with plasma metformin (ρ = 0.42–0.55, P &lt; 0.0001) and increased up to 7.2-fold in the supra-therapeutic group (&gt; 2000 ng/mL). While N-lactoyl-amino acids were consistently detected in the nanomolar range, they still displayed robust and dose-dependent associations with metformin. Broader metabolic changes in T2D included elevated lactate, organic acids, and branched-chain amino acids, together with reduced urea cycle metabolites. Lipidomics showed increases in saturated triacylglycerols and diacylglycerols and decreases in cholesteryl esters, sphingomyelins, and phospholipids. These findings establish N-lactoyl-amino acids as robust, dose-responsive plasma biomarkers of metformin exposure. Despite being up to four orders of magnitude less abundant than their amino acid precursors, they sensitively reflect mitochondrial lactate overflow and pharmacodynamic adaptation, offering objective assessment of adherence.</p>

New blood biomarkers reveal how faithfully diabetes patients take metformin

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The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Waters ACQUITY Advanced Polymer Chromatography (APC) Calibration Standards Kits

Eliminate manual preparation of custom standard calibration mixes with ACQUITY Advanced Polymer Chromatography (APC) Calibration Standards.

<div><div><h3><strong>Frequent calibration for greater confidence in your results</strong></h3></div></div><div><div><p><strong>Eliminate manual preparation of custom standard calibration mixes with ACQUITY Advanced Polymer Chromatography (APC) Calibration Standards, which provide the right number of data points for your targeted molecular weight (MW) range. ACQUITY APC Calibration Standards are specifically designed to match the molecular weight range of the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1950"><strong>ACQUITY APC Columns</strong></a><strong>.</strong></p><p>ACQUITY APC polymethylmethacrylate and polystyrene standards are configured into <strong>Low</strong>, <strong>Middle</strong>, and <strong>High Molecular Weight Calibration Kits</strong>, as well as a convenient<strong> Method Development Kit </strong>that includes the full separation range of all three kits combined. These chromatography standards are designed to provide a maximum range of narrow standard data points for a specific column set or molar mass range.</p><p>With ACQUITY APC Calibration Standards, you can conduct calibration with<strong> 3-5x shorter cycle times</strong>, enabling you to run more replicates and more easily include calibration with each test set. With increased calibration frequency, you can have higher confidence in the accuracy of each test run.</p><div><div><ul><li><strong>Simple and easy</strong>&nbsp;to use by adding solvent and injecting</li><li><strong>Shorter preparation time</strong> resulting in faster calibration cycle time</li><li><strong>Greater confidence</strong> in molecular weight determination of samples</li><li><strong>Reduce variances</strong> in analysis providing increased product quality</li></ul><div><div><p><strong>Recommended Use:&nbsp;</strong>For <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/194"><strong>advanced polymer chromatography </strong></a>calibration.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_Calibration_Standards_Kits_2_1e32010bc1.jpg" alt="Waters ACQUITY Advanced Polymer Chromatography (APC) Calibration Standards Kits: The ACQUITY Advanced Polymer Chromatography (APC) Calibration Standards are available in polystyrene and polymethylmethacrylate configured into Low, Middle, and High Molecular Weight Calibration Kits. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Advanced_Polymer_Chromatography_APC_Calibration_Standards_Kits_2_1e32010bc1.jpg 245w," sizes="100vw" width="1024" height="565"></p></div></div></div></div></div></div>

Waters AccQ·Tag Ultra Chemistry kit

Waters AccQ•Tag Ultra kits offer accurate amino acid analysis for diverse matrices, with manual and automated options, optimized columns, stable derivatization, and compatibility with UPLC and robotic pipetting platforms.

<h4><strong>Manual Options</strong></h4><p><strong>AccQ•Tag Ultra </strong>and <strong>AccQ•Tag chemistries</strong> are the first step in enabling your laboratory to obtain accurate amino acid composition from protein/peptide hydrolysates, physiologic fluids, feeds, foods, pharmaceutical preparations, and many other sample matrices. Combined with traditional HPLC, UHPLC, or the Waters ACQUITY UPLC, you can now have a system that is customized to separate amino acids from protein hydrolysates, cell culture media, and food/feed samples to get enhanced resolution. The end result is reliability with precise qualitative and quantitative results.</p><p><strong>AccQ•Tag Ultra and AccQ•Tag chemistry kits include:</strong></p><ul><li>Pre-column derivatization reagents</li><li>Dedicated reversed-phase columns QC tested for amino acid analysis</li><li>Eluents and standards</li><li>Documentation on methods for the analysis of these important biocompounds</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Acc_Q_Tag_Ultra_Chemistry_kit_1_879ccc4140/Waters-AccQTag-Ultra-Chemistry-kit-1.jpg" alt="Waters: AccQ·Tag Ultra Chemistry kit" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Acc_Q_Tag_Ultra_Chemistry_kit_1_879ccc4140/thumbnail_Waters-AccQTag-Ultra-Chemistry-kit-1.jpg 234w," sizes="100vw" width="660" height="440"></p><h4><strong>Automation Options</strong></h4><p><strong>AccQ•Tag Ultra Derivatization Automation Kit </strong>provides simplified tools to enhance high throughput amino acid automation via an easy-to-use, automation friendly format that maximizes workflow and accommodates residual volume. Compatible with Tecan, Hamilton, and Andrew Alliance systems, the AccQ•Tag Ultra Derivatization Automation Kit provides fast, accurate, and precise amino acid analyses, translating into cost and time savings for your lab.</p><ul><li>Parallel high-throughput sample prep (process up to 96 samples at a time)</li><li>Minimal user intervention</li><li>Larger reagent volume to accommodate automation needs</li><li>Starter kits include reagents, column, eluents, application standards and labware</li><li>Scripts ready for multiple automated platforms<ul><li>Tecan, Hamilton, and Andrew Alliance</li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Acc_Q_Tag_Ultra_Chemistry_kit_2_36d9723e92/Waters-AccQTag-Ultra-Chemistry-kit-2.jpg" alt="Waters: AccQ•Tag Ultra Derivatization Automation Kit " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Acc_Q_Tag_Ultra_Chemistry_kit_2_36d9723e92/thumbnail_Waters-AccQTag-Ultra-Chemistry-kit-2.jpg 240w," sizes="100vw" width="1200" height="780"></p><h4><strong>Let Andrew+ Pipette for You</strong></h4><p>One of the largest pain points in sample preparation is repetitive pipetting. Minimizing sources of contamination is also critical. The Andrew+ robotic pipetting platform helps alleviate those pain points and provides confidence and reliability when doing derivatization.</p><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/208"><strong>Andrew+ Pipetting Robot</strong></a><strong> provides:</strong></p><ul><li>Flexibility in the number of samples run using AccQ•Tag Ultra Automation</li><li>Sample Preparation Kit (32, 64, 96 sample)</li><li>Verified protocols available in <strong>OneLab</strong></li><li>Compatible with additional <strong>connected devices</strong></li><li>Easy-to-use, no in-depth training required</li><li>Self-guided installation, online troubleshooting, and help</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Andrew_Pipetting_Robot_ab82a4584b.jpg" alt="Waters: Andrew+ Pipetting Robot" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Andrew_Pipetting_Robot_ab82a4584b.jpg 245w," sizes="100vw" width="1200" height="726"></p><h4><strong>Amino Acid Reference Standards</strong></h4><p>Waters offers reference standards for Amino Acid Analysis (AAA) required in many applications in pharmaceutical and food and feed industries. A variety of standards containing free amino acids are offered for qualitative and quantitative determination of amino acids, method development, and troubleshooting of the AccQ•Tag Ultra and AccQ•Tag methods.</p><p><strong>Available standards include:</strong></p><ul><li>Cell Culture Standard Kit</li><li>Food &amp; Feed Standard Kit</li><li>Amino Acid Hydrolysates Standard</li><li>Internal Standard (Nva)</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Amino_Acid_Reference_Standards_fd1db2e697.jpg" alt="Waters: Amino Acid Reference Standards" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Amino_Acid_Reference_Standards_fd1db2e697.jpg 234w," sizes="100vw" width="838" height="559"></p><h4><strong>AccQ•Tag Ultra and AccQ•Tag Derivitization Chemistry</strong></h4><p>This line of products is a comprehensive, fully tested set of reagents, columns, eluents, and methods. &nbsp;</p><p>AccQ•Tag is optimized for use with HPLC/UHPLC.</p><p>AccQ•Tag Ultra is optimized for use with the UPLC Amino Acid Analysis Application Solution.</p><ul><li>Both methods are based on the AccQ•Tag pre-column derivatization method</li><li>Primary and secondary amino acids are reacted with a single reagent (AccQ•Fluor) in a high-throughput batch process resulting in exceptionally stable derivatives</li><li>AccQ•Tag Ultra provides high-resolution separations achieved using the AccQ•Tag Ultra UPLC column (1.7 µm particles) and mobile phases</li><li>Derivatized amino acids resolved and quantified to sub-pmol levels with single wavelength UV detection</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_kits_9c7f40f8c4.jpg" alt="Waters: AccQ•Tag Ultra and AccQ•Tag Derivitization Chemistry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_kits_9c7f40f8c4.jpg 133w," sizes="100vw" width="352" height="413"></p>

Waters SARS-CoV-2 LC-MS Kit (RUO)

Advance virus research with Waters' RUO LC-MS kit for SARS-CoV-2. Detect and quantify NCAP peptides with high sensitivity and reproducibility using SISCAPA antibody enrichment and automation-ready workflows.

<h4><strong>Detect and quantify SARS-CoV-2 NCAP peptides to advance virus research</strong></h4><p>The global <strong>COVID-19 pandemic</strong> created an unprecedented need to quickly deploy emergency tests for SARS-CoV-2 infection. Now, scientists can harness the flexibility and reproducibility of LC-MS to advance critical SARS-CoV-2 research.</p><p><strong>Waters SARS-CoV-2 LC-MS Kit (RUO)</strong> is a <strong>Research Use Only kit</strong> to directly <strong>detect and quantify SARS-CoV-2</strong> signature nucleocapsid peptides (NCAPs) without the need to amplify the target analytes – so you can ensure accuracy, reproducibility, and sensitivity for your most critical research.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SARS_Co_V_2_LC_MS_Kit_RUO_2_50b4ae9b00/Waters-SARS-CoV-2-LC-MS-Kit-(RUO)-2.jpg" alt="Waters: SARS-CoV-2 LC-MS Kit (RUO)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SARS_Co_V_2_LC_MS_Kit_RUO_2_50b4ae9b00/thumbnail_Waters-SARS-CoV-2-LC-MS-Kit-(RUO)-2.jpg 234w," sizes="100vw" width="660" height="440"></p><h4><strong>Overview</strong></h4><ul><li>Achieve <strong>reproducible results</strong> between and within labs &nbsp;</li><li>Ensure <strong>high accuracy</strong> and analytical <strong>sensitivity</strong> to enable critical research &nbsp;</li><li><strong>Empower research</strong> and development of pioneering SARS-CoV-2 testing with an alternative and complementary technology to common infectious pathogen research &nbsp;</li><li>Enable <strong>broader research with an LC-MS method </strong>with the potential to be multiplexed with other peptides and biomarkers&nbsp;</li></ul><p><i><strong>* </strong>This kit is for research use only and has not been approved for use in clinical diagnostic procedures. This RUO kit has not been tested with clinical samples. The SARS-CoV-2 kit for SARS-CoV-2 nucleocapsid peptides is not available in all countries, please contact your Waters representative for more details.</i></p><p><strong>Recommended Use:</strong> For the detection and quantification of SARS-CoV-2 signature NCAP peptides.</p><h4><strong>LC-MS enables cutting-edge SARS-CoV-2 research</strong></h4><p>The Waters SARS-CoV-2 LC-MS Kit (RUO) is a Research Use Only kit intended for the quantitative measurement of three proteolytic peptides derived from the SARS-CoV-2 Nucleocapsid (NCAP) protein. The method has been optimized on an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/199"><strong>ACQUITY UPLC I-Class PLUS</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/195"><strong>Xevo TQ-XS System</strong></a> and is also intended for use with the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/208"><strong>Andrew+ Pipetting Robot</strong></a>. Optimization on other instrument platforms is possible. &nbsp;</p><p>Further investigation is needed to collect objective evidence in promising research applications, however, based on the properties of the analytical test method, the SARS-CoV-2 LC-MS Kit might be leveraged for the following research studies: &nbsp;</p><ul><li>Peptide concentration to quantitate SARS CoV-2 signature peptides at different stages of infection&nbsp;</li><li>Research of infection and long-term effects through peptide quantitation&nbsp;</li></ul><p>Future pandemic preparedness studies and research of signature peptide-based biomarkers unique to other infections </p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_SARS_Co_V_2_LC_MS_Kit_RUO_allows_for_easy_sample_preparation_sample_enrichment_and_sample_detection_f0aca034ad.jpg" alt="Waters: The SARS-CoV-2 LC-MS Kit (RUO) allows for easy sample preparation, sample enrichment, and sample detection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_SARS_Co_V_2_LC_MS_Kit_RUO_allows_for_easy_sample_preparation_sample_enrichment_and_sample_detection_f0aca034ad.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Achieve confidence in results</strong></h4><p>Ensure accurate and consistent results with highly analytically selective antibody magnetic bead enrichment. With the innovative SISCAPA® anti-peptide antibody enrichment sample preparation method from SISCAPA Assay Technologies, Inc. in the SARS-CoV-2 LC-MS Kit (RUO), you can improve the performance of mass spectrometry for measurement of pre-selected protein targets.</p><p>With the SARS-CoV-2 LC-MS Kit (RUO) and SISCAPA, you can achieve the analytical sensitivity you need to detect low levels of SARS-CoV-2 peptides from complex digested samples with stable isotope standards and capture by anti-peptide antibodies. Increase laboratory efficiency with all the components your busy research laboratory needs to quickly deploy the supplied method - all in one package.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_SARS_Co_V_2_method_minimizes_sample_media_interference_providing_greater_flexibility_for_the_analysis_of_multiple_research_samples_fe3a56c686.jpg" alt="Waters: The SARS-CoV-2 method minimizes sample media interference, providing greater flexibility for the analysis of multiple research samples." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_SARS_Co_V_2_method_minimizes_sample_media_interference_providing_greater_flexibility_for_the_analysis_of_multiple_research_samples_fe3a56c686.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Ensure reproducibility with trusted chemistries and consumables</strong></h4><p>Ensuring reproducible quantitation from sample-to-sample, run-to-run, and lab-to-lab provides the confidence you need for critical research decisions. Ensuring reproducibility starts with minimizing variability risks, including the risk of unpredictable non-specific binding of peptides to surfaces. The SARS-CoV-2 LC-MS Kit uses QuanRecovery Plates with MaxPeak HPS and a MaxPeak Premier Peptide Column, minimizing non-specific binding of peptides to surfaces while enhancing recovery and signal.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Analytical_sensitivity_of_the_ADE_AYN_and_NPA_peptides_in_VTM_at_2_3_5_10_and_20_amol_L_following_antibody_enrichment_145d5249ef.jpg" alt="Waters: Analytical sensitivity of the ADE, AYN, and NPA peptides in VTM at 2, 3, 5, 10, and 20 amolµL following antibody enrichment." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Analytical_sensitivity_of_the_ADE_AYN_and_NPA_peptides_in_VTM_at_2_3_5_10_and_20_amol_L_following_antibody_enrichment_145d5249ef.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Let Andrew+ pipette for you</strong></h4><p>Save valuable time and focus on your research with reliable and reproducible sample preparation using the Andrew+ Pipetting Robot. The SARS-CoV-2 LC-MS Kit (RUO) comes in an automation-friendly format with liquid handling protocols for the Andrew+ Pipetting Robot available on OneLab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SARS_Co_V_LC_MS_Kit_RUO_automation_protocol_available_for_Andrew_Pipetting_Robot_It_provides_a_flexible_automation_platform_easily_adaptable_to_multiple_workflows_8dca9a99e0.jpg" alt="Waters: SARS-CoV-LC-MS Kit (RUO) automation protocol available for Andrew + Pipetting Robot. It provides a flexible automation platform easily adaptable to multiple workflows." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SARS_Co_V_LC_MS_Kit_RUO_automation_protocol_available_for_Andrew_Pipetting_Robot_It_provides_a_flexible_automation_platform_easily_adaptable_to_multiple_workflows_8dca9a99e0.jpg 234w," sizes="100vw" width="1024" height="682"></p>

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