Waters SARS-CoV-2 LC-MS Kit (RUO)

Detect and quantify SARS-CoV-2 NCAP peptides to advance virus research

The global COVID-19 pandemic created an unprecedented need to quickly deploy emergency tests for SARS-CoV-2 infection. Now, scientists can harness the flexibility and reproducibility of LC-MS to advance critical SARS-CoV-2 research.

Waters SARS-CoV-2 LC-MS Kit (RUO) is a Research Use Only kit to directly detect and quantify SARS-CoV-2 signature nucleocapsid peptides (NCAPs) without the need to amplify the target analytes – so you can ensure accuracy, reproducibility, and sensitivity for your most critical research. 

Waters: SARS-CoV-2 LC-MS Kit (RUO)

Overview

• Achieve reproducible results between and within labs  
• Ensure high accuracy and analytical sensitivity to enable critical research  
• Empower research and development of pioneering SARS-CoV-2 testing with an alternative and complementary technology to common infectious pathogen research  
• Enable broader research with an LC-MS method with the potential to be multiplexed with other peptides and biomarkers 

* This kit is for research use only and has not been approved for use in clinical diagnostic procedures. This RUO kit has not been tested with clinical samples. The SARS-CoV-2 kit for SARS-CoV-2 nucleocapsid peptides is not available in all countries, please contact your Waters representative for more details.

Recommended Use: For the detection and quantification of SARS-CoV-2 signature NCAP peptides.

LC-MS enables cutting-edge SARS-CoV-2 research

The Waters SARS-CoV-2 LC-MS Kit (RUO) is a Research Use Only kit intended for the quantitative measurement of three proteolytic peptides derived from the SARS-CoV-2 Nucleocapsid (NCAP) protein. The method has been optimized on an ACQUITY UPLC I-Class PLUS and Xevo TQ-XS System and is also intended for use with the Andrew+ Pipetting Robot. Optimization on other instrument platforms is possible.  

Further investigation is needed to collect objective evidence in promising research applications, however, based on the properties of the analytical test method, the SARS-CoV-2 LC-MS Kit might be leveraged for the following research studies:  

• Peptide concentration to quantitate SARS CoV-2 signature peptides at different stages of infection 
• Research of infection and long-term effects through peptide quantitation 

Future pandemic preparedness studies and research of signature peptide-based biomarkers unique to other infections 

Waters: The SARS-CoV-2 LC-MS Kit (RUO) allows for easy sample preparation, sample enrichment, and sample detection.

Achieve confidence in results

Ensure accurate and consistent results with highly analytically selective antibody magnetic bead enrichment. With the innovative SISCAPA® anti-peptide antibody enrichment sample preparation method from SISCAPA Assay Technologies, Inc. in the SARS-CoV-2 LC-MS Kit (RUO), you can improve the performance of mass spectrometry for measurement of pre-selected protein targets.

With the SARS-CoV-2 LC-MS Kit (RUO) and SISCAPA, you can achieve the analytical sensitivity you need to detect low levels of SARS-CoV-2 peptides from complex digested samples with stable isotope standards and capture by anti-peptide antibodies. Increase laboratory efficiency with all the components your busy research laboratory needs to quickly deploy the supplied method - all in one package.

Waters: The SARS-CoV-2 method minimizes sample media interference, providing greater flexibility for the analysis of multiple research samples.

Ensure reproducibility with trusted chemistries and consumables

Ensuring reproducible quantitation from sample-to-sample, run-to-run, and lab-to-lab provides the confidence you need for critical research decisions. Ensuring reproducibility starts with minimizing variability risks, including the risk of unpredictable non-specific binding of peptides to surfaces. The SARS-CoV-2 LC-MS Kit uses QuanRecovery Plates with MaxPeak HPS and a MaxPeak Premier Peptide Column, minimizing non-specific binding of peptides to surfaces while enhancing recovery and signal.

Waters: Analytical sensitivity of the ADE, AYN, and NPA peptides in VTM at 2, 3, 5, 10, and 20 amolµL following antibody enrichment.

Let Andrew+ pipette for you

Save valuable time and focus on your research with reliable and reproducible sample preparation using the Andrew+ Pipetting Robot. The SARS-CoV-2 LC-MS Kit (RUO) comes in an automation-friendly format with liquid handling protocols for the Andrew+ Pipetting Robot available on OneLab.

Waters: SARS-CoV-LC-MS Kit (RUO) automation protocol available for Andrew + Pipetting Robot. It provides a flexible automation platform easily adaptable to multiple workflows.