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Waters
Waters
Waters creates business advantages for laboratory-dependent organizations by delivering ultra performance liquid chromatography (UPLC), high-performance liquid chromatography (HPLC), chromatography columns and chemistry products, mass spectrometry systems, laboratory informatics solutions, and comprehensive service programs to enable significant advancement in healthcare delivery, environmental management, food safety, and water quality.
Distributor
Waters Corporation (Europe)
Waters makes scientific ambitions a reality through the application of HPLC, MS and TA instruments, consumables, and informatics as well as industry-leading scientific expertise.
33 1 3048 7200
Waters ACQUITY UPLC I-Class PLUS SystemWith the ACQUITY UPLC I-Class PLUS System, your lab can achieve highly efficient, rapid separations from ultra-low dispersion and delay volume.
Features

Waters ACQUITY UPLC I-Class PLUS System

Complex chromatography challenges, solved

Looking for answers to the most complex scientific challenges is what you do, and the scientific tools you deploy and the information they provide can make all the difference. With industry-leading separations performance, the ACQUITY UPLC I-Class PLUS System provides new possibilities for maximizing the resolution and sensitivity of your methods, enhancing the characterization of your samples, and improving productivity to advance the science of your laboratory.

With the ACQUITY UPLC I-Class PLUS System, your lab can achieve highly efficient, rapid separations from ultra-low dispersion and delay volume. The system enables your lab to get narrow, ultra-efficient peaks, enhancing the sensitivity of any mass spectrometer and simplifying the characterization of the most complex sample.

  • Achieve precise and accurate binary solvent blending with the Binary Solvent Manager, ideal for up to four solvents with integrated solvent-select valve
  • Get sample injection versatility, depending upon your application with the flow-through needle and fixed loop injector options
  • Manage ultra-low carryover through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers
  • Get accurate temperature control across the entire column, configurable for 1 to 2 columns with active preheating
  • Improve the performance of any mass spectrometer with the highest chromatographic resolution which minimizes interference from co-elutions
  • Minimize the time and cost associated with annual qualification with the Waters Empower-based automated system qualification tool (SQT)
  • Supported by Empower, Masslynx, UNIFI, and several third-party software packages
Recommended Use

Enhance the characterization of your samples, while improving productivity to advance the science of your laboratory.

Waters ACQUITY UPLC I-Class PLUS System: ACQUITY UPLC I-Class PLUS System FTN-H PDA angled.Waters ACQUITY UPLC I-Class PLUS System: ACQUITY UPLC I-Class PLUS System FTN-H PDA angled.

Get a clearer picture of your sample

Get improved resolution through reduced system dispersion with the ACQUITY UPLC I-Class PLUS System, providing separations that can amplify your research.

Shorten analysis times, reduce solvent usage, and speed access to the data you need for critical decisions. Designed to fit into your existing LC workflow, the ACQUITY UPLC I-Class PLUS System provides a clear view into what lies within the sample.

Waters ACQUITY UPLC I-Class PLUS System: In this example, the impurity analysis of tetracaine was run under the same conditions on the ACQUITY UPLC I-Class PLUS System (system band spread of 4 µL) and a UHPLC system (system band spread of 20 µL). Significantly better resolution was achieved on the ACQUITY UPLC I-Class PLUS System.Waters ACQUITY UPLC I-Class PLUS System: In this example, the impurity analysis of tetracaine was run under the same conditions on the ACQUITY UPLC I-Class PLUS System (system band spread of 4 µL) and a UHPLC system (system band spread of 20 µL). Significantly better resolution was achieved on the ACQUITY UPLC I-Class PLUS System.

An inlet that improves the performance of any MS

The ACQUITY UPLC I-Class PLUS System is designed specifically for the rapid pace of laboratories on the cutting edge of research where LC-MS plays a critical role.

With the ACQUITY UPLC I-Class PLUS System, your lab will:

  • Improve resolution and ionization efficiency with narrow peak widths, enhancing mass spectrometry sensitivity
  • Enhance sensitivity through industry-leading carryover performance
  • Improve sample characterization through selective isolation with multidimensional UPLC configurations
  • Achieve exceptionally fast analysis times with ultra-low delay volume
  • Achieve ultimate peak capacity with CORTECS Columns

Waters ACQUITY UPLC I-Class PLUS System: A high sensitivity UPLC-MS/MS bioanalytical methodology for the quantification of midazolam and imipramine in rat plasma using the Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer in combination with an ACQUITY UPLC I-Class PLUS System.Waters ACQUITY UPLC I-Class PLUS System: A high sensitivity UPLC-MS/MS bioanalytical methodology for the quantification of midazolam and imipramine in rat plasma using the Xevo TQ Absolute Tandem Quadrupole Mass Spectrometer in combination with an ACQUITY UPLC I-Class PLUS System.

Achieve ultimate peak capacity with CORTECS Columns

When paired with CORTECS 1.6 µm solid-core columns, the ACQUITY UPLC I-Class PLUS System enables scientists to achieve new levels of resolution, sensitivity, and chromatographic performance. With CORTECS Columns and the ACQUITY UPLC I-Class PLUS System, you can increase resolution for even your toughest samples and get the flexibility and power you need to rapidly separate a wide array of compounds.

Waters ACQUITY UPLC I-Class PLUS System: By pairing the ultra-low dispersion ACQUITY UPLC I-Class PLUS System with high-efficiency CORTECS Columns, you’ll achieve new levels of UPLC performance. These 1.6 µm columns deliver exceptional levels of efficiency, performance, and throughput, resulting in narrower peaks and higher peak capacity.Waters ACQUITY UPLC I-Class PLUS System: By pairing the ultra-low dispersion ACQUITY UPLC I-Class PLUS System with high-efficiency CORTECS Columns, you’ll achieve new levels of UPLC performance. These 1.6 µm columns deliver exceptional levels of efficiency, performance, and throughput, resulting in narrower peaks and higher peak capacity.

Specifications

  • Maximum operating pressure: 18,000 psi
  • pH Range*: 1–12.5
  • Operating flow rate range: Up to 2.0 mL/min
  • Sample flow path: Stainless-steel
  • Sample carryover: <0.001% (Caffeine) under UV conditions
  • Sample compartment: 4–40 °C
  • Pump options: Binary
  • Solvent conditioning: Active Pre-heating
  • Column tracking: eCord Technology tracks column information and archives column usage
  • Column capacity: Up to 2 columns of 150 mm length and up to 4.6 mm I.D.
  • Maximum sample capacity: Up to 20 plates (with Sample Organizer)
  • Detector options
    • PDA Detector
    • TUV Detector
    • FLR Detector
    • RI Detector
    • ELS Detector
    • Mass Spectrometers
  • External control
  • Physical specifications (QSM or BSM, SM-FTN, CHA):
    • Width: 34.3 cm (13.5 in.)
    • Height: 71.1 cm (28.0 in.)
    • Depth: 71.2 cm (28.0 in.)
Manufacturer
Waters
Waters
Waters creates business advantages for laboratory-dependent organizations by delivering ultra performance liquid chromatography (UPLC), high-performance liquid chromatography (HPLC), chromatography columns and chemistry products, mass spectrometry systems, laboratory informatics solutions, and comprehensive service programs to enable significant advancement in healthcare delivery, environmental management, food safety, and water quality.
Distributor
Waters Corporation (Europe)
Waters makes scientific ambitions a reality through the application of HPLC, MS and TA instruments, consumables, and informatics as well as industry-leading scientific expertise.
33 1 3048 7200
 

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News from LabRulezLCMS Library - Week 39, 2025
Article | Application

News from LabRulezLCMS Library - Week 39, 2025

This week we bring you application notes by Agilent Technologies, Shimadzu and Waters Corporation and poster by Thermo Fisher Scientific / HPLC Symposium!
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Soft Independent Modeling of Class Analogies for the Screening of New Psychoactive Substances through UPLC-HRMS/MS
Scientific article | Science and research

Soft Independent Modeling of Class Analogies for the Screening of New Psychoactive Substances through UPLC-HRMS/MS

Using UPLC-HRMS and SIMCA, 159 NPS standards were analyzed to build classification models. The approach showed strong validation and accurate identification of seized samples, aiding forensic drug analysis.
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