EU Regulation 396/2005: Pesticide Residue Testing and the Critical Role of QuEChERS Evaporation in Food Safety

<div><div>Researchers led by <a target="_blank" rel="noopener noreferrer" href="https://kudova.group.uochb.cz/en">Eva Kudová</a> from IOCB Prague and Jitka Viktorová from UCT Prague have identified new androstane-based steroid derivatives that can significantly improve the effectiveness of existing antibiotics against multidrug-resistant Staphylococcus aureus.</div></div><div>The team screened dozens of natural steroidal hormones and synthetic derivatives to see whether they could block bacterial efflux pumps – mechanisms that bacteria use to eject antibiotics and survive treatment. Two compounds emerged as particularly promising: they inhibited efflux pumps and lowered the effective doses of antibiotics such as ciprofloxacin and erythromycin.Further analysis showed that one of the compounds also suppressed genes linked to bacterial virulence. Another key finding is that the most active molecules are non-toxic to human immune cells and showed no detectable endocrine activity, suggesting a favorable safety profile.These findings support the idea that rationally designed steroid-based molecules could act as antibiotic adjuvants, helping existing drugs overcome bacterial resistance.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/IOCB_Prague_Steroidal_hormones_and_neurosteroids_novel_therapeutic_strategies_in_bacterial_infections_8e5d2a7b48.jpg" alt="IOCB Prague: Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_IOCB_Prague_Steroidal_hormones_and_neurosteroids_novel_therapeutic_strategies_in_bacterial_infections_8e5d2a7b48.jpg 222w," sizes="100vw" width="1258" height="886"><blockquote><h4>Original Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S0223523426001613?via%3Dihub">Steroidal hormones and neurosteroids - novel therapeutic strategies in bacterial infections: Design, synthesis, and biological evaluation</a></h4>Daniela Brdová, Bára Křížkovská, Jan Špaček, Zdeněk Míchal, Eva Jablonská, Ondřej Strnad, Hana Chodounská, Eszter Szánti-Pintér, Marina Morozovová, Václav Hanžl, Jan Tkadlec, Martijn Riool, Jan Lipov, Jitka Viktorová, Eva Kudová&nbsp;Eur. J. Med. Chem., 2026, 308, 118716<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1016/j.ejmech.2026.118716">https://doi.org/10.1016/j.ejmech.2026.118716</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>The global rise of antibiotic resistance necessitates novel therapeutic strategies for infectious diseases. Inhibition of bacterial efflux pumps, which contribute to multidrug resistance, represents a promising approach to restore or even increase the efficacy of existing antibiotics. Using fluorescence-based ethidium bromide accumulation, broth microdilution, and checkerboard assays, we evaluated 26 endogenous steroidal hormones and neurosteroids, along with 30 synthetic derivatives, for their ability to enhance antibiotic susceptibility in multidrug-resistant Staphylococcus aureus. Structure-activity relationship analysis identified compounds 13 and 16 as lead candidates, exhibiting strong efflux pump inhibition and marked reductions in the minimum inhibitory concentrations of ciprofloxacin and erythromycin. Both compounds showed additive effects in checkerboard assays. Modifications at C-3 (polar substitution) and C-17 (3α,5β-stereochemistry and nonpolar substitution) were essential for potent efflux inhibition and sensitization, although these modifications were not additive when combined. Transcriptome analysis further revealed that compound 13 significantly downregulated S. aureus virulence-associated genes when administered alone or in combination with antibiotics. Cytotoxicity assessment in human peripheral blood mononuclear cells and receptor transactivation assays for estrogen, androgen, and progesterone receptors indicated that the most active derivatives were non-toxic and lacked detectable endocrine activity, suggesting a favorable safety profile. Overall, these findings support the concept that rationally designed andostane-based steroidal scaffolds can function as competitive bacterial efflux pump inhibitors and serve as potential antibiotic adjuvants to mitigate efflux-mediated resistance.<h4>Instrumentation</h4><h5>Structural characterization</h5><ul><li>AVANCE III 400 MHz NMR spectrometer (Bruker)</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=LTQ+Orbitrap+XL">LTQ Orbitrap XL HRMS</a> (Thermo Fisher Scientific, ESI)</li></ul></div>

Steroidal hormones and neurosteroids – novel therapeutic strategies in bacterial infections

Metformin is currently the first-line oral drug of choice for the treatment of type 2 diabetes. It reduces glucose production in the liver, improves tissue sensitivity to insulin, and does not cause weight gain or hypoglycemia, which sets it apart from some other antidiabetic drugs. Moreover, its long-term beneficial effects on the risk of cardiovascular complications and mortality in people with type 2 diabetes have been well established. Researchers from the Institute of Physiology CAS (IPHYS) have identified a new group of blood metabolites that could help physicians objectively monitor whether patients with type 2 diabetes are taking their metformin as prescribed.<h4>New biomarkers for metformin use</h4>A team led by Tomáš Čajka from the Laboratory of Translational Metabolism at IPHYS analyzed plasma samples from 637 patients with type 2 diabetes treated with metformin and 143 non-diabetic controls using advanced metabolomics and lipidomics. Among 614 detected metabolites, they identified five from the group of N-lactoyl-amino acids (e.g. N‑lactoyl-phenylalanine), which had previously been seen as unknown signals due to missing reference spectra in databases. The levels of these metabolites in the blood closely reflected the plasma concentrations of metformin. In patients with the highest metformin exposure, the concentrations of these metabolites were up to 7.2 times higher than in controls.<h4>A sensitive “fingerprint” of the drug’s effect</h4>N-Lactoyl-amino acids are formed in cells by combining lactate and amino acids, thus reflecting the metformin-induced changes in cellular energy metabolism. “Importantly, even though they occur in plasma only at nanomolar concentrations, they reliably distinguish patients who take metformin regularly from those who take it irregularly or not at all,” emphasizes T. Čajka.<h4>Metabolomics in practice and international collaboration</h4>The study also provides a detailed description of broader metabolic changes in type 2 diabetes, including increases in lactate, organic acids, and branched-chain amino acids, as well as extensive remodelling of the lipid profile. In addition to T. Čajka’s team, collaborators from the Institute for Clinical and Experimental Medicine in Prague and the West Coast Metabolomics Center (University of California, Davis) also participated in the study.The results demonstrate that advanced metabolomics approaches developed at IPHYS within the CarDia project can find highly practical applications both in clinical studies and in personalized monitoring of treatment in patients with diabetes.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.70205">Untargeted Metabolomics Identifies N-Lactoyl-Amino Acids as Dose-Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes</a></h4>Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin HaluzikClin Pharmacol Ther, 119: 1057-1069<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/cpt.70205">https://doi.org/10.1002/cpt.70205</a><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites. Patients were stratified by plasma metformin into sub-therapeutic, therapeutic, and supra-therapeutic groups, and associations were evaluated by multiple linear regression and composite metabolite ranking. Five previously unannotated features were structurally identified as N-lactoyl-amino acids, whose levels correlated strongly with plasma metformin (ρ = 0.42–0.55, P &lt; 0.0001) and increased up to 7.2-fold in the supra-therapeutic group (&gt; 2000 ng/mL). While N-lactoyl-amino acids were consistently detected in the nanomolar range, they still displayed robust and dose-dependent associations with metformin. Broader metabolic changes in T2D included elevated lactate, organic acids, and branched-chain amino acids, together with reduced urea cycle metabolites. Lipidomics showed increases in saturated triacylglycerols and diacylglycerols and decreases in cholesteryl esters, sphingomyelins, and phospholipids. These findings establish N-lactoyl-amino acids as robust, dose-responsive plasma biomarkers of metformin exposure. Despite being up to four orders of magnitude less abundant than their amino acid precursors, they sensitively reflect mitochondrial lactate overflow and pharmacodynamic adaptation, offering objective assessment of adherence.

New blood biomarkers reveal how faithfully diabetes patients take metformin

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The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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KNAUER AZURA® Bio Compact AC FPLC System

The AZURA Compact AC system qualifies for fast and reliable affinity chromatography. 

KNAUER protein purification: The flexible FPLC platformAZURA® Bio purification systems&nbsp;complete solutions for FPLC on a minimum footprint: AZURA FPLC systems combine flexibility and reliability. The biocompatible/metal-free FPLC is the perfect choice for your protein purification task.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_Bio_Compact_AC_FPLC_System_6_a874551078.jpg" alt="KNAUER: AZURA® Bio Compact AC FPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_Bio_Compact_AC_FPLC_System_6_a874551078.jpg 245w," sizes="100vw" width="1506" height="600">Design your AZURA Bio purification system to fit your needs. Multiple functionalities such as automatic sample injection via autosampler, column switching, buffer and sample selection, and fraction collection enable automation of the purification process.A wide range of detectors ensures the visibility of target molecules. Various flow rates and compatibility with columns from all vendors provide maximum flexibility. The intuitive PurityChrom® software integrates all the advantages of a versatile purification system.<h3>AZURA® Bio Compact AC FPLC System</h3><h4>For affinity chromatography</h4>The AZURA Compact AC system qualifies for fast and reliable affinity chromatography. Select your sample, washing, and elution buffer using the selection valve. Your proteins of interest are detected by UV and automatically collected via the fractionation valve.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_Bio_Compact_AC_FPLC_System_4_bef2309e7d.jpg" alt="KNAUER: AZURA® Bio Compact AC FPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_Bio_Compact_AC_FPLC_System_4_bef2309e7d.jpg 245w," sizes="100vw" width="1666" height="513"><h3>Key features</h3><ul><li data-start="93" data-end="153">Flow rate: 0.01–50 ml/min (recommended: 1–40 ml/min)</li><li data-start="154" data-end="193">Maximum system pressure: 50 bar</li><li data-start="194" data-end="278">Sample and buffer selection: Automatic valve for up to 12 buffers or samples</li><li data-start="279" data-end="349">Detection: Variable single wavelength UV detector (190–500 nm)</li><li data-start="350" data-end="429">Column compatibility: Compatible with affinity columns from all vendors</li><li data-start="430" data-end="574">Fraction collection: 16-port fractionation valve, capable of collecting up to 16 fractions for flow-through, wash, and elution fractions</li><li data-start="575" data-end="663">Software: Intuitive and powerful PurityChrom® software, 21 CFR Part 11 compliant</li><li data-start="664" data-end="737">Affinity purification: Designed for tagged proteins or antibodies</li><li data-start="738" data-end="867">Compact system: User-friendly and cost-efficient, with the ability to upgrade for more complex protein purification tasks</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_Bio_Compact_AC_FPLC_System_5_17f4f13731.jpg" alt="KNAUER AZURA® Bio Compact AC FPLC System: Protein purification based on high affinity Chromatogram &amp; Legend." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_Bio_Compact_AC_FPLC_System_5_17f4f13731.jpg 209w," sizes="100vw" width="1024" height="766">&nbsp;

KNAUER AZURA® Bio Lab Pilot FPLC System

Configure your FPLC system based on your purification requirements. The Pilot system is designed for scale-up and process applications. All system modules can be expanded with additional modules.

KNAUER protein purification: The flexible FPLC platformAZURA® Bio purification systems&nbsp;complete solutions for FPLC on a minimum footprint: AZURA FPLC systems combine flexibility and reliability. The biocompatible/metal-free FPLC is the perfect choice for your protein purification task.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_Bio_Compact_AC_FPLC_System_6_a874551078.jpg" alt="KNAUER: AZURA® Bio Compact AC FPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_Bio_Compact_AC_FPLC_System_6_a874551078.jpg 245w," sizes="100vw" width="1506" height="600">Design your AZURA Bio purification system to fit your needs. Multiple functionalities such as automatic sample injection via autosampler, column switching, buffer and sample selection, and fraction collection enable automation of the purification process.A wide range of detectors ensures the visibility of target molecules. Various flow rates and compatibility with columns from all vendors provide maximum flexibility. The intuitive PurityChrom® software integrates all the advantages of a versatile purification system.<h3>AZURA® Bio Lab Pilot FPLC System</h3><h4>High Flow Bio Purification FPLC System – up to 1000 ml/min</h4>Configure your FPLC system based on your purification requirements. The Pilot system is designed for scale-up and process applications. All system modules can be expanded with additional modules.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_Bio_Lab_Pilot_FPLC_System_e208baf41d.jpg" alt="KNAUER: AZURA® Bio Lab Pilot FPLC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_Bio_Lab_Pilot_FPLC_System_e208baf41d.jpg 156w," sizes="100vw" width="1000" height="1000"><h3>Key features</h3><ul data-start="93" data-end="1069"><li data-start="93" data-end="129">Flow rate: 0.001–1000 ml/min</li><li data-start="130" data-end="192">Injection system: Sample pump for large sample volumes</li><li data-start="193" data-end="351">Detection system:<ul data-start="221" data-end="351"><li data-start="221" data-end="276">Variable single wavelength UV detector (190–500 nm)</li><li data-start="279" data-end="351">Conductivity and pH-monitoring, pressure, and air sensors (optional)</li></ul></li><li data-start="352" data-end="465">Fraction collection: XY fraction collector for reliable collection of large volumes or numerous fractions</li><li data-start="466" data-end="559">Suitable for SEC, AC, IEX, and HIC, with upscaling capabilities</li><li data-start="560" data-end="651">Automation: High-flow buffer delivery and mixing for large-scale purification tasks</li><li data-start="652" data-end="739">System design: Same footprint as <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1625">AZURA Lab FPLC systems</a> for compact scalability</li><li data-start="740" data-end="871">Software:<ul data-start="760" data-end="871"><li data-start="760" data-end="831">Intuitive and powerful PurityChrom® software in basic configuration</li><li data-start="834" data-end="871">21 CFR Part 11 compliant software</li></ul></li><li data-start="872" data-end="1069">Scalability:<ul data-start="895" data-end="1069"><li data-start="895" data-end="965">Configure your FPLC system based on your purification requirements</li><li data-start="968" data-end="1069">Scale-up is possible with the same flexibility and software while maintaining a minimal footprint</li></ul></li></ul>

KNAUER AZURA® SEC Lab System

The AZURA SEC Lab systems are ideal for labs requiring top analytical performance, offering unmatched flow precision and ultra-low pulsation for exceptional retention volume accuracy and reproducibility.

<h3>Highest analytical performance and robustness for SEC and GPC applications</h3>The AZURA SEC Lab systems are the perfect choice for laboratories that demands highest analytical performance. The system shows unsurpassed flow precision paired with ultra-low pulsation for outstanding retention volume precision and reproducibility.The autosampler can inject from up to 768 positions via microtiter plates or 108 standard 1.5 ml sample vials and is therefore the perfect choice for larger sample amount as well as for high sample throughput laboratories. Thanks to the reliable and robust design it is the workhorse in any laboratory.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_SEC_Lab_System_e161ecef84.webp" alt="KNAUER: AZURA® SEC Lab System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_SEC_Lab_System_e161ecef84.webp 203w," sizes="100vw" width="1886" height="1452"><h3>Key Features</h3><ul><li>Injection volume: 1 –1000 µl&nbsp;</li><li>Easy maintenance</li><li>Great selection of SEC/GPC columns</li><li>Unsurpassed flow precision paired with ultra-low pulsation for</li><li>Highest analytical performance</li><li>Suitable for organic and aqueous eluents</li><li>Highest level of automation</li><li>Choose the matching hardware version for aqueous SEC of biomolecules or organic GPC of polymers</li></ul><h3>Upgrade Options</h3><ul><li>Save operating costs with an automatic solvent recycle valve</li><li>Degasser</li><li>Detector (RI, UV, ELSD, PDA, FLD, ECD)</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_SEC_Lab_System_2_2cbe13a95d.webp" alt="KNAUER: AZURA® SEC Lab System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_SEC_Lab_System_2_2cbe13a95d.webp 234w," sizes="100vw" width="953" height="635"> All wetted parts are available in either bioinert materials or for standard phase solvents.

KNAUER AZURA® SEC Semi-Prep System

The AZURA SEC Semi-prep systems enable fractionation of specific molecular weight ranges or purification tasks, with a pump delivering up to 50 ml/min, making it ideal for all semi-preparative GPC/SEC columns.

<h3>Automated system for semi-preparative SEC and GPC</h3>The AZURA SEC Semi-prep systems offer the possibility of fractionating specific molecular weight ranges or purification tasks. The pump can deliver flow rates of up to 50 ml/min and is therefore suitable for every semi-preparative GPC/SEC column.Thanks to the modular concept of the AZURA platform and the dedicated PurityChrom® software, the systems can be highly adapted to any separation task.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_SEC_Semi_Prep_System_12215b2eda.webp" alt="KNAUER: AZURA® SEC Semi-Prep System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_SEC_Semi_Prep_System_12215b2eda.webp 203w," sizes="100vw" width="1886" height="1452"><h3>Fraction Collection</h3>Collect large quantities or large numbers of fractions:<ul style="list-style-type:disc;"><li style="tab-stops:list 36.0pt;">Manually – collection by direct control</li><li style="tab-stops:list 36.0pt;">Volume-based – collection at defined volumes</li><li style="tab-stops:list 36.0pt;">Peak-based – collection according to detector signal</li><li style="tab-stops:list 36.0pt;">From switching valve to fraction collector solutions</li></ul><h3>Key Features</h3><ul><li data-start="70" data-end="134">Modular concept for any separation and purification task</li><li data-start="135" data-end="169">Flow rates: 0.01–50 ml/min</li><li data-start="170" data-end="249">Injection options: Manual or autosampler (up to 10 ml injection volume)</li><li data-start="250" data-end="320">Eluent compatibility: Suitable for organic and aqueous eluents</li><li data-start="321" data-end="390">Column selection: Wide range of SEC and GPC columns available</li><li data-start="563" data-end="649">Efficiency features: Automatic solvent recycle valve to reduce operating costs</li><li data-start="650" data-end="757">Hardware options: Choose a version for aqueous SEC (biomolecules) or organic GPC (polymers)</li><li data-start="758" data-end="813">Software options: ClarityChrom® or PurityChrom®</li></ul><h3>Available Detectors for Semi-prep</h3>The AZURA SEC Semi-prep systems can be equipped with a dedicated high-flow RI detector that can be used up to 10 ml/min as well as with the UV Detectors UVD 2.1S and UVD 2.1L.

KNAUER AZURA® GPC Cleanup System

Do not waste time and labor with manual sample preparation. The AZURA GPC Cleanup system automates work-intensive and time-consuming cleanup tasks based on gel permeation chromatography (GPC).

<h3>Save time with automatic sample preparation</h3>Do not waste time and labor with manual sample preparation. The AZURA GPC Cleanup system automates work-intensive and time-consuming cleanup tasks based on gel permeation chromatography (GPC). Further, reproducibility and quality of the cleanup are improved.After sample loading, the dedicated system fully automated processes up to 15 samples while requiring minimal bench space. Based on the versatile AZURA device platform the system can be customized to fulfill individual requirements. The cost-effective software Mobile Control provides a touch-optimized user interface for intuitive device control directly at the system.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_GPC_Cleanup_System_224a241335.webp" alt="KNAUER: AZURA® GPC Cleanup System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_GPC_Cleanup_System_224a241335.webp 203w," sizes="100vw" width="1886" height="1452"><h3>Key Features</h3><ul><li data-start="69" data-end="102">Flow rate: 0.01–10 ml/min</li><li data-start="103" data-end="169">Enhanced reproducibility – consistent and reliable results</li><li data-start="170" data-end="214">Handles viscous and complex matrices</li><li data-start="215" data-end="269">Fully automated processing of up to 15 samples</li><li data-start="270" data-end="320">Supports AOAC, EPA, and European Standards</li><li data-start="321" data-end="365">Adaptable to specific lab procedures</li><li data-start="366" data-end="405">Compact, space-efficient system</li><li data-start="406" data-end="466">Touch-optimized Mobile Control for device management</li><li data-start="467" data-end="551">Automated workflows for streamlined sample preparation and higher efficiency</li><li data-start="552" data-end="606">Optimized cleanup tasks for better performance</li><li data-start="607" data-end="658">Easily adaptable for different applications</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_AZURA_GPC_Cleanup_System_2_27867ae999.jpg" alt="KNAUER: AZURA® GPC Cleanup System: Chromatogram of US EPA method 3640A calibration standard containing 1) Corn oil matrix 2) Bis-(2-ethylhexyl)phalate 3) Methoxychlor 4) Perylene." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_AZURA_GPC_Cleanup_System_2_27867ae999.jpg 245w," sizes="100vw" width="1247" height="626">In accordance with established methods to determine pesticide residues<ul><li>Method 984.21 – AOAC international</li><li>EPA SW-846 Method 3640A – US Environmental Protection Agency</li><li>AEN 12393 and EN 1528 – European Standard</li><li>L 00.00-34 Method in accordance with §64 LFGB (formerly § 35 LMBG)</li></ul>

Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system

The Inuvion Core system gives you all the benefits of chemical suppression and higher-pressure operation, with manual eluent preparation.

<h3>Welcome to the evolution of everyday IC reliability</h3>The new Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system makes ion analysis simpler and more intuitive than ever before. And it delivers exactly what a busy analytical testing lab is looking for: consistently excellent results-every shift, every day, for every operator.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_2_6400708696.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_2_6400708696.jpg 245w," sizes="100vw" width="825" height="498"><h3>Start with Inuvion Core</h3>The Inuvion Core system gives you all the benefits of chemical suppression and higher-pressure operation, with manual eluent preparation. You still enjoy the same robust Dionex Inuvion platform-easily configurable and economically upgradeable to full-featured capabilities as budget allows.<figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_Core_ion_chromatography_system_6c8824cb1d.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_Core_ion_chromatography_system_6c8824cb1d.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3>SIMPLE, INTUITIVE USER EXPERIENCE&nbsp;</h3><ul><li>Smart, function-driven design lets you quickly and safely access everything on the instrument—no hard-to-reach compartments, and no step stools or extra tools needed!</li><li>Automated startup and shutdown routines ensure the system is quickly ready for the day’s work without user intervention.&nbsp;</li><li>Built-in how-to videos reduce training time and simplify setup and operation.</li></ul><h3>ULTRA-RELIABLE PERFORMANCE&nbsp;</h3><ul><li>Advanced high-performance pump technology and electronics let you take advantage of a wider range of columns and chemistries to improve the speed and quality of your results.</li><li>Fast, flexible, convenient electrolytic suppression: Just connect the suppressor; no external pump or offline conditioning needed for regeneration.</li><li>Reagent-free IC (RFIC™) capability makes eluent preparation as simple as “just add water,” while ensuring more consistent results and enabling optimized gradient separations.</li></ul><h3>EASILY CONFIGURABLE AND UPGRADEABLE</h3><ul><li>Versatile, adaptable platform lets you configure the exact Dionex Inuvion IC system for today’s needs and budget, with confidence that your system will also meet your future needs.</li><li>Multiple options and peripherals extend IC capabilities, letting you easily—and cost-effectively—adapt to changing sample types and workflow requirements.</li></ul><h3>Simply the best system for everyday ion analysis</h3><figure class="image"><img style="aspect-ratio:1107/755;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_d855feb2a8.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_d855feb2a8.jpg 229w," sizes="100vw" width="1107" height="755"></figure>1. Operator-friendly engineering saves time and reduces errors by allowing easy, unobstructed access to all components, connections and consumables2. Compact design helps you make the most of valuable bench space3. Digital gas pressure regulator increases precision of gas delivery for maximum day-to-day consistency (optional)4. Temperature-controlled conductivity cell improves reproducibility and ensures baseline stability5. Vacuum degassing capability enables more consistent peak identification from smoother baselines6. Seal wash pump reduces maintenance costs when using manually prepared eluents (optional)&nbsp;7. Reagent-free IC (RFIC) saves time and ensures greater day-to-day and operator-to-operator consistency, while also allowing the use of gradient separations8. Electrolytic suppression entirely eliminates the need for manual regenerant preparation (or, opt for a continuously regenerated, always- ready-to-go chemical suppressor)9. Thermo Scientific™ Dionex™ IC PEEK Viper™ fittings ensure confident, low dead volume connections every time—no tools required! (optional)10. Integrated column heater minimizes the impact of fluctuations in lab temperature that can adversely affect results (optional)11. 6- or 10-port auxiliary valve lets you automate in-line sample preparation12. State-of-the-art high-pressure pump (up to 5000 psi) lets you increase flow rates with smaller particle columns to reduce run times or add additional separation capacity with longer column length13. System self-diagnostics automatically detect any issues with hardware and consumables14. Self-service capabilities and user-swappable parts help you get back up and running in a hurry Automatic eluent monitor alerts the operator to low solution levels, avoiding potential system damage or failed runs (optional)15. Automatic eluent monitor alerts the operator to low solution levels, avoiding potential system damage or failed runs (optional)<h3>Flexible, adaptable Dionex Inuvion platform</h3>You can configure your Dionex Inuvion system to meet specific analytical and budget requirements, and easily reconfigure as needed. Multiple configurations and peripherals extend IC capabilities, letting you easily-and cost-effectively-adapt to changing sample types and workflow requirements.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_3_fa8233bcd4.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_3_fa8233bcd4.jpg 245w," sizes="100vw" width="1246" height="572"><h3>Consistently excellent results every day</h3>The Dionex Inuvion IC system supports a full range of columns to improve the speed and quality of results, for both anions and cations. Expanded capabilities, such as Reagent-Free IC (RFIC), enhance operator-to-operator consistency, while enabling the use of eluent gradients to optimize separations.<h4>Rapid results</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_2_Ukazka_rychle_separace_zakladnich_aniontu_s_uhlicitanovou_MF_Zkraceni_doby_analyzy_diky_typu_kolony_a_vyssimu_prutoku_0e610b919d.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 1. Elution of seven common inorganic anions using carbonate eluent. Short columns and fast flow rates let you reduce run times." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Obr_2_Ukazka_rychle_separace_zakladnich_aniontu_s_uhlicitanovou_MF_Zkraceni_doby_analyzy_diky_typu_kolony_a_vyssimu_prutoku_0e610b919d.jpg 245w," sizes="100vw" width="1622" height="739"><h4>Exceptional reproducibility</h4><figure class="image"><img style="aspect-ratio:1693/754;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_3_Ukazka_reprodukovatelnosti_analyzy_zakladnich_aniontu_40_nastriku_Spickova_technologie_cerpadla_a_elektronika_pristroje_poskytuji_konzistentni_a_reprodukovatelne_vysledky_f66e7430cf.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 2. Overlay of 40 replicate injections. State-of-the-art pump technology and Electronics deliver consistent, reproducible results." width="1693" height="754"></figure><h4>Increased sensitivity and consistency</h4><figure class="image"><img style="aspect-ratio:1860/836;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_4_Ukazka_vysoce_citlive_analyzy_aniontu_ve_vodach_Eluent_generator_KOH_a_elektrolyticka_suprese_snizuji_pozadi_cimz_dochazi_ke_zvyseni_citlivosti_da55facfd0.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 3. Determination of inorganic anions in drinking and surface waters. KOH eluent generation and electrolytic suppression yield lower backgrounds for greater sensitivity and increased day-to-day consistency." width="1860" height="836"></figure><h4>Method optimization</h4><figure class="image"><img style="aspect-ratio:1799/889;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_5_Ukazka_optimalizace_metody_zkraceni_doby_analyzy_pouzitim_gradientu_mobilni_faze_fc1fbe9cb0.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 4. Comparison of isocratic and gradient runs using eluent generation. Reduce run length and sharpen later-eluting peaks with the same ease as an isocratic run with no need for two separate eluents or a proportioning pump." width="1799" height="889"></figure><h3>Compliance-ready Chromeleon CDS</h3>A trusted industry standard all over the world, ”Simply Intelligent” <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) software </a>brings out the full power of the Dionex Inuvion IC system. Easy to learn and easy to use, it automates and optimizes daily tasks and helps even inexperienced users achieve consistent, high quality results.<img style="aspect-ratio:3700/1660;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Thermo_Scientific_Dionex_Inuvion_2_303a6eb73b.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system." width="3700" height="1660">

Thermo Scientific Vanquish Tandem LC Systems

The Thermo Scientific Vanquish Tandem LC Systems increase throughput and maximize detector output by using a second pump and intelligent column switching to eliminate the time required for column equilibration in a gradient elution. 

<h3>Optimize your productivity</h3>In today’s challenging research and production environments, you are being asked to be more productive without increasing spending or compromising quality.&nbsp;At the same time, advancements and innovations are needed to improve operational efficiency and performance. How do you accomplish this? It’s easy with the Thermo Scientific™ Vanquish™ High-throughput LC systems built for enhanced productivity. Vanquish High-throughput LC systems combine individual Vanquish components and software wizards to deliver increased throughput or detector utilization.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg 191w," sizes="100vw" width="1325" height="1086"><h3>Two flow paths for maximized productivity</h3>Your laboratory may be facing increased pressure to improve working efficiency and deal with limiting resources, such as budget, space, or manpower. Vanquish High-throughput LC systems are designed to overcome these limitations by providing multiple flow paths for parallelization of specific stages of the LC run.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg 245w," sizes="100vw" width="955" height="591"><h4>Unique dual technology</h4>The Vanquish platform contains two unique dual modules. Vanquish dual pumps merge two individual, low pressure mixing pumps in one housing enabling separate eluents and gradients for each pump.Vanquish dual split samplers possess two independently controlled injection units including separate injection valves and injection needles. Used in Dual LC and LC-MS workflows only, this enables high throughput and extensive sample characterization workflows.<h3>Two configurations to best serve your needs</h3>Vanquish High-throughput workflows are configured with Thermo Scientific™ Vanquish™ Core system, Thermo Scientific™ Vanquish™ Flex system or Thermo Scientific™ Vanquish™ Horizon system modules. Both workflows make use of two pumps to increase instrument productivity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Two configurations to best serve your needs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg 245w," sizes="100vw" width="1682" height="735"><h4>Vanquish Duo UHPLC Systems</h4><ul><li>Supported systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li></ul></li><li>Sampler: Dual split sampler</li><li>Detector: Two out of the complete detector portfolio</li><li>Software control:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1838">Thermo Scientific™ Standard Instrument Integration (SII)</a> for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Waters™ Empower™ 3 CDS</a></li></ul></li></ul><h4>Vanquish Tandem LC Systems</h4><ul><li>Supported systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/397">Vanquish Core</a></li></ul></li><li>Sampler: Split sampler</li><li>Detector: One out of the complete detector portfolio and/or one mass spectrometer</li><li>Software control:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a></li><li>Standard System Integration for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758">Thermo Scientific™ Xcalibur™ software</a></li></ul></li></ul><h3>Vanquish Tandem LC systems</h3><div><div><div><div>Gradient separations are commonly used in LC or LC-MS. Column reconditioning, such as washing and re-equilibration, takes time and reduces your overall sample throughput. The Vanquish Tandem LC systems eliminate these limitations and improve productivity by:<ul><li>Increasing sample throughput without modifying a validated method</li><li>Improving return on investment by maximizing mass spectrometer utilization</li><li>Reducing column carry over through extended column washing without sacrificing throughput</li><li>Simplifying method setup with automatic method conversion from your original gradient method</li></ul></div></div></div></div><div>&nbsp;</div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_4_a031ad3221.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_4_a031ad3221.jpg 245w," sizes="100vw" width="1749" height="530"><h4>Throughput increase using Tandem LC</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_3_6bc55942ed.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Throughput increase by Tandem LC is between 10–80% for most common conditions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_3_6bc55942ed.jpg 245w," sizes="100vw" width="894" height="434">The Vanquish Tandem LC system splits the analysis between two pumps and two columns. One pump delivers the analytical gradient while the second pump runs the reconditioning gradient. This configuration allows you to use two identical columns to run your sequence faster without compromising data quality.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_5_d818007fe4.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Reproducible results for the Thermo Scientific™ Vanquish™ Horizon Tandem UHPLC system—Thermo Scientific™ Q Exactive™ HF hybrid quadrupole-Orbitrap™ mass spectrometer showing an overlay of five total ion current chromatograms. The sample shown is digested Infliximab using the Thermo Scientific™ SMART ™ Digest Kit." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_5_d818007fe4.jpg 245w," sizes="100vw" width="1123" height="499"><h4>Simply upgrade your method</h4>Implementing Tandem LC-MS into your workflow is easy with compliance-ready Chromeleon software for LC or LC-MS users and Thermo Scientific Standard Instrument Integration (SII) for Thermo Scientific Xcalibur software for LC-MS users.A simple dedicated instrument method wizard enables you to create new methods without the need for additional training.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_0c7f310b1e.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_0c7f310b1e.jpg 193w," sizes="100vw" width="353" height="285"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Tandem_LC_Systems_2_47128950b2.jpg" alt="Thermo Scientific Vanquish Tandem LC Systems: Chromeleon CDS and SII for Xcalibur guides users through the implementation of a Tandem LC or LC-MS method with automatic system volume considerations and gradient formation of the reconditioning pump." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Tandem_LC_Systems_2_47128950b2.jpg 160w," sizes="100vw" width="361" height="353"><h3>Thermo Scientific LC portfolio overview</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg" alt="Thermo Scientific LC portfolio overview." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg 188w," sizes="100vw" width="795" height="660">

Thermo Scientific Cindion Combustion Ion Chromatography System

Fully integrated C-IC system for automated screening of halogens, sulfur compounds, and PFAS in solid, liquid, and gas samples.

<h4>Automated halogen, sulfur, and PFAS screening in solid, liquid, and gas samples.</h4>The Thermo Scientific™ Cindion™ Combustion Ion Chromatography (C-IC) System is a fully integrated platform designed for screening corrosive and toxic halogens, sulfur compounds, and PFAS in a wide range of sample matrices. Whether analyzing solids, liquids, or gases, the system delivers low background levels, high sensitivity, and robust automated workflows—all in a compact footprint.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_6_e1eda9de2f.jpg" alt="Thermo Scientific™ Cindion™ Combustion Ion Chromatography System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_6_e1eda9de2f.jpg 207w," sizes="100vw" width="650" height="490"><h3>Key Features</h3><ul><li>Compact system footprint: A novel combustion tube design ensures complete combustion over a shorter path, saving bench space and enhancing efficiency.</li><li>Fully automated workflow: From sample introduction to combustion, absorption, ion chromatographic separation, and data reporting—automation minimizes user intervention.</li><li>PFAS-free sample path: Components in the sample flow path are PFAS-free to eliminate contamination and enable ultra-sensitive PFAS detection (EPA Method 1621).</li><li>Reagent-Free Ion Chromatography (RFIC™): Automated eluent generation—just add water. Electrolytic suppression ensures consistent results with no external pump.</li><li>Versatile sample compatibility: Supports AOX and AOF determinations, as well as total and inorganic fluorine (TF/TIF) analysis in environmental, food, industrial, and petrochemical applications.</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS integration</a>: A single software platform for full control of C-IC operations including sequence setup, system control, and reporting.</li><li>High throughput: Accommodates up to 45 solid or 120 liquid samples; includes smart hydration and reduced carryover for faster cycle times.</li><li>Application-ready: Backed by extensive application notes and 50+ years of Thermo Scientific expertise in ion chromatography.</li></ul><h3>Typical Applications</h3><ul><li>Environmental testing: AOX/AOF screening in water and wastewater; PFAS monitoring.</li><li>Food and packaging: Determination of organic fluorine content in food contact materials.</li><li>Petrochemicals: Halogen and sulfur analysis in fuels and oils to prevent equipment corrosion and meet emission standards.</li><li>Electronics and polymers: Detection of restricted brominated and fluorinated substances in plastics and E&amp;E components.</li><li>Mining and metallurgy: Screening for corrosive species in ores and geological samples.</li></ul><h3>System Components</h3><ul><li>Sample delivery module: Liquid/solid autosampler or gas injector.</li><li>Combustion/absorption unit: Integrated with autosampler and absorption tube.</li><li>Ion chromatography system: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1078">Thermo Scientific™ Dionex™ IC with RFIC™</a> technology.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_3_79a361351d.jpg" alt="Thermo Scientific™ Cindion™ Combustion Ion Chromatography System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_3_79a361351d.jpg 243w," sizes="100vw" width="1509" height="971"><ol><li>Versatile autosampler. Load up to 45 (solid) or 120 (liquid) samples and easily switch between sample types without the need for tools.</li><li>Peltier cooled sample introduction. Reduce cycle time by accelerating the cooling of the boat between samples.</li><li>Compact combustion tube. Enhanced oxygen flow reduces time needed for complete combustion by increasing efficiency.</li><li>Smart hydration. Peristaltic pump delivers water only during sample combustion to minimize usage and preserve tube integrity.</li><li>Variable absorption volume. Optimize the absorption volume based on analytical need.</li><li>Reduced sample pathway. Lower baseline contamination and low sample carryover to decrease wash time between samples.</li><li>Advanced high-performance pump technology and electronics. Take advantage of a wider range of columns and chemistries improving speed and quality of results.</li><li>Function driven design. Quickly and safely access everything on the instrument.</li><li>Fast, flexible, convenient electrolytic suppression. Just connect the suppressor; no external pump or offline conditioning needed for regeneration.</li><li>Thermo Scientific™ Dionex™ Reagent-Free™ Ion Chromatography (RFIC™). Makes eluent preparation as simple as “just add water,” while ensuring more consistent results and enabling optimized gradient separations.</li></ol><h3>Results you can count on</h3>Getting analytes into solution is only part of the process. Being able to resolve them so that each peak can be accurately quantified is equally integral to reliable, accurate results.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_4_96814c59fb.jpg" alt="Thermo Scientific™ Cindion™ Combustion Ion Chromatography System: Figure 1. PFAS as adsorbable organic fluorine (AOF) in municipal wastewater. C-IC can be used as a screening tool for presence of PFAS compounds by adsorption onto granular activated carbon, subsequent combustion and IC analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_4_96814c59fb.jpg 245w," sizes="100vw" width="1032" height="541">Our IC systems are paired with an unmatched portfolio of columns that are optimized to deliver the capacity, selectivity and resolution you need to get the answers you seek.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_5_b47f92752f.jpg" alt="Thermo Scientific™ Cindion™ Combustion Ion Chromatography System: Figure 2. PFAS in food contact material. PFAS, as organic fluorine, can be determined by subtracting values for total inorganic fluorine (TIF) from total fluorine (TF) by IC and C-IC, respectively." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_5_b47f92752f.jpg 245w," sizes="100vw" width="1184" height="588">

Thermo Scientific Transcend Multichannel UHPLC Systems

Thermo Scientific Transcend Multichannel UHPLC Systems are advanced LC-MS systems with a multichannel UHPLC architecture that increase analytical productivity and maximize mass spectrometer utilization without compromising data quality.

Thermo Scientific™ Transcend™ Multichannel UHPLC Systems are advanced LC-MS platforms designed for laboratories that demand higher throughput, improved efficiency, and stronger return on investment. Their multichannel UHPLC architecture connects up to four fully independent LC channels to a single mass spectrometer, dramatically increasing system utilization without compromising data quality.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_8_5f824e5e08.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: The Transcend LX systems feature either 2 or 4 (shown) completely independent LC channels." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_8_5f824e5e08.jpg 245w," sizes="100vw" width="955" height="404"><h3>Key benefits</h3><ul><li>Significantly increased LC-MS throughput</li><li>Maximized mass spectrometer utilization</li><li>Maintained sensitivity, selectivity, and robustness</li><li>Reduced operating costs and analysis time</li><li>Scalable configurations tailored to laboratory needs</li></ul><h3>Multichannel UHPLC architecture</h3>Conventional single-channel LC-MS systems process samples sequentially, leaving the mass spectrometer idle during injection, column washing, and equilibration. Transcend systems overcome this limitation by intelligently interleaving injections from multiple LC channels, delivering data to the mass spectrometer only during relevant retention time windows and enabling substantial productivity gains.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_5_ab4093366d.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Injections are interleaved to maximize throughput and mass spectrometer use." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_5_ab4093366d.jpg 169w," sizes="100vw" width="831" height="764"><h3>Vanquish UHPLC platform</h3>Thermo Scientific™ Transcend™ Multichannel UHPLC Systems are built on proven <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=40&amp;manufacturerItems=3&amp;search=vanquish">Thermo Scientific Vanquish UHPLC</a> technology. The Transcend multichannel architecture integrates up to four independent Vanquish-based UHPLC channels into a single LC-MS platform.The Vanquish UHPLC platform provides:<ul><li>high mechanical and operational robustness</li><li>reproducible long-term performance</li><li>precise gradient formation and stable flow control suitable for multichannel operation</li><li>flexible pump configurations (binary or quaternary) tailored to application requirements</li></ul>By combining the Transcend multichannel concept with Vanquish UHPLC technology, laboratories can achieve high throughput without compromising chromatographic performance, sensitivity, or system reliability.<h3>System configurations</h3><ul><li>Transcend LX and VLX Designed for high-throughput LC-MS workflows without on-line sample cleanup<ul><li>2- and 4-channel configurations</li><li>Fully independent LC channels</li></ul></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_1567f69a93.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Transcend LX UHPLC Systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_1567f69a93.jpg 245w," sizes="100vw" width="968" height="500"><ul><li>Transcend TLX Designed for workflows requiring automated on-line sample cleanup<ul><li>1-, 2-, and 4-channel configurations</li><li>Integrated TurboFlow™ technology</li></ul></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_2_8ac2e32016.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Transcend TLX UHPLC Systems" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_2_8ac2e32016.jpg 245w," sizes="100vw" width="1674" height="523">Each LC channel operates independently, allowing identical methods to run in parallel or multiple methods to be combined within a single system.<h3>On-line sample cleanup with TurboFlow™ technology (TLX)</h3>TurboFlow™ technology enables rapid on-line removal of matrix interferences directly within the LC-MS system, resulting in:<ul><li>Reduced or eliminated manual sample preparation</li><li>Direct injection of complex biological and environmental samples</li><li>Improved sensitivity and reproducibility</li><li>Increased method robustness and simplified workflows</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_3_efccaa3928.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: On-line sample cleanup with TurboFlow™ technology (TLX)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_3_efccaa3928.jpg 245w," sizes="100vw" width="1105" height="556"><h3>System control and software</h3>All system functions are managed by Thermo Scientific™ Aria™ MX software, providing:<ul><li>Control of pumps, valves, gradients, and injection scheduling</li><li>Intuitive multichannel method setup</li><li>Parallel execution of up to four methods</li><li>A user-friendly graphical interface for complex LC-MS workflows</li></ul>Aria MX software is fully compatible with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758">Thermo Scientific™ Xcalibur™</a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77">Thermo Scientific™ TraceFinder™</a> software.<h3>Mass spectrometer compatibility</h3>Transcend systems are designed as a flexible LC-MS platform compatible with a broad range of Thermo Fisher Scientific mass spectrometers, including:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=20&amp;manufacturerItems=3&amp;search=tsq">TSQ triple quadrupole systems</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=134&amp;manufacturerItems=3&amp;search=orbitrap">High-resolution Orbitrap instruments</a></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_4_fc2c09672b.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Transcend TLX-2 system with a TSQ Altis Plus triple quadrupole mass spectrometer." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_4_fc2c09672b.jpg 245w," sizes="100vw" width="1178" height="646"><h3>Typical application areas</h3><ul><li>Clinical research and bioanalysis</li><li>Pharmaceutical development and quality control</li><li>Toxicology</li><li>Environmental analysis</li><li>High-throughput screening workflows</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_6_db70763211.jpg" alt="Thermo Scientific™ Transcend™ Multichannel UHPLC Systems: Retention time (A) and peak area (B) reproducibility of a high-throughput targeted proteomics assay for quantifying SARS-CoV-2 peptides in clinical research samples across five days. The Transcend TLX-4 UHPLC system was used for on-line sample clean-up and analysis of 500 respiratory tract swab samples per day. (Cardozo, K.H.M., Lebkuchen, A., Okai, G.G. et al. Establishing a mass spectrometry-based system for rapid detection of SARS-CoV-2 in large clinical sample cohorts. Nat Commun 11, 6201 (2020))" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Transcend_Multichannel_UHPLC_Systems_6_db70763211.jpg 245w," sizes="100vw" width="1489" height="862">

KNAUER AZURA HTQC UHPLC System

KNAUER AZURA HTQC UHPLC (1240 bar) enables high-throughput QC with parallel analysis and column re-equilibration for faster workflows.

The KNAUER AZURA HTQC UHPLC (1240 bar) is a high-performance UHPLC system designed for high-throughput quality control (QC) where speed, robustness, and reproducibility are essential.The system features a unique concept of parallel analysis and offline column re-equilibration, significantly increasing productivity. With two gradient pumps, one column performs the analytical run while the second is re-equilibrated in backflush mode.This architecture enables:<ul><li>≥30% reduction in cycle time</li><li>increased sample throughput</li><li>column protection from matrix contamination</li><li>consistent retention times</li></ul>It is ideal for pharmaceutical QC laboratories requiring automation and validated workflows.<h4>Key Features</h4><ul><li>UHPLC system up to 1240 bar (124 MPa)</li><li>Dual gradient pumps (HPG + LPG)</li><li>Parallel analysis and column re-equilibration</li><li>Backflush mode for column protection</li><li>≥30% faster analysis cycles</li><li>High flow reproducibility</li><li>Autosampler with cooling</li><li>Column thermostat (Peltier)</li><li>Fully automated modular system</li><li>MS detector compatibility</li></ul><h4>System Configuration</h4>Included components:<ul><li>Eluent tray E 2.1L</li><li>Pump P 8.1L (HPG)</li><li>Pump P 6.1L (LPG)</li><li>Liquid handler LH 8.1 + Robotic Cooler</li><li>Column thermostat CT 2.1</li><li>Column switching &amp; backflush valve</li><li>Accessories and tools</li></ul><h3>Technical Specifications</h3><h4>Pumps</h4><h5>P 8.1L (HPG – analytical pump):</h5><ul><li>Max pressure: 1240 bar</li><li>Flow rate: up to 5 mL/min</li><li>Adaptive pulsation compensation</li><li>Degasser + binary solvent selection</li><li>Low baseline noise</li></ul><h5>P 6.1L (LPG – re-equilibration):</h5><ul><li>Quaternary gradient</li><li>Integrated degasser</li><li>Low dwell volume</li><li>Inline filter</li></ul><h4>Autosampler</h4><h5>LH 8.1:</h5><ul><li>XYZ autosampler</li><li>Capacity: up to 390 samples</li><li>Temperature: 4–40 °C</li><li>Low carryover</li></ul><h4>Column Thermostat</h4><h5>CT 2.1:</h5><ul><li>Peltier controlled</li><li>Above and below ambient operation</li><li>High precision</li></ul><h4>Valve System</h4><ul><li>Column switching + backflush</li><li>Up to 1200 bar</li><li>Parallel column operation</li></ul><h4>Detection</h4><ul><li>Compatible with all HPLC detectors</li><li>Ideal for LC-MS coupling</li></ul><h4>HTQC Concept</h4><ul><li>Independent flow paths (analysis vs re-equilibration)</li><li>Backflush re-equilibration</li><li>Parallel operation</li><li>Increased throughput without compromise</li></ul><h4>Typical Applications</h4><ul><li>Pharmaceutical QC</li><li>Routine validated workflows</li><li>High sample throughput environments</li><li>Reversed-phase HPLC</li></ul>

Products from category Liquid chromatographs - page 1

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