<p><strong>Scientists at IOCB Prague are uncovering new details of gene transcription. They have identified a previously unknown molecular mechanism by which the transcription of genetic information from deoxyribonucleic acid (DNA) into ribonucleic acid (RNA) can be initiated. The researchers focused on a specific class of molecules known as alarmones, which are found in cells across a wide range of organisms and whose levels often increase under conditions of cellular stress. The results were published in the prestigious scientific journal </strong><i><strong>Nature Chemical Biology</strong></i><strong>.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Hana Cahová, head of the Chemical Biology of Nucleic Acids research group." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_bc2bfffa6c.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Molecules of ribonucleic acid can carry a variety of chemical modifications at one end, known as caps. In eukaryotic organisms, including human cells, the best-known cap plays an important role in RNA stability and in regulating its subsequent fate. In recent years, however, it has become clear that alternative, non-canonical RNA caps also exist, although their formation and the mechanisms by which they are attached to RNA remain only partially understood. These include alarmone caps, formed by dinucleoside polyphosphate molecules, that protect cellular RNA at moments when the cell is under threat.</p><p>In their study,<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://cahova.group.uochb.cz/en"><strong>Dr. Hana Cahová</strong></a> and colleagues examined bacterial RNA polymerase and investigated how this enzyme can initiate transcription using dinucleoside polyphosphates (NpNs) instead of the standard RNA building blocks. For the first time, the scientists described, at the atomic level, how RNA bearing an alarmone cap can be generated directly at the initiation of gene transcription. They also observed that NpNs bind through a different type of base pairing than is typically observed.</p><p>The work was significantly shaped by <strong>Valentina Serianni from Hana Cahová’s team</strong>, who demonstrated the ability of dinucleoside polyphosphates to initiate gene transcription, and by <strong>Jana Škerlová</strong>, who focused on the structural analysis of RNA polymerase. Using cryogenic electron microscopy data, she showed how dinucleoside polyphosphate molecules bind within the active site of RNA polymerase – that is, the core of the enzyme where genetic information is transcribed. Together, their findings help to elucidate the processes that accompany the transcription of genetic information from DNA to RNA.</p><p>Hana Cahová adds: <i>“We’re describing something that truly occurs in cells and that we’re now able to observe directly at the level of individual molecules. This allows us to answer fundamental questions about cellular processes, such as how cells adapt to stress. RNA plays a central role in this, as it carries the cascade of information underlying any cellular response – for example, to threatening conditions caused by nutrient deprivation or temperature shock.”</i></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg" alt="IOCB Prague/Tomáš Belloň: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: Dr. Tomáš Kouba, head of the Cryogenic Electron Microscopy core facility." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_2_0fe88ff9e9.jpg 234w," sizes="100vw" width="2000" height="1335"></p><div><p>Cryogenic electron microscopy (cryo-EM) was central to the project. This part of the work was led by<strong> Dr. Tomáš Kouba</strong>, one of the authors of the study. <i>“Cryogenic electron microscopy allows us to freeze biological molecules in a state very close to their natural form and then determine their three-dimensional structure. This makes it possible to look directly into the active centers of enzymes and observe their function down to the atomic level,”</i> he explains.</p><p>Last year, IOCB Prague opened a new <a target="_blank" rel="noopener noreferrer" href="https://cryoem.group.uochb.cz/en"><strong>cryo-EM center</strong></a><strong> </strong>that is unique within the Czech research environment. State-of-the-art cryogenic electron microscopes are housed in a specially designed building and enable the study of biological processes with exceptional structural precision.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg" alt="IOCB Prague: Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription: This work shows how NpnNs initiate bacterial transcription. Cryo-EM reveals how nucleobases pair with the template: one in canonical and one in reverse Watson–Crick mode, providing a structural basis for their function as non-canonical RNA caps." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_UOCHB_Vyzkum_z_UOCHB_odhaluje_dosud_nepoznany_zpusob_prepisu_geneticke_informace_3_4d881e7a58.jpg 245w," sizes="100vw" width="2000" height="1077"></p><blockquote><h4><strong>The Original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-025-02134-5"><strong>Molecular insight into 5′ RNA capping with Np<sub>n</sub>Ns by bacterial RNA polymerase</strong></a></h4><p>Valentina M. Serianni, Jana Škerlová, Anna Knopp Dubánková, Anton Škríba, Hana Šváchová, Tereza Vučková, Anatolij Filimoněnko, Milan Fábry, Pavlína Řezáčová, Tomáš Kouba &amp; Hana Cahova&nbsp;</p><p>Nat. Chem. Biol. 21 (2026)</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-025-02134-5">https://doi.org/10.1038/s41589-025-02134-5</a></p><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>RNA capped with dinucleoside polyphosphates has been discovered in bacteria and eukaryotes only recently. The likely mechanism of this specific capping involves direct incorporation of dinucleoside polyphosphates by RNA polymerase as noncanonical initiating nucleotides. However, how these compounds bind into the active site of RNA polymerase during transcription initiation is unknown. Here, we explored transcription initiation in vitro, using a series of DNA templates in combination with dinucleoside polyphosphates and model RNA polymerase from <i>Thermus</i> <i>thermophilus</i>. We observed that the transcription start site can vary on the basis of the compatibility of the specific template and dinucleoside polyphosphate. Cryo-electron microscopy structures of transcription initiation complexes with dinucleoside polyphosphates revealed that both nucleobase moieties can pair with the DNA template. The first encoded nucleotide pairs in a canonical Watson–Crick manner, whereas the second nucleobase pairs noncanonically in a reverse Watson–Crick manner. Our work provides a structural explanation of how dinucleoside polyphosphates initiate RNA transcription.</p></div></div>

Research from IOCB Prague reveals a previously unknown mechanism of genetic transcription

<p><strong>Food adulteration is a phenomenon with a long history that has gained increasing importance in recent years due to the globalization of food supply chains and strong economic pressures. Whether it involves diluting olive oil with cheaper oils, adding sugar to honey, or the hidden use of substitutes in protein supplements, the result is a loss of consumer trust and, in some cases, a potential risk to health. Analytical chemistry plays a key role in this area by providing methods and technologies capable of identifying and quantifying target compounds as well as unwanted impurities in a wide range of food matrices.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Praha_Falsovani_potravin_a_jak_ho_odhali_analyticka_chemie_6912db5492.jpg" alt="Watrex: Food Adulteration and How It Is Revealed by Analytical Chemistry" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Praha_Falsovani_potravin_a_jak_ho_odhali_analyticka_chemie_6912db5492.jpg 245w," sizes="100vw" width="1600" height="900"></p><h4><strong>The Role of Chromatography in Forensic Food Analysis</strong></h4><p>Chromatography, particularly liquid chromatography (HPLC), is one of the most effective analytical tools for separating complex mixtures of molecules. It enables:</p><ul><li>qualitative identification of individual components in a sample,</li><li>quantitative determination of their concentrations,</li><li>detection of impurities and unexpected components that may indicate<br>adulteration.</li></ul><p>In practice, HPLC is often combined with various types of detectors (UV/VIS, DAD, refractive index detectors) or with other techniques (e.g., mass spectrometry) to increase selectivity and sensitivity.</p><h4><strong>Isocratic vs. Gradient Elution</strong></h4><p>In the analysis of food samples, chromatographic methods are selected according to the analytical goal:</p><ul><li><strong>Isocratic HPLC </strong>uses a constant mobile phase composition throughout the analysis. It is simple, robust, and ideal for routine determinations of well-defined target analytes (e.g., sugars or vitamins).</li><li><strong>Gradient HPLC</strong> changes the mobile phase composition during separation, enabling better resolution of complex mixtures with a wide range of polarities (e.g., peptides or phenolic compounds).</li></ul><p>Gradient methods are particularly useful when analytes have very different properties and high separation efficiency is required.</p><h4><strong>Watrex Praha and the Contribution of Modern Systems to Food Analysis</strong></h4><p><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha, s.r.o.</strong></a> is one of the leading Czech manufacturers and distributors of liquid chromatography systems and instruments, with a long tradition dating back to 1990. The company has successfully transformed from a distributor into a manufacturer of its own HPLC and related technologies, focusing on modular, robust systems suitable even for demanding analytical tasks.</p><p>Their <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?manufacturerItems=93&amp;search=streamline"><strong>Streamline™ product line</strong></a><strong> </strong>includes several HPLC system concepts suitable for food analysis:</p><ul><li><strong>Isocratic HPLC system</strong> – a simple yet precise configuration with a single pump, column thermostat, and UV/VIS detector; suitable for routine determination of known analytes (e.g., basic carbohydrates, food additives).</li><li><strong>Binary gradient HPLC system</strong> – equipped with two pumps enabling mobile phase gradient formation, which enhances separation performance for complex mixtures<br>(e.g., phenolic profiles of wine, components of aromatic extracts).</li><li><strong>GPC/SEC system (Gel Permeation / Size Exclusion Chromatography)</strong> – a specialized solution for the determination of macromolecules and polymers, also relevant for the analysis of high-molecular-weight components in foods (e.g., polysaccharides).</li></ul><blockquote><p class="cke-user_style-important"><strong>👉</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Watrex_catalog_2024_ba97395f92.pdf"><strong>Product catalogue HERE</strong></a></p></blockquote><p>Thanks to the modular nature of these systems, analysts can easily adapt the configuration to a specific analytical problem, from simple routine analyses to complex characterization of food samples.</p><h4><strong>Practical Examples of Adulteration Revealed by HPLC</strong></h4><ul><li><strong>Detection of olive oil dilution: </strong>HPLC can separate and quantify characteristic triacylglycerols and fatty acids; unusual patterns indicate the presence of cheaper oils.</li><li><strong>Estimation of sugar addition in honey:</strong> Isocratic HPLC with a refractive index detector can determine sugar profiles (glucose, fructose, sucrose), revealing dilution or the addition of sugar syrups.</li><li><strong>Identification of aromatic adulterants in wine:</strong> Gradient HPLC with a PDA detector can reveal phenolic and aromatic profiles that are altered by the addition of synthetic compounds.</li></ul><h4><strong>Conclusion</strong></h4><p>Food adulteration remains a current issue that requires reliable and sensitive analytical methods. Liquid chromatography, and in particular modern HPLC systems, represent one of the most powerful tools for detecting unwanted additives, impurities, and unexpected components in complex food samples. Manufacturers such as <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha</strong></a> provide flexible chromatographic platforms covering a wide range of analytical tasks from simple isocratic to advanced gradient and GPC/SEC applications thereby supporting analysts in ensuring food quality and consumer protection.</p><blockquote><p>Did you find this article interesting? Follow <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_clanky_HPLCsystemy"><strong>Watrex Praha</strong></a> on their social media (<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/company/watrex/?viewAsMember=true"><strong>LinkedIn</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://www.facebook.com/WatrexPrague"><strong>Facebook</strong></a>) for more engaging topics.</p></blockquote>

Food Adulteration and How It Is Revealed by Analytical Chemistry

<p><strong>Join us for a fascinating conversation with Dr. Subhoja Chakraborty from the University of Central Florida, whose cutting-edge research targets the global challenge of malaria drug resistance. Dr. Chakraborty shares her journey from structure-based drug design during her PhD to her recent collaborative work repurposing human kinase inhibitors as rapid, selective antimalarials against drug-resistant Plasmodium falciparum strains.</strong></p><h4><strong>In this episode, you'll learn:</strong></h4><ul><li>How structure-guided approaches reveal potential drug targets, including cysteine proteases like falcipain-2, and kinases implicated in malaria's complex life cycle.</li><li>The power of repurposing kinase inhibitors originally developed for cancer and other diseases, focusing on compound 12, which blocks hemozoin formation and protein kinase 6—key steps in parasite survival.</li><li>Lab techniques such as affinity, gel filtration, and size exclusion chromatography for recombinant protein purification—and how troubleshooting is crucial for high-yield, stable complexes.</li><li>Advances in mass spectrometry for characterizing protein interactions, validating drug targets, and mapping molecular pathways pivotal to malaria therapeutics.</li><li>Tips and lessons for new researchers facing the challenges of sample preparation, complex protocols, and working as part of a collaborative team.</li></ul><p>Dr. Chakraborty’s insights bridge the gap between basic science and translational drug discovery, offering hope for more effective, targeted malaria treatments in a world where resistance to frontline therapies threatens millions.</p><h4><strong>Referenced Papers:</strong></h4><ul><li>"Plasmodium falciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity" (Cell Chemical Biology, 2025)</li><li>"New insights of falcipain 2 structure from Plasmodium falciparum 3D7 strain" (BBRC, 2022)</li><li>"Structure-Based Optimization of Protease−Inhibitor Interactions to Enhance Specificity of Human Stefin‑A against Falcipain‑2 from the Plasmodium falciparum 3D7 Strain" (Biochemistry, 2023)</li></ul><p>If you’re a student, scientist, or simply passionate about advances in infectious disease research, this episode offers actionable insights, inspiring advice, and a front-row seat to innovation in combating malaria.</p><h3><strong>Video Transcription</strong></h3><h4><strong>From Structural Biology to Drug Discovery: Chromatography and Mass Spectrometry in Malaria Research</strong></h4><h5><strong>Introduction</strong></h5><p>In this discussion, Subhoja shares insights into her research journey, focusing on malaria drug discovery and the role of modern analytical techniques in biological and biomedical research. The conversation is aimed primarily at undergraduate students and early-career researchers interested in chemistry, biotechnology, and life sciences.</p><h5><strong>Research Focus: Malaria Drug Discovery and Kinase Targets</strong></h5><p>Subhoja is currently involved in malaria drug discovery research at the University of Central Florida, where she has been working since beginning her postdoctoral position two years ago. Her earlier PhD research focused on structure-based drug design in malaria, using a combination of in silico approaches, recombinant protein expression, and X-ray crystallography to determine precise three-dimensional structures of target proteins and their inhibitors.</p><p>This structural perspective provided a foundation for her current work, which centers on drug discovery through compound screening and repurposing. A recent publication from her laboratory explores the use of repurposed mammalian CDK-like kinase inhibitors as potential antimalarial agents. While such kinase inhibitors are well known in cancer and cardiovascular research, their application to malaria targets represents a novel and promising approach.</p><p>Kinases are attractive drug targets because of their central role in cell signaling and growth pathways. By targeting specific kinases involved in different stages of the malaria parasite life cycle—whether asexual growth, gametocytogenesis, or differentiation—it may be possible to significantly inhibit parasite growth and progression.</p><h5><strong>Chromatography in Protein Expression and Purification Workflows</strong></h5><p>Chromatography plays a critical role throughout Subhoja’s research. Her experience spans from basic chromatography techniques during her early training to advanced protein purification workflows using affinity chromatography, gel filtration (size exclusion chromatography), and ion exchange chromatography.</p><p>Recombinant proteins are routinely purified using affinity resins such as nickel or cobalt, followed by further purification to remove contaminants. Fast Protein Liquid Chromatography (FPLC) enables compact, stepwise purification workflows suitable for producing proteins for in vitro assays.</p><p>A recurring challenge in this process is the expression of high-molecular-weight proteins, which often accumulate in insoluble fractions or inclusion bodies. Careful selection of expression vectors, host systems, and induction conditions is therefore essential to maximize yield and solubility.</p><h5><strong>Integrating Size Exclusion Chromatography into the Workflow</strong></h5><p>Size exclusion chromatography (SEC) is typically used after affinity purification to further improve protein purity. Following elution with imidazole or glutathione, desalting is required to prevent buffer components from interfering with downstream assays. This is often achieved using desalting columns such as G-25 or PD-10.</p><p>To remove lower-molecular-weight contaminants, finer SEC media—such as Superdex or Sephacryl columns—are employed. Concentration steps using molecular-weight cut-off filters are then applied to obtain the desired protein concentration for functional studies.</p><p>These iterative purification and troubleshooting steps are a routine part of protein biochemistry and reflect the importance of methodical optimization and careful validation.</p><h5><strong>The Role of Mass Spectrometry in Biomolecular Characterization</strong></h5><p>Mass spectrometry is a key analytical tool in Subhoja’s research pipeline, particularly for target identification and validation. In both malaria and cancer research, MS is used alongside chromatography, immunoprecipitation, and pull-down assays to study protein interactions and molecular recognition events.</p><p>Affinity-based mass spectrometry enables the identification of binding partners and interactors, whether studying proteins, long non-coding RNAs, or protein complexes. Techniques such as native MS, tandem affinity purification, and proximity labeling (e.g., TurboID-based workflows) provide deeper insights into molecular networks and signaling pathways.</p><p>These approaches are essential for understanding how candidate drug targets function within complex biological systems.</p><h5><strong>Sample Preparation Challenges in Biological Research</strong></h5><p>Sample preparation remains one of the most challenging aspects of biological experimentation. Whole-cell lysates contain proteases, nucleases, and other components that can rapidly degrade target molecules. Preventing degradation requires minimizing preparation time, maintaining low temperatures, and using appropriate inhibitor cocktails.</p><p>Reproducibility is also critical: biological experiments require multiple replicates, and variability is often unavoidable. Careful handling, protocol optimization, and continuous troubleshooting are essential to ensure reliable results, whether preparing samples for chromatography, mass spectrometry, sequencing, or immunoprecipitation.</p><h5><strong>Advances in Chromatography and MS for Malaria Research</strong></h5><p>Modern advances in chromatography and mass spectrometry significantly enhance malaria research by enabling precise target identification, quantification, and functional characterization. Drug discovery workflows begin with construct design and recombinant expression, followed by purification and interaction studies.</p><p>In malaria research, stage-specific parasite biology requires careful extraction and analysis of proteins from different life cycle stages. Tandem affinity MS, immunoprecipitation, and in vivo validation studies help confirm target relevance and therapeutic potential.</p><p>Recent work on repurposed kinase inhibitors has shown promising results, including inhibition of hemozoin formation—a key detoxification pathway for the malaria parasite—highlighting the potential of such compounds for further development.</p><h5><strong>Malaria, Drug Resistance, and Global Impact</strong></h5><p>Malaria remains a major global health burden, with over 600,000 deaths annually and widespread drug resistance complicating treatment. Artemisinin resistance, particularly associated with mutations in the K13 propeller domain, has driven the search for new targets and therapies.</p><p>During her PhD, Subhoja focused on falcipain-2, a cysteine protease involved in hemoglobin degradation within the parasite. This pathway is critical for parasite survival and has emerged as a promising drug target. Her work revealed that falcipain-2 operates within a larger protein complex responsible for hemoglobin processing and amino acid release.</p><p>Understanding these molecular mechanisms is essential for developing robust, stage-specific antimalarial strategies.</p><h5><strong>Advice for Early-Career Researchers</strong></h5><p>For researchers just starting out, Subhoja emphasizes the importance of hands-on experience. Working directly with cells, lysates, and analytical tools is essential for truly understanding experimental systems. Failure is an inherent part of research, and perseverance is key.</p><p>Motivation, teamwork, careful sample handling, and thorough preparation all contribute to long-term success. Reading extensively, critically evaluating one’s own work, and appreciating incremental progress are vital aspects of a sustainable research career.</p><p>Every successful experiment—no matter how small—represents meaningful progress and contributes to the broader goals of science and medicine.</p><h5><strong>Closing Remarks</strong></h5><p>The discussion highlights how interdisciplinary approaches combining chromatography, mass spectrometry, structural biology, and biochemistry are driving advances in malaria drug discovery. Through careful experimental design, analytical rigor, and collaborative teamwork, researchers can address complex biological challenges and contribute to global health solutions.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

Affinity, Gel Filtration, Size Exclusion Chromatography: Repurposing Kinase Inhibitors for Malaria

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Product

Video

Scientists

Food

Interview

Science and research

The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

WATREX Prague is the distributor and producer of HPLC techniques in the Czech Republic and Slovakia. Main Chromatografic and Related Techniques Supported: LC, GPC, IC, IEC, Automated SPE, LC Columns and special column packings, LC method development, Software development, Laboratory Robots.

Watrex Praha

Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system

The new Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system delivers exactly what a busy analytical testing lab is looking for: consistently excellent results-every shift, every day, for every operator.

<h3><strong>Welcome to the evolution of everyday IC reliability</strong></h3><p>The new<strong> Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system</strong> makes ion analysis simpler and more intuitive than ever before. And it delivers exactly what a busy analytical testing lab is looking for: <strong>consistently excellent results-every shift, every day, for every operator.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_2_6400708696.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_2_6400708696.jpg 245w," sizes="100vw" width="825" height="498"></p><h3><strong>SIMPLE, INTUITIVE USER EXPERIENCE&nbsp;</strong></h3><ul><li><strong>Smart, function-driven design</strong> lets you quickly and safely access everything on the instrument—no hard-to-reach compartments, and no step stools or extra tools needed!</li><li><strong>Automated startup and shutdown routines</strong> ensure the system is quickly ready for the day’s work without user intervention.&nbsp;</li><li><strong>Built-in how-to videos</strong> reduce training time and simplify setup and operation.</li></ul><h3><strong>ULTRA-RELIABLE PERFORMANCE&nbsp;</strong></h3><ul><li><strong>Advanced high-performance pump technology and electronics</strong> let you take advantage of a wider range of columns and chemistries to improve the speed and quality of your results.</li><li><strong>Fast, flexible, convenient electrolytic suppression: </strong>Just connect the suppressor; no external pump or offline conditioning needed for regeneration.</li><li><strong>Reagent-free IC (RFIC™) capability</strong> makes eluent preparation as simple as “just add water,” while ensuring more consistent results and enabling optimized gradient separations.</li></ul><h3><strong>EASILY CONFIGURABLE AND UPGRADEABLE</strong></h3><ul><li><strong>Versatile, adaptable platform</strong> lets you configure the exact Dionex Inuvion IC system for today’s needs and budget, with confidence that your system will also meet your future needs.</li><li><strong>Multiple options and peripherals </strong>extend IC capabilities, letting you easily—and cost-effectively—adapt to changing sample types and workflow requirements.</li></ul><h3><strong>Simply the best system for everyday ion analysis</strong></h3><figure class="image"><img style="aspect-ratio:1107/755;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_d855feb2a8.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_d855feb2a8.jpg 229w," sizes="100vw" width="1107" height="755"></figure><p><strong>1. Operator-friendly engineering </strong>saves time and reduces errors by allowing easy, unobstructed access to all components, connections and consumables</p><p><strong>2. Compact design </strong>helps you make the most of valuable bench space</p><p><strong>3. Digital gas pressure regulator </strong>increases precision of gas delivery for maximum day-to-day consistency (optional)</p><p><strong>4. Temperature-controlled conductivity cell </strong>improves reproducibility and ensures baseline stability</p><p><strong>5. Vacuum degassing capability</strong> enables more consistent peak identification from smoother baselines</p><p><strong>6. Seal wash pump</strong> reduces maintenance costs when using manually prepared eluents (optional)&nbsp;</p><p><strong>7. Reagent-free IC (RFIC)</strong> saves time and ensures greater day-to-day and operator-to-operator consistency, while also allowing the use of gradient separations</p><p><strong>8. Electrolytic suppression</strong> entirely eliminates the need for manual regenerant preparation (or, opt for a continuously regenerated, always- ready-to-go chemical suppressor)</p><p><strong>9. Thermo Scientific™ Dionex™ IC PEEK Viper™ fittings</strong> ensure confident, low dead volume connections every time—no tools required! (optional)</p><p><strong>10. Integrated column heater</strong> minimizes the impact of fluctuations in lab temperature that can adversely affect results (optional)</p><p><strong>11. 6- or 10-port auxiliary valve</strong> lets you automate in-line sample preparation</p><p><strong>12. State-of-the-art high-pressure pump (up to 5000 psi)</strong> lets you increase flow rates with smaller particle columns to reduce run times or add additional separation capacity with longer column length</p><p><strong>13. System self-diagnostics </strong>automatically detect any issues with hardware and consumables</p><p><strong>14. Self-service capabilities and user-swappable parts</strong> help you get back up and running in a hurry Automatic eluent monitor alerts the operator to low solution levels, avoiding potential system damage or failed runs (optional)</p><p><strong>15. Automatic eluent monitor </strong>alerts the operator to low solution levels, avoiding potential system damage or failed runs (optional)</p><h3><strong>Flexible, adaptable Dionex Inuvion platform</strong></h3><p>You can <strong>configure your Dionex Inuvion system</strong> to meet specific analytical and budget requirements, and easily reconfigure as needed. Multiple configurations and peripherals extend IC capabilities, letting you easily-and cost-effectively-adapt to changing sample types and workflow requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_3_fa8233bcd4.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_3_fa8233bcd4.jpg 245w," sizes="100vw" width="1246" height="572"></p><h3><strong>Consistently excellent results every day</strong></h3><p>The <strong>Dionex Inuvion IC system supports a full range of columns </strong>to improve the speed and quality of results, for both<strong> anions and cations.</strong> Expanded capabilities, such as Reagent-Free IC (RFIC), enhance operator-to-operator consistency, while enabling the use of eluent gradients to optimize separations.</p><h4><strong>Rapid results</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_2_Ukazka_rychle_separace_zakladnich_aniontu_s_uhlicitanovou_MF_Zkraceni_doby_analyzy_diky_typu_kolony_a_vyssimu_prutoku_0e610b919d.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system: Figure 1. Elution of seven common inorganic anions using carbonate eluent. Short columns and fast flow rates let you reduce run times." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Obr_2_Ukazka_rychle_separace_zakladnich_aniontu_s_uhlicitanovou_MF_Zkraceni_doby_analyzy_diky_typu_kolony_a_vyssimu_prutoku_0e610b919d.jpg 245w," sizes="100vw" width="1622" height="739"></p><h4><strong>Exceptional reproducibility</strong></h4><figure class="image"><img style="aspect-ratio:1693/754;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_3_Ukazka_reprodukovatelnosti_analyzy_zakladnich_aniontu_40_nastriku_Spickova_technologie_cerpadla_a_elektronika_pristroje_poskytuji_konzistentni_a_reprodukovatelne_vysledky_f66e7430cf.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system: Figure 2. Overlay of 40 replicate injections. State-of-the-art pump technology and Electronics deliver consistent, reproducible results." width="1693" height="754"></figure><h4><strong>Increased sensitivity and consistency</strong></h4><figure class="image"><img style="aspect-ratio:1860/836;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_4_Ukazka_vysoce_citlive_analyzy_aniontu_ve_vodach_Eluent_generator_KOH_a_elektrolyticka_suprese_snizuji_pozadi_cimz_dochazi_ke_zvyseni_citlivosti_da55facfd0.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system: Figure 3. Determination of inorganic anions in drinking and surface waters. KOH eluent generation and electrolytic suppression yield lower backgrounds for greater sensitivity and increased day-to-day consistency." width="1860" height="836"></figure><h4><strong>Method optimization</strong></h4><figure class="image"><img style="aspect-ratio:1799/889;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_5_Ukazka_optimalizace_metody_zkraceni_doby_analyzy_pouzitim_gradientu_mobilni_faze_fc1fbe9cb0.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system: Figure 4. Comparison of isocratic and gradient runs using eluent generation. Reduce run length and sharpen later-eluting peaks with the same ease as an isocratic run with no need for two separate eluents or a proportioning pump." width="1799" height="889"></figure><h3><strong>Compliance-ready Chromeleon CDS</strong></h3><p>A trusted industry standard all over the world, ”Simply Intelligent”<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) software</strong></a><strong> </strong>brings out the full power of the Dionex Inuvion IC system. Easy to learn and easy to use, it automates and optimizes daily tasks and helps even inexperienced users achieve consistent, high quality results.</p><figure class="image"><img style="aspect-ratio:3700/1660;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Thermo_Scientific_Dionex_Inuvion_2_303a6eb73b.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." width="3700" height="1660"></figure>

Thermo Scientific™ Dionex™ Easion™ Ion Chromatography System

Compact IC system with built-in suppressor, heated conductivity detection, and automated sample handling—ideal for routine anion and cation analysis in water and environmental labs.

<h4><strong>Compact, intuitive IC system for routine anion and cation analysis</strong></h4><p><strong>The Dionex Easion IC system is a small yet powerful ion chromatography solution designed for routine water and environmental analysis. With its compact footprint, easy setup, and intuitive Chromeleon™ CDS control, the system enables fast, reliable quantification of both anions and cations—even for inexperienced users. Built-in chemical suppression, minimal maintenance, and preconfigured analysis kits make it ideal for any lab performing standard IC workflows.</strong></p><h3><strong>Key Features and Benefits</strong></h3><h4>🧪 <strong>Simple, Complete System</strong></h4><ul><li>Fully integrated setup includes suppressor, columns, eluent and regenerant concentrates</li><li>Ready to operate in under <strong>90 minutes</strong>—no extra pumps or accessories needed</li><li>Compatible with 2, 3, and 4 mm anion and cation columns</li></ul><h4>📏 <strong>Reliable, Reproducible Performance</strong></h4><ul><li><strong>Heated bipolar conductivity cell</strong> ensures signal stability and low noise</li><li>Chemical suppression with <strong>Dionex CRS 500</strong> suppressor—no regeneration steps needed</li><li>Fixed-loop valve for <strong>manual or automated injections</strong></li><li>Flow range: 0.01–5.00 mL/min; pressure up to 5000 psi</li></ul><h4>💡 <strong>Smart and Compact Design</strong></h4><ul><li>All-PEEK flow path—metal-free and chemically inert</li><li>Simple eluent preparation with concentrates and high-purity water</li><li>Bench-friendly size (33 × 24 × 40 cm, 10 kg) with minimal maintenance</li></ul><h4>🔁 <strong>Automation Ready</strong></h4><ul><li>Supports <strong>Dionex AS-DV, AS-AP, and AS-HV autosamplers</strong></li><li>Built-in sample filtration (with AS-DV) and dilution workflows</li><li>Autosampler-based inline filtration and degassing options available</li></ul><h4>🧠 <strong>Controlled by</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong> Chromeleon™ CDS</strong></a></h4><ul><li>Intuitive system setup with ProcedureWizards™ and application templates</li><li>Built-in calibration memory and audit trail</li><li>Virtual column simulator and multi-vendor instrument integration</li></ul><h3><strong>Applications</strong></h3><ul><li><strong>Drinking water</strong> and <strong>wastewater</strong> monitoring</li><li><strong>Inorganic ion analysis</strong> (F⁻, Cl⁻, NO₃⁻, PO₄³⁻, SO₄²⁻, etc.)</li><li><strong>Routine ammonium and cation detection</strong> (Li⁺, Na⁺, NH₄⁺, Ca²⁺...)</li><li><strong>Educational and QA/QC laboratories</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Easion_System_news_1f1d3e6c64/Thermo-Dionex-Easion-System-news.jpg" alt="Thermo Scientific™ Dionex™ Easion™ Ion Chromatography System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Easion_System_news_1f1d3e6c64/thumbnail_Thermo-Dionex-Easion-System-news.jpg 215w," sizes="100vw" width="1103" height="800"></p>

Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system

The Inuvion Core system gives you all the benefits of chemical suppression and higher-pressure operation, with manual eluent preparation.

<h3><strong>Welcome to the evolution of everyday IC reliability</strong></h3><p>The new<strong> Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system</strong> makes ion analysis simpler and more intuitive than ever before. And it delivers exactly what a busy analytical testing lab is looking for: <strong>consistently excellent results-every shift, every day, for every operator.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_2_6400708696.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_2_6400708696.jpg 245w," sizes="100vw" width="825" height="498"></p><h3><strong>Start with Inuvion Core</strong></h3><p>The <strong>Inuvion Core system</strong> gives you<strong> </strong>all the benefits of chemical suppression and higher-pressure operation, with manual eluent preparation. You still enjoy the<strong> same robust Dionex Inuvion platform</strong>-easily configurable and economically upgradeable to full-featured capabilities as budget allows.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_Core_ion_chromatography_system_6c8824cb1d.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_Core_ion_chromatography_system_6c8824cb1d.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3><strong>SIMPLE, INTUITIVE USER EXPERIENCE&nbsp;</strong></h3><ul><li><strong>Smart, function-driven design</strong> lets you quickly and safely access everything on the instrument—no hard-to-reach compartments, and no step stools or extra tools needed!</li><li><strong>Automated startup and shutdown routines</strong> ensure the system is quickly ready for the day’s work without user intervention.&nbsp;</li><li><strong>Built-in how-to videos</strong> reduce training time and simplify setup and operation.</li></ul><h3><strong>ULTRA-RELIABLE PERFORMANCE&nbsp;</strong></h3><ul><li><strong>Advanced high-performance pump technology and electronics</strong> let you take advantage of a wider range of columns and chemistries to improve the speed and quality of your results.</li><li><strong>Fast, flexible, convenient electrolytic suppression: </strong>Just connect the suppressor; no external pump or offline conditioning needed for regeneration.</li><li><strong>Reagent-free IC (RFIC™) capability</strong> makes eluent preparation as simple as “just add water,” while ensuring more consistent results and enabling optimized gradient separations.</li></ul><h3><strong>EASILY CONFIGURABLE AND UPGRADEABLE</strong></h3><ul><li><strong>Versatile, adaptable platform</strong> lets you configure the exact Dionex Inuvion IC system for today’s needs and budget, with confidence that your system will also meet your future needs.</li><li><strong>Multiple options and peripherals </strong>extend IC capabilities, letting you easily—and cost-effectively—adapt to changing sample types and workflow requirements.</li></ul><h3><strong>Simply the best system for everyday ion analysis</strong></h3><figure class="image"><img style="aspect-ratio:1107/755;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_d855feb2a8.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_d855feb2a8.jpg 229w," sizes="100vw" width="1107" height="755"></figure><p><strong>1. Operator-friendly engineering </strong>saves time and reduces errors by allowing easy, unobstructed access to all components, connections and consumables</p><p><strong>2. Compact design </strong>helps you make the most of valuable bench space</p><p><strong>3. Digital gas pressure regulator </strong>increases precision of gas delivery for maximum day-to-day consistency (optional)</p><p><strong>4. Temperature-controlled conductivity cell </strong>improves reproducibility and ensures baseline stability</p><p><strong>5. Vacuum degassing capability</strong> enables more consistent peak identification from smoother baselines</p><p><strong>6. Seal wash pump</strong> reduces maintenance costs when using manually prepared eluents (optional)&nbsp;</p><p><strong>7. Reagent-free IC (RFIC)</strong> saves time and ensures greater day-to-day and operator-to-operator consistency, while also allowing the use of gradient separations</p><p><strong>8. Electrolytic suppression</strong> entirely eliminates the need for manual regenerant preparation (or, opt for a continuously regenerated, always- ready-to-go chemical suppressor)</p><p><strong>9. Thermo Scientific™ Dionex™ IC PEEK Viper™ fittings</strong> ensure confident, low dead volume connections every time—no tools required! (optional)</p><p><strong>10. Integrated column heater</strong> minimizes the impact of fluctuations in lab temperature that can adversely affect results (optional)</p><p><strong>11. 6- or 10-port auxiliary valve</strong> lets you automate in-line sample preparation</p><p><strong>12. State-of-the-art high-pressure pump (up to 5000 psi)</strong> lets you increase flow rates with smaller particle columns to reduce run times or add additional separation capacity with longer column length</p><p><strong>13. System self-diagnostics </strong>automatically detect any issues with hardware and consumables</p><p><strong>14. Self-service capabilities and user-swappable parts</strong> help you get back up and running in a hurry Automatic eluent monitor alerts the operator to low solution levels, avoiding potential system damage or failed runs (optional)</p><p><strong>15. Automatic eluent monitor </strong>alerts the operator to low solution levels, avoiding potential system damage or failed runs (optional)</p><h3><strong>Flexible, adaptable Dionex Inuvion platform</strong></h3><p>You can <strong>configure your Dionex Inuvion system</strong> to meet specific analytical and budget requirements, and easily reconfigure as needed. Multiple configurations and peripherals extend IC capabilities, letting you easily-and cost-effectively-adapt to changing sample types and workflow requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_3_fa8233bcd4.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_3_fa8233bcd4.jpg 245w," sizes="100vw" width="1246" height="572"></p><h3><strong>Consistently excellent results every day</strong></h3><p>The <strong>Dionex Inuvion IC system supports a full range of columns </strong>to improve the speed and quality of results, for both<strong> anions and cations.</strong> Expanded capabilities, such as Reagent-Free IC (RFIC), enhance operator-to-operator consistency, while enabling the use of eluent gradients to optimize separations.</p><h4><strong>Rapid results</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_2_Ukazka_rychle_separace_zakladnich_aniontu_s_uhlicitanovou_MF_Zkraceni_doby_analyzy_diky_typu_kolony_a_vyssimu_prutoku_0e610b919d.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 1. Elution of seven common inorganic anions using carbonate eluent. Short columns and fast flow rates let you reduce run times." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Obr_2_Ukazka_rychle_separace_zakladnich_aniontu_s_uhlicitanovou_MF_Zkraceni_doby_analyzy_diky_typu_kolony_a_vyssimu_prutoku_0e610b919d.jpg 245w," sizes="100vw" width="1622" height="739"></p><h4><strong>Exceptional reproducibility</strong></h4><figure class="image"><img style="aspect-ratio:1693/754;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_3_Ukazka_reprodukovatelnosti_analyzy_zakladnich_aniontu_40_nastriku_Spickova_technologie_cerpadla_a_elektronika_pristroje_poskytuji_konzistentni_a_reprodukovatelne_vysledky_f66e7430cf.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 2. Overlay of 40 replicate injections. State-of-the-art pump technology and Electronics deliver consistent, reproducible results." width="1693" height="754"></figure><h4><strong>Increased sensitivity and consistency</strong></h4><figure class="image"><img style="aspect-ratio:1860/836;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_4_Ukazka_vysoce_citlive_analyzy_aniontu_ve_vodach_Eluent_generator_KOH_a_elektrolyticka_suprese_snizuji_pozadi_cimz_dochazi_ke_zvyseni_citlivosti_da55facfd0.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 3. Determination of inorganic anions in drinking and surface waters. KOH eluent generation and electrolytic suppression yield lower backgrounds for greater sensitivity and increased day-to-day consistency." width="1860" height="836"></figure><h4><strong>Method optimization</strong></h4><figure class="image"><img style="aspect-ratio:1799/889;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_5_Ukazka_optimalizace_metody_zkraceni_doby_analyzy_pouzitim_gradientu_mobilni_faze_fc1fbe9cb0.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system: Figure 4. Comparison of isocratic and gradient runs using eluent generation. Reduce run length and sharpen later-eluting peaks with the same ease as an isocratic run with no need for two separate eluents or a proportioning pump." width="1799" height="889"></figure><h3><strong>Compliance-ready Chromeleon CDS</strong></h3><p>A trusted industry standard all over the world, ”Simply Intelligent”<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) software </strong></a>brings out the full power of the Dionex Inuvion IC system. Easy to learn and easy to use, it automates and optimizes daily tasks and helps even inexperienced users achieve consistent, high quality results.</p><p><img style="aspect-ratio:3700/1660;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Thermo_Scientific_Dionex_Inuvion_2_303a6eb73b.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ Core ion chromatography system." width="3700" height="1660"></p>

Thermo Scientific Cindion Combustion Ion Chromatography System

Fully integrated C-IC system for automated screening of halogens, sulfur compounds, and PFAS in solid, liquid, and gas samples.

<h4><strong>Automated halogen, sulfur, and PFAS screening in solid, liquid, and gas samples.</strong></h4><p>The <strong>Thermo Scientific™ Cindion™ Combustion Ion Chromatography (C-IC) System</strong> is a fully integrated platform designed for screening corrosive and toxic halogens, sulfur compounds, and PFAS in a wide range of sample matrices. Whether analyzing solids, liquids, or gases, the system delivers low background levels, high sensitivity, and robust automated workflows—all in a compact footprint.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_6_e1eda9de2f.jpg" alt="Thermo Scientific™ Cindion™ Combustion Ion Chromatography System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_6_e1eda9de2f.jpg 207w," sizes="100vw" width="650" height="490"></p><h3><strong>Key Features</strong></h3><ul><li><strong>Compact system footprint:</strong> A novel combustion tube design ensures complete combustion over a shorter path, saving bench space and enhancing efficiency.</li><li><strong>Fully automated workflow:</strong> From sample introduction to combustion, absorption, ion chromatographic separation, and data reporting—automation minimizes user intervention.</li><li><strong>PFAS-free sample path:</strong> Components in the sample flow path are PFAS-free to eliminate contamination and enable ultra-sensitive PFAS detection (EPA Method 1621).</li><li><strong>Reagent-Free Ion Chromatography (RFIC™):</strong> Automated eluent generation—just add water. Electrolytic suppression ensures consistent results with no external pump.</li><li><strong>Versatile sample compatibility:</strong> Supports AOX and AOF determinations, as well as total and inorganic fluorine (TF/TIF) analysis in environmental, food, industrial, and petrochemical applications.</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon CDS integration</strong></a><strong>:</strong> A single software platform for full control of C-IC operations including sequence setup, system control, and reporting.</li><li><strong>High throughput:</strong> Accommodates up to 45 solid or 120 liquid samples; includes smart hydration and reduced carryover for faster cycle times.</li><li><strong>Application-ready:</strong> Backed by extensive application notes and 50+ years of Thermo Scientific expertise in ion chromatography.</li></ul><h3><strong>Typical Applications</strong></h3><ul><li><strong>Environmental testing:</strong> AOX/AOF screening in water and wastewater; PFAS monitoring.</li><li><strong>Food and packaging:</strong> Determination of organic fluorine content in food contact materials.</li><li><strong>Petrochemicals:</strong> Halogen and sulfur analysis in fuels and oils to prevent equipment corrosion and meet emission standards.</li><li><strong>Electronics and polymers:</strong> Detection of restricted brominated and fluorinated substances in plastics and E&amp;E components.</li><li><strong>Mining and metallurgy:</strong> Screening for corrosive species in ores and geological samples.</li></ul><h3><strong>System Components</strong></h3><ul><li><strong>Sample delivery module:</strong> Liquid/solid autosampler or gas injector.</li><li><strong>Combustion/absorption unit:</strong> Integrated with autosampler and absorption tube.</li><li><strong>Ion chromatography system:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1078"><strong>Thermo Scientific™ Dionex™ IC with RFIC™</strong></a> technology.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_3_79a361351d.jpg" alt="Thermo Scientific™ Cindion™ Combustion Ion Chromatography System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_3_79a361351d.jpg 243w," sizes="100vw" width="1509" height="971"></p><ol><li><strong>Versatile autosampler.</strong> Load up to 45 (solid) or 120 (liquid) samples and easily switch between sample types without the need for tools.</li><li><strong>Peltier cooled sample introduction.</strong> Reduce cycle time by accelerating the cooling of the boat between samples.</li><li><strong>Compact combustion tube.</strong> Enhanced oxygen flow reduces time needed for complete combustion by increasing efficiency.</li><li><strong>Smart hydration.</strong> Peristaltic pump delivers water only during sample combustion to minimize usage and preserve tube integrity.</li><li><strong>Variable absorption volume.</strong> Optimize the absorption volume based on analytical need.</li><li><strong>Reduced sample pathway.</strong> Lower baseline contamination and low sample carryover to decrease wash time between samples.</li><li><strong>Advanced high-performance pump technology and electronics.</strong> Take advantage of a wider range of columns and chemistries improving speed and quality of results.</li><li><strong>Function driven design.</strong> Quickly and safely access everything on the instrument.</li><li><strong>Fast, flexible, convenient electrolytic suppression.</strong> Just connect the suppressor; no external pump or offline conditioning needed for regeneration.</li><li><strong>Thermo Scientific™ Dionex™ Reagent-Free™ Ion Chromatography (RFIC™).</strong> Makes eluent preparation as simple as “just add water,” while ensuring more consistent results and enabling optimized gradient separations.</li></ol><h3><strong>Results you can count on</strong></h3><p>Getting analytes into solution is only part of the process. Being able to resolve them so that each peak can be accurately quantified is equally integral to reliable, accurate results.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_4_96814c59fb.jpg" alt="Thermo Scientific™ Cindion™ Combustion Ion Chromatography System: Figure 1. PFAS as adsorbable organic fluorine (AOF) in municipal wastewater. C-IC can be used as a screening tool for presence of PFAS compounds by adsorption onto granular activated carbon, subsequent combustion and IC analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_4_96814c59fb.jpg 245w," sizes="100vw" width="1032" height="541"></p><p>Our IC systems are paired with an unmatched portfolio of columns that are optimized to deliver the capacity, selectivity and resolution you need to get the answers you seek.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_5_b47f92752f.jpg" alt="Thermo Scientific™ Cindion™ Combustion Ion Chromatography System: Figure 2. PFAS in food contact material. PFAS, as organic fluorine, can be determined by subtracting values for total inorganic fluorine (TIF) from total fluorine (TF) by IC and C-IC, respectively." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Cindion_Combustion_Ion_Chromatography_System_5_b47f92752f.jpg 245w," sizes="100vw" width="1184" height="588"></p>

Thermo Scientific™ Dionex™ Aquion™ Ion Chromatography (IC) System

Perform basic anion or cation analyses reliably with Dionex™ Aquion™ IC system bundles that include hardware, software, and consumables for easy ordering.

<h4><strong>Reliable, budget-friendly ion chromatography for routine anion and cation analysis</strong></h4><p>Simplify ion analysis in your laboratory with the <strong>Dionex™ Aquion™ IC system</strong>, a compact and easy-to-operate platform designed for routine applications in <strong>environmental, food safety, and academic labs</strong>. Ideal for budget-conscious operations, the Aquion system delivers dependable performance, quick startup, and low operating costs.</p><h3><strong>Key system features</strong></h3><ul><li><strong>Chemically inert PEEK flow path</strong></li><li><strong>Serial dual-piston pump</strong><ul><li>Flow rate: 0.01–5.0 mL/min</li><li>Pressure: up to 5000 psi</li></ul></li><li><strong>High-pressure pulse dampener</strong></li><li><strong>Electrically actuated, PEEK, 6-port Rheodyne injection valve</strong></li><li><strong>Conductivity detection with digital signal processing</strong><ul><li>Range: 0–15,000 μS</li><li>Temperature-controlled conductivity cell for signal stability</li></ul></li><li><strong>Support for electrolytic or chemical suppressors</strong></li><li><strong>Optional column heater</strong></li><li><strong>Built-in inline vacuum degasser</strong></li></ul><h3><strong>Benefits of electrolytic suppression</strong></h3><ul><li>Lower background conductivity and reduced detection limits</li><li>Faster system startup</li><li>Superior sensitivity for both anion and cation analysis</li><li>No need for manual regenerant preparation</li></ul><h3><strong>Optimized detection with conductivity</strong></h3><p>The Aquion system is optimized for conductivity detection using a <strong>thermostated high-performance cell</strong> that ensures stability against ambient temperature fluctuations. Digital signal control offers a wide dynamic range for simultaneous detection of analytes with varying concentrations.</p><h3><strong>Seamless control with Chromeleon™ CDS software</strong></h3><p>Included in every system bundle, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</strong></a> software provides intuitive instrument control, automated workflows, and streamlined data handling:</p><ul><li><strong>eWorkflows</strong>: auto-load instrument conditions and processing templates</li><li><strong>Calibration Wizard</strong>: step-by-step guidance for method setup and quantification</li><li><strong>Wellness Trending</strong>: monitor system performance over time for predictive maintenance</li></ul><h3><strong>Anion and Cation System Bundles</strong></h3><p>Each bundle includes everything needed to get started:</p><h4><strong>Included in all system bundles:</strong></h4><ul><li>Dionex Aquion IC System with power cable</li><li>Dionex Aquion Analysis Kit (anion or cation specific)</li><li>Chromeleon SE software and license</li><li>3-year warranty (parts-only coverage in years 2 and 3)<br>→ Optional extended warranty available including labor and travel in years 2 and 3</li></ul><h4><strong>Anion Analysis Kit includes:</strong></h4><ul><li><strong>Dionex IonPac AG22 (4 × 50 mm) guard column</strong></li><li><strong>Dionex IonPac AS22 (4 × 250 mm) analytical column</strong></li><li><strong>Dionex AERS 500 Carbonate (4 mm) suppressor</strong></li><li><strong>Combined Seven Anion Standard II</strong><br><i>Note: Eluent concentrate must be ordered separately.</i></li></ul><h4><strong>Cation Analysis Kit includes:</strong></h4><ul><li><strong>Dionex IonPac CG12A (4 × 50 mm) guard column</strong></li><li><strong>Dionex IonPac CS12A (4 × 250 mm) analytical column</strong></li><li><strong>Dionex CDRS 600 (4 mm) suppressor</strong><br><i>Note: Eluent concentrate and standards must be ordered separately.</i></li></ul><h3><strong>Why choose Dionex Aquion?</strong></h3><ul><li>Proven IC platform with straightforward operation</li><li>Reliable results and stable performance</li><li>Full compatibility with standard and microbore column formats (2–5 mm)</li><li>Low cost of ownership with high-quality support and service</li><li>Ideal entry point for labs new to ion chromatography</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Aquion_Iontovy_Chromatograf_2_8c661a76f1/Thermo-Dionex-Aquion-Iontovy-Chromatograf-2.jpg" alt="Thermo Scientific™ Dionex™ Aquion™ Ion Chromatography (IC) System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Aquion_Iontovy_Chromatograf_2_8c661a76f1/thumbnail_Thermo-Dionex-Aquion-Iontovy-Chromatograf-2.jpg 156w," sizes="100vw" width="650" height="650"></p>

Thermo Scientific Dionex Integrion HPIC System 

Achieve versatile and efficient separations that meet your routine ion analysis demands with the reliable Thermo Scientific Dionex Integrion HPIC system. 

<div><div id="container-9240b945f2"><div><div id="title-b4d119a2b1"><h3 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Dionex Integrion HPIC System: An easy solution for routine analysis</strong></h3></div></div><div><div id="container-2c24fcced5"><div><div id="text-1819779492"><p><strong>Achieve versatile and efficient separations that meet your routine ion analysis demands with the reliable Thermo Scientific Dionex Integrion HPIC system. Its high-pressure ion chromatography (HPIC) capabilities enable faster analysis without compromising data quality. The Dionex Integrion&nbsp;HPIC system is designed for routine&nbsp;ion chromatography (IC) applications for water, food and beverage, biofuels and pharmaceutical analysis.</strong></p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Integrion_Iontovy_Chromatograf_2_7a7f2ce86a/Thermo-Dionex-Integrion-Iontovy-Chromatograf-2.jpg" alt="Thermo Scientific Dionex Integrion HPIC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Integrion_Iontovy_Chromatograf_2_7a7f2ce86a/thumbnail_Thermo-Dionex-Integrion-Iontovy-Chromatograf-2.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div></div></div></div><div><div id="container-ee4e409cf5"><div><div id="sectiontitle-d7eca6bc0f"><h3><strong>Highlights</strong></h3></div></div><div><div id="container-94710c6880"><div><div><div id="container-006293a352"><div><div><div id="text-328176320"><h4><strong>Simple plumbing layout</strong></h4><p><strong>The plumbing layout </strong>of this high-pressure ion chromatography system is based on a logical flow path for <strong>easy component access</strong> in a compact platform with a small physical footprint.</p></div></div></div></div></div><div><div id="container-9133f3a75a"><div><div><div id="text-1491634964"><h4><strong>Inert, reliable components</strong></h4><p><strong>Inert, nonmetallic PEEK components</strong> throughout the <strong>Dionex Integrion HPIC system </strong>ensure <strong>compatibility with corrosive eluents and analyses free from metal contamination.</strong> Easy-to-install<strong> IC PEEK Viper fittings</strong> have <strong>low dead volume</strong> and require no special training or tools.</p></div></div></div></div></div><div><div id="container-1d936b69ba"><div><div><div id="text-644579526"><h4><strong>Wide range of IC columns</strong></h4><p>The Dionex Integrion HPIC system is<strong> compatible with a wide variety of column sizes,</strong> including<strong> smaller-particle-size 4 µm columns for HPIC capabilities, </strong>which provide faster run times and better resolution, to meet the requirements of your applications. &nbsp;</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Integrion_Iontovy_Chromatograf_3_bf2f665361/Thermo-Dionex-Integrion-Iontovy-Chromatograf-3.jpg" alt="Thermo Scientific Dionex Integrion HPIC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Integrion_Iontovy_Chromatograf_3_bf2f665361/thumbnail_Thermo-Dionex-Integrion-Iontovy-Chromatograf-3.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div></div></div><div><div id="container-f643098693"><div><div><div id="text-1278873072"><h4><strong>Automated Eluent Generation (EG)</strong></h4><p>Optional <strong>Reagent-Free Ion Chromatography</strong> with Eluent Generation (RFIC-EG) combines<strong> automated eluent generators and electrolytically regenerated suppressors</strong> to create eluents and regenerants.</p></div></div></div></div></div></div></div></div><div><div id="container-1021b10e17"><div><div><div id="container-a6d8f5fdb8"><div><div><div id="text-1022646706"><h4><strong>Flexible detector options</strong></h4><p>The Dionex Integrion HPIC system allows for easy, swappable integration with either a <strong>conductivity detector</strong> <strong>(CD)</strong> or an <strong>electrochemical detector (ED)</strong>. The system is also compatible with<strong> various external detectors</strong>, including a <strong>mass spectrometer (MS) </strong>or a<strong> variable wavelength detector (VWD).</strong></p></div></div></div></div></div></div></div></div><div><div id="container-cd507ea43e"><div><div><div id="container-3bdbc48a4f"><div><div><div id="text-1802479128"><h4><strong>CDS Software</strong></h4><p>The Dionex Integrion HPIC system comes with the easy-to-use <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific Chromeleon Chromatography Data System (CDS)</strong></a><strong>.</strong> This software platform provides powerful control and data processing for IC and offers eWorkflows that make all our essential applications easily accessible.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Dionex_Integrion_Iontovy_Chromatograf_a_ICS_4000_c7b3adbeea/Pragolab-Thermo-Dionex-Integrion-Iontovy-Chromatograf-a-ICS-4000.jpg" alt="Thermo Scientific Dionex Integrion HPIC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Dionex_Integrion_Iontovy_Chromatograf_a_ICS_4000_c7b3adbeea/thumbnail_Pragolab-Thermo-Dionex-Integrion-Iontovy-Chromatograf-a-ICS-4000.jpg 236w," sizes="100vw" width="965" height="638"></p></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific™ Dionex™ ICS-4000 Capillary HPIC™ System

Capillary HPIC system for high-resolution, reagent-free ion chromatography with 24/7 readiness, ultra-low eluent use, and versatile detection in a compact format.

<h4><strong>Always on, always ready — high-resolution capillary IC in a compact platform</strong></h4><p>The <strong>Dionex ICS-4000</strong> is the world’s first <strong>dedicated capillary high-pressure reagent-free ion chromatography (HPIC) system</strong>. Designed for high-resolution, low-flow separations, it delivers exceptional chromatographic performance, fast analysis times, and 24/7 on-demand readiness. With integrated control, capillary-optimized detectors, and minimal eluent consumption, it offers a new standard for reliable, low-maintenance ion chromatography.</p><h3><strong>Key Features and Benefits</strong></h3><h4>🧪 <strong>Capillary HPIC Performance</strong></h4><ul><li>Supports <strong>high-pressure separations</strong> with 4 µm columns</li><li><strong>Fast, high-resolution gradients</strong> in minutes</li><li>Continuous operation with <strong>no equilibration needed</strong></li></ul><h4>♻️ <strong>Reagent-Free Simplicity</strong></h4><ul><li><strong>Eluent generation</strong> from deionized water via EGC cartridge</li><li>Just <strong>15 mL of water/day</strong> for continuous operation</li><li>Eluent cartridges last up to <strong>18 months</strong></li></ul><h4>🧠 <strong>Integrated Smart Design</strong></h4><ul><li>Fully integrated system in <strong>compact footprint</strong></li><li><strong>Tilt-up lid</strong>, color-coded connections, and pre-cut tubing</li><li><strong>Vacuum degassing</strong>, seal wash (option), and inline shut-off valves</li></ul><h4>🧲 <strong>Versatile Detection Options</strong></h4><ul><li><strong>Conductivity Detector (CD)</strong> – with self-regenerating suppressor</li><li><strong>Electrochemical Detector (ED)</strong> – ideal for cyanide, amines, carbohydrates</li><li><strong>QD Charge Detector</strong> – signal proportional to ion charge and concentration</li></ul><h4>🔁 <strong>Flexible Column Chemistry</strong></h4><ul><li>Compatible with <strong>over 20 capillary columns</strong></li><li>Suitable for a wide range of inorganic and organic ions, sugars, acids, amines</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_ICS_4000_Iontovy_Chromatograf_2_64107dbdca/Thermo-Dionex-ICS-4000-Iontovy-Chromatograf-2.jpg" alt="Thermo Scientific™ Dionex™ ICS-4000 Capillary HPIC™ System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_ICS_4000_Iontovy_Chromatograf_2_64107dbdca/thumbnail_Thermo-Dionex-ICS-4000-Iontovy-Chromatograf-2.jpg 156w," sizes="100vw" width="650" height="650"></p><h3><strong>Automation and Sample Handling</strong></h3><ul><li>Compatible with <strong>Dionex AS-DV</strong> and <strong>AS-AP</strong> autosamplers</li><li>Advanced prep (dilution, derivatization, matrix removal)</li><li>Supports <strong>vials, well plates</strong>, and &lt;30 s injection cycles</li><li>Optional <strong>Sample Conductivity &amp; pH Accessory</strong> with conditional logic</li></ul><h3><strong>Software Integration</strong></h3><ul><li>Controlled by <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon™ Chromatography Data System (CDS)</strong></a></li><li>eWorkflows™ simplify analysis from injection to report</li><li>Interactive charts and MiniPlots for intuitive data interpretation</li></ul><h3><strong>Ideal for Applications in</strong></h3><ul><li>Food and beverage (e.g., sugars, organic acids, preservatives)</li><li>Environmental (e.g., drinking water, wastewater)</li><li>Pharmaceutical (e.g., excipients, counterions)</li><li>Educational and routine analytical labs</li></ul>

Thermo Scientific Dionex ICS-6000 HPIC System

The modular Thermo Scientific Dionex ICS-6000 HPIC system is a highly configurable ion chromatography (IC) system with high pressure capabilities.

<h3><strong>Dionex ICS-6000 HPIC System: Run different methods simultaneously</strong></h3><p><strong>The modular Thermo Scientific Dionex ICS-6000 HPIC system is a highly configurable ion chromatography (IC) system with high pressure capabilities. It enables you to develop and run different methods for a single sample or for different samples simultaneously. The robust design of this system enables operation at up to 5000 psi and produces consistent, reliable results. As a top-of-the-line ion chromatography system, the Dionex ICS-6000 HPIC system is designed to adapt to the needs of users and push the boundaries of what is possible in ion analysis.</strong></p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_ICS_6000_Iontovy_Chromatograf_3_cd832a923f/Thermo-Dionex-ICS-6000-Iontovy-Chromatograf-3.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_ICS_6000_Iontovy_Chromatograf_3_cd832a923f/thumbnail_Thermo-Dionex-ICS-6000-Iontovy-Chromatograf-3.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3><strong>Highlights</strong></h3><h4><strong>Flexible configurations</strong></h4><p>Dionex ICS-6000 HPIC systems<strong> come in a variety of configurations</strong>, with the ability operate <strong>as a single- or dual-channel system</strong> to run samples concurrently. This high-pressure IC system can address a full range of IC applications, from <strong>2-D IC</strong> for trace-level analysis to<strong> high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) </strong>for complex carbohydrate analysis.</p><h4><strong>Wide range of IC columns</strong></h4><p>The Dionex ICS-6000 HPIC system is compatible with<strong> 4 μm-particle-size IC columns,</strong> which are available in <strong>150 or 250 mm lengths.</strong> The 150 mm-length columns decrease run times while maintaining chromatographic resolution. The 250 mm-length columns offer improved peak resolution.</p><h4><strong>Automated Eluent Generation (EG)</strong></h4><p>For unmatched method reproducibility and accuracy, the system can electrolytically generate <strong>high-purity hydroxide, carbonate, bicarbonate, or methanesulfonic acid (MSA) eluents </strong>when provided with a source of high-purity deionized water. Using the <strong>Dual EGC mode</strong>, the Dionex ICS-6000 HPIC system can <strong>also generate potassium hydroxide/potassium methanesulfonate (KOH/KMSA) eluents </strong>for complex carbohydrate analysis.</p><figure class="image"><img style="aspect-ratio:1246/940;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ICS_6000_HPIC_System_66f622c7f9.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System: Feutin alditol oligosaccharide analysis using (a) manually prepared eluents (NaOH/NaOAc) (b) Dual EGC mode (KOH/KMSA) with 1 mm column format (c) Dual EGC mode (KOH/KMSA) with 0.4 mm column format." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ICS_6000_HPIC_System_66f622c7f9.jpg 206w," sizes="100vw" width="1246" height="940"></figure><h4><strong>Versatile detection capabilities</strong></h4><p>The system is<strong> </strong>compatible with a wide variety of detectors, including <strong>suppressed conductivity, electrochemical, UV-Vis absorbance, inductively coupled plasma mass spectrometry (ICP-MS), and mass spectrometry (MS).</strong></p><h4><strong>Mass spectrometry compatible</strong></h4><p>The Dionex ICS-6000 HPIC system is the<strong> ideal IC system to work in tandem with mass spectrometry, </strong>as it can used for a wide variety of sample analyses. From single quadrupole to high resolution accurate mass (HRAM) <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3&amp;search=Orbitrap"><strong>Thermo Scientific Orbitrap mass spectrometers</strong></a>, IC-MS analysis provides improved selectivity and higher sensitivity.</p><figure class="image"><img style="aspect-ratio:1245/682;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ICS_6000_HPIC_System_3_ecfef0173d.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System: HRAM MS/MS fragments facilitate identification of unknown compounds. IC, combined with HRAM mass spectrometry, is an ideal solution for component identification in non-targeted and unknown workflows. In this figure, identification of lithium-ion battery failure analysis products using HRAM MS/MS offers four-decimal-point accuracy to distinguish between species. The unique fragmentation signature enhances that confidence." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ICS_6000_HPIC_System_3_ecfef0173d.jpg 245w," sizes="100vw" width="1245" height="682"></figure><figure class="image"><img style="aspect-ratio:1362/727;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ICS_6000_HPIC_System_2_64749e2b9d.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System: Targeted MS/MS analysis enables quantitation of molecules in a wide variety of matrices. IC, combined with triple quadrupole mass spectrometry, is an ideal solution for resolving molecules that are often difficult to separate from a matrix using conventional liquid chromatography techniques. In this chromatogram, glyphosate in drinking water is detected at a level of 5 ng/L. The linearity of the assay allows quantitation over 3 orders of magnitude, from 5 ng/L to 1000 ng/L, enabling a wide detection range without having to dilute samples." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ICS_6000_HPIC_System_2_64749e2b9d.jpg 245w," sizes="100vw" width="1362" height="727"></figure><h4><strong>CDS Software</strong></h4><p>The Dionex ICS-6000 HPIC system comes with the<strong> easy-to-use Thermo Scientific Chromeleon Chromatography Data System (CDS)</strong>. This software provides powerful control and data processing for IC and offers eWorkflows that make all our essential applications easily accessible. Additionally,<strong> the Chromeleon CDS can control mass spectrometry systems, enabling seamless IC-MS analyses.</strong></p>

Products from category Ion chromatographs - page 1

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