KNAUER AZURA HTQC UHPLC System

The KNAUER AZURA HTQC UHPLC (1240 bar) is a high-performance UHPLC system designed for high-throughput quality control (QC) where speed, robustness, and reproducibility are essential.

The system features a unique concept of parallel analysis and offline column re-equilibration, significantly increasing productivity. With two gradient pumps, one column performs the analytical run while the second is re-equilibrated in backflush mode.

This architecture enables:

• ≥30% reduction in cycle time
• increased sample throughput
• column protection from matrix contamination
• consistent retention times

It is ideal for pharmaceutical QC laboratories requiring automation and validated workflows.

Key Features

• UHPLC system up to 1240 bar (124 MPa)
• Dual gradient pumps (HPG + LPG)
• Parallel analysis and column re-equilibration
• Backflush mode for column protection
• ≥30% faster analysis cycles
• High flow reproducibility
• Autosampler with cooling
• Column thermostat (Peltier)
• Fully automated modular system
• MS detector compatibility

System Configuration

Included components:

• Eluent tray E 2.1L
• Pump P 8.1L (HPG)
• Pump P 6.1L (LPG)
• Liquid handler LH 8.1 + Robotic Cooler
• Column thermostat CT 2.1
• Column switching & backflush valve
• Accessories and tools

Technical Specifications

Pumps

P 8.1L (HPG – analytical pump):

• Max pressure: 1240 bar
• Flow rate: up to 5 mL/min
• Adaptive pulsation compensation
• Degasser + binary solvent selection
• Low baseline noise

P 6.1L (LPG – re-equilibration):

• Quaternary gradient
• Integrated degasser
• Low dwell volume
• Inline filter

Autosampler

LH 8.1:

• XYZ autosampler
• Capacity: up to 390 samples
• Temperature: 4–40 °C
• Low carryover

Column Thermostat

CT 2.1:

• Peltier controlled
• Above and below ambient operation
• High precision

Valve System

• Column switching + backflush
• Up to 1200 bar
• Parallel column operation

Detection

• Compatible with all HPLC detectors
• Ideal for LC-MS coupling

HTQC Concept

• Independent flow paths (analysis vs re-equilibration)
• Backflush re-equilibration
• Parallel operation
• Increased throughput without compromise

Typical Applications

• Pharmaceutical QC
• Routine validated workflows
• High sample throughput environments
• Reversed-phase HPLC